Abstract: Provided is a pharmaceutical composition for enhancing the anticancer effect of cancer. More specifically, it was confirmed that when a composition including an IU1-series compound known to inhibit ubiquitin-specific protease 14 (USP14), which is a deubiquitinase, is administered in combination with and proteolysis-targeting chimera (PROTAC), the cancer prevention or treatment effect of PROTAC was significantly enhanced. Furthermore, with the pharmaceutical composition of the present disclosure, cancer can be effectively treated even when a lower dose of PROTAC is used, thereby freeing from the problems of toxicity and side effects, and improving the application limitations and problems arising from the sole use of PROTAC. Accordingly, the combinatorial treatment of PROTAC and IU1-series compound can be widely used in the field of cancer treatment.

Abstract: A monolithic metal thermal insulating sleeve liner for fluid flow devices such as valves and piping used in severe industrial applications is additively manufactured (e.g., by 3D printing) to fit the bore of a protected fluid flow device. Tessellated support structures obliquely extending between inside surfaces of inner and outer shells provide increased resistance to thermal conduction while also providing increased strength against compression forces. Example support structures include an array of four obliquely oriented elongated members mutually intersecting mid-way between the inside surfaces of inner and outer cylindrical shells. If internal interstices are sealed they can be vacuumed or pressurized to enhance thermal insulating properties. A pressure equalizing aperture can be provided on or through the sleeve if needed in some applications.

Abstract: Disclosed herein are expandable introducer sheaths and methods of making and using the same. The sheaths minimize trauma to a patient's vasculature by allowing for temporary expansion of a portion of the sheath to accommodate passage of a delivery system for an implant, then return to a non-expanded state after the passage of the device. The sheath includes a foldable inner member having a detached flap structure at its distal tip that facilitates expansion of the sheath lumen to increased diameters, and an elastomeric distal end that reduces push and retrieval forces therethrough. The sheath can include a hemostasis seal on its proximal end to prevent the leakage of blood out of the sheath and prevent ballooning of outer layer of the sheath.

Abstract: A liquid delivery system cap device is provided. In some embodiments, an example cap device includes a body defining a cavity configured to receive at least a portion of a liquid delivery device, and a sensor carriage movable within the cavity and including a first sensor. The sensor carriage may be movable between a first position and a second position relative to the cavity while the liquid delivery device is in a fixed positon relative to the cavity.

Abstract: A blockchain based system for managing credentials in batch with selective attributes disclosing/hiding capability and auditable Merkle tree are disclosed with include a SmartCert unit coupled to a blockchain ecosystem and a public key infrastructure (PKI); the SmartCert unit further includes an issuer SmartCert and SmartCert verifier interface so that the holder can select to hide optional components completely from the verifier; and the verifier can check the certificate using the auditable Merkle tree.

Abstract: Provided is an electronic device including: a housing; a camera module oriented in a first direction inside the housing; a camera window arranged in front of the camera module in the first direction; a cover including an opening into which the camera window is insertable, the cover coupled to the housing; and a window frame supporting the camera window and mounted on the cover. The window frame includes: a frame body including a support portion arranged in the opening and supporting the camera window, and a mounting portion extending from the support portion in a second direction that is perpendicular to the first direction and overlapped by the cover in the first direction; a retention member retaining a first gap between the mounting portion and the cover in the first direction; and a waterproof body configured to be elastically deformed while arranged between the mounting portion and the cover.

Abstract: A liquid delivery system cap device is provided. In some embodiments, an example cap device includes a body defining a cavity configured to receive at least a portion of a liquid delivery device, a first sensor configured to output a first sensor signal indicative of a plunger of the liquid delivery device, and a processor configured to detect a plunger of the liquid delivery device based on a variation in the sensor signal of the first sensor.

Abstract: A multi-layer printed circuit board having a first landing pad in a first layer and along a first axis arranged to receive a positive signal and a second landing pad in the first layer and along a second axis that is spaced away from the first axis longitudinally in the first layer and where the second landing pad arranged to receive a negative signal. A first buried in a second layer and along the first axis is spaced away from the first landing pad along the first axis. A second buried in the second layer and along the second axis is spaced away from the second landing pad along the second axis. A first signal connector provides a first electrical connection between the first landing pad and the second buried via and a second signal connector provides a second electrical connection between the second landing pad and the first buried via.

Abstract: A liquid delivery system cap device is provided. In some embodiments, an example cap device includes a body defining a cavity configured to receive at least a portion of a liquid delivery device, and a sensor carriage movable within the cavity and including a first sensor. The sensor carriage may be movable between a first position and a second position relative to the cavity while the liquid delivery device is in a fixed positon relative to the cavity.

Abstract: Techniques are described for providing a scaled-out transport supported by interconnected data processing units (DPUs) that operates as a single system bus connection proxy for device-to-device communications within a data center. As one example, this disclosure describes techniques for providing a Peripheral Component Interconnect Express (PCIe) proxy for device-to-device communications employing the PCIe standard. The disclosed techniques include adding PCIe proxy logic on top of a host unit of a DPU to expose a PCIe proxy model to application processors, storage devices, network interface controllers, field programmable gate arrays, or other PCIe endpoint devices. The PCIe proxy model may be implemented as a physically distributed Ethernet-based switch fabric with PCIe proxy logic at the edge and fronting the PCIe endpoint devices. The interconnected DPUs and the distributed Ethernet-based switch fabric together provide a reliable, low-latency, and scaled-out transport that operates as a PCIe proxy.

Abstract: A two-piece valve shell (body and bolted-on top bonnet) structure reduces possible leakage paths while also providing a top-side ball/stem installation/removal path (when the bonnet piece is not present) to facilitate initial valve assembly as well as subsequent inspection/removal of the ball/stem and other valve internals for conducting valve maintenance without requiring the valve body to be removed from its process connections. Internal wetted valve surfaces are coated with tantalum to provide a tantalum ball valve suitable for use as a sulfuric acid feed valve in severe high-temperature high-pressure industrial processes such as HPAL processes. Sealing cavities created by spaced-apart body-to-bonnet and/or stem-to-bonnet sealing structures can be inertly pressurized to hermetically isolate the sealing structures from ingress/leakage of corrosive process materials.

Abstract: A control system for a power generation system includes a generator coupled to a turbine via a shaft. The control system includes a memory storing instructions. The control system also includes a processor coupled to the memory and configured to execute the instructions. When the instructions are executed it causes the processor to receive a direct current (DC)-link voltage from an automatic voltage regulator (AVR), wherein the AVR is configured to control voltage characteristics of the generator, and to determine a speed of the generator based on the DC-link voltage.

Abstract: Techniques are described herein that are capable of using variable voltage sources to control respective thermoelectric coolers independently in a thermal testing environment. The variable voltage sources create temperature differentials between first and second opposing surfaces of the thermoelectric coolers by applying input voltages to the respective thermoelectric coolers. Heat is transferred, by first heat exchanger(s), between a fluid and respective subset(s) of the thermoelectric coolers Heat is transferred, by second heat exchanger(s), between semiconductor device(s) and the subset(s) of the thermoelectric coolers.

Abstract: In a method and apparatus for extreme-light image enhancement, an input image is passed to a lighting classification module in order to be classified into two categories: an under-exposed lighting condition and an over-exposed light condition. Then the classified image is subsequently passed to an enhancement module which comprises a first image enhancement unit and a second image enhancement unit using a mapping function based on a gamma mapping function for mapping the classified image to an output image, respectively. A parameter of the gamma mapping function is estimated by a parameter estimation network, based on the classified image. The parameter estimation network may be a lightweight CNN network which is trained by an unsupervised approach.

Abstract: Techniques are described for providing a scaled-out transport supported by interconnected data processing units (DPUs) that operates as a single system bus connection proxy for device-to-device communications within a data center. As one example, this disclosure describes techniques for providing a Peripheral Component Interconnect Express (PCIe) proxy for device-to-device communications employing the PCIe standard. The disclosed techniques include adding PCIe proxy logic on top of a host unit of a DPU to expose a PCIe proxy model to application processors, storage devices, network interface controllers, field programmable gate arrays, or other PCIe endpoint devices. The PCIe proxy model may be implemented as a physically distributed Ethernet-based switch fabric with PCIe proxy logic at the edge and fronting the PCIe endpoint devices. The interconnected DPUs and the distributed Ethernet-based switch fabric together provide a reliable, low-latency, and scaled-out transport that operates as a PCIe proxy.

Abstract: A multi-layer printed circuit board having a first landing pad in a first layer and along a first axis arranged to receive a positive signal and a second landing pad in the first layer and along a second axis that is spaced away from the first axis longitudinally in the first layer and where the second landing pad arranged to receive a negative signal. A first buried in a second layer and along the first axis is spaced away from the first landing pad along the first axis. A second buried in the second layer and along the second axis is spaced away from the second landing pad along the second axis. A first signal connector provides a first electrical connection between the first landing pad and the second buried via and a second signal connector provides a second electrical connection between the second landing pad and the first buried via.

Abstract: The present invention is directed to a hearing aid which includes a lateral ear canal assembly and a medial ear canal assembly. In embodiments of the invention the medial ear canal assembly may include smart circuitry adapted to control parameters and outputs of the medial ear canal assembly. In embodiments of the invention various methods and circuitry are described, wherein the methods and circuitry are adapted to improve the performance and efficiency of the hearing aid.

Abstract: A two-piece valve shell (body and bolted-on top bonnet having external fins to dissipate heat) structure reduces possible leakage paths while also providing a top-side ball/stem installation/removal path (when the bonnet piece is not present) to facilitate initial valve assembly as well as subsequent inspection/removal of the ball/stem and other valve internals for conducting valve maintenance without requiring the valve body to be removed from its process connections. In some implementations, a second/bottom bonnet is also attached to the body such that it covers another opening to the ball cavity.

Abstract: Disclosed are systems, including client devices and servers, and methods for creating a collaborative virtual session between client devices, wherein each of the client devices is associable with a coupler agent for interfacing with a communicating entity (such as a person). A client device includes a processor and memory operable to: generate a locally instantiated virtual room; instantiate a virtual representation of a first entity associated with the client device in the locally instantiated virtual room; transmit metadata representative of the first entity to a second client device; receive metadata representative of a second entity associated with the second client device; and, instantiate a virtual representation of the second entity as a function of the received metadata, from a perspective of the first entity, in the locally instantiated virtual room. A server can be utilized to join the client devices in the collaborative virtual session and exchange the metadata.

Abstract: The present invention is directed to a hearing aid which includes a lateral ear canal assembly and a medial ear canal assembly. In embodiments of the invention the medial ear canal assembly may include smart circuitry adapted to control parameters and outputs of the medial ear canal assembly. In embodiments of the invention various methods and circuitry are described, wherein the methods and circuitry are adapted to improve the performance and efficiency of the hearing aid.