Patents by Inventor Thomas Maduskuie

Thomas Maduskuie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors
    Publication number: 20070135461
    Abstract: The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
    Type: Application
    Filed: December 12, 2006
    Publication date: June 14, 2007
    Inventors: James Rodgers, Stacey Shepard, Thomas Maduskuie, Haisheng Wang, Nikoo Falahatpisheh, Maria Rafalski, Argyrios Arvanitis, Louis Storace, Ravi Jalluri, Jordan Fridman, Krishna Vaddi
  • Succinoylamino lactams as inhibitors of a-beta protein production
    Publication number: 20060264417
    Abstract: This invention relates to novel lactams having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A?-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to ?-amyloid production such as Alzheimer's disease and Down's Syndrome.
    Type: Application
    Filed: July 26, 2006
    Publication date: November 23, 2006
    Applicant: BRISTOL-MYERS SQUIBB PHARMA COMPANY
    Inventors: Richard Olson, Thomas Maduskuie, Lorin Thompson
  • Succinoylamino lactams as inhibitors of A-beta protein production
    Publication number: 20060258638
    Abstract: This invention relates to novel lactams having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A?-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to ?-amyloid production such as Alzheimer's disease and Down's Syndrome.
    Type: Application
    Filed: July 25, 2006
    Publication date: November 16, 2006
    Applicant: BRISTOL-MYERS SQUIBB PHARMA COMPANY
    Inventors: Richard Olson, Thomas Maduskuie, Lorin Thompson
  • Tetracyclic inhibitors of Janus kinases
    Publication number: 20060106020
    Abstract: The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.
    Type: Application
    Filed: April 27, 2005
    Publication date: May 18, 2006
    Inventors: James Rodgers, Darius Robinson, Argrios Arvanitis, Thomas Maduskuie, Stacey Shepard, Louis Storace, Haisheng Wang, Maria Rafalski, Ravi Jalluri, Andrew Combs, Matthew Crawley
  • Succinoylamino lactams as inhibitors of A-beta protein production
    Publication number: 20050245501
    Abstract: This invention relates to novel lactams having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A?-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to ?-amyloid production such as Alzheimer's disease and Down's Syndrome.
    Type: Application
    Filed: July 6, 2005
    Publication date: November 3, 2005
    Applicant: BRISTOL-MYERS SQUIBB PHARMA COMPANY
    Inventors: Richard Olson, Thomas Maduskuie, Lorin Thompson