Publication number: 20160152599
Abstract: Compounds of formula (I): wherein Ra, Rb, Rc, Rd, R3, R4, R5, A1, A2, T and W are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
Type:
Application
Filed:
July 22, 2014
Publication date:
June 2, 2016
Applicants:
Les Laboratoires Servier, Vernails (R&D) Limited
Inventors:
Patrick CASARA, Thierry LE DIGUARHER, Jean-Michel HENLIN, Jéröme-Benoit STARCK, Arnaud LE TIRAN, Guillaume DE NANTEUIL, Olivier GENESTE, James Edward Paul DAVIDSON, James Brooke MURRAY, I-Jen CHEN, Claire WALMSLEY, Christopher John GRAHAM, Stuart RAY, Daniel MADDOX, Simon BEDFORD
Patent number: 6638962
Abstract: Compound of formula (I):
wherein:
X represents a bond or alkylene, CO, S(O)n, —S(O)n—A1—, —CO—A1—, —A—S(O)n—A′1— or —A1—CO—A′1—,
Y represents aryl, heteroaryl, cycloalkyl or heterocycloalkyl, each unsubstituted or substituted,
R1, R2, R3 and R4 each independently of the others represent hydrogen or aryl, heteroaryl, cycloalkyl or heterocycloalkyl, each unsubstituted or substituted,
or R1, R2, R3 and R4, taken in pairs, together form a bond, or form a fused benzene ring or a fused aromatic or partially unsaturated heterocycle,
T represents —CH(R5)—, —N(R5)— or —N(R5)CO—,
V represents hydrogen or unsubstituted or substituted aryl or heteroaryl,
A2 represents [C(R6)(R′6)]p,
R7 and R8 are as defined in the description,
their isomers and addition salts thereof with a pharmaceutically acceptable acid or base and medicinal products containing t
Type:
Grant
Filed:
January 16, 2002
Date of Patent:
October 28, 2003
Assignee:
Les Laboratoires Servier
Inventors:
Patrick Casara, Thierry Le Diguarher, Gilbert Dorey, John Hickman, Alain Pierre, Gordon Tucker, Nicolas Guilbaud
Patent number: 6605604
Abstract: The invention concerns a compound of formula (I) wherein: n is equal to 0 or 1; R1, R2, R3, R4 represent a hydrogen or an alkyl group, or R1 and R3 together form a cycloalkyl group; R5 represents a hydrogen, an alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, hetereoalkylalkyl, hetereocycloalkyl, hetereocycloalkylalkyl group (all optionally substituted), or a —CO—R6 group; and R6 represents R7 or OR7 or NR7R8, with R7 representing an aryl, arylalkyl, heteroaryl or heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl group (all optionally substituted), and R8 representing an alkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl (all optionally substituted); or R5 and R6 form with the nitrogen atom and the Z group bearing them a saturated monocyclic, bicyclic or tricyclic group, partially unsaturated or unsaturated, with 5 to 16 chain links containing 1 to 7 heteroatoms and optionally substituted; R10 represents a hydrogen atom or a hydroxy group, and in the latter case R1, R2, R
Type:
Grant
Filed:
December 26, 2000
Date of Patent:
August 12, 2003
Assignee:
Les Laboratoires Servier
Inventors:
Patrick Casara, Anne Marie Chollet, Thierry Le Diguarher, Ghanem Atassi, Jacqueline Bonnet, Alain Pierre, Massimo Sabatini, Gordon Tucker, Nicolas Guilbaud
