Abstract: A composition comprising, a polymeric crystalline structure having lamellae and/or multilamellar structures and being devoid of trace of amorphous material, detectable by Scanning Electron Microscopy (SEM) with a magnification of ×2,300 at working distance of 10 mm and acceleration voltage of 15 kV.

Abstract: The invention provides a diagnostic composition for detecting both aspiration and gastroesophageal reflux comprising bio-degradable microspheres having a diameter of about 0.1-10 microns.

Abstract: A formulation effective in reducing the pH in a menstruating vagina or in a tampon inserted therein to below pH 5.5, comprising (a) 3-100% by weight of glycolide; (b) optionally 97-15% by weight of a solid organic acid; and (c) optionally 5-30% of a wetting agent. Also disclosed is a catamenial tampon for insertion in a human vagina which comprises the pH reducing formulation.

Abstract: The present invention relates to novel bioabsorbable polymeric compositions based upon AB polyester polyether or related diblocks and triblocks. Compositions according to the present invention may be used in medical applications, for example, for reducing or preventing adhesion formation subsequent to medical procedures such as surgery, for producing surgical articles including stents and grafts, as coatings, sealants, lubricants, as transient barriers in the body, for materials which control the release of bioactive agents in the body, for wound and burn dressings and producing biodegradable articles, among numerous others.

Abstract: A formulation effective in reducing the pH in a menstruating vagina or in a tampon inserted therein to below pH 5.5, comprising (a) 3–80% by weight of a solid organic acid polymer; (b) 92–15% by weight of a solid organic acid; and (c) 5–30% of a wetting agent. Also disclosed is a delivery system for releasing an active agent comprising: (a) a deposition comprising the active agent; and (b) a polymeric support on which the deposition is deposited. The delivery system is especially useful in a catamenial tampon for insertion in a human vagina which comprises (a) an inner core comprising an absorbent material; (b) an outer layer comprising a liquid permeable material; and (c) the delivery system.

Abstract: A transvaginal drug delivery system comprising: (a) a deposition comprising an effective amount of said drug and, optionally, a wetting agent; and (b) a polymeric support on which said deposition is deposited. Also disclosed is a catamenial tampon for insertion in a human vagina comprising: (a) an inner core comprising an absorbent material; (b) an outer layer comprising a liquid-permeable material; and (c) a delivery system according to the invention. A method of transvaginal drug delivery is also described.

Abstract: The invention provides a diagnostic composition for detecting both aspiration and gastroesophageal reflux comprising bio-degradable microspheres having a diameter of about 0.1-10 microns.

Abstract: A formulation effective in reducing the pH in a menstruating vagina or in a tampon inserted therein to below pH 5.5, comprising (a) 3-100% by weight of glycolide; (b) optionally 97-15% by weight of a solid organic acid; and (c) optionally 5-30% of a wetting agent. Also disclosed is a catamenial tampon for insertion in a human vagina which comprises the pH reducing formulation.

Abstract: A formulation effective in reducing the pH in a menstruating vagina or in a tampon inserted therein to below pH 5.5, comprising (a) 3-80% by weight of a solid organic acid polymer; (b) 92-15% by weight of a solid organic acid, and (c) 5-30% of a wetting agent. Also disclosed is a delivery system for releasing an active agent comprising: (a) a deposition comprising the active agent; and (b) a polymeric support on which the deposition is deposited. The delivery system is especially useful in a catamenial tampon for insertion in a human vagina which comprises (a) an inner core comprising an absorbent material; (b) an outer layer comprising a liquid permeable material; and (c) the delivery system.

Abstract: A formulation effective in reducing the pH in a menstruating vagina or in a tampon inserted therein to below pH 5.5, comprising (a) 3-80% by weight of a solid organic acid polymer; (b) 92-15% by weight of a solid organic acid; and (c) 5-30% of a wetting agent. Also disclosed is a delivery system for releasing an active agent comprising: (a) a deposition comprising the active agent; and (b) a polymeric support on which the deposition is deposited. The delivery system is especially useful in a catamenial tampon for insertion in a human vagina which comprises (a) an inner core comprising an absorbent material; (b) an outer layer comprising a liquid permeable material; and (c) the delivery system.

Abstract: A transvaginal drug delivery system comprising: (a) a deposition comprising an effective amount of said drug and, optionally, a wetting agent; and (b) a polymeric support on which said deposition is deposited. Also disclosed is a catamenial tampon for insertion in a human vagina comprising: (a) an inner core comprising an absorbent material; (b) an outer layer comprising a liquid-permeable material; and (c) a delivery system according to the invention. A method of transvaginal drug delivery is also described.

Abstract: A formulation effective in reducing the pH in a menstruating vagina or in a tampon inserted therein to below pH 5.5, comprising (a) 3-80% by weight of a solid organic acid polymer; (b) 92-15% by weight of a solid organic acid, and (c) 5-30% of a wetting agent. Also disclosed is a delivery system for releasing an active agent comprising: (a) a deposition comprising the active agent; and (b) a polymeric support on which the deposition is deposited, The delivery system is especially useful in a catamenial tampon for insertion in a human vagina which comprises (a) an inner core comprising an absorbent material; (b) an outer layer comprising a liquid permeable material; and (c) the delivery system.

Abstract: The present invention relates to novel bioabsorbable polymeric compositions based upon AB polyester polyether or related diblocks and triblocks. Compositions according to the present invention may be used in medical applications, for example, for reducing or preventing adhesion formation subsequent to medical procedures such as surgery, for producing surgical articles including stents and grafts, as coatings, sealants, lubricants, as transient barriers in the body, for materials which control the release of bioactive agents in the body, for wound and bum dressings and producing biodegradable articles, among numerous others.

Abstract: The present invention relates to novel bioabsorbable polymeric compositions based upon AB polyester polyether or related diblocks and triblocks. Compositions according to the present invention may be used in medical applications, for example, for reducing or preventing adhesion formation subsequent to medical procedures such as surgery, for producing surgical articles including stents and grafts, as coatings, sealants, lubricants, as transient barriers in the body, for materials which control the release of bioactive agents in the body, for wound and bum dressings and producing biodegradable articles, among numerous others.