Patents by Inventor Thomas Johannes Woltering

Thomas Johannes Woltering has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted pyrazolo [1,5-A] pyrimidines as metabotropic glutamate antagonists
    Patent number: 8349844
    Abstract: The present invention relates to compounds of formula (I) wherein A, E G, J, L, M, R1, R2, and R3 are as defined in the specification and claims. The invention also relates to pharmaceutical compositions containing such compounds and methods for preparing the compounds and compositions. The compounds are metabotropic glutamate receptor antagonists and are useful for the treatment of a variety of CNS disorders.
    Type: Grant
    Filed: October 28, 2011
    Date of Patent: January 8, 2013
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Silvia Gatti McArthur, Erwin Goetschi, Juergen Wichmann, Thomas Johannes Woltering
  • Pyridine derivatives as mGluR2 antagonists
    Patent number: 8183262
    Abstract: The present invention relates to compounds of formula (I), a process for the manufacture thereof, pharmaceutical compositions containing them, and their use for treating CNS disorders: wherein A, B, X, Y, R1, R2, R3 and R4 are as defined in the description and claims.
    Type: Grant
    Filed: September 1, 2009
    Date of Patent: May 22, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Silvia Gatti McArthur, Erwin Goetschi, Juergen Wichmann, Thomas Johannes Woltering
  • SUBSTITUTED PYRAZOLO [1,5-A] PYRIMIDINES AS METABOTROPIC GLUTAMATE ANTAGONISTS
    Publication number: 20120041002
    Abstract: The present invention relates to compounds of formula (I) wherein A, E G, J, L, M, R1, R2, and R3 are as defined in the specification and claims. The invention also relates to pharmaceutical compositions containing such compounds and methods for preparing the compounds and compositions. The compounds are metabotropic glutamate receptor antagonists and are useful for the treatment of a variety of CNS disorders.
    Type: Application
    Filed: October 28, 2011
    Publication date: February 16, 2012
    Inventors: Silvia Gatti McArthur, Erwin Goetschi, Juergen Wichmann, Thomas Johannes Woltering
  • Substituted pyrazolo [1,5-a] pyrimidines as metabotropic glutamate antagonists
    Patent number: 8093263
    Abstract: The present invention relates to compounds of formula (I) wherein A, E G, J, L, M, R1, R2, and R3 are as defined in the specification and claims. The invention also relates to pharmaceutical compositions containing such compounds and methods for preparing the compounds and compositions. The compounds are metabotropic glutamate receptor antagonists and are useful for the treatment of a variety of CNS disorders.
    Type: Grant
    Filed: January 6, 2009
    Date of Patent: January 10, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Silvia Gatti McArthur, Erwin Goetschi, Juergen Wichmann, Thomas Johannes Woltering
  • Acetylenyl-pyrazolo-pyrimidine derivatives
    Patent number: 8063048
    Abstract: The present invention relates to compounds of formula (I): wherein R1 to R3, A, M, L, E, G, and J are as defined in the description and claims. The invention also relates to a process for the manufacture of such compounds, pharmaceutical compositions containing them, and methods for treating CNS disorders.
    Type: Grant
    Filed: March 29, 2010
    Date of Patent: November 22, 2011
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Silvia Gatti McArthur, Erwin Goetschi, Wylie Solang Palmer, Juergen Wichmann, Thomas Johannes Woltering
  • ACETYLENYL-PYRAZOLO-PYRIMIDINE DERIVATIVES
    Publication number: 20100210642
    Abstract: The present invention relates to compounds of formula (I): wherein R1 to R3, A, M, L, E, G, and J are as defined in the description and claims. The invention also relates to a process for the manufacture of such compounds, pharmaceutical compositions containing them, and methods for treating CNS disorders.
    Type: Application
    Filed: March 29, 2010
    Publication date: August 19, 2010
    Inventors: Silvia Gatti McArthur, Erwin Goetschi, Wylie Solang Palmer, Juergen Wichmann, Thomas Johannes Woltering
  • Acetylenyl-pyrazolo-pyrimidine derivatives
    Patent number: 7718661
    Abstract: The present invention relates to compounds of formula (I): wherein R1 to R3, A, M, L, E, G, and J are as defined in the description and claims. The invention also relates to a process for the manufacture of such compounds, pharmaceutical compositions containing them, and methods for treating CNS disorders.
    Type: Grant
    Filed: August 12, 2008
    Date of Patent: May 18, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Silvia Gatti McArthur, Erwin Goetschi, Wylie Solang Palmer, Juergen Wichmann, Thomas Johannes Woltering
  • Phenyl-substituted pyrimidine derivatives as mGluR antagonists
    Patent number: 7642264
    Abstract: The present invention relates to compounds of formula (Ia), a process for the manufacture thereof, pharmaceutical compositions containing them, and their use for treating CNS disorders: wherein A, B, R1, R2, R3 and R4 are as defined in the description and claims.
    Type: Grant
    Filed: March 22, 2007
    Date of Patent: January 5, 2010
    Assignee: Hoffman-La Roche Inc.
    Inventors: Silvia Gatti McArthur, Erwin Goetschi, Juergen Wichmann, Thomas Johannes Woltering
  • PYRIDINE AND PYRIMIDINE DERIVATIVES AS MGLUR 2 ANTAGONISTS
    Publication number: 20090318474
    Abstract: The present invention relates to compounds of formula (I), a process for the manufacture thereof, pharmaceutical compositions containing them, and their use for treating CNS disorders: wherein A, B, X, Y, R1, R2, R3 and R4 are as defined in the description and claims.
    Type: Application
    Filed: September 1, 2009
    Publication date: December 24, 2009
    Inventors: Silvia Gatti McArthur, Erwin Goetschi, Juergen Wichmann, Thomas Johannes Woltering
  • SUBSTITUTED PYRAZOLO [1,5-a] PYRIMIDINES AS METABOTROPIC GLUTAMATE ANTAGONISTS
    Publication number: 20090143580
    Abstract: The present invention relates to compounds of formula (I) wherein A, E G, J, L, M, R1, R2, and R3 are as defined in the specification and claims. The invention also relates to pharmaceutical compositions containing such compounds and methods for preparing the compounds and compositions. The compounds are metabotropic glutamate receptor antagonists and are useful for the treatment of a variety of CNS disorders.
    Type: Application
    Filed: January 6, 2009
    Publication date: June 4, 2009
    Inventors: Silvia Gatti McArthur, Erwin Goetschi, Juergen Wichmann, Thomas Johannes Woltering
  • Substituted pyrazolo[1,5-a]pyrimidines as inhibitors of metabotropic glutamate receptors
    Patent number: 7514443
    Abstract: The present invention relates to novel pyrazolo- and imidazo-pyrimidine derivatives of formula I wherein A, D, E, L, M, Q, R1, R2 and R3 are as defined hereinabove. The present invention also relates to a process for their preparation, a pharmaceutical composition containing said derivatives and a method of treating or preventing acute or chronic neurological disorder comprising administering to a patient in need of such treatment a pharmaceutical composition comprising a therapeutically effective amount of at least one such derivatives. These disorders include acute and chronic disorders.
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: April 7, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Juergen Wichmann, Thomas Johannes Woltering
  • Dihydro-benzo[B][1,4]diazepin-2-one sulfonamide derivatives
    Patent number: 7511033
    Abstract: The present invention relates to compounds of formula (I), a process for the manufacture thereof, their use for the preparation of medicaments for treating CNS disorders and pharmaceutical compositions containing them. Compounds of formula (I) are represented by general formula (I) wherein R1, R2, R3 and R4 are defined as in the specification.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: March 31, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Silvia Gatti McArthur, Juergen Wichmann, Thomas Johannes Woltering
  • Compounds as metabotropic glutamate receptor antagonists
    Patent number: 7504404
    Abstract: The present invention relates to compounds of formula (I) wherein A, E G, J, L, M, R1, R2, and R3 are as defined in the specification and claims. The invention also relates to pharmaceutical compositions containing such compounds and methods for preparing the compounds and compositions. The compounds are metabotropic glutamate receptor antagonists and are useful for the treatment of a variety of CNS disorders.
    Type: Grant
    Filed: September 20, 2006
    Date of Patent: March 17, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Silvia Gatti McArthur, Erwin Goetschi, Juergen Wichmann, Thomas Johannes Woltering
  • ACETYLENYL-PYRAZOLO-PYRIMIDINE DERIVATIVES
    Publication number: 20080300250
    Abstract: The present invention relates to compounds of formula (I): wherein R1 to R3, A, M, L, E, G, and J are as defined in the description and claims. The invention also relates to a process for the manufacture of such compounds, pharmaceutical compositions containing them, and methods for treating CNS disorders.
    Type: Application
    Filed: August 12, 2008
    Publication date: December 4, 2008
    Inventors: Silvia Gatti McArthur, Erwin Goetschi, Wylie Solang Palmer, Juergen Wichmann, Thomas Johannes Woltering
  • Acetylenyl-pyrazolo-pyrimidine derivatives
    Patent number: 7446113
    Abstract: The present invention relates to compounds of formula (I): wherein R1 to R3, A, M, L, E, G, and J are as defined in the description and claims. The invention also relates to a process for the manufacture of such compounds, pharmaceutical compositions containing them, and methods for treating CNS disorders.
    Type: Grant
    Filed: March 23, 2007
    Date of Patent: November 4, 2008
    Assignee: Hoffman-La Roche Inc.
    Inventors: Silvia Gatti McArthur, Erwin Goetschi, Wylie Solang Palmer, Juergen Wichmann, Thomas Johannes Woltering
  • DIHYDRO-BENZO[B][1,4]DIAZEPIN-2-ONE SULFONAMIDE DERIVATIVES
    Publication number: 20080261957
    Abstract: The present invention relates to compounds of formula (I), a process for the manufacture thereof, their use for the preparation of medicaments for treating CNS disorders and pharmaceutical compositions containing them. Compounds of formula (I) are represented by general formula (I) wherein R1, R2, R3 and R4 are defined as in the specification.
    Type: Application
    Filed: April 14, 2008
    Publication date: October 23, 2008
    Inventors: Silvia Gatti McArthur, Juergen Wichmann, Thomas Johannes Woltering
  • Pyrazolo-pyrimidine derivatives
    Patent number: 7378417
    Abstract: The invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5 and p are as defined in the description and to pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing such compounds, to the manufacture of such compounds and compositions, and to methods of treating or preventing acute and/or chronic central nervous system disorders by administering such compounds.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: May 27, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Erwin Goetschi, Juergen Wichmann, Thomas Johannes Woltering
  • Pyrrazolo-pyrimidine derivatives
    Patent number: 7361659
    Abstract: The present invention relates to pyrrazolo-pyrimidine derivatives of formula (I): wherein R1 to R4 and A are as defined in the specification, a process for the manufacture thereof, their use for treating or preventing metabotropic glutamate receptors mediated disorders, their use for the preparation of medicaments for treating such disorders and pharmaceutical compositions containing said derivatives.
    Type: Grant
    Filed: February 6, 2006
    Date of Patent: April 22, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Silvia Gatti McArthur, Erwin Goetschi, Juergen Wichmann, Thomas Johannes Woltering
  • Pyrazolo-pyridine
    Patent number: 7329662
    Abstract: The present invention relates to novel pyrazolo- and imidazo-pyrimidine derivatives of formula I wherein A, D, E, L, M, Q, R1, R2 and R3 are as defined hereinabove. The present invention also relates to a process for their preparation, a pharmaceutical composition containing said derivatives and a method of treating or preventing acute or chronic neurological disorder comprising administering to a patient in need of such treatment a pharmaceutical composition comprising a therapeutically effective amount of at least one such derivatives.
    Type: Grant
    Filed: September 24, 2004
    Date of Patent: February 12, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Juergen Wichmann, Thomas Johannes Woltering
  • Pyridine and pyrimidine derivatives as mGIuR2 antagonists
    Publication number: 20070232583
    Abstract: The present invention relates to compounds of formula (I), a process for the manufacture thereof, pharmaceutical compositions containing them, and their use for treating CNS disorders: wherein A, B, X, Y, R1, R2, R3 and R4 are as defined in the description and claims.
    Type: Application
    Filed: March 22, 2007
    Publication date: October 4, 2007
    Inventors: Silvia Gatti McArthur, Erwin Goetschi, Juergen Wichmann, Thomas Johannes Woltering