Abstract: A chimeric live, infectious, attenuated virus containing a yellow fever virus, in which the nucleotide sequence for a prM-E protein is either deleted, truncated, or mutated, so that functional prM-E protein is not expressed, and integrated into the genome of the yellow fever virus, a nucleotide sequence encoding a prM-E protein of a second, different flavivirus, so that the prM-E protein of the second flavivirus is expressed.

Abstract: A chimeric live, infectious, attenuated virus containing a yellow fever virus, in which the nucleotide sequence for a prM-E protein is either deleted, truncated, or mutated, so that functional prM-E protein is not expressed, and integrated into the genome of the yellow fever virus, a nucleotide sequence encoding a prM-E protein of a second, different flavivirus, so that the prM-E protein of the second flavivirus is expressed.

Abstract: A chimeric live, infectious, attenuated virus containing a yellow fever virus, in which the nucleotide sequence for a prM-E protein is either deleted, truncated, or mutated, so that functional prM-E protein is not expressed, and integrated into the genome of the yellow fever virus, a nucleotide sequence encoding a prM-E protein of a second, different flavivirus, so that the prM-E protein of the second flavivirus is expressed.

Abstract: A chimeric live, infectious, attenuated virus containing a yellow fever virus, in which the nucleotide sequence for a prM-E protein is either deleted, truncated, or mutated, so that functional prM-E protein is not expressed, and integrated into the genome of the yellow fever virus, a nucleotide sequence encoding a prM-E protein of a second, different flavivirus, so that the prM-E protein of the second flavivirus is expressed.

Abstract: A deformable intraocular lens injecting apparatus including a transverse hinged lens cartridge for allowing the lens cartridge to be opened and closed for loading the deformable intraocular lens into the lens cartridge. A preferred embodiment includes a lens cartridge including a lens holding portion connected to a nozzle portion. In this preferred embodiment, the lens holding portion includes a movable wall portion with a protrusion for folding the deformable intraocular lens into a lens delivery passageway of the lens cartridge when closing the movable wall portion.

Abstract: A chimeric live, infectious, attenuated virus containing a yellow fever virus, in which the nucleotide sequence for a prM-E protein is either deleted, truncated, or mutated, so that functional prM-E protein is not expressed, and integrated into the genome of the yellow fever virus, a nucleotide sequence encoding a prM-E protein of a second, different flavivirus, so that the prM-E protein of the second flavivirus is expressed.

Abstract: A method of changing the shape and/or size of an intracorneal ring in situ. The intracorneal ring can be a lens. Preferably, the intracorneal ring is made of a collagen-based polymer material such as COLLAMER.

Abstract: A deformable intraocular lens having frosted and/or colored haptic portions. The frosted haptic portions increase the frictional resistance to movement or rotation within the inner structure of the eye once implanted.

Abstract: A deformable intraocular lens insertion system comprising a lens injecting device and a lens cartridge with a rotary connecting arrangement between the lens injecting device and the lens cartridge. The invention includes preloading the deformable intraocular lens insertion system, in particularly the lens cartridge to reduce the amount of packaging, prevent damage to the deformable intraocular lens during packaging and shipping, allow the preloaded lens cartridge to be autoclaved as a unit, and eliminate the step of loading the lens cartridge with the deformable intraocular lens by the end user to prevent potential damage during this step.

Abstract: A deformable intraocular lens injecting apparatus for inserting a deformable intraocular lens through a small incision into an eye. The apparatus includes a lens injecting body including a lens receiver configured to be operated between an open configuration and a closed configuration, and a nozzle portion provided with a tip portion configured to be inserted through a small incision into an eye. The nozzle portion is configured for connection to the lens receiver of the lens injecting body, and the nozzle portion and the lens receiver defining a lens delivery passageway. A plunger is slidably disposed relative to the lens delivery passageway and configured to engage a deformable intraocular lens within the lens delivery passageway of the lens receiver, and to move the deformable intraocular lens out of the lens delivery passageway into the eye.

Abstract: A deformable intraocular lens injecting apparatus for inserting a deformable intraocular lens through a small incision into an eye. The lens injecting apparatus includes a lens injecting body including a lens receiver configured to be operated between an open configuration and a closed configuration and a nozzle portion provided with a tip portion configured to be inserted through a small incision into an eye. The nozzle portion is configured for connection to the lens injecting body and the nozzle portion and the lens receiver define a lens delivery passageway.

Abstract: A deformable intraocular lens having a resilient haptic portion anchored into a deformable lens portion. Preferably, the haptic portion is anchored in a manner to the lens portion to provide a compressive type of connection therebetween. This anchoring configuration is particularly suitable for use with deformable intraocular lenses made of a collagen-based lens material (e.g. “Collamer”).

Abstract: A deformable intraocular lens insertion system comprising a lens injecting device and a lens cartridge with a rotary connecting arrangement between the lens injecting device and the lens cartridge. The invention includes preloading the deformable intraocular lens insertion system, in particularly the lens cartridge to reduce the amount of packaging, prevent damage to the deformable intraocular lens during packaging and shipping, allow the preloaded lens cartridge to be autoclaved as a unit, and eliminate the step of loading the lens cartridge with the deformable intraocular lens by the end user to prevent potential damage during this step.

Abstract: A deformable intraocular lens injecting apparatus including a spring biased plunger. A preferred embodiment of the lens injecting apparatus includes a separate lens injecting device having a lens cartridge receiver, and a separate one-piece lens cartridge having a lens holding portion connected to a nozzle portion. The lens cartridge is preferably connected into the lens cartridge receiver by a bayonet-type connection.

Abstract: A deformable intraocular lens having frosted and/or colored haptic portions. The frosted haptic portions increase the frictional resistance to movement or rotation within the inner structure of the eye once implanted.

Abstract: A deformable intraocular lens injecting apparatus including a spring biased plunger. A preferred embodiment of the lens injecting apparatus includes a separate lens injecting device having a lens cartridge receiver, and a separate one-piece lens cartridge having a lens holding portion connected to a nozzle portion. The lens cartridge is preferably connected into the lens cartridge receiver by a bayonet-type connection.

Abstract: A lens injecting device comprising a slidable plunger and means for providing a force in a direction opposite to the direction of advancement of the slidable plunger to provide controlled release of the deformable intraocular lens from the lens injecting device. Further, a method of implantation of a deformable intraocular lens in the eye by forcing the deformable intraocular lens in a folded or condensed configuration through a passageway through an incision in the eye while applying an opposing force to control release of the deformable intraocular lens into the eye.

Abstract: A lens injecting device comprising a slidable plunger and means for providing a force in a direction opposite to the direction of advancement of the slidable plunger to provide controlled release of the deformable intraocular lens from the lens injecting device. Further, a method of implantation of a deformable intraocular lens in the eye by forcing the deformable intraocular lens in a folded or condensed configuration through a passageway through an incision in the eye while applying an opposing force to control release of the deformable intraocular lens into the eye.

Abstract: A deformable intraocular lens injecting apparatus including a transverse hinged lens cartridge for allowing the lens cartridge to be opened and closed for loading the deformable intraocular lens into the lens cartridge. A preferred embodiment includes a lens cartridge including a lens holding portion connected to a nozzle portion. In this preferred embodiment, the lens holding portion includes a movable wall portion with a protrusion for folding the deformable intraocular lens into a lens delivery passageway of the lens cartridge when closing the movable wall portion.

Abstract: A deformable intraocular lens injecting apparatus including a transverse hinged lens cartridge for allowing the lens cartridge to be opened and closed for loading the deformable intraocular lens into the lens cartridge. A preferred embodiment includes a lens cartridge including a lens holding portion connected to a nozzle portion. In this preferred embodiment, the lens holding portion includes a movable wall portion with a protrusion for folding the deformable intraocular lens into a lens delivery passageway of the lens cartridge when closing the movable wall portion.