Patents by Inventor Thomas J. Lobl
Thomas J. Lobl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11890112Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).Type: GrantFiled: March 6, 2020Date of Patent: February 6, 2024Assignee: Cognos Therapeutics Inc.Inventors: Yehoshua Shachar, Thomas Chen, Thomas J. Lobl, Jeffrey A. Brydle, Juan R. Gonzalez, Virote Indravudh, Christian Merot, Allan R. Schwartz, Chad Srisathapat
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Patent number: 11890111Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).Type: GrantFiled: March 6, 2020Date of Patent: February 6, 2024Assignee: Cognos Therapeutics Inc.Inventors: Yehoshua Shachar, Thomas Chen, Thomas J. Lobl, Jeffrey A. Brydle, Juan R. Gonzalez, Virote Indravudh, Christian Merot, Allan R. Schwartz, Chad Srisathapat
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Patent number: 11883203Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).Type: GrantFiled: February 28, 2020Date of Patent: January 30, 2024Assignee: Cognos Therapeutics Inc.Inventors: Yehoshua Shachar, Thomas Chen, Thomas J. Lobl, Jeffrey A. Brydle, Juan R. Gonzalez, Virote Indravudh, Christian Merot, Allan R. Schwartz, Chad Srisathapat
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Publication number: 20210121624Abstract: Implantable infusion devices and methods that provide closed loop control.Type: ApplicationFiled: October 23, 2020Publication date: April 29, 2021Applicant: The Alfred E. Mann Foundation for Scientific ResearchInventors: Robert J. GREENBERG, Harshit R. Suri, Thomas J. Lobl, Brian M. Shelton, Sam W. Bowman
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Patent number: 10786155Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).Type: GrantFiled: May 12, 2017Date of Patent: September 29, 2020Assignee: Cognos Therapeutics Inc.Inventors: Yehoshua Shachar, Thomas Chen, Thomas J. Lobl, Jeffrey A. Brydle, Juan R. Gonzalez, Virote Indravudh, Christian Merot, Allan R. Schwartz, Chad Srisathapat
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Publication number: 20200214567Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).Type: ApplicationFiled: March 6, 2020Publication date: July 9, 2020Applicant: Cognos Therapeutics Inc.Inventors: Yehoshua Shachar, Thomas Chen, Thomas J. Lobl, Jeffrey A. Brydle, Juan R. Gonzalez, Virote Indravudh, Christian Merot, Allan R. Schwartz, Chad Srisathapat
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Publication number: 20200205663Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).Type: ApplicationFiled: March 6, 2020Publication date: July 2, 2020Applicant: Cognos Therapeutics Inc.Inventors: Yehoshua Shachar, Thomas Chen, Thomas J. Lobl, Jeffrey A. Brydle, Juan R. Gonzalez, Virote Indravudh, Christian Merot, Allan R. Schwartz, Chad Srisathapat
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Publication number: 20200196868Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).Type: ApplicationFiled: February 28, 2020Publication date: June 25, 2020Applicant: Cognos Therapeutics Inc.Inventors: Yehoshua Shachar, Thomas Chen, Thomas J. Lobl, Jeffrey A. Brydle, Juan R. Gonzalez, Virote Indravudh, Christian Merot, Allan R. Schwartz, Chad Srisathapat
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Publication number: 20170325685Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).Type: ApplicationFiled: May 12, 2017Publication date: November 16, 2017Applicant: Cognos Therapeutics Inc.Inventors: Yehoshua Shachar, Thomas Chen, Thomas J. Lobl, Jeffrey A. Brydle, Juan R. Gonzalez, Virote Indravudh, Christian Merot, Allan R. Schwartz, Chad Srisathapat
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Patent number: 8298176Abstract: Drug solutions (or other combinations of vehicle with entrained drug) are prepared by removing drug from one or more masses of a solid form of the drug. The solid form of the drug may be sparingly soluble or insoluble in water. Examples of devices for holding solid drug and facilitating delivery of such drug to targeted regions are also described.Type: GrantFiled: July 19, 2010Date of Patent: October 30, 2012Assignee: NeuroSystec CorporationInventors: Thomas J. Lobl, Anna Imola Nagy, Jacob E. Pananen, John V. Schloss
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Patent number: 8267905Abstract: Implantable drug delivery systems target delivery of small volumes of drugs to specific tissues. In some cases, a drug delivery system includes an implantable osmotic pump connected to a drug-containing housing, with that housing connected to a needle, cochlear implant or other type of component for ultimate delivery to the target tissue. In some implementations, a subcutaneous port receives a fluid from an external pump. The port is connected to a needle or other component for delivery of one or more drugs to the target tissue. Both solid and liquid drug formulations can be used. In embodiments using solid drugs, a separate drug vehicle (such as saline) can be used to dissolve a portion of the solid drug, with the drug-loaded vehicle then delivered to the target tissue.Type: GrantFiled: May 1, 2006Date of Patent: September 18, 2012Assignee: NeuroSystec CorporationInventors: Thomas J. Lobl, Stephen J. McCormack, Anna Imola Nagy, Jacob E. Pananen, John V. Schloss
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Patent number: 8034787Abstract: The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the enzyme Thimet oligopeptidase, or TOP. Also disclosed are methods of designing prodrugs by utilizing TOP-cleavable sequences within the conjugate and methods of treating patients with prodrugs of the invention.Type: GrantFiled: August 14, 2008Date of Patent: October 11, 2011Assignee: Medarex, Inc.Inventors: Vincent Dubois, Ann Marie Fernandez, Sanjeev Gangwar, Evan Lewis, Thomas J. Lobl, Matthew H. Nieder, Lesley B. Pickford, Andre Trouet, Geoffrey T. Yarranton
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Patent number: 8034959Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.Type: GrantFiled: March 2, 2009Date of Patent: October 11, 2011Assignee: Medarex, Inc.Inventors: Howard P. Ng, Zhi-Hong Li, Danny P. C. McGee, Oliver L. Saunders, Guoxian Wu, David John King, Valeri Martichonok, Sharon Elaine Boyd, Thomas J. Lobl
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Publication number: 20110077579Abstract: An apparatus for providing fluid communication with a cochlear lumen, the apparatus includes a delivery-tube configured for insertion into the cochlear lumen. Delivery-tube orifices on the delivery-tube provide fluid communication between a lumen defined by the delivery-tube and the cochlear lumen.Type: ApplicationFiled: March 23, 2006Publication date: March 31, 2011Inventors: William V. Harrison, Thomas J. Lobl, Stephen J. McCormack
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Publication number: 20110071493Abstract: Drug solutions (or other combinations of vehicle with entrained drug) are prepared by removing drug from one or more masses of a solid form of the drug. The solid form of the drug may be sparingly soluble or insoluble in water. Examples of devices for holding solid drug and facilitating delivery of such drug to targeted regions are also described.Type: ApplicationFiled: July 19, 2010Publication date: March 24, 2011Applicant: NEUROSYSTEC CORPORATIONInventors: Thomas J. Lobl, Anna Imola Nagy, Jacob E. Pananen, John V. Schloss
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Publication number: 20100305551Abstract: A drug-delivery unit suitable for implantation into a patient body may include a valveless impedance pump. In some implementations the unit may include an actuator, control electronics and a battery, and may communicate with an external patient interface unit. The patient interface unit can be used to control operation of the implant and to download data from the implant. The patient interface unit can also be used to charge the implant and/or a separate charger can be used. In other implementations, a drug-delivery implant unit may lack internal electronics and instead rely on an externally-supplied magnetic field to actuate the pump.Type: ApplicationFiled: June 4, 2010Publication date: December 2, 2010Applicant: NEUROSYSTEC CORP.Inventors: Thomas J. Lobl, Jacob E. Pananen, David L. Canfield, Anna I. Nagy, Adrian L. Krag
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Patent number: 7816317Abstract: The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide of three amino acids, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by a trouase enzyme such as Thimet oligopeptidase. Also disclosed are methods of making and using the prodrug compounds.Type: GrantFiled: March 27, 2007Date of Patent: October 19, 2010Assignee: Medarex, Inc.Inventors: Christopher R. Bebbington, Vincent Dubois, Sanjeev Gangwar, Thomas J. Lobl, Matthew H. Nieder, Lesley B. Pickford, Andre Trouet, Geoffrey T. Yarranton
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Patent number: 7803148Abstract: Drug solutions (or other combinations of vehicle with entrained drug) are prepared by removing drug from one or more masses of a solid form of the drug. The solid form of the drug may be sparingly soluble or insoluble in water. Examples of devices for holding solid drug and facilitating delivery of such drug to targeted regions are also described.Type: GrantFiled: June 7, 2007Date of Patent: September 28, 2010Assignee: NeuroSystec CorporationInventors: Thomas J. Lobl, Anna Imola Nagy, Jacob E. Pananen, John V. Schloss
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Patent number: 7696313Abstract: The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide having an isoleucine residue, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by an enzyme associated with the target cell. Methods of making and using the compounds are also disclosed.Type: GrantFiled: January 16, 2008Date of Patent: April 13, 2010Assignee: Medarex, Inc.Inventors: Lesley B. Pickford, Sanjeev Gangwar, Thomas J. Lobl, Matthew H. Nieder, Geoffrey T. Yarranton
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Publication number: 20090209945Abstract: A drug-delivery unit suitable for implantation into a patient body may include a valveless impedance pump. In some implementations the unit may include an actuator, control electronics and a battery, and may communicate with an external patient interface unit. The patient interface unit can be used to control operation of the implant and to download data from the implant. The patient interface unit can also be used to charge the implant and/or a separate charger can be used. In other implementations, a drug-delivery implant unit may lack internal electronics and instead rely on an externally-supplied magnetic field to actuate the pump.Type: ApplicationFiled: January 19, 2009Publication date: August 20, 2009Applicant: NEUROSYSTEC CORPORATIONInventors: Thomas J. Lobl, Jacob E. Pananen, David L. Canfield, Anna I. Nagy, Adrian L. Krag