Abstract: A prefilled syringe and a method of filling a syringe with a pegfilgrastim solution to provide a target extracted volume of pegfilgrastim solution from the syringe are described. A method includes selecting the target extracted volume of pegfilgrastim solution, determining an estimated drug transfer loss, determining an estimated syringe dead volume, filling the syringe with a volume of pegfilgrastim solution comprising at least the target extracted volume plus the estimated drug transfer loss plus the estimated syringe dead volume.

Abstract: A tip for dispensing liquid for mounting on a container. A valve includes at least two elements that are mobile in relation to one another, each mobile element including a bearing zone against the other mobile element. One of the mobile elements bears anti-microbial material on or in the immediate proximity of a part of its bearing zone forming a blocking barrier and all surfaces of the dispensing tip in contact with the inside are free of anti-microbial material.

Abstract: The syringe comprises a body containing the liquid and having fitted thereto an endpiece for fastening a needle carrier. The safety device comprises a protective sheath and a syringe support that is received inside the sheath. The sheath and the support are axially movable relative to each other between two positions, namely an uncovered position of the needle, and a retracted position of said needle. The support includes anti-rotation means for constraining it in rotation about its axis and comprising at least one pawl urged resiliently into a position in which the pawl is designed to co-operate with complementary anti-rotation means of the fastener endpiece. The sheath and the support include complementary anti-rotation means for constraining them in rotation relative to each other about their axes and activated at least when the sheath and the support are in their uncovered position of the needle.

Abstract: A tip for dispensing liquid for mounting on a container. A valve includes at least two elements that are mobile in relation to one another, each mobile element including a bearing zone against the other mobile element. One of the mobile elements bears anti-microbial material on or in the immediate proximity of a part of its bearing zone forming a blocking barrier and all surfaces of the dispensing tip in contact with the inside are free of anti-microbial material.

Abstract: A tip for dispensing liquid for mounting on a container. A valve includes at least two elements that are mobile in relation to one another, each mobile element including a bearing zone against the other mobile element. One of the mobile elements bears anti-microbial material on or in the immediate proximity of a part of its bearing zone forming a blocking barrier and all surfaces of the dispensing tip in contact with the inside are free of anti-microbial material.

Abstract: A tip for dispensing liquid for mounting on a container. A valve includes at least two elements that are mobile in relation to one another, each mobile element including a bearing zone against the other mobile element. One of the mobile elements bears anti-microbial material on or in the immediate proximity of a part of its bearing zone forming a blocking barrier and all surfaces of the dispensing tip in contact with the inside are free of anti-microbial material.

Abstract: A tip for dispensing liquid for mounting on a container. A valve includes at least two elements that are mobile in relation to one another, each mobile element including a bearing zone against the other mobile element. One of the mobile elements bears anti-microbial material on or in the immediate proximity of a part of its bearing zone forming a blocking barrier and all surfaces of the dispensing tip in contact with the inside are free of anti-microbial material.

Abstract: A syringe assembly including a syringe and a safety device, the syringe including a barrel of tubular shape, the safety device including a member of tubular shape referred to as a syringe support in which the barrel is arranged such that the syringe support and the barrel are secured on the same axis. The syringe barrel has a flange at a proximal end that is prevented from moving in translation between a peripheral bearing seat and an abutment of the support. Interposed between the seat and the flange, the assembly includes at least one compression pad between the seat and the flange and made of a material presenting a coefficient of friction relative to at least one of the materials of the flange and of the seat that is greater than the coefficient of friction of the materials of the flange and of the seat relative to each other.

Abstract: An injection device which is configured to be pre-filled, including a vessel for storing the liquid, having two opposing ends, each provided with an opening, referred to as proximal end and distal end, and arranged to receive a sliding piston in order to exert pressure on the liquid. The vessel includes a wall including at least two vertically adjacent layers, each including vertically adjacent plastic material, the first and second layers having different gas permeability.

Abstract: A device for dispensing liquid including a liquid reservoir which can be deformed so as to dispense liquid by pressing on the reservoir, a liquid-dispensing end piece fitted on the reservoir, a channel for the passage of liquid, a channel for the passage of air from the outside to the inside of the reservoir, the channel for the passage of air being closed off by a member made of an air-permeable polymeric material, this material being non-porous, the member being called the air-permeable member.

Abstract: A syringe assembly including a syringe and a safety device, the syringe including a barrel of tubular shape, the safety device including a member of tubular shape referred to as a syringe support in which the barrel is arranged such that the syringe support and the barrel are secured on the same axis. The syringe barrel has a flange at a proximal end that is prevented from moving in translation between a peripheral bearing seat and an abutment of the support. Interposed between the seat and the flange, the assembly includes at least one compression pad between the seat and the flange and made of a material presenting a coefficient of friction relative to at least one of the materials of the flange and of the seat that is greater than the coefficient of friction of the materials of the flange and of the seat relative to each other.

Abstract: A tip for dispensing liquid for mounting on a container. A valve includes at least two elements that are mobile in relation to one another, each mobile element including a bearing zone against the other mobile element. One of the mobile elements bears anti-microbial material on or in the immediate proximity of a part of its bearing zone forming a blocking barrier and all surfaces of the dispensing tip in contact with the inside are free of anti-microbial material.

Abstract: The invention concerns a device for injecting a solid medicine (10) comprising a body (2) inside which moves along a general forward moving axis (X-X) a bevelled (34) needle (4) wherein is introduced the medicine (10), said injection device (1) further comprising retaining means for preventing the medicine from falling (10) prior to being injected. The invention is characterized in that the medicine (10) is retained through an elastic deformation imparted to the needle (4) by the retaining means or by an elastic deformation of the retaining means themselves, or still by the combined flexibility of those two means.

Abstract: The invention relates to a safety device (1) for a syringe (2), the device comprising a protective sheath (20) in which the syringe (2) can slide, said sheath (20) presenting an opening (36) at a distal portion (33), which opening is suitable for allowing the syringe (2) to project beyond the sheath (20). According to the invention, the sheath (20) presents radial resilience at its distal portion (33) suitable for enabling the sheath (20) to receive a cylinder (3, 19) of diameter greater than that of said opening (36).

Abstract: A device for dispensing liquid including a liquid reservoir which can be deformed so as to dispense liquid by pressing on the reservoir,a liquid-dispensing end piece fitted on the reservoir, a channel for the passage of liquid, a channel for the passage of air from the outside to the inside of the reservoir, the channel for the passage of air being closed off by a member made of an air-permeable polymeric material, this material being non-porous, the member being called the air-permeable member.

Abstract: The invention relates to a device which is used to inject an implant (6) into tissues (50). The inventive device is characterized in that it comprises: a main hollow body (2; 2?) having a hollow needle (4; 4?) fixed thereto, into which the implant (6) is introduced; a secondary body (26; 26?) which is disposed coaxially inside the main body (2; 2?) and which surrounds the needle (4; 4?); and a plunger rod (36; 36?) which can slide coaxially inside the hollow needle (4; 4?).

Abstract: The invention concerns a device for back injecting an implant (30) into the skin (22) of a subject, said device (1) include a hollow main body (10), to which a hollow needle (28) is fixed into which the implant (30) is introduced, a secondary body (12; 114) coaxially arranged inside the main body (10) and surrounding the needle (28) and a piston rod (88) able to slide coaxially inside said hollow needle (28) and whose position relative to said needle (28) remains unchanged when the back injection device (1) is pressed against the subject's skin (22) to allow the needle (28) to penetrate said subject's skin and when the secondary body (12) retracts inside the main body (10), the piston rod (88) penetrating the interior of the hollow needle (28) to hold the implant (30) at the required depth in the subject's skin (22) during withdrawal of the hollow needle (28) from the subject's skin (22), during which the secondary body (12; 114) exits the main body (10), characterized in that it includes means for the elasti

Abstract: The assembly comprises a body forming a reservoir for the liquid, the body being provided with a liquid-injection needle, a plunger mounted to be axially movable in the body between a ready position and an end-of-injection position, and a sheath in which the body is mounted to be axially movable between an active position in which the needle projects from a distal end of the sheath, and a protecting position in which the needle is retracted inside the sheath. The assembly also comprises means for axially securing the plunger and the sheath in a relative position of said plunger and said sheath serving firstly to position the body in its protecting position relative to the sheath and secondly to position the plunger in its end-of-injection position relative to the body.

Abstract: The invention concerns a device for injecting a solid medicine (10) comprising a body (2) inside which moves along a general forward moving axis (X-X) a bevelled (34) needle (4) wherein is introduced the medicine (10), said injection device (1) further comprising retaining means for preventing the medicine from falling (10) prior to being injected. The invention is characterized in that the medicine (10) is retained through an elastic deformation imparted to the needle (4) by the retaining means or by an elastic deformation of the retaining means themselves, or still by the combined flexibility of those two means.

Abstract: The invention relates to a device which is used to inject an implant (6) into tissues (50). The inventive device is characterized in that it comprises : a main hollow body (2; 2?) having a hollow needle (4; 4?) fixed thereto, into which the implant (6) is introduced; a secondary body (26; 26?) which is disposed coaxially inside the main body (2; 2?) and which surrounds the needle (4; 4?); and a plunger rod (36; 36?) which can slide coaxially inside the hollow needle (4; 4?).