Abstract: Methods and system for producing combined photoacoustic/ultrasonic image frames use a low-power narrow beam laser to direct sequential pulses along a path overlying an internal region of interest. Photoacoustic responses are received and used to generate sub-frames. Between each of the laser pulses a plurality of ultrasound pulse-echo beams are sequentially emitted towards the region of interest, and the reflections are received and used to generate ultrasound sub-frames. The photoacoustic sub-frames are combined to produce a photoacoustic frame, and the ultrasound sub-frames are combined to produce an ultrasound frame. The photoacoustic and ultrasound frames are combined to produce an image frame. The method and system are suitable for producing real-time, high-contrast video.

Abstract: An example fluidic device may include a plurality of channels including one or more curved channels having a channel input and a channel output. Each of the one or more curved channels may have a substantially circular cross-section. The fluidic device may also include an input interface between the channel input of the one or more curved channels and an exterior of the fluidic device. The input interface may be configured to receive a biological tissue sample. The fluidic device may also include an output interface between the channel output of the one or more curved channels and the exterior of the fluidic device.

Abstract: Methods and system for producing combined photoacoustic/ultrasonic image frames use a low-power narrow beam laser to direct sequential pulses along a path overlying an internal region of interest. Photoacoustic responses are received and used to generate sub-frames. Between each of the laser pulses a plurality of ultrasound pulse-echo beams are sequentially emitted towards the region of interest, and the reflections are received and used to generate ultrasound sub-frames. The photoacoustic sub-frames are combined to produce a photoacoustic frame, and the ultrasound sub-frames are combined to produce an ultrasound frame. The photoacoustic and ultrasound frames are combined to produce an image frame. The method and system are suitable for producing real-time, high-contrast video.

Abstract: An example fluidic device may include a plurality of channels including one or more curved channels having a channel input and a channel output. Each of the one or more curved channels may have a substantially circular cross-section. The fluidic device may also include an input interface between the channel input of the one or more curved channels and an exterior of the fluidic device. The input interface may be configured to receive a biological tissue sample. The fluidic device may also include an output interface between the channel output of the one or more curved channels and the exterior of the fluidic device.

Abstract: The present disclosure provides systems, methods, and devices for improved generation and application of radiation force to a material. In one aspect, a system for producing an acoustic radiation force to generate displacement in a material comprises an ultrasonic transducer array, one or more processors, and memory. The memory can comprise instructions that, when executed by the one or more processors, cause the system to generate a push acoustic energy focused to a push focal region in the material using the ultrasonic transducer array, so as to produce the acoustic radiation force to generate displacement in the material. The push focal region can comprise a first width along a first direction transverse to a direction of propagation of the push acoustic energy greater than a second width along a second direction transverse to the direction of propagation of the push acoustic energy.