Patents by Inventor Thomas Joseph Kardos

Thomas Joseph Kardos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200289818
    Abstract: This invention comprises an improved electroporation electrode system comprising a single needle and a ring or donut shaped electrode wherein the difference in surface area of the electrodes provide for a substantial reduction of current density near the surface of the treated tissue and a more concentrated current density sufficient for electroporation only in tissues adjacent to the terminal portion of the single needle electrode. Thus, this invention provides for targeting specific tissue for electroporation and also should provide for lessening the sensation of electric current in the treated tissue.
    Type: Application
    Filed: February 28, 2020
    Publication date: September 17, 2020
    Inventors: Rune KJEKEN, Stephen Vincent KEMMERRER, Feng LIN, Dietmar RABUSSAY, Thomas Joseph KARDOS
  • Patent number: 10610684
    Abstract: This invention comprises an improved electroporation electrode system comprising a single needle and a ring or donut shaped electrode wherein the difference in surface area of the electrodes provide for a substantial reduction of current density near the surface of the treated tissue and a more concentrated current density sufficient for electroporation only in tissues adjacent to the terminal portion of the single needle electrode. Thus, this invention provides for targeting specific tissue for electroporation and also should provide for lessening the sensation of electric current in the treated tissue.
    Type: Grant
    Filed: July 14, 2010
    Date of Patent: April 7, 2020
    Assignee: Genetronics, Inc.
    Inventors: Rune Kjeken, Stephen Vincent Kemmerrer, Feng Lin, Dietmar Rabussay, Thomas Joseph Kardos
  • Publication number: 20190167983
    Abstract: Devices and methods for delivering an electropermeabilizing pulse of electric energy to a tissue surface to enable delivery into cells in the tissue therapeutic substances. The device incorporates a source capable of generating a sufficient voltage potential to deliver a spark across a gap and delivers same to the tissue surface.
    Type: Application
    Filed: February 11, 2019
    Publication date: June 6, 2019
    Applicant: VGX Pharmaceuticals, LLC
    Inventors: Thomas Joseph KARDOS, Stephen Vincent KEMMERRER, Rune KJEKEN, Kate BRODERICK, Jay MCCOY, Michael P. FONS
  • Patent number: 10232173
    Abstract: Devices and methods for delivering an electropermeabilizing pulse of electric energy to a tissue surface to enable delivery into cells in the tissue therapeutic substances. The device incorporates a source capable of generating a sufficient voltage potential to deliver a spark across a gap and delivers same to the tissue surface.
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: March 19, 2019
    Assignee: VGX Pharmaceuticals, LLC
    Inventors: Thomas Joseph Kardos, Stephen Vincent Kemmerer, Rune Kjeken, Kate Broderick, Jay McCoy, Michael P Fons
  • Publication number: 20120046598
    Abstract: Devices and methods for delivering an electropermeabilizing pulse of electric energy to a tissue surface to enable delivery into cells in the tissue therapeutic substances. The device incorporates a source capable of generating a sufficient voltage potential to deliver a spark across a gap and delivers same to the tissue surface.
    Type: Application
    Filed: April 16, 2010
    Publication date: February 23, 2012
    Applicant: VGX PHARMACEUTICALS, LLC
    Inventors: Thomas Joseph Kardos, Stephen Vincent Kemmerer, Rune Kjeken, Kate Broderick, Jay McCoy, Michael P Fons
  • Publication number: 20110009807
    Abstract: This invention comprises an improved electroporation electrode system comprising a single needle and a ring or donut shaped electrode wherein the difference in surface area of the electrodes provide for a substantial reduction of current density near the surface of the treated tissue and a more concentrated current density sufficient for electroporation only in tissues adjacent to the terminal portion of the single needle electrode. Thus, this invention provides for targeting specific tissue for electroporation and also should provide for lessening the sensation of electric current in the treated tissue.
    Type: Application
    Filed: July 14, 2010
    Publication date: January 13, 2011
    Applicant: GENETRONICS, INC.
    Inventors: Rune KJEKEN, Stephen Vincent KEMMERRER, Feng LIN, Dietmar RABUSSAY, Thomas Joseph KARDOS
  • Publication number: 20100249488
    Abstract: This invention provides a novel method of tissue electroporation that eliminates the need for electrodes that conduct electricity to the tissues. This invention creates electric currents and fields sufficient for porating cell membranes for improving the delivery of polynucleotides such as plasmid and linear DNA and RNA constructs, and polypeptides such as antigen protein constructs into mammalian eucaryotic cells purely by magnetic field pulses that does not require the use of contacting electrodes to conduct electric or ionic current. This invention thus provides a method for improving transfection and immunogenicity of pharmaceutical substances without direct contact with a living body, and may be called magnetopermeabilization. A concomitant aspect of the invention is the method by which a drug such as a solution containing DNA is delivered to a targeted tissue bed that is optimal in conjunction with magnetopermeabilization for maximal transgene expression and drug effect.
    Type: Application
    Filed: March 26, 2010
    Publication date: September 30, 2010
    Applicant: MagneGene, Inc.
    Inventors: Thomas Joseph Kardos, Dietmar Paul Rabussay