Patents by Inventor Thomas R. LaHann
Thomas R. LaHann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5935944Abstract: A process and product formulated by complexing boronophenylalanine (BPA) and related compounds with a saccharide in an aqueous solution are disclosed. Formation of the complex is facilitated by raising the pH of the solution to a higher pH of about 10 or by lowering the pH of the solution to a lower pH of about 2 and then readjusting the pH to a body physiological pH of about 7.4. This BPA saccharide complex can then be delivered by i.v. or other injection or administered orally as a key component of the BNCT cancer treatment process The pH manipulation causes a much higher solubility of BPA or related compounds and thus a higher boron concentration in the tumor, thereby improving the therapy.Type: GrantFiled: February 20, 1996Date of Patent: August 10, 1999Assignee: Neutron Technology CorporationInventor: Thomas R. LaHann
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Patent number: 5492900Abstract: A process and product formulated by complexing d,1- or 1-p-boronophenylalanine (BPA) with a saccharide in an aqueous solution formation of the complex being facilitated by raising the pH of this solution to a higher pH of about 10 or lowering the pH of the solution to a lower pH of about 2 and then readjusting the pH to a body physiological pH of about 7.4. This BPA saccharide complex can then be delivered by i.v. or other injection or administered orally as a key component of the BNCT cancer treatment process. The pH manipulation causes a much higher solubility of BPA and thus a higher boron concentration in the tumor, thereby improving the therapy.Type: GrantFiled: September 10, 1993Date of Patent: February 20, 1996Assignee: Neutron Technology CorporationInventor: Thomas R. LaHann
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Patent number: 4898887Abstract: Trienamide and tetraenamide compounds, and pharmaceutically-acceptable salts thereof, of the formula: ##STR1## wherein R is a straight or branched chain tri-unsaturated or tetra-unsaturated fatty acid amide having from 14 to 24 carbon atoms, exhibit anit-inflammatory and analgesic activity when administered to humans or lower animals.Type: GrantFiled: August 22, 1986Date of Patent: February 6, 1990Assignee: The Procter & Gamble CompanyInventors: John M. Janusz, Maurice E. Loomans, Thomas R. LaHann, Gerald B. Kasting
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Patent number: 4599342Abstract: An analgesic composition comprising capsaicin or a capsaicin analog and an analgesic selected from the class of opioids is disclosed. This combination has been found to exhibit unexpectedly enhanced analgesic activity in humans and lower animals without a corresponding increase in undesirable side effects.Type: GrantFiled: January 16, 1984Date of Patent: July 8, 1986Assignee: The Procter & Gamble CompanyInventor: Thomas R. LaHann
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Patent number: 4564633Abstract: A composition, useful for producing analgesia in humans or lower animals, comprising a safe and effective amount of: an N-[(substituted pheynl)methyl]-cis-monounsaturated alkenamide pharmaceutically-acceptable salts thereof, or mixtures thereof; and a pharmaceutically-acceptable carrier. Preferably, these alkenamides are N-vanillyl-cis-monounsaturated alkenamides. Methods of treatment, comprising administering a safe and effective amount of these alkenamides, pharmaceutically-acceptable salts thereof, or mixtures thereof, include methods of parenteral, oral, and topical administration.Type: GrantFiled: November 28, 1984Date of Patent: January 14, 1986Assignee: The Procter & Gamble CompanyInventors: Thomas R. LaHann, Brian L. Buckwalter
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Patent number: 4546112Abstract: A method for preventing or reducing dermal irritation caused by thioglycolate depilatories by applying capsaicin and/or its salt(s) to at least a portion of the depilated area.Type: GrantFiled: December 2, 1983Date of Patent: October 8, 1985Assignee: The Procter & Gamble CompanyInventors: Thomas R. LaHann, Ralph W. Farmer
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Patent number: 4544669Abstract: Alkadienamide compounds, and pharmaceutically-acceptable salts thereof, of the formula: ##STR1## wherein X is O or S; R is straight or branched diene having from 11 to 23 carbon atoms; R.sub.1 is H, OH, or OCH.sub.3 ; R.sub.2 is OH or a short-chain ester; and wherein at least one of R.sub.1 and R.sub.2 is OH or OCH.sub.3. Compositions, useful for producing analgesia in humans or lower animals, comprise a safe and effective amount of: an alkadienamide, pharmaceutically-acceptable salts thereof, or mixtures thereof; and a pharmaceutically-acceptable carrier. Preferably, these alkadienamides are N-vanillyl-alkadienamides. Methods of treatment, comprising administering a safe and effective amount of these alkadienamides, pharmaceutically-acceptable salts thereof, or mixtures thereof, include methods of parenteral, oral, and topical administration.Type: GrantFiled: July 14, 1983Date of Patent: October 1, 1985Assignee: The Procter & Gamble CompanyInventors: Thomas R. LaHann, John M. Janusz, Brian L. Buckwalter
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Patent number: 4544668Abstract: Methylenealkanamide compounds, and pharmaceutically-acceptable salts thereof, of the formula: ##STR1## wherein X is O or S; R is straight or branched methylene substituted alkane having from 11 to 23 carbon atoms; R.sub.1 is H, OH, or OCH.sub.3 ; R.sub.2 is OH or a short-chain ester; and wherein at least one of R.sub.1 and R.sub.2 is OH or OCH.sub.3. Compositions, useful for producing analgesia in humans or lower animals, comprise a safe and effective amount of: a methylenealkanamide, pharmaceutically-acceptable salts thereof, or mixtures thereof; and a pharmaceutically-acceptable carrier. Preferably, these methylenealkanamides are N-vanillyl-methylenealkanamides. Methods of treatment, comprising administering a safe and effective amount of these methylenealkanamides, pharmaceutically-acceptable salts thereof, or mixtures thereof, include methods of parenteral, oral and topical administration.Type: GrantFiled: July 14, 1983Date of Patent: October 1, 1985Assignee: The Procter & Gamble CompanyInventors: John M. Janusz, Brian L. Buckwalter, Thomas R. LaHann
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Patent number: 4532139Abstract: Alkynamide compounds, and pharmaceutically-acceptable salts thereof, of the formula: ##STR1## wherein X is O or S; R is straight or branched alkyne having from 11 to 23 carbon atoms; R.sub.1 is H, OH, or OCH.sub.3 ; R.sub.2 is OH or a short-chain ester; and wherein at least one of R.sub.1 and R.sub.2 is OH or OCH.sub.3. Compositions, useful for producing analgesia in humans or lower animals, comprise a safe and effective amount of: an alkynamide, pharmaceutically-acceptable salts thereof, or mixtures thereof; and a pharmaceutically-acceptable carrier. Preferably, these alkynamides are N-vanillyl-alkynamides. Methods of treatment, comprising administering a safe and effective amount of these alkynamides, pharmaceutically-acceptable salts thereof, or mixtures thereof, include methods of parenteral, oral, and topical administration.Type: GrantFiled: July 14, 1983Date of Patent: July 30, 1985Assignee: The Procter & Gamble CompanyInventors: John M. Janusz, Thomas R. LaHann
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Patent number: 4493848Abstract: A composition, useful for producing analgesia in humans or lower animals, comprising a safe and effective amount of: an N-[(substituted phenyl)methyl]-cis-monounsaturated alkenamide pharmaceutically-acceptable salts thereof, or mixtures thereof; and a pharmaceutically-acceptable carrier. Preferably, these alkenamides are N-vanillyl-cis-monounsaturated alkenamides. Methods of treatment, comprising administering a safe and effective amount of these alkenamides, pharmaceutically-acceptable salts thereof, or mixtures thereof, include methods of parenteral, oral, and topical administration.Type: GrantFiled: July 14, 1983Date of Patent: January 15, 1985Assignee: The Procter & Gamble CompanyInventors: Thomas R. LaHann, Brian L. Buckwalter
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Patent number: 4460602Abstract: A compound, or pharmaceutically acceptable salt thereof, having the formula: ##STR1## wherein X is O or S; wherein n=1 or 0; wherein R is C.sub.3 -C.sub.12 alkyl or aralkyl, branched or unbranched, aryl or haloaryl, or C.sub.3 -C.sub.22 alkenyl, branched or unbranched; wherein R.sub.1 is OCH.sub.3, and wherein R.sub.2 is OH. These urea derivatives have analgesic and anti-irritant activity when administered to humans and lower animals.Type: GrantFiled: May 25, 1982Date of Patent: July 17, 1984Assignee: The Procter & Gamble CompanyInventors: Brian L. Buckwalter, Thomas R. LaHann
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Patent number: 4443473Abstract: A compound, or pharmaceutically acceptable salt thereof, having the formula: ##STR1## wherein X is O or S; wherein R is C.sub.3 -C.sub.12 alkyl or aralkyl, branched or unbranched, aryl or haloaryl, C.sub.3 -C.sub.22 alkenyl, branched or unbranched, or benzyl; wherein R.sub.1 is H, OH or OCH.sub.3, and R.sub.2 is H or OH, at least one of R.sub.1 and R.sub.2 being OH or OCH.sub.3. These carbamates have analgesic and anti-irritant activity when administered to humans and lower animals.Type: GrantFiled: June 3, 1982Date of Patent: April 17, 1984Assignee: The Procter & Gamble CompanyInventors: Brian L. Buckwalter, Thomas R. LaHann
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Patent number: 4424205Abstract: A compound, or pharmaceutically acceptable salt thereof, having the formula: ##STR1## wherein R is a linear or branched C.sub.3 -C.sub.11 alkyl, alkynyl or aralkyl group, a linear or branched C.sub.3 -C.sub.22 alkenyl group, or an unbranched or branched C.sub.6 -C.sub.11 cycloalkyl or cycloalkenyl group; and wherein one of R.sub.1 and R.sub.2 is OH, the other being OH or H. These hydroxyphenylacetamides have analgesic and/or anti-irritant activity when administered either topically or systemically.Type: GrantFiled: March 18, 1982Date of Patent: January 3, 1984Assignee: The Procter & Gamble CompanyInventors: Thomas R. LaHann, Brian L. Buckwalter
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Patent number: 4401663Abstract: A compound, or pharmaceutically acceptable salt thereof, having the formula: ##STR1## wherein X is ##STR2## wherein R is C.sub.3 -C.sub.12 alkyl or aralkyl, branched or unbranched, unsubstituted aryl, haloaryl, or C.sub.3 -C.sub.22 alkenyl, branched or unbranched; wherein R.sub.1 is H, OH or OCH.sub.3, and wherein R.sub.2 is OH or H, at least one of R.sub.1 and R.sub.2 being OH or OCH.sub.3. These sulfonamides have analgesic and anti-irritant activity when administered to humans and lower animals.Type: GrantFiled: March 23, 1982Date of Patent: August 30, 1983Assignee: The Procter & Gamble CompanyInventors: Brian L. Buckwalter, Thomas R. LaHann
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Patent number: 4313958Abstract: Capsaicin (8-methyl-N-vanillyl-6-noneanamide) is a useful, potent analgesic.Type: GrantFiled: October 24, 1980Date of Patent: February 2, 1982Assignee: The Procter & Gamble CompanyInventor: Thomas R. LaHann