Patents by Inventor Thomas Lavergne

Thomas Lavergne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210406254
    Abstract: Provenance analysis systems and methods. Datums representing relationships between entities can be stored in a knowledge store. Datums can be received from agents as agents perform activities. Activity records are be stored in a provenance graph, the activity record and associate received datums with any input datums used in the activity. Provenance subgraphs can be retrieved by traversing the provenance graph for selected datums and presented through a user interface. Provenance subgraphs can be augmented with trust modifiers determined based on attributions, confidences, and refutations provided by a user. Trust modifiers can be propagated downstream to enable the addressing of junctions in variable confidence.
    Type: Application
    Filed: June 26, 2020
    Publication date: December 30, 2021
    Inventors: Scott Ehrlich Friedman, Jeffrey Mathew Rye, David Thomas LaVergne
  • Publication number: 20210406257
    Abstract: Provenance analysis systems and methods. Datums representing relationships between entities can be stored in a knowledge store. Datums can be received from agents as agents perform activities. Activity records are be stored in a provenance graph, the activity record and associate received datums with any input datums used in the activity. Provenance subgraphs can 5 be retrieved by traversing the provenance graph for selected datums and presented through a user interface. Provenance subgraphs can be augmented with trust modifiers determined based on attributions, confidences, and refutations provided by a user. Trust modifiers can be propagated downstream to enable the addressing of junctions in variable confidence.
    Type: Application
    Filed: September 11, 2020
    Publication date: December 30, 2021
    Inventors: Scott Ehrlich Friedman, Jeffrey Mathew Rye, David Thomas LaVergne
  • Patent number: 10626138
    Abstract: Provided herein are analogs of unnatural nucleotides bearing predominantly hydrophobic nucleobase analogs that form unnatural base pairs during DNA polymerase-mediated replication of DNA or RNA polymerase-mediated transcription of RNA. In this manner, the unnatural nucleobases can be introduced in a site-specific way into oligonucleotides (single or double stranded DNA or RNA), where they can provide for site-specific cleavage, or can provide a reactive linker than can undergo functionalization with a cargo-bearing reagent by means of reaction with a primary amino group or by means of click chemistry with an alkyne group of the unnatural nucleobase linker.
    Type: Grant
    Filed: August 8, 2014
    Date of Patent: April 21, 2020
    Assignees: THE SCRIPPS RESEARCH INSTITUTE NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT NIH DIVISION OF EXTRAMURAL INVENTIONS AND TECHNOLOGY RESOURCES (DEITR)
    Inventors: Floyd E. Romesberg, Denis A. Malyshev, Lingjun Li, Thomas Lavergne, Zhengtao Li
  • Publication number: 20200040027
    Abstract: Provided herein are analogs of unnatural nucleotides bearing predominantly hydrophobic nucleobase analogs that form unnatural base pairs during DNA polymerase-mediated replication of DNA or RNA polymerase-mediated transcription of RNA. In this manner, the unnatural nucleobases can be introduced in a site-specific way into oligonucleotides (single or double stranded DNA or RNA), where they can provide for site-specific cleavage, or can provide a reactive linker than can undergo functionalization with a cargo-bearing reagent by means of reaction with a primary amino group or by means of click chemistry with an alkyne group of the unnatural nucleobase linker.
    Type: Application
    Filed: July 22, 2019
    Publication date: February 6, 2020
    Inventors: Floyd E. ROMESBERG, Denis A. MALYSHEV, Lingjun LI, Thomas LAVERGNE, Zhengtao LI
  • Publication number: 20200017540
    Abstract: Provided herein are analogs of unnatural nucleotides bearing predominantly hydrophobic nucleobase analogs that form unnatural base pairs during DNA polymerase-mediated replication of DNA or RNA polymerase-mediated transcription of RNA. In this manner, the unnatural nucleobases can be introduced in a site-specific way into oligonucleotides (single or double stranded DNA or RNA), where they can provide for site-specific cleavage, or can provide a reactive linker than can undergo functionalization with a cargo-bearing reagent by means of reaction with a primary amino group or by means of click chemistry with an alkyne group of the unnatural nucleobase linker.
    Type: Application
    Filed: August 8, 2019
    Publication date: January 16, 2020
    Inventors: Floyd E. ROMESBERG, Denis A. MALYSHEV, Lingjun LI, Thomas LAVERGNE, Zhengtao LI
  • Publication number: 20160168187
    Abstract: Provided herein are analogs of unnatural nucleotides bearing predominantly hydrophobic nucleobase analogs that form unnatural base pairs during DNA polymerase-mediated replication of DNA or RNA polymerase-mediated transcription of RNA. In this manner, the unnatural nucleobases can be introduced in a site-specific way into oligonucleotides (single or double stranded DNA or RNA), where they can provide for site-specific cleavage, or can provide a reactive linker than can undergo functionalization with a cargo-bearing reagent by means of reaction with a primary amino group or by means of click chemistry with an alkyne group of the unnatural nucleobase linker.
    Type: Application
    Filed: August 8, 2014
    Publication date: June 16, 2016
    Applicant: Synthorx, Inc.
    Inventors: Floyd E. ROMESBERG, Denis A. MALYSHEV, Lingjun LI, Thomas LAVERGNE, Zhengtao LI
  • Patent number: 8536318
    Abstract: The invention relates to a method for the chemical synthesis of RNA, comprising the following steps: a) bonding to a solid support of a monomer having formula (II) in which—X1 is a dimethoxytrityl group,—X6 is H or an OAc group or OX3, in which X3 is a group having formula (A), in which X is O or S, R? is H or CH3 and R is selected from a linear or branched alkyl group at C1 to C4 and a R1—O—R2 group in which R1 is an alkyl group at C1 to C2 and R2 is a CH3 group or CH2CH2—O—CH3 or aryl; b) assembly with the monomer having formula (II) bound to the support thereof obtained in step (a) of at least one monomer having formula (III) in which X1, Bp, X3 are as defined for formula (II) and X5 is a hydrogen phosphonate monoester or phosphoramidite group, preferably a 2-cyanoethyl-N,N-diisopropylphosphoramidite group, which is used to obtain a protected single-strand RNA bound to a support.
    Type: Grant
    Filed: May 28, 2009
    Date of Patent: September 17, 2013
    Assignees: Centre National de la Recherche Scientifique, Universite Montpellier 2
    Inventors: Françoise Debart, Jean-Jacques Vasseur, Thomas Lavergne
  • Publication number: 20110275793
    Abstract: The invention relates to a method for the chemical synthesis of RNA, comprising the following steps: a) bonding to a solid support of a monomer having formula (II) in which—X1 is a dimethoxytrityl group,—X6 is H or an OAc group or OX3, in which X3 is a group having formula (A), in which X is O or S, R? is H or CH3 and R is selected from a linear or branched alkyl group at C1 to C4 and a R1—O—R2 group in which R1 is an alkyl group at C1 to C2 and R2 is a CH3 group or CH2CH2—O—CH3 or aryl; b) assembly with the monomer having formula (II) bound to the support thereof obtained in step (a) of at least one monomer having formula (III) in which X1, Bp, X3 are as defined for formula (II) and X5 is a hydrogen phosphonate monoester or phosphoramidite group, preferably a 2-cyanoethyl-N,N-diisopropylphosphoramidite group, which is used to obtain a protected single-strand RNA bound to a support.
    Type: Application
    Filed: May 28, 2009
    Publication date: November 10, 2011
    Inventors: Françoise Debart, Jean-Jacques Vasseur, Thomas Lavergne