Patents by Inventor Thomas B. Tomasi

Thomas B. Tomasi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for regulating the expression of MHC antigens and CD40 by inhibitors of histone deacetylation
    Patent number: 6518012
    Abstract: The present invention discloses compositions and methods for enhancing the expression of major histocompatability complex (MHC) and costimulatory antigens on tumor cells. The method comprises exposing the tumor cells to inhibitors of histone deacetylation.
    Type: Grant
    Filed: March 31, 2000
    Date of Patent: February 11, 2003
    Assignee: Health Research, Inc.
    Inventor: Thomas B. Tomasi
  • PEG-modified antibody with reduced affinity for cell surface Fc receptors
    Patent number: 4732863
    Abstract: PEG-modified protein molecules characterized by reduced immunogenicity are prepared by covalent modification of the protein with PEG employing an active ester intermediate. Antibodies so modified exhibit decreased binding capacity for Fc cell surface receptors, are non-toxic and retain full antigen binding activity, and are consequently useful in a variety of immunologically-based diagnostic and therapeutic procedures.
    Type: Grant
    Filed: December 31, 1984
    Date of Patent: March 22, 1988
    Assignee: University of New Mexico
    Inventors: Thomas B. Tomasi, William L. Anderson