Patents by Inventor Thomas Erdenberger

Thomas Erdenberger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210041272
    Abstract: A probe assembly for inserting a probe into a flexible or semi-rigid object is provided. The probe assembly includes an aseptic connector for coupling to the object, a probe sheath that extends longitudinally from the aseptic connector, and an actuator for deploying the probe within the object. The probe sheath has a plurality of concentric sheath elements and an inner longitudinal volume that is configured to permit longitudinal movement of the probe within the probe sheath. The actuator moves the probe longitudinally within the probe sheath by telescoping a first sheath element of the plurality within another sheath element of the plurality such that the probe is moved to a position sufficient to measure at least one parameter within the object.
    Type: Application
    Filed: October 23, 2020
    Publication date: February 11, 2021
    Applicant: GLOBAL LIFE SCIENCES SOLUTIONS USA LLC
    Inventors: RICHARD L. DAMREN, COLIN R. TUOHEY, THOMAS ERDENBERGER, MICHAEL FISHER, JONATHAN A. KENNEY, PARRISH M. GALLIHER, JOSEPH D. CROWELL
  • Patent number: 10857510
    Abstract: A bioprocess mixer (1), which comprises: —a support vessel (2) with at least one side wall (3, 4, 5, 6) and a bottom wall (7), where the walls define a support vessel inner volume (8), and at least a first (9) and a second (10) magnetic impeller drive unit; and —a flexible bag (11, 111) adapted to fit inside the support vessel inner volume, where the bag has at least one bag side wall (12, 112, 13, 113, 14, 15), a bag bottom wall (16, 116) and a bag top wall (17, 117) defining a bag inner volume (18), and at least a first (19) and a second (20) magnetic impeller rotatably attached to a bag wall in the bag inner volume.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: December 8, 2020
    Assignee: Global Life Sciences Solutions USA LLC
    Inventors: Patrik Berndt Akerstrom, Richard Lee Damren, Colin R. Tuohey, Thomas Erdenberger, Jonathan Kenney, David Lawrence Brazell, Wei Jin, Roberto Miguel Cabral, Sampath Telikcherla Kandala
  • Patent number: 10859412
    Abstract: A probe assembly for inserting a probe into a flexible or semi-rigid object is provided. The probe assembly includes an aseptic connector for coupling to the object, a probe sheath that extends longitudinally from the aseptic connector, and an actuator for deploying the probe within the object. The probe sheath has a plurality of concentric sheath elements and an inner longitudinal volume that is configured to permit longitudinal movement of the probe within the probe sheath. The actuator moves the probe longitudinally within the probe sheath by telescoping a first sheath element of the plurality within another sheath element of the plurality such that the probe is moved to a position sufficient to measure at least one parameter within the object.
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: December 8, 2020
    Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLC
    Inventors: Richard L. Damren, Colin R. Tuohey, Thomas Erdenberger, Michael Fisher, Jonathan A. Kenney, Parrish M. Galliher, Joseph D. Crowell
  • Patent number: 10792618
    Abstract: A platform has a filter system with a first set of filter modules and a second set of filter modules that is different from the first set of filter modules. Each set of filter modules includes an inflow channel and an outflow channel. A fluid inlet is connected to the first set of filter modules, a fluid outlet is connected to the second set of filter modules, and a separation interface separates the first and second sets of filter modules. The separation interface has a first interface channel to connect to the module outflow channel of the first set of filter modules, and a second interface channel to connect to the module inflow channel of the second set of filter modules. The filter system receives fluid through the fluid inlet and, after the fluid has passed through each set of filter modules, discharges the fluid through the fluid outlet.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: October 6, 2020
    Assignee: Sartorius Stedim Biotech GmbH
    Inventor: Thomas Erdenberger
  • Patent number: 10774299
    Abstract: Disclosed is a jacketed, tiered baffle, bioreactor tank comprising an outer cylindrical-shaped jacket and a cylindrical tank having an inner tank surface defining a chamber configured for supporting a flexible bag disposed within the chamber, and an outer tank surface having tiered baffles configured for routing a heat exchange fluid around the entirety of the outer tank surface, the cylindrical tank disposed axially within the outer cylindrical-shaped jacket. The outer cylindrical-shaped jacket is sealed to the cylindrical tank in a manner sufficient to prevent or minimize loss of the heat exchange fluid.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: September 15, 2020
    Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLC
    Inventors: Parrish M. Galliher, Thomas Erdenberger, Colin R. Tuohey, Joseph D. Crowell, Richard L. Damren
  • Patent number: 10767154
    Abstract: A heat exchange module for use in a chemical, pharmaceutical or biological reactor system includes a generally hollow body having an interior space for receiving a replaceable or single use reactant container, and at least one thermally conductive surface adapted to contact the replaceable reactant container to facilitate heat transfer, a fluid circulation path formed within the body between an outer wall of the body and an inner wall of the body through which a heat exchange fluid can be circulated, and at least one baffle protruding from the inner wall of the body into the interior space.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: September 8, 2020
    Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLC
    Inventors: Richard L. Damren, Thomas Erdenberger, Colin R. Tuohey, Joseph D. Crowell, Parrish M. Galliher, Kenneth P Clapp, Peter A. Mitchell
  • Publication number: 20190381457
    Abstract: A platform has a filter system with a first set of filter modules and a second set of filter modules that is different from the first set of filter modules. Each set of filter modules includes an inflow channel and an outflow channel. A fluid inlet is connected to the first set of filter modules, a fluid outlet is connected to the second set of filter modules, and a separation interface separates the first and second sets of filter modules. The separation interface has a first interface channel to connect to the module outflow channel of the first set of filter modules, and a second interface channel to connect to the module inflow channel of the second set of filter modules. The filter system receives fluid through the fluid inlet and, after the fluid has passed through each set of filter modules, discharges the fluid through the fluid outlet.
    Type: Application
    Filed: June 19, 2018
    Publication date: December 19, 2019
    Inventor: Thomas Erdenberger
  • Patent number: 10442674
    Abstract: Disclosed herein are embodiments of a valve assembly for preventing dead leg spaces in a container or tubing, the embodiments including a three-way valve system for controlling back-pressure in a fluid generating device, such as a single-use high pressure bioreactor. Also disclosed is a pressurized reactor system for bioprocessing, comprising a single-use container including a flexible wall or a semi-rigid wall.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: October 15, 2019
    Assignee: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: Colin R. Tuohey, Thomas Erdenberger, Richard L. Damren, Kenneth Clapp, Parrish M. Galliher, Jonathan Kenney
  • Patent number: 10221383
    Abstract: A system for condensing moisture in a moist gas stream entering or leaving a bioreactor includes a condenser container, the condenser container comprising: an outer wall surface and an inner wall surface, the inner wall surface defining an interior chamber for holding a fluid; and a first fitment attached to the outer wall surface and forming a first port configured to allow the moist gas stream to flow into the interior chamber; a second fitment attached to the outer wall surface and forming a second port configured to allow a dried gas to flow from the interior chamber and out of the second port; and a cooling device in contact with at least one portion of the outer wall surface and arranged to cool the at least one portion of the outer wall surface.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: March 5, 2019
    Assignee: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: Richard Damren, Colin Touhey, Thomas Erdenberger, Michael Fisher, Geoffrey Hodge, Patrick Guertin, Parrish Galliher
  • Publication number: 20180237736
    Abstract: Disclosed is a single-use bioreactor bag design providing substantially equivalent maximum shear rate at the impeller tip and average or bulk shear rate over a range of power per unit working volume and rpm needed for bio culture processing. The uniformity in shear profile of the bag design providing a unique advantage when used as a scale-down or scale-up platform. Also disclosed is a linearly scalable, single-use, bioreactor system for use in carrying out a scalable biomanufacturing process, the system comprising two single-use bioreactor bags of different volumes, wherein the ratio H/D of the height of the working volume H to the diameter D of the tank, or of the bag is equal to about 1.5, and the bulk shear in each of the bags is substantially constant.
    Type: Application
    Filed: April 17, 2018
    Publication date: August 23, 2018
    Applicant: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: COLIN TUOHEY, TED DELOGGIO, THOMAS ERDENBERGER, KENNETH P. CLAPP, RICHARD DAMREN, PARRISH M. GALLIHER, PATRICK GUERTIN, JIYOUNG LEE, MICHAEL FISHER
  • Publication number: 20180143042
    Abstract: A probe assembly for inserting a probe into a flexible or semi-rigid object is provided. The probe assembly includes an aseptic connector for coupling to the object, a probe sheath that extends longitudinally from the aseptic connector, and an actuator for deploying the probe within the object. The probe sheath has a plurality of concentric sheath elements and an inner longitudinal volume that is configured to permit longitudinal movement of the probe within the probe sheath. The actuator moves the probe longitudinally within the probe sheath by telescoping a first sheath element of the plurality within another sheath element of the plurality such that the probe is moved to a position sufficient to measure at least one parameter within the object.
    Type: Application
    Filed: January 3, 2018
    Publication date: May 24, 2018
    Applicant: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: RICHARD L. DAMREN, COLIN R. TUOHEY, THOMAS ERDENBERGER, MICHAEL FISHER, JONATHAN A. KENNEY, PARRISH M. GALLIHER, JOSEPH D. CROWELL
  • Patent number: 9969965
    Abstract: Disclosed is a single-use bioreactor bag design providing substantially equivalent maximum shear rate at the impeller tip and average or bulk shear rate over a range of power per unit working volume and rpm needed for bioculture processing. The uniformity in shear profile of the bag design providing a unique advantage when used as a scale-down or scale-up platform. Also disclosed is a linearly scalable, single-use, bioreactor system for use in carrying out a scalable biomanufacturing process, the system comprising two single-use bioreactor bags of different volumes, wherein the ratio H/D of the height of the working volume H to the diameter D of the tank, or of the bag is equal to about 1.5, and the bulk shear in each of the bags is substantially constant. The disclosed small scale system models larger scale systems from both a shear/scalability/performance basis and also from a validation and regulatory basis.
    Type: Grant
    Filed: January 11, 2012
    Date of Patent: May 15, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: Colin Tuohey, Ted Deloggio, Thomas Erdenberger, Kenneth P. Clapp, Richard Damren, Parrish M. Galliher, Patrick Guertin, Jiyoung Lee, Michael Fisher
  • Publication number: 20180126344
    Abstract: A bioprocess mixer (1), which comprises: —a support vessel (2) with at least one side wall (3, 4, 5, 6) and a bottom wall (7), where the walls define a support vessel inner volume (8), and at least a first (9) and a second (10) magnetic impeller drive unit; and —a flexible bag (11, 111) adapted to fit inside the support vessel inner volume, where the bag has at least one bag side wall (12, 112, 13, 113, 14, 15), a bag bottom wall (16, 116) and a bag top wall (17, 117) defining a bag inner volume (18), and at least a first (19) and a second (20) magnetic impeller rotatably attached to a bag wall in the bag inner volume.
    Type: Application
    Filed: April 11, 2016
    Publication date: May 10, 2018
    Inventors: Patrik Berndt Akerstrom, Richard Lee Damren, Colin R. Tuohey, Thomas Erdenberger, Jonathan Kenney, David Lawrence Brazell, Wei Jin, Roberto Miguel Cabral, Sampath Telikcherla Kandala
  • Patent number: 9891080
    Abstract: A probe assembly for inserting a probe into a flexible or semi-rigid vessel or tubing having a distal aseptic connector for coupling to the vessel or tubing, the probe sheath comprising at least a portion that is rigid, the probe sheath extending longitudinally from the aseptic connector and having at least one inner longitudinal lumen configured to receive an elongate sensor or probe body and to permit longitudinal movement of the sensor/probe body within the probe sheath lumen, and an actuator for deploying a probe within the vessel or tubing by advancing the probe body through the aseptic connector to a position where the probe can measure at least one parameter within the vessel or tubing is disclosed herein.
    Type: Grant
    Filed: October 28, 2012
    Date of Patent: February 13, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: Richard L. Damren, Colin R. Tuohey, Thomas Erdenberger, Michael Fisher, Jonathan A. Kenney, Parrish M. Galliher, Joseph D. Crowell
  • Patent number: 9719705
    Abstract: Disclosed herein is a system and method for condensing moisture in a moist gas stream entering a bioreactor or leaving a bioreactor, the system comprising: a condenser container capable of holding a fluid, the condenser container comprising: an outer wall surface and an inner wall surface, the inner wall surface defining an interior chamber for holding the fluid; and a first fitment attached to the outer wall surface of the condenser container, the first fitment forming a first port configured to allow the moist gas stream to flow through the first port and into the interior chamber; a second fitment attached to the outer wall surface of the condenser container, the second fitment forming a second port configured to allow a dried gas to flow from the interior chamber and out of the second port; and a cooling device in contact with at least one portion of the outer wall surface of the condenser container and arranged to cool the at least one portion of the outer wall surface of the condenser container, thereby
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: August 1, 2017
    Assignee: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: Patric Fricking, Parrish Galliher, Geoffrey Hodge, Michael Fisher, Patrick Guertin, Richard Damren, Colin Tuohey, Thomas Erdenberger
  • Publication number: 20170051246
    Abstract: Disclosed is a jacketed, tiered baffle, bioreactor tank comprising an outer cylindrical-shaped jacket and a cylindrical tank having an inner tank surface defining a chamber configured for supporting a flexible bag disposed within the chamber, and an outer tank surface having tiered baffles configured for routing a heat exchange fluid around the entirety of the outer tank surface, the cylindrical tank disposed axially within the outer cylindrical-shaped jacket. The outer cylindrical-shaped jacket is sealed to the cylindrical tank in a manner sufficient to prevent or minimize loss of the heat exchange fluid.
    Type: Application
    Filed: November 8, 2016
    Publication date: February 23, 2017
    Applicant: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: PARRISH M. GALLIHER, THOMAS ERDENBERGER, COLIN R. TUOHEY, JOSEPH D. CROWELL, RICHARD L. DAMREN
  • Patent number: 9550157
    Abstract: Disclosed are magnetic agitation mixing systems for use with flexible container reaction vessels. In one aspect of the invention, the orientation of magnetic coupling between the impeller magnets and the external driver magnets is modified such that the coupling is neither strictly axial nor strictly radial. Also disclosed are “receiver-less” retainer configurations whereby the single-use container need not have a rigid base that defines a cup or post to engage of rotatable agitator.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: January 24, 2017
    Assignee: GE HEATHCARE BIO-SCIENCES CORP
    Inventors: Thomas Erdenberger, Richard L. Damren, Colin R. Tuohey, Michael Fisher, Parrish M. Galliher, Jonathan A. Kenney
  • Publication number: 20170008752
    Abstract: Disclosed herein are embodiments of a valve assembly for preventing dead leg spaces in a container or tubing, the embodiments including a three-way valve system for controlling back-pressure in a fluid generating device, such as a single-use high pressure bioreactor. Also disclosed is a pressurized reactor system for bioprocessing, comprising a single-use container including a flexible wall or a semi-rigid wall.
    Type: Application
    Filed: July 29, 2016
    Publication date: January 12, 2017
    Applicant: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: COLIN R. TUOHEY, THOMAS ERDENBERGER, RICHARD L. DAMREN, KENNETH CLAPP, PARRISH M. GALLIHER, JONATHAN KENNEY
  • Patent number: 9534196
    Abstract: Disclosed is a heat exchange module for use in a chemical, pharmaceutical or biological reactor system, the module configured to be disposed in the reactor system having a flexible single use container, and including at least one thermally conductive surface adapted to contact the flexible single use container to facilitate heat transfer, and a fluid circulation path through which a heat exchange fluid can be circulated.
    Type: Grant
    Filed: January 14, 2013
    Date of Patent: January 3, 2017
    Assignee: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: Parrish M. Galliher, Thomas Erdenberger, Colin R. Tuohey, Joseph D. Crowell, Richard L. Damren
  • Publication number: 20160376539
    Abstract: Disclosed herein is a system and method for condensing moisture in a moist gas stream entering a bioreactor or leaving a bioreactor, the system comprising: a condenser container capable of holding a fluid, the condenser container comprising: an outer wall surface and an inner wall surface, the inner wall surface defining an interior chamber for holding the fluid; and a first fitment attached to the outer wall surface of the condenser container, the first fitment forming a first port configured to allow the moist gas stream to flow through the first port and into the interior chamber; a second fitment attached to the outer wall surface of the condenser container, the second fitment forming a second port configured to allow a dried gas to flow from the interior chamber and out of the second port; and a cooling device in contact with at least one portion of the outer wall surface of the condenser container and arranged to cool the at least one portion of the outer wall surface of the condenser container, thereby
    Type: Application
    Filed: September 8, 2016
    Publication date: December 29, 2016
    Applicant: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: Richard Damren, Colin Touhey, Thomas Erdenberger, Michael Fisher, Geoffrey Hodge, Patrick Guertin, Parrish Galliher