Patents by Inventor Thomas H. Faitg

Thomas H. Faitg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrazolylaminopyridines as inhibitors of FAK
    Patent number: 9446034
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: September 20, 2016
    Assignee: GlaxoSmithKline LLC
    Inventors: Jerry Leroy Adams, Thomas H. Faitg, Neil W. Johnson, Hong Lin, Xin Peng
  • PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK
    Publication number: 20160095841
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.
    Type: Application
    Filed: October 20, 2015
    Publication date: April 7, 2016
    Inventors: Jerry Leroy ADAMS, Thomas H. FAITG, Neil W. JOHNSON, Hong LIN, Xin PENG
  • PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK
    Publication number: 20150265589
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.
    Type: Application
    Filed: March 30, 2015
    Publication date: September 24, 2015
    Inventors: Jerry Leroy ADAMS, Thomas H. Faitg, Neil W. Johnson, Hong Lin, Xin Peng
  • Pyrazolylaminopyridines as inhibitors of FAK
    Patent number: 9012479
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.
    Type: Grant
    Filed: October 7, 2013
    Date of Patent: April 21, 2015
    Assignee: GlaxoSmithKline LLC
    Inventors: Jerry Leroy Adams, Thomas H. Faitg, Neil W. Johnson, Hong Lin, Xin Peng
  • PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK
    Publication number: 20140155410
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.
    Type: Application
    Filed: February 6, 2014
    Publication date: June 5, 2014
    Applicant: GlaxoSmithKline LLC
    Inventors: Jerry Leroy Adams, Thomas H. Faitg, Neil W. Johnson, Jiri Kasparec, Hong Lin, Mark Mellinger, Xin Peng, Ren Xie
  • PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK
    Publication number: 20140107131
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.
    Type: Application
    Filed: October 7, 2013
    Publication date: April 17, 2014
    Applicant: GlaxoSmithKline LLC
    Inventors: Jerry Leroy ADAMS, Thomas H. FAITG, Neil W. JOHNSON, Jiri KASPAREC, Hong LIN, Mark MELLINGER, Xin PENG, Ren XIE
  • PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK
    Publication number: 20110207743
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.
    Type: Application
    Filed: October 27, 2009
    Publication date: August 25, 2011
    Inventors: Jerry Leroy Adams, Thomas H Faitg, Neil W Johnson, Hong Lin
  • Anthranilamide inhibitors of aurora kinase
    Patent number: 7884098
    Abstract: The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; wherein R1, R1? R2, R3, R4, R5, r and s are as defined herein. Compounds of the present invention are useful in the treatment of diseases associated with Aurora kinase activity such as cancer.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: February 8, 2011
    Assignee: GlaxoSmithKline LLC
    Inventors: Jeffrey Michael Axten, Deborah L. Bryan, David Harold Drewry, Thomas H Faitg, Timothy Francis Gallagher, Neil W Johnson, Jiri Kasparec, Jeffrey M Ralph, Domingos J. Silva
  • ANILINOPYRIDINES AS INHIBITORS OF FAK
    Publication number: 20100317663
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, Q, Z, r, and p are as defined herein. Compounds of the present invention are useful in the treatment of diseases associated with FAK overexpression, including proliferative diseases.
    Type: Application
    Filed: February 19, 2009
    Publication date: December 16, 2010
    Inventors: Jerry Leroy Adams, Thomas H. Faitg, Neil W. Johnson, Xin Peng
  • QUINOXALINE DERIVATIVES AS PI3 KINASE INHIBITORS
    Publication number: 20100234386
    Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using quinoxaline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoxaline derivatives.
    Type: Application
    Filed: May 8, 2008
    Publication date: September 16, 2010
    Inventors: Amita Chaudhari, Dashyant Dhanak, Carla Ann Donatelli, Thomas H. Faitg, Yanhong Feng, Steven David Knight, Cynthia A. Parrish, Jeffrey M. Ralph, Martha A. Sarpong, Domingos J. Silva
  • PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK
    Publication number: 20100113475
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.
    Type: Application
    Filed: October 27, 2009
    Publication date: May 6, 2010
    Inventors: Jerry Leroy ADAMS, Thomas H. Faitg, Neil W. Johnson, Hong Lin
  • Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis C viral infections and associated diseases
    Patent number: 7666863
    Abstract: The present invention relates to benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: February 23, 2010
    Assignees: ViroPharma Incorporated, WYETH
    Inventors: Ashis K. Saha, Christopher J Burns, Alfred M. Del Vecchio, Thomas R. Bailey, Jason A. Reinhardt, Bheemashankar A. Kulkarni, Thomas H. Faitg, Hao Feng, Susan R. Rippin, Charles W. Blackledge, David J. Rys, Thomas A. Lessen, John Swestock, Yijun Deng, Theodore J. Nitz
  • ANTHRANILAMIDE INHIBITORS OF AURORA KINASE
    Publication number: 20100016318
    Abstract: The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; wherein R1, R1? R2, R3, R4, R5, r and s are as defined herein. Compounds of the present invention are useful in the treatment of diseases associated with Aurora kinase activity such as cancer.
    Type: Application
    Filed: January 25, 2008
    Publication date: January 21, 2010
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Jeffrey Michael Axten, Deborah L. Bryan, David Harold Drewry, Thomas H. Faitg, Timothy Francis Gallagher, Neil W. Johnson, Jiri Kasparec, Jeffrey M. Ralph, Domingos J. Silva
  • BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES
    Publication number: 20090281336
    Abstract: The present invention relates to novel benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.
    Type: Application
    Filed: July 9, 2009
    Publication date: November 12, 2009
    Inventors: Ashis K. Saha, Christopher J. Burns, Alfred M. Del Vecchio, Thomas R. Bailey, Jason A. Reinhardt, Bheemashankar A. Kulkarni, Thomas H. Faitg, Hao Feng, Susan R. Rippin, Charles W. Blackledge, David J. Rys, Thomas A. Lessen, John Swestock, Yijun Deng, Theodore J. Nitz
  • QUINOXALINE DERIVATIVES AS PI3 KINASE INHIBITORS
    Publication number: 20080293706
    Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using quinoxaline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoxaline derivatives.
    Type: Application
    Filed: May 8, 2008
    Publication date: November 27, 2008
    Inventors: Amita CHAUDHARI, Dashyant DHANAK, Carla Ann DONATELLI, Thomas H. FAITG, Yanhong FENG, Steven David KNIGHT, Cynthia A. PARRISH, Jeffrey M. RALPH
  • Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases
    Publication number: 20080242667
    Abstract: The present invention provides a compound represented by Formula (I): or a salt thereof, or a solvate thereof, or a combination thereof, wherein the substituents are as defined herein. The present invention also relates to a composition comprising the compound of formula (I) and diluents, carriers, or excipients. Furthermore, the present invention relates to a method of treating a disease of cell proliferation comprising administering to a patient in need thereof a pharmaceutically effective amount of the compound of formula (I) or a salt thereof, or a solvate thereof, or a combination thereof.
    Type: Application
    Filed: August 23, 2006
    Publication date: October 2, 2008
    Inventors: Jerry Leroy Adams, Thomas H. Faitg, Jeffrey M. Ralph, Domingos J. Silva
  • Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis C viral infections and associated diseases
    Patent number: 7265152
    Abstract: The present invention relates to novel benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: September 4, 2007
    Assignees: ViroPharma Incorporated, Wyeth
    Inventors: Ashis K. Saha, Christopher J Burns, Alfred M. Del Vecchio, Thomas R. Bailey, Jason A. Reinhardt, Bheemashankar A. Kulkarni, Thomas H. Faitg, Hao Feng, Susan R. Rippin, Charles W. Blackledge, David J. Rys, Thomas A. Lessen, John Swestock, Yijun Deng, Theodore J. Nitz
  • Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis C viral infections and associated diseases
    Publication number: 20040162318
    Abstract: The present invention relates to novel benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.
    Type: Application
    Filed: October 31, 2003
    Publication date: August 19, 2004
    Inventors: Ashis K. Saha, Christopher J. Burns, Alfred M. Del Vecchio, Thomas R. Bailey, Jason A. Reinhardt, Bheemashankar A. Kulkarni, Thomas H. Faitg, Hao Feng, Susan R. Rippin, Charles W. Blackledge, David J. Rys, Thomas A. Lessen, John Swestock, Yijun Deng, Theodore J. Nitz