Abstract: The present invention is directed to a process for the preparation of benzyl [(3aS,4R,6S,6aR)-6-hydroxy-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl]carbamate (VI), to products of said process and the use thereof.

Abstract: The present invention is directed to a process for the preparation of benzyl [(3aS,4R,6S,6aR)-6-hydroxy-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl]carbamate (VI), to products of said process and the use thereof.

Abstract: The present invention relates to a pyrimidine compound (I) useful as a pharmaceutical intermediate, to a process for preparing said pyrimidine compound, to intermediates used in said process, and to the use of said pyrimidine compound in the preparation of pharmaceuticals.

Abstract: The present invention relates to a pyrimidine compound (I) useful as a pharmaceutical intermediate, to a process for preparing said pyrimidine compound, to intermediates used in said process, and to the use of said pyrimidine compound in the preparation of pharmaceuticals.

Abstract: The present invention relates to a pyrimidine compound (I) useful as a pharmaceutical intermediate, to a process for preparing said pyrimidine compound, to intermediates used in said process, and to the use of said pyrimidine compound in the preparation of pharmaceuticals.

Abstract: A process for preparing a protected amidine group of formula (I): wherein R6 represents, for example, C1-10 alkyl (optionally substituted), aryl, C1-3 alkylaryl or C1-3 alkyloxyaryl; which comprises reacting a nitrile containing compound with an oxyamine of formula (II): R6ONH2 wherein R6 is as defined above for (I); in the presence of a thio-keto activating agent of formula (III): HS—Ry, —C(O)-Z wherein Z is -(1-4C)alkyl, —OH, —O-(1-4C)alkyl, —SH, —S(1-4C)alkyl, —NH2, —NH(1-4C)alkyl or —N[(1-4C)alkyl]2; Ry is (1-2C)alkyl (optionally substituted); or Z and Ry are linked so as to form a 5- or 6-membered ring of formula (IV): wherein X is —CH2—, —O—, —NH— or —N(1-4C)alkyl; p is 1 or 2; m is 1 or 2 and Rz is independently selected from H, (1-4C)alkyl, halo and amino.

Abstract: The present invention relates to a pyrimidine compound (I) useful as a pharmaceutical intermediate, to a process for preparing said pyrimidine compound, to intermediates used in said process, and to the use of said pyrimidine compound in the preparation of pharmaceuticals.

Abstract: The present invention relates to a pyrimidine compound (I) useful as a pharmaceutical intermediate, to a process for preparing said pyrimidine compound, to intermediates used in said process, and to the use of said pyrimidine compound in the preparation of pharmaceuticals.

Abstract: The present invention relates to a pyrimidine compound (I) useful as a pharmaceutical intermediate, to a process for preparing said pyrimidine compound, to intermediates used in said process, and to the use of said pyrimidine compound in the preparation of pharmaceuticals.

Abstract: There is provided a process for the production of melagatran, Formula (I) ex vivo, which process comprises the hydrolysis of a compound of Formula II, wherein R is C1-6 alkyl or a benzylic group, to form, in substantially salt-free form, an intermediate compound of formula II followed by reduction of that intermediate.

Abstract: Pyrimidine compound (I) useful as a pharmaceutical intermediate, a process for preparing the pyrimidine compound (I), to intermediates used in the process, and use of the pyrimidine compound (I) in the preparation of pharmaceuticals. The process comprises hydrogenating a compound of formula (IV): wherein Ar is a phenyl optionally substituted by halogen, C1-4 alkyl or C1-4 alkoxy; to give a compound of formula (II): and reacting the compound of formula (II) with a salt of a compound of formula (III): to provide the compound of formula (I).

Abstract: The present invention relates to a pyrimidine compound (I) useful as a pharmaceutical intermediate, to a process for preparing said pyrimidine compound, to intermediates used in said process, and to the use of said pyrimidine compound in the preparation of pharmaceuticals.

Abstract: The present invention relates to a pyrimidine compound (I) useful as a pharmaceutical intermediate, to a process for preparing said pyrimidine compound, to intermediates used in said process, and to the use of said pyrimidine compound in the preparation of pharmaceuticals.

Abstract: 4-Benzoylisoxazole derivatives of formula (I), wherein R 1

Abstract: 4-Benzoylisoxazole derivatives of the formula wherein R is H or an ester; R1 is alkyl, haloalkyl or optionally substituted cycloalkyl; R2 is halogen, optionally halogenated alkyl, alkenyl or alkynyl; alkyl substituted with one or more —OR5; —NO2, —CN, —CO2R5, —S(O)pR6, —O(CH2)mOR5, —COR5, —NR5R6, —N(R8)SOqR7, —CONR9R10 or —OR51; or optionally substituted phenyl; R3 is —S(O)qR7; X is —N(R8)—; n is 0, 1, 2, 3, or 4; R5, R51 and R6 are independently H; optionally halogenated alkyl, alkenyl or alkynyl; optionally substituted phenyl; or cycloalkyl; R7 is optionally halogenated alkyl, alkenyl or alkynyl; cycloalkyl; optionally substituted phenyl; or optionally substituted amino; R8 is H; optionally halogenated alkyl, alkenyl or alkynyl; cycloalkyl; optionally substituted phenyl; or alkoxy; m is 1, 2 or 3; p is 0, 1 or 2; q is 0 or 2; and their use as herbicides are described.

Abstract: Herbicides derived from 2-cyano-1,3-diones have the formula: ##STR1## wherein R, R.sup.1, R.sup.2 R.sup.3, R.sup.4 and R.sup.5 are as defined in the description. The compounds are intended for use pre- and post-emergence as selective herbicides in maize and a large number of other monocotyledon crops.

Abstract: The invention relates to 4-benzoylisoxazole derivatives of formula (I): ##STR1## wherein R represents hydrogen or --CO.sub.2 R.sup.4 ; R.sup.1 represents alkyl, haloalkyl or optionally substituted cycloalkyl;R.sup.2 represents halogen, alkyl, haloalkyl, alkyl substituted by one or more groups --OR.sup.5 ; ora group selected from nitro, cyano, --CO.sub.2 R.sup.5, --S(O).sub.p R.sup.6, --O(CH.sub.2).sub.m OR.sup.5, --COR.sup.5, --OR.sup.5 and --N(R.sup.8)SO.sub.2 R.sup.7 ;R.sup.3 represents --SO.sub.2 R.sup.7 ;X represents the oxygen atom;n represents zero or an integer from one to four;R.sup.4 represents alkyl or haloalkyl;R.sup.5 and R.sup.6, independently represent alkyl, haloalkyl or optionally substituted phenyl;R.sup.7 represents alkyl, haloalkyl, optionally substituted phenyl or --NR.sup.5 R.sup.6 ;R.sup.8 represents hydrogen, optionally halogenated alkyl, alkenyl or alkynyl; cycloalkyl, optionally substituted phenyl, --SO.sub.2 R.sup.6 or --OR.sup.