Publication number: 20080214654
Abstract: The present invention relates to novel substituted benzyloxy-phenylmethylamide derivatives, processes for their preparation, and their use in medicaments, especially for the prophylaxis and treatment of diseases associated with Cold Menthol Receptor 1 (CMR-1) activity, in particular for the treatment of urological diseases or disorders, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor oeractivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pulmonary (or airways) disease (COPD).
Type:
Application
Filed:
October 12, 2005
Publication date:
September 4, 2008
Applicant:
Bayer HealthCare AG
Inventors:
Thomas Lampe, Cristina Alonso-Alija, Beatrix Stelte-Ludwig, Peter Sandner, Marcus Bauser, Hartmut Beck, Klemens Lustig, Ulrich Rosentreter, Elke Stahl, Hiroko Takagi