Patents by Inventor Thomas D. Dziubla

Thomas D. Dziubla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190314512
    Abstract: Disclosed are methods for delivering a reactive hydroxyl compound, systems comprising a delivery composition comprising a reactive hydroxyl compound and a trigger, and kits which incorporate a reactive hydroxyl compound and a trigger.
    Type: Application
    Filed: April 16, 2019
    Publication date: October 17, 2019
    Inventors: Thomas D. Dziubla, James Zach Hilt, Carolyn T. Jordan
  • Patent number: 8642087
    Abstract: Antioxidant polymeric compounds are provided that comprise a plurality of monomeric portions, where each monomeric portion includes an antioxidant molecule interposed between at least two acrylate molecules, and where at least one acrylate molecule of each monomeric portion is linked by a diamine molecule to an acrylate molecule of an adjacent monomeric portion to thereby form the polymer. Methods of synthesizing polymeric compounds and methods of using the antioxidant polymeric compounds to reduce oxidative stress are also provided.
    Type: Grant
    Filed: November 7, 2011
    Date of Patent: February 4, 2014
    Assignee: University of Kentucky Research Foundation
    Inventors: Thomas D. Dziubla, J. Zach Hilt, Dipti Biswal, David B. Cochran, Paritosh P. Wattamwar
  • Patent number: 8568786
    Abstract: A method of controlling a physical characteristic of polymeric nanocarrier-encapsulated protein particles includes altering or selecting a weight percentage of a hydrophobic polymer block in a total amphiphilic diblock copolymer of a primary emulsion of a double emulsion, freeze-thaw technique. The primary emulsion is formed using a freeze-thaw cycle of the amphiphilic diblock copolymer and a protein having a molecular weight of up to or equal to 300,000 Da. Selection of the hydrophobic polymer block percentage alters one or more characteristics of the resulting nanoparticles, such as shape. Thus, as one aspect, a method of producing filamentous polymeric nanocarrier-encapsulated protein (i.e.
    Type: Grant
    Filed: October 27, 2008
    Date of Patent: October 29, 2013
    Assignee: The Trustees of the Universtiy of Pennsylvania
    Inventors: Eric Simone, Vladimir R. Muzykantov, Thomas D. Dziubla
  • Patent number: 8329225
    Abstract: The present invention is a method for encapsulating active protein in a polymeric nanocarrier. The instant method employs homogenization at subzero temperatures so that enzyme activity is retained. Enzymes which can be encapsulated by the present method include, for example, antioxidant enzymes and xenobiotic detoxifying enzymes. Encapsulation of an enzyme protects it from protease degradation and increases therapeutic half-life. Advantageously, polymeric nanoparticles of the invention are permeable to enzyme substrates and therefore enzymes encapsulated by the instant method can exert their effect without release from the nanocarrier. Methods for decomposing a reactive oxygen species, protecting against vascular oxidative stress, and detoxifying a xenobiotic are also provided.
    Type: Grant
    Filed: June 10, 2009
    Date of Patent: December 11, 2012
    Assignee: Trustees of the University of Pennsylvania
    Inventors: Vladimir R. Muzykantov, Thomas D. Dziubla
  • Patent number: 7927629
    Abstract: A method of controlling a physical characteristic of polymeric nanocarrier-encapsulated protein particles includes altering or selecting a weight percentage of a hydrophobic polymer block in a total amphiphilic diblock copolymer of a primary emulsion of a double emulsion, freeze-thaw technique. The primary emulsion is formed using a freeze-thaw cycle of the amphiphilic diblock copolymer and a protein having a molecular weight of up to or equal to 300,000 Da. Selection of the hydrophobic polymer block percentage alters one or more characteristics of the resulting nanoparticles, such as shape. Thus, as one aspect, a method of producing filamentous polymeric nanocarrier-encapsulated protein (i.e.
    Type: Grant
    Filed: October 27, 2007
    Date of Patent: April 19, 2011
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Eric Simone, Vladimir R. Muzykantov, Thomas D. Dziubla
  • Publication number: 20100316571
    Abstract: A method of controlling a physical characteristic of polymeric nanocarrier-encapsulated protein particles includes altering or selecting a weight percentage of a hydrophobic polymer block in a total amphiphilic diblock copolymer of a primary emulsion of a double emulsion, freeze-thaw technique. The primary emulsion is formed using a freeze-thaw cycle of the amphiphilic diblock copolymer and a protein having a molecular weight of up to or equal to 300,000 Da. Selection of the hydrophobic polymer block percentage alters one or more characteristics of the resulting nanoparticles, such as shape. Thus, as one aspect, a method of producing filamentous polymeric nanocarrier-encapsulated protein (i.e.
    Type: Application
    Filed: October 27, 2008
    Publication date: December 16, 2010
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Eric Simone, Vladimir R. Muzykantov, Thomas D. Dziubla
  • Publication number: 20090258078
    Abstract: The present invention is a method for encapsulating active protein in a polymeric nanocarrier. The instant method employs homogenization at subzero temperatures so that enzyme activity is retained. Enzymes which can be encapsulated by the present method include, for example, antioxidant enzymes and xenobiotic detoxifying enzymes. Encapsulation of an enzyme protects it from protease degradation and increases therapeutic half-life. Advantageously, polymeric nanoparticles of the invention are permeable to enzyme substrates and therefore enzymes encapsulated by the instant method can exert their effect without release from the nanocarrier. Methods for decomposing a reactive oxygen species, protecting against vascular oxidative stress, and detoxifying a xenobiotic are also provided.
    Type: Application
    Filed: June 10, 2009
    Publication date: October 15, 2009
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Vladimir R. Muzykantov, Thomas D. Dziubla
  • Publication number: 20090110741
    Abstract: A method of controlling a physical characteristic of polymeric nanocarrier-encapsulated protein particles includes altering or selecting a weight percentage of a hydrophobic polymer block in a total amphiphilic diblock copolymer of a primary emulsion of a double emulsion, freeze-thaw technique. The primary emulsion is formed using a freeze-thaw cycle of the amphiphilic diblock copolymer and a protein having a molecular weight of up to or equal to 300,000 Da. Selection of the hydrophobic polymer block percentage alters one or more characteristics of the resulting nanoparticles, such as shape. Thus, as one aspect, a method of producing filamentous polymeric nanocarrier-encapsulated protein (i.e.
    Type: Application
    Filed: October 27, 2007
    Publication date: April 30, 2009
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Eric Simone, Vladimir R. Muzykantov, Thomas D. Dziubla