Abstract: A wakeboat creates a wake, the performance level of the wake varying depending upon the mass of the wakeboat, the wakeboat including a hull; an engine supported by the hull; a controller supported by the hull; a processor coupled to the controller; a memory coupled to the processor; a sensor configured to measure at least one parameter of the wakeboat, the controller being coupled to the sensor and being configured to receive data from the sensor, the controller being configured to derive the present mass of the wakeboat from said sensor data, the controller being configured to determine the present wake performance level of the wakeboat based on the present mass of the wakeboat; and a tablet computer coupled to the controller, the controller being configured to use the tablet computer to indicate the present wake performance level of the wakeboat.

Abstract: In various embodiments, a stylization subsystem automatically modifies a three-dimensional (3D) object design. In operation, the stylization subsystem generates a simplified quad mesh based on an input triangle mesh that represents the 3D object design, a preferred orientation associated with at least a portion of the input triangle mesh, and mesh complexity constraint(s). The stylization subsystem then converts the simplified quad mesh to a simplified T-spline. Subsequently, the stylization subsystem creases one or more of edges included in the simplified T-spline to generate a stylized T-spline. Notably, the stylized T-spline represents a stylized design that is more convergent with the preferred orientation(s) than the 3D object design. Advantageously, relative to prior art approaches, the stylization subsystem can more efficiently modify the 3D object design to improve overall aesthetics and manufacturability.

Abstract: Devices and methods may allow for the removal of material from a remote location in the vasculature. In an example of such a remote location, the device may be used in the vasculature of a lower extremity in combination with an external cuff. The external cuff may create a dam preventing material from flowing throughout the body. With the external cuff in place, the device of the present disclosure may be utilized to suction the material from the vasculature while rotating the catheter to assist in the removal of the material.

Abstract: Systems and methods are provided herein for improved short range object detection in LiDAR systems. The associated systems may include a first portion and a second portion configured to rotate relative to one another. The system may also include a first magnet located on the second portion and arranged with a north pole of the first magnet facing a first direction. The system may also include a second magnet located on the second portion and arranged with a south pole of the second magnet facing the first direction. The system may also include a first sensor located on the first portion, wherein the first sensor is further configured to measure a first magnetic field of the first magnet and a second magnetic field of the second magnet as the first portion and second portion rotate relative to one another.

Abstract: In one aspect, a light module is disclosed, which includes a housing providing a hollow chamber extending from a proximal end to a distal end, and a lens positioned in the hollow chamber, where the lens has a lens body comprising an input surface for receiving light from a light source and an output surface through which light exits the lens body, said lens further comprising a collar at least partially encircling said lens body. The light module further includes at least one shoulder on which the lens collar can be seated for positioning the lens within the housing. A light source, e.g., an LED, is coupled to the hollow chamber, e.g., at its proximal end, for providing light to the lens. In some embodiments, an optical window is disposed in the hollow chamber and is optically coupled to the output surface of the lens such that the light exiting the lens passes through the optical window before exiting the light module. In some embodiments, the shoulder can be formed as part of the housing.

Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

Abstract: A vehicle sensing system may include a housing for containing sensor electronics, the housing having at least one window being aligned with at least one of the sensor electronics within the housing, a fan arranged on the housing and configured to provide airflow through the housing, and a conditioning element having a plurality of fins forming configured to receive the airflow from the fan to cool the sensor electronics and to direct warmed air from the fins onto the window to provide the warmed air to the window.

Abstract: Neutron shielding. The neutron shielding comprises a plurality of absorption layers (201, 203), and at least one moderating layer (202). The plurality of absorption layers each comprise tungsten boride or tungsten carbide. The at least one moderating layer comprises a metal hydride. Each moderating layer is between at least two absorption layers.

Abstract: A system and method that guides a user to record initial and final walkthrough videos, along with audio, of their rental property is disclosed. The embodiments also provide a system that can scan a lease for the rental property, as well as audio from a user's narration of the video, and extract and tag particular features of the video for efficient querying at a later time. The system can interpret portions of the lease that are relevant to particular items or components in the apartment (for example, major appliances) and guide the user to perform a comprehensive inspection of the items mentioned in the lease.

Abstract: In one aspect, a handheld lighting system is disclosed, which comprises a handheld housing extending from a proximal end to a distal end, and a light module disposed at least partially in the housing. The handheld lighting system further includes a removable and replaceable power module that is coupled to the housing (e.g., it is at least partially disposed within the housing) and is electrically coupled to the light module, e.g., through a pair of electrical leads, for providing electrical power thereto. Light intensity from the light module may be controlled from a knob on the power module. Various adapters can allow the lighting system to attach to a multitude of medical, industrial, dental or veterinary endoscopes or other instruments.

Abstract: Devices and methods may allow for the removal of material from a remote location in the vasculature. In an example of such a remote location, the device may be used in the vasculature of a lower extremity in combination with an external cuff. The external cuff may create a dam preventing material from flowing throughout the body. With the external cuff in place, the device of the present disclosure may be utilized to suction the material from the vasculature while rotating the catheter to assist in the removal of the material.

Abstract: In one aspect, a light module is disclosed, which includes a housing providing a hollow chamber extending from a proximal end to a distal end, and a lens positioned in the hollow chamber, where the lens has a lens body comprising an input surface for receiving light from a light source and an output surface through which light exits the lens body, said lens further comprising a collar at least partially encircling said lens body. The light module further includes at least one shoulder on which the lens collar can be seated for positioning the lens within the housing. A light source, e.g., an LED, is coupled to the hollow chamber, e.g., at its proximal end, for providing light to the lens.

Abstract: Devices and methods may allow for the removal of material from a remote location in the vasculature. In an example of such a remote location, the device may be used in the vasculature of a lower extremity in combination with an external cuff. The external cuff may create a dam preventing material from flowing throughout the body. With the external cuff in place, the device of the present disclosure may be utilized to suction the material from the vasculature while rotating the catheter to assist in the removal of the material.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, to share information in a community of robots and users to perform tasks. In one aspect, a method includes registering a plurality of robots in a system including creating for each robot a robot profile; publishing the robot profile; collecting operational data related to performance of tasks, the operational data including situational awareness information from at least a first of the plurality of registered robots; evaluating the collected operational data including performing statistical analysis, modeling, and extrapolation using the collected operational data; and in response to a request to transfer relevant data to at least a second of the plurality of registered robots, determining relevant data from the evaluated collected operational data, the relevant data including at least a portion of the situational awareness information; and sending the relevant data to at least the second registered robot.

Abstract: Devices and methods may allow for the removal of material from a remote location in the vasculature. In an example of such a remote location, the device may be used in the vasculature of a lower extremity in combination with an external cuff. The external cuff may create a dam preventing material from flowing throughout the body. With the external cuff in place, the device of the present disclosure may be utilized to suction the material from the vasculature while rotating the catheter to assist in the removal of the material.

Abstract: In various embodiments, a stylization subsystem automatically modifies a three-dimensional (3D) object design. In operation, the stylization subsystem generates a simplified quad mesh based on an input triangle mesh that represents the 3D object design, a preferred orientation associated with at least a portion of the input triangle mesh, and mesh complexity constraint(s). The stylization subsystem then converts the simplified quad mesh to a simplified T-spline. Subsequently, the stylization subsystem creases one or more of edges included in the simplified T-spline to generate a stylized T-spline. Notably, the stylized T-spline represents a stylized design that is more convergent with the preferred orientation(s) than the 3D object design. Advantageously, relative to prior art approaches, the stylization subsystem can more efficiently modify the 3D object design to improve overall aesthetics and manufacturability.

Abstract: The present invention relates to methods for modulating endosomal GPCR signaling. In particular, the present invention relates to use of polymeric nanoparticles for the targeted delivery of hydrophobic modulators of endosomal GPCRs and their use in the treatment of associated diseases and disorder.

Abstract: In various embodiments, a stylization subsystem automatically modifies a three-dimensional (3D) object design. In operation, the stylization subsystem generates a simplified quad mesh based on an input triangle mesh that represents the 3D object design, a preferred orientation associated with at least a portion of the input triangle mesh, and mesh complexity constraint(s). The stylization subsystem then converts the simplified quad mesh to a simplified T-spline. Subsequently, the stylization subsystem creases one or more of edges included in the simplified T-spline to generate a stylized T-spline. Notably, the stylized T-spline represents a stylized design that is more convergent with the preferred orientation(s) than the 3D object design. Advantageously, relative to prior art approaches, the stylization subsystem can more efficiently modify the 3D object design to improve overall aesthetics and manufacturability.

Abstract: An automatic card shuffler to shuffle eight decks of cards (or less) and deal a round of Baccarat. The automatic shuffler comprises two pre-shuffle bins, each receiving approximately four decks of cards wherein the pre-shuffle bins are spaced apart from one another with card slides directing to a card-receiving area. Cards are randomly selected from the cards in each of the pre-shuffle bins and propelled onto the card slides directing the cards to the card-receiving area. Once a sufficient number of buffer cards (e.g., seven) have been deposited into the card-receiving area, a card flipper moves the seven cards against a face plate of an integral dealing shoe. A buffer-holder member maintains the buffer cards against the face plate for dealing as the card flipper returns to a home position to receive more shuffled cards while buffer cards are being dealt in a round of Baccarat.

Abstract: In one aspect, a handheld lighting system is disclosed, which comprises a handheld housing extending from a proximal end to a distal end, and a light module disposed at least partially in the housing. The handheld lighting system further includes a removable and replaceable power module that is coupled to the housing (e.g., it is at least partially disposed within the housing) and is electrically coupled to the light module, e.g., through a pair of electrical leads, for providing electrical power thereto. Light intensity from the light module may be controlled from a knob on the power module. Various adapters can allow the lighting system to attach to a multitude of medical, industrial, dental or veterinary endoscopes or other instruments.