Abstract: Oral pediatric trimethobenzamide compositions and methods for treating and controlling nausea and/or vomiting are disclosed in warm blooded animals, especially humans including children. The oral pediatric trimethobenzamide compositions and methods of the present invention are believed to be at least as effective as a 200 mg intramuscular (I.M.) trimethobenzamide HCl injectable formulation when administered at a dose of about 100 mg. In addition, an oral pediatric composition containing about 120 mg of trimethobenzamide HCl is believed to be uniquely approximately bioequivalent to a 200 mg intramuscular (I.M.) trimethobenzamide HCl injectable formulation when administered at a dose of about 100 mg.

Abstract: Oral trimethobenzamide compositions and methods for treating and controlling nausea and/or vomiting are disclosed in warm blooded animals, especially humans including children. The oral trimethobenzamide compositions and methods of the present invention are at least as effective as a 200 mg intramuscular (I.M.) trimethobenzamide HCl injectable formulation. In addition, an oral composition containing about 300 mg of trimethobenzamide HCl is uniquely approximately bioequivalent to a 200 mg intramuscular (I.M.) trimethobenzamide HCl injectable formulation. The oral pediatric trimethobenzamide compositions and methods of the present invention are believed to be at least as effective as a 200 mg intramuscular (I.M.) trimethobenzamide HCl injectable formulation when administered at a dose of about 100 mg. In addition, an oral pediatric composition containing about 120 mg of trimethobenzamide HCl is believed to be uniquely approximately bioequivalent to a 200 mg intramuscular (I.M.

Abstract: Olefin polymerization catalysts of the type prepared by (1) drying an inorganic oxide, such as silica, having surface hydroxyl groups to remove adsorbed water, (2) slurrying the dried inorganic oxide in an inert liquid hydrocarbon, such as a hydrocarbon boiling in the C.sub.4 -C.sub.8 range, (3) reacting the surface hydroxyl groups of the dried inorganic oxide with an organometallic compound, such as a trialkylaluminum, and (4) reacting the thus-treated support with a vanadium compound, such as vanadium oxytrichloride, are made reproducibly uniform at commercial scale by modifying the catalyst syntheses so as to (a) conduct the reactions with agitation in an amount of inert liquid hydrocarbon such as to provide a weight/unit volume solids content of about 10 to 50% and (b) add the vanadium compound to the agitated slurry of treated inorganic oxide particles at a rate such as to ensure substantially uniform coverage of those particles with the vanadium compound as it reacts therewith.