Patents by Inventor Thomas D. Pfister

Thomas D. Pfister has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-CD133 monoclonal antibodies and related compositions and methods
    Patent number: 11352435
    Abstract: Anti-CD133 monoclonal antibodies having advantageous properties, products, compositions and kits comprising the monoclonal antibodies, methods (processes) of making the monoclonal antibodies and related compositions, as well as methods of using the monoclonal antibodies in analytical, diagnostic and therapeutic applications.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: June 7, 2022
    Assignee: The United States of America, as Represented by the Secretary, Department of Health and Human Services
    Inventors: Thomas D. Pfister, Robert J. Kinders, Tony Navas
  • Anti-pY1235-MET immunological binding reagent
    Patent number: 11340219
    Abstract: Methods and compositions are described herein for assaying the presence or absence of pY1235-MET or a fragment thereof.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: May 24, 2022
    Assignee: The United States Of America, As Represented by the Secretary, Department Of Health And Human Services
    Inventors: Apurva K. Srivastava, Thomas D. Pfister, Tony Navas, Ralph E. Parchment, James E. Doroshow
  • ANTI-CD133 MONOCLONAL ANTIBODIES AND RELATED COMPOSITIONS AND METHODS
    Publication number: 20200354468
    Abstract: Anti-CD133 monoclonal antibodies having advantageous properties, products, compositions and kits comprising the monoclonal antibodies, methods (processes) of making the monoclonal antibodies and related compositions, as well as methods of using the monoclonal antibodies in analytical, diagnostic and therapeutic applications.
    Type: Application
    Filed: June 12, 2020
    Publication date: November 12, 2020
    Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC
    Inventors: Thomas D. Pfister, Robert J. Kinders, Tony Navas
  • ANTI-pY1235-MET IMMUNOLOGICAL BINDING REAGENT
    Publication number: 20200292537
    Abstract: Methods and compositions are described herein for assaying the presence or absence of pY1235-MET or a fragment thereof.
    Type: Application
    Filed: March 16, 2017
    Publication date: September 17, 2020
    Applicant: THEUNITEDSTATES OF AMERICA ASREPRESENTEDBYTHE SECRETARYOF THEDEPARMENT OF HEALTH AND HUMAN SERVICE
    Inventors: Apurva K. Srivastava, Thomas D. Pfister, Tony Navas, Ralph E. Parchment, James E. Doroshow
  • Anti-CD133 monoclonal antibodies and related compositions and methods
    Patent number: 10711068
    Abstract: Anti-CD133 monoclonal antibodies having advantageous properties; products, compositions and kits comprising the monoclonal antibodies; methods (processes) of making the monoclonal antibodies and related compositions, as well as methods of using the monoclonal antibodies in analytical, diagnostic and therapeutic applications.
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: July 14, 2020
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Thomas D. Pfister, Robert J. Kinders, Tony Navas
  • ANTI-CD133 MONOCLONAL ANTIBODIES AND RELATED COMPOSITIONS AND METHODS
    Publication number: 20180105598
    Abstract: Anti-CD133 monoclonal antibodies having advantageous properties; products, compositions and kits comprising the monoclonal antibodies; methods (processes) of making the monoclonal antibodies and related compositions, as well as methods of using the monoclonal antibodies in analytical, diagnostic and therapeutic applications.
    Type: Application
    Filed: March 28, 2016
    Publication date: April 19, 2018
    Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SERECTARY, DEPARTMENT OF H
    Inventors: Thomas D. Pfister, Robert J. Kinders, Tony Navas
  • Antibodies that specifically bind ataxia telangiectasia-mutated and RAD3-related kinase phosphorylated at position 1989 and their use
    Patent number: 9644037
    Abstract: Monoclonal antibodies that specifically bind ataxia telangiectasia-mutated and RAD3-related kinase phosphorylated at position 1989 (pT1989 ATR), antigen binding fragments, conjugates thereof, and the use of these antibodies, antigen binding fragments and conjugates are disclosed herein. Also disclosed are nucleic acids encoding these antibodies, vectors including these antibodies, and isolated host cells transformed with these nucleic acids and vectors. Methods are also disclosed for using these antibodies, such as to detect pT1989 ATR, or to determine the dose of an agent of use to treat a subject. The antibodies are also of use for identifying ATR inhibitors.
    Type: Grant
    Filed: October 8, 2014
    Date of Patent: May 9, 2017
    Assignee: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services
    Inventors: Thomas D. Pfister, Allison M. Marrero, Ralph E. Parchment, James H. Doroshow, Robert J. Kinders
  • ANTIBODIES THAT SPECIFICALLY BIND ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED KINASE PHOSPHORYLATED AT POSITION 1989 AND THEIR USE
    Publication number: 20160251447
    Abstract: Monoclonal antibodies that specifically bind ataxia telangiectasia-mutated and RAD3-related kinase phosphorylated at position 1989 (pT1989 ATR), antigen binding fragments, conjugates thereof, and the use of these antibodies, antigen binding fragments and conjugates are disclosed herein. Also disclosed are nucleic acids encoding these antibodies, vectors including these antibodies, and isolated host cells transformed with these nucleic acids and vectors. Methods are also disclosed for using these antibodies, such as to detect pT1989 ATR, or to determine the dose of an agent of use to treat a subject. The antibodies are also of use for identifying ATR inhibitors.
    Type: Application
    Filed: October 8, 2014
    Publication date: September 1, 2016
    Applicant: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human...
    Inventors: Thomas D. Pfister, Allison M. Marrero, Ralph E. Parchment, James H. Doroshow