Patents by Inventor Thomas M. Grogan

Thomas M. Grogan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170262984
    Abstract: Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of interest (AOI) within an image of the cell sample are generated. Hyperspectral or multispectral data from each FOV is organized into an image stack containing one or more z-layers, with each z-layer containing intensity data for a single marker at each pixel in the FOV. A cluster analysis is applied to the image stacks, wherein the clustering algorithm groups pixels having a similar ratio of detectable marker intensity across layers of the z-axis, thereby generating a plurality of clusters having similar expression patterns.
    Type: Application
    Filed: May 26, 2017
    Publication date: September 14, 2017
    Inventors: Michael Barnes, David Chafin, Karl Garsha, Thomas M. Grogan, Esteban Roberts, Benjamin Stevens, Franklin Ventura, Christophe Chefd'hotel, Kandavel Shanmugam, Joe Gray, Damien Ramunno-Johnson, Tania Vu
  • Publication number: 20170212122
    Abstract: Disclosed herein are multiplex methods for co-detecting a B cell marker, TP53 nucleic acid, and Chromosome 17 centromere DNA in a single sample. Samples stained for the B cell marker (e.g., CD79a protein), TP53 nucleic acid, and Chromosome 17 centromere DNA may allow for the identification of the subtype of chronic lymphocytic leukemia (CLL) with the 17p deletion. The methods feature staining the B cell marker (e.g., CD79a) a first distinct color, TP53 in a second distinct color, and chromosome 17 centromere DNA in a third distinct color. Further disclosed are nucleic acid probes specific for 19q12, INSR, ATM, DLEU2, TP53, and 13q12.
    Type: Application
    Filed: March 28, 2017
    Publication date: July 27, 2017
    Inventors: Nelson R. Alexander, Thomas M. Grogan, Leigh A. Henricksen, Brian D. Kelly, Hiro Nitta, Stacey Stanislaw, Alisa Tubbs
  • Patent number: 7851145
    Abstract: The present disclosure provides methods of diagnosing cervical dysplasia and cervical cancer by detecting Na+, K+-ATPase expression. For example, it is demonstrated herein that expression of the Na+, K+-ATPase ?1-subunit increases in cervical dysplasia and cervical cancer, relative to normal cervical tissue. Also provided are methods of treating cervical dysplasia and cervical cancer by decreasing the biological activity of the Na+, K+-ATPase. For example, therapeutically effective amounts of one or more Na+, K+-ATPase inhibitors can be applied to the cervix to treat cervical dysplasia and cervical cancer.
    Type: Grant
    Filed: December 27, 2006
    Date of Patent: December 14, 2010
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Hiroaki Nitta, Thomas M. Grogan, Phillip Miller
  • Patent number: 7470541
    Abstract: An automated immunostaining apparatus having a reagent application zone and a reagent supply zone. The apparatus has a carousel slide support supporting a plurality of slide supports thereon, and drive means engaging the carousel slide support for consecutively positioning each of a plurality of slide supports in the reagent application zone. The apparatus also has a carousel reagent support having a plurality of reagent container supports thereon, and drive means engaging the carousel for rotating the carousel and positioning a preselected reagent container support in the reagent supply zone. The apparatus also has a reagent delivery actuator means positioned for engaging a reagent container positioned on a container support in the reagent delivery zone and initiating reagent delivery from the reagent container to a slide supported on a slide support in the reagent receiving zone.
    Type: Grant
    Filed: November 17, 2004
    Date of Patent: December 30, 2008
    Assignee: Ventana Medical System, Inc.
    Inventors: Keith G. Copeland, Thomas M. Grogan, Charles Hassen, William Ross Humphreys, Charles D. Lemme, Philip C. Miller, William L. Richards, Wayne A. Showalter
  • Publication number: 20080299555
    Abstract: The present invention provides compositions, kits, assembles of articles and methodology for detecting multiple target molecules in a sample, such as in a tissue sample. In particular, site-specific deposition of elemental metal is used in conjunction with other means of detection, such as other chromogenic, radioactive, chemiluminescent and fluorescent labeling, to simultaneously detect multiple targets, such a gene, a protein, and a chromosome, in a biological sample. More particularly the multiple targets may be labeled with the specifically deposited metal and other chromogenic labels to allow chromogenic immunohistochemical (IHC) detection in situ by using bright field light microscope.
    Type: Application
    Filed: May 30, 2007
    Publication date: December 4, 2008
    Inventors: Hiroaki Nitta, Thomas M. Grogan
  • Publication number: 20080286386
    Abstract: The present disclosure provides methods of diagnosing cervical dysplasia and cervical cancer by detecting Na+, K+-ATPase expression. For example, it is demonstrated herein that expression of the Na+, K+-ATPase ?1-subunit increases in cervical dysplasia and cervical cancer, relative to normal cervical tissue. Also provided are methods of treating cervical dysplasia and cervical cancer by decreasing the biological activity of the Na+, K+-ATPase. For example, therapeutically effective amounts of one or more Na+, K+-ATPase inhibitors can be applied to the cervix to treat cervical dysplasia and cervical cancer.
    Type: Application
    Filed: December 27, 2006
    Publication date: November 20, 2008
    Inventors: Hiroaki Nitta, Thomas M. Grogan, Phillip Miller
  • Patent number: 7118918
    Abstract: An automated immunostaining apparatus having a reagent application zone and a reagent supply zone. The apparatus has a carousel slide support supporting a plurality of slide supports thereon, and drive engaging the carousel slide support for consecutively positioning each of a plurality of slide supports in the reagent application zone. The apparatus also has a carousel reagent support having a plurality of reagent container supports thereon, and drive engaging the carousel for rotating the carousel and positioning a preselected reagent container support in the reagent supply zone. The apparatus also has a reagent delivery actuator positioned for engaging a reagent container positioned on a container support in the reagent delivery zone and initiating reagent delivery from the reagent container to a slide supported on a slide support in the reagent receiving zone.
    Type: Grant
    Filed: August 16, 2001
    Date of Patent: October 10, 2006
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Keith G. Copeland, Thomas M. Grogan, Charles Hassen, William Ross Humphreys, Charles D. Lemme, Phillip C. Miller, William L. Richards, Wayne A. Showalter
  • Patent number: 6943029
    Abstract: An automated immunostaining apparatus having a reagent application zone and a reagent supply zone. The apparatus has a carousel slide support supporting a plurality of slide supports thereon, and drive means engaging the carousel slide support for consecutively positioning each of a plurality of slide supports in the reagent application zone. The apparatus also has a carousel reagent support having a plurality of reagent container supports thereon, and drive means engaging the carousel for rotating the carousel and positioning a preselected reagent container support in the reagent supply zone. The apparatus also has a reagent delivery actuator means positioned for engaging a reagent container positioned on a container support in the reagent delivery zone and initiating reagent delivery from the reagent container to a slide supported on a slide support in the reagent receiving zone.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: September 13, 2005
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Keith G. Copeland, Thomas M. Grogan, Charles Hassen, William Ross Humphreys, Charles D. Lemme, Phillip C. Miller, William L. Richards, Wayne A. Showalter
  • Patent number: 6827901
    Abstract: An automated immunostaining apparatus having a reagent application zone and a reagent supply zone. The apparatus has a carousel slide support supporting a plurality of slide supports thereon, and drive means engaging the carousel slide support for consecutively positioning each of a plurality of slide supports in the reagent application zone. The apparatus also has a carousel reagent support having a plurality of reagent container supports thereon, and drive means engaging the carousel for rotating the carousel and positioning a preselected reagent container support in the reagent supply zone. The apparatus also has a reagent delivery actuator means positioned for engaging a reagent container positioned on a container support.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: December 7, 2004
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Keith G. Copeland, Thomas M. Grogan, Charles Hassen, William Ross Humphreys, Charles D. Lemme, Phillip C. Miller, William L. Richards, Wayne A. Showalter
  • Publication number: 20020114733
    Abstract: An automated immunostaining apparatus having a reagent application zone and a reagent supply zone. The apparatus has a carousel slide support supporting a plurality of slide supports thereon, and drive means engaging the carousel slide support for consecutively positioning each of a plurality of slide supports in the reagent application zone. The apparatus also has a carousel reagent support having a plurality of reagent container supports thereon, and drive means engaging the carousel for rotating the carousel and positioning a preselected reagent container support in the reagent supply zone. The apparatus also has a reagent delivery actuator means positioned for engaging a reagent container positioned on a container support in the reagent delivery zone and initiating reagent delivery from the reagent container to a slide supported on a slide support in the reagent receiving zone.
    Type: Application
    Filed: May 2, 2002
    Publication date: August 22, 2002
    Inventors: Keith G. Copeland, Thomas M. Grogan, Charles Hassen, William Ross Humphreys, Charles D. Lemme, Phillip C. Miller, William L. Richards, Wayne A. Showalter
  • Publication number: 20020072122
    Abstract: An automated immunostaining apparatus having a reagent application zone and a reagent supply zone. The apparatus has a carousel slide support supporting a plurality of slide supports thereon, and drive means engaging the carousel slide support for consecutively positioning each of a plurality of slide supports in the reagent application zone. The apparatus also has a carousel reagent support having a plurality of reagent container supports thereon, and drive means engaging the carousel for rotating the carousel and positioning a preselected reagent container support in the reagent supply zone. The apparatus also has a reagent delivery actuator means positioned for engaging a reagent container positioned on a container support in the reagent delivery zone and initiating reagent delivery from the reagent container to a slide supported on a slide support in the reagent receiving zone.
    Type: Application
    Filed: January 22, 2002
    Publication date: June 13, 2002
    Applicant: Ventana Medical Systems, Inc.
    Inventors: Keith G. Copeland, Thomas M. Grogan, Charles Hassen, William Ross Humphreys, Charles D. Lemme, Phillip C. Miller, William L. Richards, Wayne A. Showalter
  • Patent number: 6352861
    Abstract: An automated immunostaining apparatus having a reagent application zone and a reagent supply zone. The apparatus has a carousel slide support supporting a plurality of slide supports thereon, and drive means engaging the carousel slide support for consecutively positioning each of a plurality of slide supports in the reagent application zone. The apparatus also has a carousel reagent support having a plurality of reagent container supports thereon, and drive means engaging the carousel for rotating the carousel and positioning a preselected reagent container support in the reagent supply zone. The apparatus also has a reagent delivery actuator means positioned for engaging a reagent container positioned on a container support in the reagent delivery zone and initiating reagent delivery from the reagent container to a slide supported on a slide support in the reagent receiving zone.
    Type: Grant
    Filed: December 1, 1999
    Date of Patent: March 5, 2002
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Keith G. Copeland, Thomas M. Grogan, Charles Hassen, William Ross Humphreys, Charles E. Lemme, Phillip C. Miller, William L. Richards, Wayne A. Showalter
  • Publication number: 20020001849
    Abstract: An automated immunostaining apparatus having a reagent application zone and a reagent supply zone. The apparatus has a carousel slide support supporting a plurality of slide supports thereon, and drive means engaging the carousel slide support for consecutively positioning each of a plurality of slide supports in the reagent application zone. The apparatus also has a carousel reagent support having a plurality of reagent container supports thereon, and drive means engaging the carousel for rotating the carousel and positioning a preselected reagent container support in the reagent supply zone. The apparatus also has a reagent delivery actuator means positioned for engaging a reagent container positioned on a container support in the reagent delivery zone and initiating reagent delivery from the reagent container to a slide supported on a slide support in the reagent receiving zone.
    Type: Application
    Filed: August 16, 2001
    Publication date: January 3, 2002
    Inventors: Keith G. Copeland, Thomas M. Grogan, Charles Hassen, William R. Humphreys, Charles D. Lemme, Phillip C. Miller, William L. Richards, Wayne A. Showalter
  • Patent number: 5654199
    Abstract: An automated immunostaining apparatus having a reagent application zone and a reagent supply zone. The apparatus has a carousel slide support (24) supporting a plurality of slide supports (26) thereon, and drive means (48) engaging the carousel slide support (24) for consecutively positioning each of a plurality of slide supports (26) in the reagent application zone. The apparatus also has a carousel reagent support (10) having a plurality of reagent container supports (11) thereon, and drive means (14) engaging the carousel for rotating the carousel and positioning a preselected reagent container support (11) in the reagent supply zone. The apparatus also has a reagent delivery actuator means (18) positioned for engaging a reagent container (12) positioned on a container support (11) in the reagent delivery zone and initiating reagent delivery from the reagent container (12) to a slide supported on a slide support (26) in the reagent receiving zone.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: August 5, 1997
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Keith G. Copeland, Thomas M. Grogan, Phillip C. Miller, William L. Richards, Wayne A. Showalter
  • Patent number: 5654200
    Abstract: An automated immunostaining apparatus having a reagent application zone and a reagent supply zone. The apparatus has a carousel slide support supporting a plurality of slide supports thereon, and drive device engaging the carousel slide support for consecutively positioning each of a plurality of slide supports in the reagent application zone. The apparatus also has a carousel reagent support having a plurality of reagent container supports thereon, and drive device engaging the carousel for rotating the carousel and positioning a preselected reagent container support in the reagent supply zone. The apparatus also has a reagent delivery actuator device positioned for engaging a reagent container positioned on a container support in the reagent delivery zone and initating reagent delivery from the reagent container to a slide supported on a slide support in the reagent receiving zone.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: August 5, 1997
    Assignee: Ventana Medical Systems, inc.
    Inventors: Keith G. Copeland, Thomas M. Grogan, Charles Hassen, William Ross Humphreys, Charles D. Lemme, Phillip C. Miller, William L. Richards, Wayne A. Showalter
  • Patent number: 5650327
    Abstract: An automated immunostaining apparatus having a reagent application zone and a reagent supply zone. The apparatus has a carousel slide support (24) supporting a plurality of slide supports (26) thereon, and drive means (48) engaging the carousel slide support (24) for consecutively positioning each of a plurality of slide supports (26) in the reagent application zone. The apparatus also has a carousel reagent support (10) having a plurality of reagent container supports (11) thereon, and drive means (14) engaging the carousel for rotating the carousel and positioning a preselected reagent container support (11) in the reagent supply zone. The apparatus also has a reagent delivery actuator means (18) positioned for engaging a reagent container (12) positioned on a container support (11) in the reagent delivery zone and initiating reagent delivery from the reagent container (12) to a slide supported on a slide support (26) in the reagent receiving zone.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 22, 1997
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Keith G. Copeland, Thomas M. Grogan, Phillip C. Miller, William L. Richards, Wayne A. Showalter
  • Patent number: 5595707
    Abstract: An automated immunostaining apparatus having a reagent application zone and a reagent supply zone. The apparatus has a carousel slide support supporting a plurality of slide supports thereon, and drive means engaging the carousel slide support for consecutively positioning each of a plurality of slide supports in the reagent application zone. The apparatus also has a carousel reagent support having a plurality of reagent container supports thereon, and drive means engaging the carousel for rotating the carousel and positioning a preselected reagent container support in the reagent supply zone. The apparatus also has a reagent delivery actuator means positioned for engaging a reagent container positioned on a container support in the reagent delivery zone and initiating reagent delivery from the reagent container to a slide supported on a slide support in the reagent receiving zone.
    Type: Grant
    Filed: December 9, 1994
    Date of Patent: January 21, 1997
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Keith G. Copeland, Thomas M. Grogan, Charles Hassen, William R. Humphreys, Charles D. Lemme, Phillip C. Miller, William L. Richards, Wayne A. Showalter