Patents by Inventor Thomas C. Furman

Thomas C. Furman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enzymatic removal of a protein amino-terminal sequence
    Patent number: 5352769
    Abstract: This disclosure relates to new compounds and to a process for the controlled conversion of such compounds to produce a Protein that comprises an amino acid sequence which is useful as a precursor to human insulin or to a modified human insulin, the amino terminus portion of which sequence does not define a cathepsin C dipeptide removal stop point. The compounds have the formula Met-Y-Protein in which Y is Tyr or Arg.
    Type: Grant
    Filed: April 6, 1992
    Date of Patent: October 4, 1994
    Assignee: Eli Lilly and Company
    Inventors: Gerald W. Becker, Thomas C. Furman, Warren C. MacKellar, James P. McDonough
  • Method for the reduction of heterogeneity of monoclonal antibodies
    Patent number: 5126250
    Abstract: Novel methods for reducing the heterogeneity of secreted monoclonal antibodies are disclosed. The first method comprises incubating the heterogeneous antibodies at low pH for a length of time sufficient to convert the heterogeneous forms of antibodies into substantially homogeneous forms. Another method produces the same result using ascites fluid, while yet another method produces the same result using carboxypeptidase. The homogeneous antibodies can then be purified in high yield.
    Type: Grant
    Filed: June 9, 1989
    Date of Patent: June 30, 1992
    Assignees: Eli Lilly and Company, Hybritech Incorporated
    Inventors: James P. McDonough, Thomas C. Furman, Richard M. Bartholomew, Rodney A. Jue
  • Enzymatic removal of a protein amino-terminal sequence
    Patent number: 5126249
    Abstract: This disclosure relates to new compounds and to a process for the controlled conversion of such compounds to produce a Protein that comprises an amino acid sequence which is useful as a precursor to human insulin or to a modified human insulin, the amino terminus portion of which sequence does not define a cathepsin C dipeptide removal stop point. The compounds have the formula Met-Y-Protein in which Y is Tyr or Arg.
    Type: Grant
    Filed: May 9, 1989
    Date of Patent: June 30, 1992
    Assignee: Eli Lilly and Company
    Inventors: Gerald W. Becker, Thomas C. Furman, Warren C. MacKellar, James P. McDonough