Abstract: The present invention relates to a protease variant which is at least 90% identical to the full length amino acid sequence of a Kumamolisin AS backbone as set forth in any of SEQ ID NOs 1-3, while maintaining proteolytic activity, or a fragment, fraction or shuffled variant thereof maintaining proteolytic activity, which protease variant demonstrates altered or improved stability compared to the Kumamolisin AS wildtype as set forth in SEQ ID NO 4, or the Kumamolisin AS backbone as set forth in any of SEQ ID NOs 1-3.

Abstract: In a sensor apparatus for detecting the temperature on a flat component, particularly on a window of a motor vehicle, having at least one sensor housing, having at least one circuit carrier, at least a section of which is arranged inside the sensor housing, and having at least one temperature sensor arranged on the circuit carrier, it is provided as essential to the invention that the circuit carrier includes at least one section embodied as a contact finger, that the temperature sensor is arrange on the contact finger, that the contact finger has a contact region for thermal coupling with the flat component, that the contact region is connected in thermally conductive manner to the temperature sensor, that the sensor housing has at least one deflection element impinging on the contact finger with a bias.

Abstract: Implementations relate to embedded programs and interfaces for chat conversations. In some implementations, a method includes initiating an embedded application in association with a chat interface displayed by a messaging application that executes at least in part on a first user device. The chat interface displays messages originating from other user devices participating in a chat conversation over a network and associated with chat users. An indication is received over the network that one or more particular devices of the other user devices have connected to an embedded session associated with the embedded application. In response, chat identities associated with particular users of the particular user devices are provided from the messaging application to the embedded application. The particular users are designated as member users of the embedded session, and the embedded application is updated based on data received from particular user devices of the embedded session.

Abstract: The present invention relates to a protease variant which is at least 90% identical to the full length amino acid sequence of a Kumamolisin AS backbone as set forth in any of SEQ ID NOs 1-3, while maintaining proteolytic activity, or a fragment, fraction or shuffled variant thereof maintaining proteolytic activity, which protease variant demonstrates altered or improved stability compared to the Kumamolisin AS wildtype as set forth in SEQ ID NO 4, or the Kumamolisin AS backbone as set forth in any of SEQ ID NOs 1-3.

Abstract: The present disclosure relates to a pharmaceutical combination comprising (a) an Mdm2 inhibitor and (b)(i) a MEK inhibitor and/or (b)(ii) Bcl2 inhibitor, particularly for use in the treatment of a cancer. This disclosure also relates to uses of such combination for preparation of a medicament for the treatment of a cancer; methods of treating a cancer in a subject in need thereof comprising administering to said subject a jointly therapeutically effective amount of said combination; pharmaceutical compositions comprising such combination and commercial packages thereto.

Abstract: Implementations relate to suggested items for use with embedded applications in chat conversations. In some implementations, a method includes causing a chat interface to be displayed by a first user device, the chat interface generated by a messaging application. The chat interface is configured to display, in a chat conversation, messages provided by user devices participating in the chat conversation over a network. An embedded interface is associated with the chat interface and displayed by an embedded application associated with the messaging application. A suggestion event is determined to occur in association with the embedded application based on received data that indicates that a particular event has occurred at one or more other user devices participating in the chat conversation. Suggested response items are obtained based on the suggestion event, and the suggested response items are displayed by the first user device.

Abstract: The present disclosure relates to pharmaceutical combinations comprising a cyclin dependent kinase 4/6 (CDdK4/6) inhibitor compound, (b) a B-Raf inhibitor compound, and optionally (c) an aipha-isoform specific phosphatidylinositol 3-kinase (P13K) inhibitor compound, for the treatment or prevention of cancer, as well as related pharmaceutical compositions, uses, and methods of treatment or prevention of cancer.

Abstract: Implementations relate to embedded programs and interfaces for chat conversations. In some implementations, a method includes initiating an embedded application in association with a chat interface displayed by a messaging application that executes at least in part on a first user device. The chat interface displays messages originating from other user devices participating in a chat conversation over a network and associated with chat users. An indication is received over the network that one or more particular devices of the other user devices have connected to an embedded session associated with the embedded application. In response, chat identities associated with particular users of the particular user devices are provided from the messaging application to the embedded application. The particular users are designated as member users of the embedded session, and the embedded application is updated based on data received from particular user devices of the embedded session.

Abstract: Implementations relate to embedded programs and interfaces for chat conversations. In some implementations, a method includes initiating an embedded application in association with a chat interface displayed by a messaging application that executes at least in part on a first user device. The chat interface displays messages originating from other user devices participating in a chat conversation over a network and associated with chat users. An indication is received over the network that one or more particular devices of the other user devices have connected to an embedded session associated with the embedded application. In response, chat identities associated with particular users of the particular user devices are provided from the messaging application to the embedded application. The particular users are designated as member users of the embedded session, and the embedded application is updated based on data received from particular user devices of the embedded session.

Abstract: The technology described herein is capable of generating and presenting graphical user interfaces for displaying shared content, configuring space objects (also simply called spaces), posting digital content items to various spaces, inviting other users to contribute digital content items to various spaces, forking digital content items posted in one space or post object to another space or post object, contextual searching, posting rich comments in association with a post including graphical and textual data, and so forth. Further, the technology may provide suggestive search based on the spaces associated with a user, generate and exchange data with other nodes on a computer network, generate notification data including notifications reflecting updates posted to spaces by various users, and coalesce related comments to reduce number of notifications that each user receives and/or through which a user may have to navigate or scroll through.

Abstract: Implementations relate to embedded programs and interfaces for chat conversations. In some implementations, a method includes initiating an embedded application in association with a chat interface displayed by a messaging application that executes at least in part on a first user device. The chat interface displays messages originating from other user devices participating in a chat conversation over a network and associated with chat users. An indication is received over the network that one or more particular devices of the other user devices have connected to an embedded session associated with the embedded application. In response, chat identities associated with particular users of the particular user devices are provided from the messaging application to the embedded application. The particular users are designated as member users of the embedded session, and the embedded application is updated based on data received from particular user devices of the embedded session.

Abstract: The present disclosure relates to pharmaceutical combinations comprising a cyclin dependent kinase 4/6 (CDK4/6) inhibitor compound, (b) a mitogen activated protein kinase (MEK) inhibitor compound, and optionally (c) an alpha-isoform specific phosphatidylinositol 3-kinase (PI3K) inhibitor compound, for the treatment or prevention of cancer, as well as related pharmaceutical compositions, uses, and methods of treatment or prevention of cancer.

Abstract: The present invention relates to a protease variant which is at least 90% identical to the full length amino acid sequence of a Kumamolisin AS backbone as set forth in any of SEQ ID NOs 1-3, while maintaining proteolytic activity, or a fragment, fraction or shuffled variant thereof maintaining proteolytic activity, which protease variant demonstrates altered or improved stability compared to the Kumamolisin AS wildtype as set forth in SEQ ID NO 4, or the Kumamolisin AS backbone as set forth in any of SEQ ID NOs 1-3.

Abstract: Implementations relate to suggested items for use with embedded applications in chat conversations. In some implementations, a method includes causing a chat interface to be displayed by a first user device, the chat interface generated by a messaging application. The chat interface is configured to display, in a chat conversation, messages provided by user devices participating in the chat conversation over a network. An embedded interface is associated with the chat interface and displayed by an embedded application associated with the messaging application. A suggestion event is determined to occur in association with the embedded application based on received data that indicates that a particular event has occurred at one or more other user devices participating in the chat conversation. Suggested response items are obtained based on the suggestion event, and the suggested response items are displayed by the first user device.

Abstract: Implementations relate to embedded programs and interfaces for chat conversations. In some implementations, a method includes initiating an embedded application in association with a chat interface displayed by a messaging application that executes at least in part on a first user device. The chat interface displays messages originating from other user devices participating in a chat conversation over a network and associated with chat users. An indication is received over the network that one or more particular devices of the other user devices have connected to an embedded session associated with the embedded application. In response, chat identities associated with particular users of the particular user devices are provided from the messaging application to the embedded application. The particular users are designated as member users of the embedded session, and the embedded application is updated based on data received from particular user devices of the embedded session.

Abstract: Implementations relate to suggested items for use with embedded applications in chat conversations. In some implementations, a method includes causing a chat interface to be displayed by a first user device, the chat interface generated by a messaging application. The chat interface is configured to display, in a chat conversation, messages provided by user devices participating in the chat conversation over a network. An embedded interface is associated with the chat interface and displayed by an embedded application associated with the messaging application. A suggestion event is determined to occur in association with the embedded application based on received data that indicates that a particular event has occurred at one or more other user devices participating in the chat conversation. Suggested response items are obtained based on the suggestion event, and the suggested response items are displayed by the first user device.

Abstract: The present disclosure relates to a pharmaceutical combination comprising (a) alpha-isoform specific PI3K inhibitor and (b) a B-RAF inhibitor; combined preparations and pharmaceutical compositions thereof; the uses of such combination in the treatment or prevention of cancer; and methods of treating or preventing cancer in a subject comprising administering a therapeutically effective amount of such combination.