Patents by Inventor THE REGENTS OF THE UNIVERSITY OF CALIF

THE REGENTS OF THE UNIVERSITY OF CALIF has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150265674
    Abstract: Methods and compositions for inhibiting entry of an anthrax toxin and/or an anthrax toxin protein into a cell are provided. Aspects of the subject methods include administering to a host an effective amount of poly-?-Glutamic acid-Fe(III) chelate. Also provided are compositions suitable for use in the subject methods, as well as pharmaceutical preparations thereof.
    Type: Application
    Filed: January 10, 2013
    Publication date: September 24, 2015
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: THE REGENTS OF THE UNIVERSITY OF CALIF
  • Publication number: 20130295619
    Abstract: A thermophilic endo-beta-1,4-xylanase derived from Acidothermus cellulolyticus is disclosed. The xylanase exhibits xylanase activity at an optimal temperature of 90° C. and an optimal pH range of about 4.5-6.0. The isolated xylanase is useful in the hydrolysis of lignocellulosic material.
    Type: Application
    Filed: October 16, 2012
    Publication date: November 7, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: THE REGENTS OF THE UNIVERSITY OF CALIF
  • Publication number: 20130150410
    Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with ion channel modulators. In these methods, the ion channel modulator compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the ion channel modulator compositions and formulations onto the auris interna target areas, or via perfusion into the auris interna structures.
    Type: Application
    Filed: February 7, 2013
    Publication date: June 13, 2013
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, OTONOMY, INC.
    Inventors: OTONOMY, INC., THE REGENTS OF THE UNIVERSITY OF CALIF
  • Publication number: 20130144155
    Abstract: NMR spectroscopy is performed on intervertebral disc tissue. Extent of degeneration is determined based on the NMR spectroscopy. Correlation between NMR spectral regions and at least one of tissue degeneration and pain are made. Accordingly, NMR spectroscopy is used to determine location and/or extent of at least one of degeneration or pain associated with a region of tissue, such as for example in particular disc degeneration, or discogenic pain. NMR spectral peak ratios, such as between N-Acetyl/cho and cho/carb, are readily acquired and analyzed to predict degree of tissue degeneration and/or pain for: tissue samples using HR-MAS spectroscopy; and larger portions of anatomy such as joint segments such as a spine, using clinical 3T MRI systems with surface head or knee coils; and tissue regions such as discs within spines of living patients using 3T MRI systems with a surface spine coil, thus providing a completely non-invasive diagnostic toolset and method to image and localize degeneration and/or pain.
    Type: Application
    Filed: November 19, 2012
    Publication date: June 6, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: THE REGENTS OF THE UNIVERSITY OF CALIF
  • Publication number: 20130143916
    Abstract: A method for producing libraries of structurally and stereochemically diverse molecules that can be screened for biological or chemical activity. A library of 91 heterocyclic compounds composed of 16 distinct scaffolds was synthesized through a sequence of phosphine-catalyzed ring-forming reactions, Tebbe reactions, Diels-Alder reactions, and, in some cases, hydrolysis to illustrate the methods. Three compounds inhibiting migration of human breast cancer cells are identified from the library.
    Type: Application
    Filed: November 9, 2012
    Publication date: June 6, 2013
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: THE REGENTS OF THE UNIVERSITY OF CALIF, Gabriel Fenteany
  • Publication number: 20130137104
    Abstract: Nucleases and methods of using these nucleases for modification of an HPRT locus and for increasing the frequency of gene modification at a targeted locus and clones and for generating animals.
    Type: Application
    Filed: October 25, 2012
    Publication date: May 30, 2013
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, SANGAMO BIOSCIENCES, INC.
    Inventors: SANGAMO BIOSCIENCES, INC., THE REGENTS OF THE UNIVERSITY OF CALIF
  • Publication number: 20130129687
    Abstract: Method for reprogramming differentiated cells into lineage restricted progenitor cells is provided. The method may include contacting differentiated cells with inhibitors of tyrosine phosphatases and apoptosis to de-differentiate differentiated cells into lineage restricted progenitor cells.
    Type: Application
    Filed: October 16, 2012
    Publication date: May 23, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: THE REGENTS OF THE UNIVERSITY OF CALIF
  • Publication number: 20130123141
    Abstract: The present invention provides compositions including peptide display scaffolds that present at least one candidate peptide and at least one detectable moiety in at least one of the N-terminal and C-terminal candidate peptide presenting domains that when expressed in a cell are accessible at a surface of the cell outermembrane. In addition, the present invention also provides kits and methods for screening a library of cells presenting the candidate peptides in peptide display scaffolds to identify a ligand for an enzyme.
    Type: Application
    Filed: September 28, 2012
    Publication date: May 16, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: THE REGENTS OF THE UNIVERSITY OF CALIF
  • Publication number: 20130123587
    Abstract: A handheld, conforming capacitive sensing apparatus configured to measure Sub-Epidermal Moisture (SEM) as a mean to detect and monitor the formation of pressure ulcers. The device incorporates an array of electrodes which are excited to measure and scan SEM in a programmable and multiplexed manner by a battery-less RF-powered chip. The scanning operation is initiated by an interrogator which excites a coil embedded in the apparatus and provides the needed energy burst to support the scanning/reading operation. Each electrode measures the equivalent sub-epidermal capacitance corresponding and representing the moisture content.
    Type: Application
    Filed: November 2, 2012
    Publication date: May 16, 2013
    Applicants: BRUIN BIOMETRICS, LLC, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: THE REGENTS OF THE UNIVERSITY OF CALIF, BRUIN BIOMETRICS, LLC
  • Publication number: 20130102880
    Abstract: A method for photomagnetic imaging of tissue includes the steps of heating the tissue using light; measuring a change in temperature of the tissue with magnetic resonance thermometry; and creating an optical property map from the measured change in temperature. An apparatus for performing photomagnetic imaging of tissue which includes a light source to heat the tissue, a magnetic resonance imaging system to measure a change in temperature of the tissue, and a data processor to generate an optical property map from the measured change in temperature. An optical property map of tissue photomagnetic imaging of tissue produced by: heating the tissue using light; measuring a change in temperature of the tissue with magnetic resonance thermometry; and creating an optical property map from the measured change in temperature.
    Type: Application
    Filed: October 17, 2012
    Publication date: April 25, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: THE REGENTS OF THE UNIVERSITY OF CALIF
  • Publication number: 20130087766
    Abstract: A quantum bit computing architecture includes a plurality of single spin memory donor atoms embedded in a semiconductor layer, a plurality of quantum dots arranged with the semiconductor layer and aligned with the donor atoms, wherein a first voltage applied across at least one pair of the aligned quantum dot and donor atom controls a donor-quantum dot coupling. A method of performing quantum computing in a scalable architecture quantum computing apparatus includes arranging a pattern of single spin memory donor atoms in a semiconductor layer, forming a plurality of quantum dots arranged with the semiconductor layer and aligned with the donor atoms, applying a first voltage across at least one aligned pair of a quantum dot and donor atom to control a donor-quantum dot coupling, and applying a second voltage between one or more quantum dots to control a Heisenberg exchange J coupling between quantum dots and to cause transport of a single spin polarized electron between quantum dots.
    Type: Application
    Filed: October 4, 2012
    Publication date: April 11, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: THE REGENTS OF THE UNIVERSITY OF CALIF
  • Publication number: 20130070094
    Abstract: Automatic registration of projectors and their images on a curved surface may be performed using non-linear optimization techniques. A camera may capture images on the curved surface. The camera may be un-calibrated. The camera parameters may be estimated using a non-linear optimization of data in the images of the curved surface. The images may be from multiple projectors. In some embodiments, registration may be view independent.
    Type: Application
    Filed: September 20, 2012
    Publication date: March 21, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION
    Inventor: THE REGENTS OF THE UNIVERSITY OF CALIF
  • Publication number: 20130057857
    Abstract: An optical nanoantenna ground plane apparatus and method which enhances electric field intensity, surface-enhanced Raman spectroscopy (scattering). A dielectric spacer layer is disposed between a nanoantenna layer and a metallic ground plane layer. Thickness of the dielectric spacer layer is determined in response to matching metal loss resistance and radiation resistance of the optical nanoantenna layer for a given optical antenna configuration and operating wavelength, such as in response to finite difference time domain (FDTD) simulations which determine dielectric spacer layer thickness when radiation quality factor and absorption quality factor are equal. The inventive ground plane can be implemented for a wide range of optical applications regardless of whether fabrication of the nanoantenna-groundplane combination is fabricated in a top-down or bottom-up sequence.
    Type: Application
    Filed: October 22, 2012
    Publication date: March 7, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: THE REGENTS OF THE UNIVERSITY OF CALIF
  • Publication number: 20130045950
    Abstract: The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
    Type: Application
    Filed: October 4, 2012
    Publication date: February 21, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: THE REGENTS OF THE UNIVERSITY OF CALIF
  • Publication number: 20130020602
    Abstract: A transparent light emitting diode (LED) includes a plurality of III-nitride layers, including an active region that emits light, wherein all of the layers except for the active region are transparent for an emission wavelength of the light, such that the light is extracted effectively through all of the layers and in multiple directions through the layers. Moreover, the surface of one or more of the III-nitride layers may be roughened, textured, patterned or shaped to enhance light extraction.
    Type: Application
    Filed: September 19, 2012
    Publication date: January 24, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: THE REGENTS OF THE UNIVERSITY OF CALIF