Patents by Inventor Thomas R. LaHann

Thomas R. LaHann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5935944
    Abstract: A process and product formulated by complexing boronophenylalanine (BPA) and related compounds with a saccharide in an aqueous solution are disclosed. Formation of the complex is facilitated by raising the pH of the solution to a higher pH of about 10 or by lowering the pH of the solution to a lower pH of about 2 and then readjusting the pH to a body physiological pH of about 7.4. This BPA saccharide complex can then be delivered by i.v. or other injection or administered orally as a key component of the BNCT cancer treatment process The pH manipulation causes a much higher solubility of BPA or related compounds and thus a higher boron concentration in the tumor, thereby improving the therapy.
    Type: Grant
    Filed: February 20, 1996
    Date of Patent: August 10, 1999
    Assignee: Neutron Technology Corporation
    Inventor: Thomas R. LaHann
  • Patent number: 5492900
    Abstract: A process and product formulated by complexing d,1- or 1-p-boronophenylalanine (BPA) with a saccharide in an aqueous solution formation of the complex being facilitated by raising the pH of this solution to a higher pH of about 10 or lowering the pH of the solution to a lower pH of about 2 and then readjusting the pH to a body physiological pH of about 7.4. This BPA saccharide complex can then be delivered by i.v. or other injection or administered orally as a key component of the BNCT cancer treatment process. The pH manipulation causes a much higher solubility of BPA and thus a higher boron concentration in the tumor, thereby improving the therapy.
    Type: Grant
    Filed: September 10, 1993
    Date of Patent: February 20, 1996
    Assignee: Neutron Technology Corporation
    Inventor: Thomas R. LaHann
  • Patent number: 4898887
    Abstract: Trienamide and tetraenamide compounds, and pharmaceutically-acceptable salts thereof, of the formula: ##STR1## wherein R is a straight or branched chain tri-unsaturated or tetra-unsaturated fatty acid amide having from 14 to 24 carbon atoms, exhibit anit-inflammatory and analgesic activity when administered to humans or lower animals.
    Type: Grant
    Filed: August 22, 1986
    Date of Patent: February 6, 1990
    Assignee: The Procter & Gamble Company
    Inventors: John M. Janusz, Maurice E. Loomans, Thomas R. LaHann, Gerald B. Kasting
  • Patent number: 4599342
    Abstract: An analgesic composition comprising capsaicin or a capsaicin analog and an analgesic selected from the class of opioids is disclosed. This combination has been found to exhibit unexpectedly enhanced analgesic activity in humans and lower animals without a corresponding increase in undesirable side effects.
    Type: Grant
    Filed: January 16, 1984
    Date of Patent: July 8, 1986
    Assignee: The Procter & Gamble Company
    Inventor: Thomas R. LaHann
  • Patent number: 4564633
    Abstract: A composition, useful for producing analgesia in humans or lower animals, comprising a safe and effective amount of: an N-[(substituted pheynl)methyl]-cis-monounsaturated alkenamide pharmaceutically-acceptable salts thereof, or mixtures thereof; and a pharmaceutically-acceptable carrier. Preferably, these alkenamides are N-vanillyl-cis-monounsaturated alkenamides. Methods of treatment, comprising administering a safe and effective amount of these alkenamides, pharmaceutically-acceptable salts thereof, or mixtures thereof, include methods of parenteral, oral, and topical administration.
    Type: Grant
    Filed: November 28, 1984
    Date of Patent: January 14, 1986
    Assignee: The Procter & Gamble Company
    Inventors: Thomas R. LaHann, Brian L. Buckwalter
  • Patent number: 4546112
    Abstract: A method for preventing or reducing dermal irritation caused by thioglycolate depilatories by applying capsaicin and/or its salt(s) to at least a portion of the depilated area.
    Type: Grant
    Filed: December 2, 1983
    Date of Patent: October 8, 1985
    Assignee: The Procter & Gamble Company
    Inventors: Thomas R. LaHann, Ralph W. Farmer
  • Patent number: 4544669
    Abstract: Alkadienamide compounds, and pharmaceutically-acceptable salts thereof, of the formula: ##STR1## wherein X is O or S; R is straight or branched diene having from 11 to 23 carbon atoms; R.sub.1 is H, OH, or OCH.sub.3 ; R.sub.2 is OH or a short-chain ester; and wherein at least one of R.sub.1 and R.sub.2 is OH or OCH.sub.3. Compositions, useful for producing analgesia in humans or lower animals, comprise a safe and effective amount of: an alkadienamide, pharmaceutically-acceptable salts thereof, or mixtures thereof; and a pharmaceutically-acceptable carrier. Preferably, these alkadienamides are N-vanillyl-alkadienamides. Methods of treatment, comprising administering a safe and effective amount of these alkadienamides, pharmaceutically-acceptable salts thereof, or mixtures thereof, include methods of parenteral, oral, and topical administration.
    Type: Grant
    Filed: July 14, 1983
    Date of Patent: October 1, 1985
    Assignee: The Procter & Gamble Company
    Inventors: Thomas R. LaHann, John M. Janusz, Brian L. Buckwalter
  • Patent number: 4544668
    Abstract: Methylenealkanamide compounds, and pharmaceutically-acceptable salts thereof, of the formula: ##STR1## wherein X is O or S; R is straight or branched methylene substituted alkane having from 11 to 23 carbon atoms; R.sub.1 is H, OH, or OCH.sub.3 ; R.sub.2 is OH or a short-chain ester; and wherein at least one of R.sub.1 and R.sub.2 is OH or OCH.sub.3. Compositions, useful for producing analgesia in humans or lower animals, comprise a safe and effective amount of: a methylenealkanamide, pharmaceutically-acceptable salts thereof, or mixtures thereof; and a pharmaceutically-acceptable carrier. Preferably, these methylenealkanamides are N-vanillyl-methylenealkanamides. Methods of treatment, comprising administering a safe and effective amount of these methylenealkanamides, pharmaceutically-acceptable salts thereof, or mixtures thereof, include methods of parenteral, oral and topical administration.
    Type: Grant
    Filed: July 14, 1983
    Date of Patent: October 1, 1985
    Assignee: The Procter & Gamble Company
    Inventors: John M. Janusz, Brian L. Buckwalter, Thomas R. LaHann
  • Patent number: 4532139
    Abstract: Alkynamide compounds, and pharmaceutically-acceptable salts thereof, of the formula: ##STR1## wherein X is O or S; R is straight or branched alkyne having from 11 to 23 carbon atoms; R.sub.1 is H, OH, or OCH.sub.3 ; R.sub.2 is OH or a short-chain ester; and wherein at least one of R.sub.1 and R.sub.2 is OH or OCH.sub.3. Compositions, useful for producing analgesia in humans or lower animals, comprise a safe and effective amount of: an alkynamide, pharmaceutically-acceptable salts thereof, or mixtures thereof; and a pharmaceutically-acceptable carrier. Preferably, these alkynamides are N-vanillyl-alkynamides. Methods of treatment, comprising administering a safe and effective amount of these alkynamides, pharmaceutically-acceptable salts thereof, or mixtures thereof, include methods of parenteral, oral, and topical administration.
    Type: Grant
    Filed: July 14, 1983
    Date of Patent: July 30, 1985
    Assignee: The Procter & Gamble Company
    Inventors: John M. Janusz, Thomas R. LaHann
  • Patent number: 4493848
    Abstract: A composition, useful for producing analgesia in humans or lower animals, comprising a safe and effective amount of: an N-[(substituted phenyl)methyl]-cis-monounsaturated alkenamide pharmaceutically-acceptable salts thereof, or mixtures thereof; and a pharmaceutically-acceptable carrier. Preferably, these alkenamides are N-vanillyl-cis-monounsaturated alkenamides. Methods of treatment, comprising administering a safe and effective amount of these alkenamides, pharmaceutically-acceptable salts thereof, or mixtures thereof, include methods of parenteral, oral, and topical administration.
    Type: Grant
    Filed: July 14, 1983
    Date of Patent: January 15, 1985
    Assignee: The Procter & Gamble Company
    Inventors: Thomas R. LaHann, Brian L. Buckwalter
  • Patent number: 4460602
    Abstract: A compound, or pharmaceutically acceptable salt thereof, having the formula: ##STR1## wherein X is O or S; wherein n=1 or 0; wherein R is C.sub.3 -C.sub.12 alkyl or aralkyl, branched or unbranched, aryl or haloaryl, or C.sub.3 -C.sub.22 alkenyl, branched or unbranched; wherein R.sub.1 is OCH.sub.3, and wherein R.sub.2 is OH. These urea derivatives have analgesic and anti-irritant activity when administered to humans and lower animals.
    Type: Grant
    Filed: May 25, 1982
    Date of Patent: July 17, 1984
    Assignee: The Procter & Gamble Company
    Inventors: Brian L. Buckwalter, Thomas R. LaHann
  • Patent number: 4443473
    Abstract: A compound, or pharmaceutically acceptable salt thereof, having the formula: ##STR1## wherein X is O or S; wherein R is C.sub.3 -C.sub.12 alkyl or aralkyl, branched or unbranched, aryl or haloaryl, C.sub.3 -C.sub.22 alkenyl, branched or unbranched, or benzyl; wherein R.sub.1 is H, OH or OCH.sub.3, and R.sub.2 is H or OH, at least one of R.sub.1 and R.sub.2 being OH or OCH.sub.3. These carbamates have analgesic and anti-irritant activity when administered to humans and lower animals.
    Type: Grant
    Filed: June 3, 1982
    Date of Patent: April 17, 1984
    Assignee: The Procter & Gamble Company
    Inventors: Brian L. Buckwalter, Thomas R. LaHann
  • Patent number: 4424205
    Abstract: A compound, or pharmaceutically acceptable salt thereof, having the formula: ##STR1## wherein R is a linear or branched C.sub.3 -C.sub.11 alkyl, alkynyl or aralkyl group, a linear or branched C.sub.3 -C.sub.22 alkenyl group, or an unbranched or branched C.sub.6 -C.sub.11 cycloalkyl or cycloalkenyl group; and wherein one of R.sub.1 and R.sub.2 is OH, the other being OH or H. These hydroxyphenylacetamides have analgesic and/or anti-irritant activity when administered either topically or systemically.
    Type: Grant
    Filed: March 18, 1982
    Date of Patent: January 3, 1984
    Assignee: The Procter & Gamble Company
    Inventors: Thomas R. LaHann, Brian L. Buckwalter
  • Patent number: 4401663
    Abstract: A compound, or pharmaceutically acceptable salt thereof, having the formula: ##STR1## wherein X is ##STR2## wherein R is C.sub.3 -C.sub.12 alkyl or aralkyl, branched or unbranched, unsubstituted aryl, haloaryl, or C.sub.3 -C.sub.22 alkenyl, branched or unbranched; wherein R.sub.1 is H, OH or OCH.sub.3, and wherein R.sub.2 is OH or H, at least one of R.sub.1 and R.sub.2 being OH or OCH.sub.3. These sulfonamides have analgesic and anti-irritant activity when administered to humans and lower animals.
    Type: Grant
    Filed: March 23, 1982
    Date of Patent: August 30, 1983
    Assignee: The Procter & Gamble Company
    Inventors: Brian L. Buckwalter, Thomas R. LaHann
  • Patent number: 4313958
    Abstract: Capsaicin (8-methyl-N-vanillyl-6-noneanamide) is a useful, potent analgesic.
    Type: Grant
    Filed: October 24, 1980
    Date of Patent: February 2, 1982
    Assignee: The Procter & Gamble Company
    Inventor: Thomas R. LaHann