Patents by Inventor Thomas L. Little

Thomas L. Little has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MASP-2 INHIBITORS AND METHODS OF USE
    Publication number: 20240092788
    Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
    Type: Application
    Filed: September 6, 2023
    Publication date: March 21, 2024
    Applicant: Omeros Corporation
    Inventors: Neil S. Cutshall, Jennifer Lynn Gage, Sara Rebecca Goldstein, Santosh Kumar Keshipeddy, Do Yeon Kwon, Robert Huerta Lemus, Thomas L. Little, Markus Metz, Jeremiah H. Nguyen, Peter Kurt Nollert Von Specht, Loren Michael Price, Jennifer Tsoung, Sudheer Babu Vaddela
  • MASP-2 inhibitors and methods of use
    Patent number: 11807641
    Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: November 7, 2023
    Assignee: Omeros Corporation
    Inventors: Michael Cicirelli, Neil S. Cutshall, Jennifer Lynn Gage, Sara Rebecca Goldstein, Santosh Kumar Keshipeddy, Do Yeon Kwon, Robert Huerta Lemus, Thomas L. Little, Markus Metz, Jeremiah H. Nguyen, Peter Kurt Nollert von Specht, Loren Michael Price, Jennifer Tsoung, Sudheer Babu Vaddela
  • Inhibitors of GPR174 and Uses Thereof
    Publication number: 20230321083
    Abstract: GPR174 is an orphan receptor that has been implicated in cancer, nervous system diseases and disorders and neuroregeneration. We have identified inhibitors of GPR174 and have identified the G-protein signaling pathways that GPR174 modulates. Based on this discovery, the present invention features methods for inhibiting GPR174 activity and thereby stimulating an immune response in a subject in need thereof, particularly in the use of treatment of non-malignant neoplasms, malignant neoplasms (i.e., cancer), nervous system diseases and disorders and neuroregeneration, as well as related compositions.
    Type: Application
    Filed: October 11, 2022
    Publication date: October 12, 2023
    Inventors: Michael Cicirelli, Neil S. Cutshall, Gregory A. Demopulos, George A. Gaitanaris, Alexander Gragerov, Thomas L. Little, Rene Onrust
  • ALKOXY COMPOUNDS FOR DISEASE TREATMENT
    Publication number: 20230218549
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt’s Disease.
    Type: Application
    Filed: August 5, 2022
    Publication date: July 13, 2023
    Inventors: Ian L. SCOTT, Vladimir A. KUKSA, Mark W. ORME, Thomas L. LITTLE, JR., Anna GALL, Feng HONG
  • MASP-2 inhibitors and methods of use
    Patent number: 11661418
    Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: May 30, 2023
    Assignee: OMEROS CORPORATION
    Inventors: Neil S. Cutshall, Jennifer Lynn Gage, Sara Rebecca Goldstein, Santosh Kumar Keshipeddy, Do Yeon Kwon, Robert Huerta Lemus, Thomas L. Little, Markus Metz, Peter Kurt Nollert Von Specht, Loren Michael Price, Jennifer Tsoung
  • MASP-2 INHIBITORS AND METHODS OF USE
    Publication number: 20230145071
    Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds and methods of making and using such compounds.
    Type: Application
    Filed: November 30, 2022
    Publication date: May 11, 2023
    Inventors: Neil S. Cutshall, Jennifer Lynn Gage, Franz A. Gruswitz, Juhienah Khalaf, Thomas L. Little, Markus Metz, Jeremiah H. Nguyen, Peter Kurt Nollert von Specht, Jennifer Tsoung, Michael Cicirelli, Sara Rebecca Goldstein, Santosh Kumar Keshipeddy, Do Yeon Kwon, Robert Huerta Lemus, Sudheer Babu Vaddela
  • MASP-2 inhibitors and methods of use
    Patent number: 11584714
    Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds and methods of making and using such compounds.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: February 21, 2023
    Assignee: OMEROS CORPORATION
    Inventors: Neil S. Cutshall, Jennifer Lynn Gage, Franz A. Gruswitz, Juhienah Khalaf, Thomas L. Little, Markus Metz, Jeremiah H. Nguyen, Peter Kurt Nollert von Specht, Jennifer Tsoung, Michael Cicirelli, Sara Rebecca Goldstein, Santosh Kumar Keshipeddy, Do Yeon Kwon, Robert Huerta Lemus, Sudheer Babu Vaddela
  • Alkoxy compounds for disease treatment
    Patent number: 11446261
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Grant
    Filed: May 1, 2020
    Date of Patent: September 20, 2022
    Assignee: Acucela Inc.
    Inventors: Ian L. Scott, Vladimir A. Kuksa, Mark W. Orme, Thomas L. Little, Jr., Anna Gall, Feng Hong
  • MASP-2 INHIBITORS AND METHODS OF USE
    Publication number: 20210179612
    Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
    Type: Application
    Filed: December 4, 2020
    Publication date: June 17, 2021
    Inventors: Neil S. CUTSHALL, Jennifer Lynn GAGE, Do Yeon KWON, Thomas L. LITTLE, Markus METZ, Peter Kurt NOLLERT VON SPECHT, Jennifer TSOUNG, Jeremiah H. NGUYEN, Melinda DAVIS, Robert Huerta LEMUS, Santosh Kumar KESHIPEDDY, Sara Rebecca GOLDSTEIN
  • MASP-2 INHIBITORS AND METHODS OF USE
    Publication number: 20210171461
    Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
    Type: Application
    Filed: December 4, 2020
    Publication date: June 10, 2021
    Inventors: Neil S. CUTSHALL, Jennifer Lynn GAGE, Sara Rebecca GOLDSTEIN, Do Yeon KWON, Thomas L. LITTLE, Markus METZ, Peter Kurt NOLLERT VON SPECHT, Jennifer TSOUNG
  • MASP-2 INHIBITORS AND METHODS OF USE
    Publication number: 20210171531
    Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
    Type: Application
    Filed: December 4, 2020
    Publication date: June 10, 2021
    Inventors: Michael CICIRELLI, Neil S. CUTSHALL, Jennifer Lynn GAGE, Sara Rebecca GOLDSTEIN, Santosh Kumar KESHIPEDDY, Do Yeon KWON, Robert Huerta LEMUS, Thomas L. LITTLE, Markus METZ, Jeremiah H. NGUYEN, Peter Kurt NOLLERT VON SPECHT, Loren Michael PRICE, Jennifer TSOUNG, Sudheer Babu VADDELA
  • MASP-2 INHIBITORS AND METHODS OF USE
    Publication number: 20210171512
    Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
    Type: Application
    Filed: December 4, 2020
    Publication date: June 10, 2021
    Inventors: Neil S. CUTSHALL, Jennifer Lynn GAGE, Sara Rebecca GOLDSTEIN, Santosh Kumar KESHIPEDDY, Do Yeon KWON, Robert Huerta LEMUS, Thomas L. LITTLE, Markus METZ, Peter Kurt NOLLERT VON SPECHT, Loren Michael PRICE, Jennifer TSOUNG
  • ALKOXY COMPOUNDS FOR DISEASE TREATMENT
    Publication number: 20210077427
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Application
    Filed: May 1, 2020
    Publication date: March 18, 2021
    Inventors: Ian L. SCOTT, Vladimir A. KUKSA, Mark W. ORME, Thomas L. LITTLE, Jr., Anna GALL, Feng HONG
  • Methods and Compositions for Treating Cancer
    Publication number: 20200345725
    Abstract: This disclosure is directed to compounds, compositions, and methods for the treatment of various diseases and/or conditions related to G protein-coupled receptor 174 (e.g., cancers).
    Type: Application
    Filed: January 10, 2020
    Publication date: November 5, 2020
    Inventors: Michael Cicirelli, Neil S. Cutshall, Gregory A. Demopulos, George A. Gaitanaris, Marc A. Gavin, Alexander Gragerov, Thomas L. Little, Rene Onrust
  • Inhibitors of GPR174 and Uses Thereof
    Publication number: 20200276190
    Abstract: GPR174 is an orphan receptor that has been implicated in cancer, nervous system diseases and disorders and neuroregeneration. We have identified inhibitors of GPR174 and have identified the G-protein signaling pathways that GPR174 modulates. Based on this discovery, the present invention features methods for inhibiting GPR174 activity and thereby stimulating an immune response in a subject in need thereof, particularly in the use of treatment of non-malignant neoplasms, malignant neoplasms (i.e., cancer), nervous system diseases and disorders and neuroregeneration, as well as related compositions.
    Type: Application
    Filed: November 13, 2019
    Publication date: September 3, 2020
    Inventors: Michael Cicirelli, Neil S. Cutshall, Gregory A. Demopulos, George A. Gaitanaris, Alexander Gragerov, Thomas L. Little, Rene Onrust
  • Alkoxy compounds for disease treatment
    Patent number: 10639286
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: May 5, 2020
    Assignee: ACUCELA INC.
    Inventors: Ian L. Scott, Vladimir A. Kuksa, Mark W. Orme, Thomas L. Little, Jr., Anna Gall, Feng Hong
  • MASP-2 INHIBITORS AND METHODS OF USE
    Publication number: 20190367452
    Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds and methods of making and using such compounds.
    Type: Application
    Filed: May 29, 2019
    Publication date: December 5, 2019
    Inventors: Neil S. Cutshall, Jennifer Lynn Gage, Franz A. Gruswitz, Juhienah Khalaf, Thomas L. Little, Markus Metz, Jeremiah H. Nguyen, Peter Kurt Nollert von Specht, Jennifer Tsoung, Michael Cicirelli, Sara Rebecca Goldstein, Santosh Kumar Keshipeddy, Do Yeon Kwon, Robert Huerta Lemus, Sudheer Babu Vaddela
  • ALKOXY COMPOUNDS FOR DISEASE TREATMENT
    Publication number: 20190183816
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Application
    Filed: July 23, 2018
    Publication date: June 20, 2019
    Inventors: Ian L. SCOTT, Vladimir A. KUKSA, Mark W. ORME, Thomas L. LITTLE, JR., Anna GALL, Feng HONG
  • Styrenyl derivative compounds for treating ophthalmic diseases and disorders
    Patent number: 10201545
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: February 12, 2019
    Assignee: ACUCELA INC.
    Inventors: Ian Leslie Scott, Vladimir Aleksandrovich Kuksa, Anna Gall, Mark W. Orme, Jennifer Gage, Thomas L. Little, Jr., Qin Jiang, Lana Michele Rossiter, Kevin F. McGee, Jr., Ryo Kubota
  • Alkoxy compounds for disease treatment
    Patent number: 10188615
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: January 29, 2019
    Assignee: ACUCELA INC.
    Inventors: Ian L. Scott, Vladimir A. Kuksa, Mark W. Orme, Thomas L. Little, Jr., Anna Gall, Feng Hong