Patents by Inventor Thomas Norbert Muller

Thomas Norbert Muller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10414730
    Abstract: The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, in particular 3-chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile [=Py-CN] to substituted 2-ethylaminopyridine derivatives, in particular 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanamine [=Py-ethanamine] or salts thereof in the presence of metal catalysts, in particular palladium catalysts.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: September 17, 2019
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Wahed Ahmed Moradi, Thomas Himmler, Thomas Norbert Müller, Albert Schnatterer, Günter Schlegel
  • Publication number: 20180244621
    Abstract: The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, in particular 3-chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile [=Py-CN] to substituted 2-ethylaminopyridine derivatives, in particular 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanamine [=Py-ethanamine] or salts thereof in the presence of metal catalysts, in particular palladium catalysts.
    Type: Application
    Filed: May 2, 2018
    Publication date: August 30, 2018
    Inventors: Wahed Ahmed Moradi, Thomas Himmler, Thomas Norbert Müller, Albert Schnatterer, Günter Schlegel
  • Patent number: 9440908
    Abstract: The present invention relates to a process for preparing N-(5-chloro-2-isopropylbenzyl)cyclopropanamine by hydrogenation of N-[(5-chloro-2-isopropylphenyl)methylene]cyclopropanamine over specific platinum catalysts.
    Type: Grant
    Filed: April 25, 2013
    Date of Patent: September 13, 2016
    Assignee: BAYER CROPSCIENCE AG
    Inventors: Thomas Himmler, Sandra Lehmann, Thomas Norbert Muller, Mathias Riedrich, Lars Rodefeld, Frank Volz, Sascha Von Morgenstern
  • Patent number: 9260378
    Abstract: The present invention relates to a process for the preparation of substituted N-(benzyl)cyclopropanamines of the general formula (II) starting from N-[(aryl)methylene]cyclopropanamine derivatives. The present invention further provides the N-[(aryl)methylene]cyclopropanamine derivatives used as starting compounds in this process according to the invention, and their use for the preparation of substituted N (benzyl)cyclopropanamines.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: February 16, 2016
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Norbert Lui, Wahed Ahmed Moradi, Thomas Norbert Muller
  • Patent number: 9169198
    Abstract: The present invention relates to a process for preparing 2-amino-5-cyano-N,3-dimethylbenzamide of formula (I) by reacting 2-amino-5-cyano-3-methylbenzoic esters or diesters with methylamine.
    Type: Grant
    Filed: July 5, 2012
    Date of Patent: October 27, 2015
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Frank Volz, Thomas Himmler, Thomas Norbert Müller, Sandra Lehmann, Sascha Von Morgenstern, Wahed Ahmed Moradi, Sergii Pazenok, Norbert Lui
  • Publication number: 20150094492
    Abstract: The present invention relates to a process for preparing N-(5-chloro-2-isopropylbenzyl)cyclopropanamine by hydrogenation of N-[(5-chloro-2-isopropylphenyl)methylene]cyclopropanamine over specific platinum catalysts.
    Type: Application
    Filed: April 25, 2013
    Publication date: April 2, 2015
    Inventors: Thomas Himmler, Sandra Lehmann, Thomas Norbert Muller, Mathias Riedrich, Lars Rodefeld, Frank Volz, Sascha Von Morgenstern
  • Patent number: 8975448
    Abstract: Process for preparing 2,2-difluoroethanol, comprising the following steps: reacting 1-chloro-2,2-difluoroethane with an alkali metal salt of formic acid or acetic acid in a suitable solvent to give the corresponding 2,2-difluoroethyl formate or 2,2-difluoroethyl acetate, and transesterifying the 2,2-difluoroethyl formate or 2,2-difluoroethyl acetate from step (i) in the presence of an alcohol and optionally of a base.
    Type: Grant
    Filed: July 16, 2012
    Date of Patent: March 10, 2015
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Thomas Norbert Müller, Norbert Lui, Stefan Moczarski
  • Patent number: 8766012
    Abstract: A process for the preparation of 2,2-difluoroethylamine of the formula (I) CHF2CH2NH2??(I) comprising the stages (i) and (ii): stage (i): reaction of 2,2-difluoro-1-haloethane of the formula (II) CHF2—CH2Hal??(II) in which Hal is chlorine, bromine or iodine, with prop-2-en-1-amine of the formula (III) to give N-(2,2-difluoroethyl)prop-2-en-1-amine of the formula (IV) preferably in the presence of an acid scavenger, and stage (ii): removal of the allyl group from the N-(2,2-difluoroethyl)prop-2-en-1-amine of the formula (IV) obtained in stage (i) to give 2,2-difluoroethylamine of the formula (I) or a salt thereof.
    Type: Grant
    Filed: November 9, 2011
    Date of Patent: July 1, 2014
    Assignee: Bayer Cropscience AG
    Inventors: Norbert Lui, Christian Funke, Jens-Dietmar Heinrich, Thomas Norbert Müller
  • Publication number: 20140148611
    Abstract: The present invention relates to a process for preparing 2-amino-5-cyano-N,3-dimethylbenzamide of formula (1) by reacting 2-amino-5-cyano-3-methylbenzoic esters or diesters with methylamine.
    Type: Application
    Filed: July 5, 2012
    Publication date: May 29, 2014
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Frank Volz, Thomas Himmler, Thomas Norbert Müller, Sandra Lehmann, Sascha Von Morgenstern, Wahed Ahmed Moradi, Sergii Pazenok, Norbert Lui
  • Publication number: 20130217910
    Abstract: The present invention relates to a process for the preparation of substituted N-(benzyl)cyclopropanamines of the general formula (II) starting from N-[(aryl)methylene]cyclopropanamine derivatives. The present invention further provides the N-[(arypmethylene]cyclopropanamine derivatives used as starting compounds in this process according to the invention, and their use for the preparation of substituted N (benzyl)cyclopropanamines.
    Type: Application
    Filed: November 4, 2011
    Publication date: August 22, 2013
    Inventors: Norbert Lui, Wahed Ahmed Moradi, Thomas Norbert Muller
  • Patent number: 8450528
    Abstract: Process for the preparation of 2,2-difluoroethylamine of the formula (I) CHF2CH2NH2??(I) comprising the stages (i) and (ii): stage (i): reaction of 2,2-difluoro-1-haloethane of the general formula (II) CHF2—CH2Hal??(II), with a benzylamine compound of the formula (III) in the presence of an acid scavenger, in which, in formula (II), Hal is chlorine, bromine or iodine, and, in the formulae (III), R1 is hydrogen or C1-C12-alkyl, and R2 is hydrogen, halogen, C1-C12-alkyl or C1-C6-alkoxy; stage (ii): catalytic hydrogenation of the N-benzyl-2,2-difluoroethanamine compound obtained in the stage (i) to give 2,2-difluoroethylamine of the formula (I) or a salt thereof.
    Type: Grant
    Filed: November 9, 2011
    Date of Patent: May 28, 2013
    Assignee: Bayer Cropscience AG
    Inventors: Norbert Lui, Jens-Dietmar Heinrich, Christian Funke, Günter Schlegel, Thomas Norbert Müller
  • Publication number: 20130109757
    Abstract: The invention is directed to method for the preparation of pyrrolines of the general formula (I) by catalytic hydration of a nitroketone of the general formula (II) employing a transition metal catalyst and gaseous hydrogen at an elevated pressure in a solvent, optionally in the presence of at least one additive selected among Lewis acids, Brønstedt acids, organic sulfur-containing compounds, organic or inorganic bases, and water scavengers, wherein in formulae (I) and (II) B1, B2, B3, B4, X, R, and T are as defined in the specification, and to a nitroketone of formula (II) to be used as intermediate in the process according to the invention and as pesticidal agent.
    Type: Application
    Filed: April 11, 2011
    Publication date: May 2, 2013
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Wahed Ahmed Moradi, Thomas Norbert Müller, Tetsuya Murata, Mamoru Hatazawa, Peter Bruechner, Eiichi Shimojo, Teruyuki Ichihara, Masashi Ataka, Katsuhiko Shibuya, Ulrich Görgens
  • Publication number: 20120142971
    Abstract: A process for the preparation of 2,2-difluoroethylamine of the formula (I) CHF2CH2NH2??(I) comprising the stages (i) and (ii): stage (i): reaction of 2,2-difluoro-1-haloethane of the formula (II) CHF2—CH2Hal??(II) in which Hal is chlorine, bromine or iodine, with prop-2-en-1-amine of the formula (III) to give N-(2,2-difluoroethyl)prop-2-en-1-amine of the formula (IV) preferably in the presence of an acid scavenger, and stage (ii): removal of the allyl group from the N-(2,2-difluoroethyl)prop-2-en-1-amine of the formula (IV) obtained in stage (i) to give 2,2-difluoroethylamine of the formula (I) or a salt thereof.
    Type: Application
    Filed: November 9, 2011
    Publication date: June 7, 2012
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Norbert LUI, Christian FUNKE, Jens-Dietmar HEINRICH, Thomas Norbert MÜLLER
  • Publication number: 20120123163
    Abstract: Process for the preparation of 2,2-difluoroethylamine of the formula (I) CHF2CH2NH2??(I) comprising the stages (i) and (ii): stage (i): reaction of 2,2-difluoro-1-haloethane of the general formula (II) CHF2—CH2Hal??(II), with a benzylamine compound of the formula (III) in the presence of an acid scavenger, in which, in formula (II), Hal is chlorine, bromine or iodine, and, in the formulae (III), R1 is hydrogen or C1-C12-alkyl, and R2 is hydrogen, halogen, C1-C12-alkyl or C1-C6-alkoxy; stage (ii): catalytic hydrogenation of the N-benzyl-2,2-difluoroethanamine compound obtained in the stage (i) to give 2,2-difluoroethylamine of the formula (I) or a salt thereof.
    Type: Application
    Filed: November 9, 2011
    Publication date: May 17, 2012
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Norbert LUI, Jens-Dietmar HEINRICH, Christian FUNKE, Günter SCHLEGEL, Thomas Norbert Müller
  • Patent number: 8143455
    Abstract: What is described is a process for preparing 2-hydroxyacetals of the general formula in which R1 is hydrogen, a branched or unbranched C1-C12-alkyl radical, an electron-deficient, halogen-, NO2—, CN—, CF3—, acyl group- or branched or unbranched alkyl group-substituted or unsubstituted C5-C6-aryl or heteroaryl, and R2 is a branched or unbranched C1-C5-alkyl radical, or both R2 radicals are bonded directly to one another or to one another via a C1-C4 unit, by reacting an enol compound of the general formula (II) in which R3 is the same and R1 is as defined for formula (Ia), with bromine to give the corresponding dibromo adduct and then reacting this dibromo adduct with an alkoxide of the general formula (III) M-O—R2 (III) in which R2 is as defined for formula (Ia) and O is oxygen and M is lithium, sodium or potassium. What is likewise described is the preparation of the corresponding 2-hydroxyalkanals from the 2-hydroxyacetals thus obtained by acidic hydrolysis.
    Type: Grant
    Filed: June 11, 2008
    Date of Patent: March 27, 2012
    Assignee: SALTIGO GmbH
    Inventors: Thomas-Norbert Müller, Michael Dockner
  • Patent number: 8124813
    Abstract: The invention relates to a novel process for preparing 2-phenoxyacetals and the corresponding 2-phenoxycarbaldehydes. These compounds are important intermediates for the preparation of active pharmaceutical ingredients.
    Type: Grant
    Filed: June 11, 2008
    Date of Patent: February 28, 2012
    Assignee: SALTIGO GmbH
    Inventors: Thomas-Norbert Müller, Michael Dockner