Patents by Inventor Thomas D. Golobish

Thomas D. Golobish has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10426158
    Abstract: The invention concerns methods of treating stored blood and blood products maximizing shelf life and/or minimizing transfusion related complications such as nonĀ¬ hemolytic transfusion reactions such as fever, transfusion-related acute lung injury (TRALI), transfusion associated dyspnea (TAD), and allergic reactions by removing undesirable molecules in the blood and blood products milieu through use of a sorbent.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: October 1, 2019
    Assignee: CytoSorbents Corporation
    Inventors: Phillip P. Chan, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
  • Publication number: 20190282608
    Abstract: The present invention concerns methods of administering a therapeutically effective dose of a sorbent for an inflammatory mediator to a patient where the inflammatory mediator is one or more of enzymes, cytokines, prostaglandins, eicosanoids, leukotrienes, kinins, complement, coagulation factors, endotoxins, enterotoxins, lipopolysaccharide, cell fragments, bile salts, fatty acids, phospholipids, interferon and immunomodulatory antibodies, biologics or drugs.
    Type: Application
    Filed: May 29, 2019
    Publication date: September 19, 2019
    Inventors: Phillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
  • Patent number: 10314859
    Abstract: Disclosed herein are compositions and methods for preventing or treating acute or chronic oral mucositis, esophagitis, enteritis, colitis, or gastrointestinal acute radiation syndrome (GI-ARS) caused by radiation exposure, using one or more enteron sorbent polymers administered gastrointestinally (e.g. orally, via feeding or gastric tube, via ostomy, or rectally).
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: June 11, 2019
    Assignee: Cytosorbents Corporation
    Inventors: Humayra Begum Ali, Thomas D. Golobish, Vincent J. Capponi, Phillip P. Chan, Wei Tai Young, Andrew Robert Scheirer
  • Publication number: 20180311273
    Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
    Type: Application
    Filed: June 26, 2018
    Publication date: November 1, 2018
    Inventors: Phillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
  • Patent number: 10064406
    Abstract: The invention concerns methods of treating blood, blood products or physiologic fluid to maximize shelf life and/or minimizing transfusion related complications such as non-hemolytic transfusion reactions such as fever, transfusion-related acute lung injury (TRALI), transfusion associated dyspnea (TAD), and allergic reactions by removing undesirable molecules in the blood, blood product or physiologic fluid milieu through use of a sorbent.
    Type: Grant
    Filed: January 5, 2012
    Date of Patent: September 4, 2018
    Assignee: CytoSorbents Corporation
    Inventors: Phillip P. Chan, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
  • Patent number: 10034894
    Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: July 31, 2018
    Assignee: CYTOSORBENTS CORPORATION
    Inventors: Phillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
  • Publication number: 20180169138
    Abstract: Disclosed herein are compositions and methods for preventing or treating acute or chronic oral mucositis, esophagitis, enteritis, colitis, or gastrointestinal acute radiation syndrome (GI-ARS) caused by radiation exposure, using one or more enteron sorbent polymers administered gastrointestinally (e.g. orally, via feeding or gastric tube, via ostomy, or rectally).
    Type: Application
    Filed: February 2, 2018
    Publication date: June 21, 2018
    Inventors: Humayra Begum Ali, Thomas D. Golobish, Vincent J. Capponi, Phillip P. Chan, Wei Tai Young, Andrew Robert Scheirer
  • Patent number: 9931457
    Abstract: The invention concerns polymer systems comprising at least one polymer with a plurality of pores where the polymer is initially functionalized on substantially all surfaces followed by a stepwise surface specific functionalization such that a different functional group resides on the external or internal pore surface of the bead. The invention also concerns use of such polymer systems in blood, blood product, or physiologic fluid purification.
    Type: Grant
    Filed: January 6, 2012
    Date of Patent: April 3, 2018
    Assignee: CytoSorbents Corporation
    Inventors: Phillip P. Chan, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
  • Patent number: 9931357
    Abstract: Disclosed herein are compositions and methods for preventing or treating acute or chronic oral mucositis, esophagitis, enteritis, colitis, or gastrointestinal acute radiation syndrome (GI-ARS) caused by radiation exposure, using one or more enteron sorbent polymers administered gastrointestinally (e.g. orally, via feeding or gastric tube, via ostomy, or rectally).
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: April 3, 2018
    Assignee: CytoSorbents Corporation
    Inventors: Humayra Begum Ali, Thomas D. Golobish, Vincent J. Capponi, Phillip P. Chan, Wei-Tai Young, Andrew Robert Scheirer
  • Publication number: 20170296574
    Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
    Type: Application
    Filed: June 28, 2017
    Publication date: October 19, 2017
    Inventors: Phillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
  • Publication number: 20170224903
    Abstract: Provided herein are materials and methods of reducing contamination in a biological substance or treating contamination in a subject by one or more toxins comprising contacting the biological substance with an effective amount of a sorbent capable of sorbing the toxin, wherein the sorbent comprises a plurality of pores ranging from 50 ? to 40,000 ? with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and sorbing the toxin. Also provided are kits to reduce contamination by one or more toxins in a biological substance comprising a sorbent capable of sorbing a toxin, wherein the sorbent comprises a plurality of pores ranging from 50 ? to 40,000 ? with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and a vessel to store said sorbent when not in use together with packaging for same.
    Type: Application
    Filed: April 26, 2017
    Publication date: August 10, 2017
    Inventors: Phillip P. Chan, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
  • Publication number: 20170216345
    Abstract: Disclosed herein are compositions and methods for preventing or treating acute or chronic oral mucositis, esophagitis, enteritis, colitis, or gastrointestinal acute radiation syndrome (GI-ARS) caused by radiation exposure, using one or more enteron sorbent polymers administered gastrointestinally (e.g. orally, via feeding or gastric tube, via ostomy, or rectally).
    Type: Application
    Filed: October 2, 2015
    Publication date: August 3, 2017
    Applicant: Cytosorbents Corporation
    Inventors: Humayra Begum ALI, Thomas D. GOLOBISH, Vincent J. CAPPONI, Phillip P. CHAN, Wei-Tai YOUNG, Andrew Robert SCHEIRER
  • Patent number: 9717755
    Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
    Type: Grant
    Filed: April 1, 2011
    Date of Patent: August 1, 2017
    Assignee: Cytosorbents Corporation
    Inventors: Phillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Robert H. Bartlett, Humayra Begum Ali
  • Patent number: 9604196
    Abstract: A size-selective hemocompatible porous polymeric adsorbent system is provided, the polymer system comprises at least one crosslinking agent and at least one dispersing agent, and the polymer has a plurality of pores with diameters in the range from about 17 to about 40,000 Angstroms.
    Type: Grant
    Filed: May 22, 2012
    Date of Patent: March 28, 2017
    Assignee: Cytosorbent, Inc.
    Inventors: Wei-Tai Young, Robert L. Albright, Thomas D. Golobish, Vincent Capponi, Philip Chan
  • Publication number: 20160279163
    Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
    Type: Application
    Filed: June 3, 2016
    Publication date: September 29, 2016
    Inventors: Phillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Robert H. Bartlett, Humayra Begum Ali
  • Publication number: 20150335576
    Abstract: Provided herein are materials and methods of reducing contamination in a biological substance or treating contamination in a subject by one or more toxins comprising contacting the biological substance with an effective amount of a sorbent capable of sorbing the toxin, wherein the sorbent comprises a plurality of pores ranging from 50 ? to 40,000 ? with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and sorbing the toxin. Also provided are kits to reduce contamination by one or more toxins in a biological substance comprising a sorbent capable of sorbing a toxin, wherein the sorbent comprises a plurality of pores ranging from 50 ? to 40,000 ? with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and a vessel to store said sorbent when not in use together with packaging for same.
    Type: Application
    Filed: June 28, 2013
    Publication date: November 26, 2015
    Inventors: Phillip P. Chan, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
  • Publication number: 20150118673
    Abstract: The invention concerns methods of treating stored blood and blood products maximizing shelf life and/or minimizing transfusion related complications such as non-hemolytic transfusion reactions such as fever, transfusion-related acute lung injury (TRALI), transfusion associated dyspnea (TAD), and allergic reactions by removing undesirable molecules in the blood and blood products milieu through use of a sorbent.
    Type: Application
    Filed: August 10, 2012
    Publication date: April 30, 2015
    Applicant: Cytosorbents Corporation
    Inventors: Phillip P. Chan, Vincent J. Capponi, Thomas D. Golobish
  • Publication number: 20140294751
    Abstract: The invention concerns methods of treating blood, blood product, or physiologic fluid to provide at least one of (i) increasing shelf life of the blood, blood product or physiologic fluid, (ii) maintaining freshness of new blood, blood product or physiologic fluid, and (iii) removing undesirable molecules from the blood, blood product or physiologic fluid; said method comprising contacting said blood, blood product or physiologic fluid with a sorbent, said sorbent being primarily in a plurality of solid forms and comprising a cross-linked polymeric material having a plurality of at least one of (1) zwitterionic moieties and (2) oligo(ethylene glycol) moieties attached to the surface of said cross-linked polymeric material.
    Type: Application
    Filed: March 31, 2014
    Publication date: October 2, 2014
    Applicant: CytoSorbents Corporation
    Inventors: Thomas D. Golobish, Vincent J. Capponi, David R. Clay
  • Publication number: 20140042097
    Abstract: The invention concerns polymer systems comprising at least one polymer with a plurality of pores where the polymer is initially functionalized on substantially all surfaces followed by a stepwise surface specific functionalization such that a different functional group resides on the external or internal pore surface of the bead. The invention also concerns use of such polymer systems in blood, blood product, or physiologic fluid purification.
    Type: Application
    Filed: January 6, 2012
    Publication date: February 13, 2014
    Inventors: Phillip P. Chan, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
  • Publication number: 20130195792
    Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
    Type: Application
    Filed: April 1, 2011
    Publication date: August 1, 2013
    Applicant: CYTOSORBENTS CORPORATION
    Inventors: Phillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Robert H. Bartlett