Patents by Inventor Thomas Fuchss

Thomas Fuchss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SGK1 inhibitors for the prophylaxis and/or therapy of viral diseases and/or carcinomas
    Patent number: 8546613
    Abstract: The present invention relates to a compound of formulas I, Ia, Ib and II, wherein R1 to R11 are herein defined.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: October 1, 2013
    Assignee: Merck Patent GmbH
    Inventors: Thomas Fuchss, Rolf Gericke, Norbert Beier, Florian Lang, Phillipp Lang, Karl Lang
  • Difluorophenyldiacylhydrazide derivatives
    Patent number: 8492440
    Abstract: Novel difluorophenyldiacylhydrazide derivatives of the formula I, in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in claim 1, are kinase inhibitors and can be used for the treatment of diseases and complaints such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and kidney diseases, generally in any type of fibroses, inflammatory processes, tumours and tumour diseases.
    Type: Grant
    Filed: November 2, 2009
    Date of Patent: July 23, 2013
    Assignee: Merck Patent GmbH
    Inventors: Thomas Fuchss, Ulrich Graedler, Norbert Beier, Rolf Gericke, Florian Lang
  • Imidazo[4,5-c]quinolines as DNA-PK inhibitors
    Publication number: 20130172337
    Abstract: The invention relates to compounds of the formulae (I) and (II) in which R1, R2, R3, R4, R5, R8, X and m have the meaning indicated in the claims, and/or physiologically acceptable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. The compounds of the formula (I) can be used for the inhibition of serine/threonine protein kinases and for the sensitisation of cancer cells to anticancer agents and/or ionising radiation. The invention also relates to the use of the compounds of the formula (I) in the prophylaxis, therapy or progress control of cancer, tumours, metastases or angiogenesis disorders, in combination with radiotherapy and/or an anticancer agent. The invention furthermore relates to a process for the preparation of the compounds of the formula (I).
    Type: Application
    Filed: July 26, 2011
    Publication date: July 4, 2013
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Thomas Fuchss, Werner Mederski, Frank Zenke
  • PYRAZOLOQUINOLINES
    Publication number: 20130150359
    Abstract: The invention relates to compounds of the formulae (I), (II) and (III), and/or physiologically acceptable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. The compounds of the formula (I) can be used for the inhibition of serine/threonine protein kinases and for the sensitisation of cancer cells to anticancer agents and/or ionising radiation. The invention also relates to the use of the compounds of the formula (I) in the prophylaxis, therapy or progress control of cancer, tumours, metastases or angiogenesis disorders, in combination with radiotherapy and/or an anticancer agent.
    Type: Application
    Filed: June 24, 2011
    Publication date: June 13, 2013
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Thomas Fuchss, Werner Mederski, Frank Zenke
  • Morpholinylquinazolines
    Publication number: 20130012489
    Abstract: The invention relates to compounds of the formulae (I), (II) and (III) in which R1, R2, R3, R4, Y, W1, W2, L, A, Alk, Cyc, Ar, Het1, Het2, Hal and n have the meaning indicated in claim 1, and/or physiologically acceptable salts, tautomers and stereo-isomers thereof, including mixtures thereof in all ratios. The compounds of the formula (I) can be used for the inhibition of serine/threonine protein kinases and for the sensitisation of cancer cells to anticancer agents and/or ionising radiation. The invention also relates to the use of the compounds of the formula (I) in the prophylaxis, therapy or progress control of cancer, tumours, metastases or angiogenesis disorders, in combination with radiotherapy and/or an anticancer agent. The invention furthermore relates to a process for the preparation of the compounds of the formula (I) by reaction of compounds of the formulae (II) and (III) and optionally conversion of a base or acid of the compounds of the formula (I) into one of their salts.
    Type: Application
    Filed: February 17, 2011
    Publication date: January 10, 2013
    Applicant: MERCK PATENT GMBH
    Inventors: Werner Mederski, Thomas Fuchss, Frank Zenke
  • DIFLUOROPHENYLDIACYLHYDRAZIDE DERIVATIVES
    Publication number: 20110224302
    Abstract: Novel difluorophenyldiacylhydrazide derivatives of the formula I, in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in claim 1, are kinase inhibitors and can be used for the treatment of diseases and complaints such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and kidney diseases, generally in any type of fibroses, inflammatory processes, tumours and tumour diseases
    Type: Application
    Filed: November 2, 2009
    Publication date: September 15, 2011
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Thomas Fuchss, Ulrich Graedler, Norbert Beier, Rolf Gericke, Florian Lang
  • SGK1 INHIBITORS FOR THE PROPHYLAXIS AND/OR THERAPY OF VIRAL DISEASES AND/OR CARCINOMAS
    Publication number: 20110060050
    Abstract: The present invention relates to a compound of the formula I, Ia and Ib, and its pharmaceutically usable tautomers, salts, stereoisomers and the enantiomers, including mixtures thereof in all ratios.
    Type: Application
    Filed: February 17, 2009
    Publication date: March 10, 2011
    Applicant: Merck Patent GmbH
    Inventors: Thomas Fuchss, Rolf Gericke, Norbert Beier, Florian Lang, Phillipp Lang, Karl Lang
  • IMIDAZOPYRIDINE DERIVATIVES USEFUL AS INOS INHIBITORS
    Publication number: 20100317650
    Abstract: The compounds of formula (I) in which R1, R11 and A have the meanings as given in the description are novel effective iNOS inhibitors.
    Type: Application
    Filed: August 3, 2010
    Publication date: December 16, 2010
    Applicant: NYCOMED GmbH
    Inventors: Thomas FUCHSS, Andreas STRUB, Wolf-Rüdiger ULRICH, Christian HESSLINGER, Martin LEHNER, Raimund Külzer, Rainer BOER, Manfrid ELTZE
  • AMINOPYRIDINE-DERIVATIVES AS INDUCTIBLE NO-SYNTHASE INHIBITORS
    Publication number: 20100280002
    Abstract: The compounds of Formula (I) in which R1, R2, R3 and R4 have the meanings as given in the description are novel effective iNOS inhibitors.
    Type: Application
    Filed: July 14, 2010
    Publication date: November 4, 2010
    Applicant: ALTANA PHARMA AG
    Inventor: Thomas FUCHSS
  • Imidazopyridine derivatives useful as iNOS inhibitors
    Patent number: 7790710
    Abstract: The compounds of formula (I) in which R1, R11 and A have the meanings as given in the description are novel effective iNOS inhibitors.
    Type: Grant
    Filed: March 29, 2006
    Date of Patent: September 7, 2010
    Assignee: NYCOMED GmbH
    Inventors: Thomas Fuchss, Andreas Strub, Wolf-Rüdiger Ulrich, Christian Hesslinger, Martin Lehner, Raimund Külzer, Rainer Boer, Manfrid Eltze
  • Aminopyridine-derivatives
    Patent number: 7781453
    Abstract: The compounds of Formula (I) in which R1, R2, R3 and R4 have the meanings as given in the description are novel effective iNOS inhibitors.
    Type: Grant
    Filed: November 16, 2007
    Date of Patent: August 24, 2010
    Assignee: Altana Pharma AG
    Inventor: Thomas Fuchss
  • Imidazopyridine Derivatives Useful as iNOS Inhibitors
    Publication number: 20090131399
    Abstract: The compounds of formula (I) in which R1, R11 and A have the meanings as given in the description are novel effective iNOS inhibitors.
    Type: Application
    Filed: March 29, 2006
    Publication date: May 21, 2009
    Applicant: NYCOMED GMBH
    Inventors: Thomas Fuchss, Andreas Strub, Wolf-Rudiger Ulrich, Christian Hesslinger, Martin Lehner, Raimund Kulzer, Rainer Boer, Manfrid Eltze
  • Novel aminopyridine-derivatives
    Publication number: 20080176894
    Abstract: The compounds of Formula (I) in which R1, R2, R3 and R4 have the meanings as given in the description are novel effective iNOS inhibitors.
    Type: Application
    Filed: November 16, 2007
    Publication date: July 24, 2008
    Inventor: Thomas Fuchss
  • Imidazo (4,5-B) pyridine-derivatives as inducible no-synthase inhibitors
    Publication number: 20080108652
    Abstract: The compounds of formula (I) in which R1, R2, R3, R4 and R11 have the meanings as given in the description are novel effective iNOS inhibitors.
    Type: Application
    Filed: December 17, 2007
    Publication date: May 8, 2008
    Inventor: Thomas Fuchss
  • Imidazo(4,5-b)pyridine-derivatives as inducible no-synthase inhibitors
    Patent number: 7329677
    Abstract: The compounds of formula (I) in which R1, R2, R3, R4 and R11 have the meanings as given in the description are novel effective iNOS inhibitors.
    Type: Grant
    Filed: September 30, 2004
    Date of Patent: February 12, 2008
    Assignee: Altana Pharma AG
    Inventor: Thomas Fuchss
  • Aminopyridine-derivatives as inductible no-synthase inhibitors
    Patent number: 7317021
    Abstract: The compounds of Formula (I) in which R1, R2, R3 and R4 have the meanings as given in the description are novel effective iNOS inhibitors.
    Type: Grant
    Filed: September 30, 2004
    Date of Patent: January 8, 2008
    Assignee: Altana Pharma AG
    Inventor: Thomas Fuchss
  • Aminopyridine-derivatives as inductible no-synthase inhibitors
    Publication number: 20070043072
    Abstract: The compounds of Formula (I) in which R1, R2, R3 and R4 have the meanings as given in the description are novel effective iNOS inhibitors.
    Type: Application
    Filed: September 30, 2004
    Publication date: February 22, 2007
    Applicant: Altana Pharma AG
    Inventor: Thomas Fuchss
  • Imidazo(4,5-b)pyridine-derivatives as inducible no-synthase inhibitors
    Publication number: 20070010549
    Abstract: The compounds of formula (I) in which R1, R2, R3, R4 and R11 have the meanings as given in the description are novel effective iNOS inhibitors.
    Type: Application
    Filed: September 30, 2004
    Publication date: January 11, 2007
    Applicant: Altana Pharma AG
    Inventor: Thomas Fuchss
  • Process and intermediates for the preparation of imidazopyridines
    Patent number: 6812349
    Abstract: The invention relates to compounds of formula (2) in which R1, R2, R3 and R4 have the meanings indicated in the description, their preparation and their further reaction to give compounds of formula (1), in which A1, A2 and R4 have the meanings indicated in the description. The compounds of the formula (1) are valuable intermediates for the preparation of medicaments.
    Type: Grant
    Filed: September 23, 2003
    Date of Patent: November 2, 2004
    Assignee: Altana Pharma AG
    Inventors: Wolf-Rüdiger Ulrich, Christian Scheufler, Thomas Fuchss, Jörg Senn-Bilfinger
  • Process and intermediates for the preparation of imidazopyridines
    Patent number: 6716990
    Abstract: The invention relates to compounds of formula (2) in which R1, R2, R3 and R4 have the meanings indicated in the description, their preparation and their further reaction to give compounds of formula (1), in which A1, A2 and R4 have the meanings indicated in the description. The compounds of the formula (1) are valuable intermediates for the preparation of medicaments.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: April 6, 2004
    Assignee: Altana Pharma AG
    Inventors: Wolf-Rüdiger Ulrich, Christian Scheufler, Thomas Fuchss, Jörg Senn-Bilfinger