Abstract: Systems, computer program products, and methods are described herein for dynamically generating linked security tests. The present invention may be configured to perform security tests on an application, generate, based on the results of the security tests, security test sequences that include at least one security test that the application failed, perform the security test sequences on the application, and, iteratively and until the application passes each security test sequence in an iteration, generate additional security test sequences. The present invention may be further configured to provide results of the security tests and security test sequences to one or more machine learning models to generate supplementary security test sequences and determine probabilities of the application failing the supplementary security test sequences.

Abstract: The ability to generate a single antibody-based construct that can recognize multiple targets simultaneously, is paramount to advance many therapeutics candidates to clinic. Often, this implies extensive protein design with vary degrees of success. In the case of multispecific antibodies, the driving of the HC/LC pairing in the Fab region represents one of the most difficult challenges yet in the field of multispecific engineering. Described here is the discovery of a new single chain Fab module that utilizes a novel linker between VL-CL and VH-CH1 domains which will further enable the production of multispecifics.

Abstract: Among other aspects, provided herein are multi-arm polymeric prodrug conjugates of taxane-based compounds and/or fluorinated forms thereof. Methods of preparing such conjugates as well as methods of administering the conjugates are also provided. Upon administration to a patient, release of the taxane-based compound is achieved.

Abstract: The present invention relates to severe acute respiratory syndrome coronavirus 2 (“SARS-CoV2”) immunogens useful for the generation of therapeutic antibodies and vaccine development. Such therapeutic antibodies include human antibodies and antigen-binding portions thereof that specifically bind to human SARS-CoV2 S protein, and that function to neutralize SARS-CoV2. The present invention also relates to methods of generating antibodies and antigen-binding portions thereof that specifically bind to human SARS-CoV2 S protein.

Abstract: Portable modular training systems are described herein. In one aspect, a modular training system includes a system container including a container front, a container rear, a container first side, a container second side, a container bottom, and a container top, defining a container cavity, and an exercise structure comprising a platform connector with a vertical support bar coupled to an interior surface of the system container and a horizontal bar coupled to the vertical support bar and extending external to the system container via an aperture defined by the system container.

Abstract: Portable modular training systems are described herein. In one aspect, a system includes a system container including a container front, a container rear, a container first side, a container second side, a container bottom, and a container top, an exercise structure including: at least one platform connector including: a mounting plate coupled to the system container; a first member coupled to the mounting plate and extending away from the mounting plate at a downward angle relative to the mounting plate; a second member coupled to the first member and the mounting plate and extending away from the mounting plate at an upward angle relative to the mounting plate; and a support arm coupled to the first member and the second member and extending perpendicularly away from the mounting plate; where the exercise structure is wholly supported by the system container when the exercise structure is securely associated system container.

Abstract: Portable modular training systems are described herein. In one aspect, a system includes a system container including a container front, a container rear, a container first side, a container second side, a container bottom, and a container top, an exercise structure including: at least one platform connector including: a mounting plate coupled to the system container; a first member coupled to the mounting plate and extending away from the mounting plate at a downward angle relative to the mounting plate; a second member coupled to the first member and the mounting plate and extending away from the mounting plate at an upward angle relative to the mounting plate; and a support arm coupled to the first member and the second member and extending perpendicularly away from the mounting plate; where the exercise structure is wholly supported by the system container when the exercise structure is securely associated system container.

Abstract: Portable modular training systems are described herein. In one aspect, a system includes a system container including a container front, a container rear, a container first side, a container second side, a container bottom, and a container top, an exercise structure including: at least one platform connector including: a mounting plate coupled to the system container; a first member coupled to the mounting plate and extending away from the mounting plate at a downward angle relative to the mounting plate; a second member coupled to the first member and the mounting plate and extending away from the mounting plate at an upward angle relative to the mounting plate; and a support arm coupled to the first member and the second member and extending perpendicularly away from the mounting plate; where the exercise structure is wholly supported by the system container when the exercise structure is securely associated system container.

Abstract: A multi-lumen sensing system (10) includes medical tubing (20) having a plurality of lumens (22A, 22B) and at least one secondary passageway (24) extending in an axial direction of the medical tubing, wherein the secondary passageway is between the plurality of lumens. The multi-lumen sensing system may include a sensing receptacle (30) defining a channel (32) in which a lengthwise portion of the medical tubing is received. A plurality of ultrasonic transmitting elements (40T, 42T) may be arranged within the secondary passageway of the medical tubing or as part of the sensing receptacle for transmitting respective ultrasonic signals across the lumens to a corresponding plurality of ultrasonic receiving elements (40R, 42R) of the sensing receptacle. Alternatively, the sensing receptacle may include a plurality of ultrasonic transmitting and receiving elements (40, 42, 44) transmitting respective signals across the lumens for return reflection at an interface of the secondary passageway.

Abstract: A Functional Training System (FTS) is provided and includes a system container, wherein the system container includes a container front, a container rear, a container first side, a container second side, a container bottom, and a container top, wherein the container front, container rear, container first side, container second side, container bottom, and container top define a container cavity. The FTS further includes an exercise structure, wherein the exercise structure includes a platform connector, wherein the platform connector is non-perpendicularly and securely associated with at least one of the container front, container rear, container first side, container second side, container bottom, and container top, and wherein when the exercise structure is securely associated with at least one of the container front, container rear, container first side, container second side, container bottom, and container top, the exercise structure is supported by the system container.

Abstract: A Building Element Lift Enhancer is described. The Building Element Lift Enhancer provides for the movement and precise placement of building elements such as blocks or sheet products by one worker. The Building Element Lift Enhancer senses the force applied by a user to the building element and converts that user applied force to mechanically assisted force from the Building Element Lift Enhancer, allowing the user to precisely move and handle large, heavy or bulky building elements by direct interaction with the building element.

Abstract: The instant disclosure relates to (among other things) compounds that are derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amine. The compounds provided possess unique effects and differences over other phenyltriazines known in the art.

Abstract: Provided herein (among other things) are protease inhibitor compounds having enhanced features, along with methods for administering such compounds. For example, the subject compounds can be administered without concomitant administration of a CYP3A4 inhibitor, have increased therapeutic index and/or increased potency, and are low-resistance inducing in nature.

Abstract: A Mortar Delivery System is described. The Mortar Delivery System provides precise control of the delivery and application of mortar in addition to the mixing and tempering of mortar. Such control eliminates the use of a hand trowel in brick, block and stone laying applications. Sensing and control are integrated with the Mortar Delivery System to make it an important element of a robotic brick laying system. The Mortar Delivery System contains sensors to measure mortar viscosity and workability, mortar flow rate, and mortar nozzle pressure. The data from the Mortar Delivery System sensors can be used to change the rotational speed of the shear blades, change the amount of water being used for mixing or tempering, and change the delivery speed of the mortar. Such changes result in precise control of mortar that is in turn suitable for automated or semi-automated building processes.

Abstract: A Functional Training System (FTS) is provided and includes a system container, wherein the system container includes a container front, a container rear, a container first side, a container second side, a container bottom, and a container top, wherein the container front, container rear, container first side, container second side, container bottom, and container top define a container cavity. The FTS further includes an exercise structure, wherein the exercise structure includes a platform connector, wherein the platform connector is non-perpendicularly and securely associated with at least one of the container front, container rear, container first side, container second side, container bottom, and container top, and wherein when the exercise structure is securely associated with at least one of the container front, container rear, container first side, container second side, container bottom, and container top, the exercise structure is supported by the system container.

Abstract: The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.

Abstract: The present invention relates generally to the co-administration of an opioid agonist compound and an analgesic compound. In addition, the invention relates to, among other things, dosage forms for co-administration of an opioid agonist compound and an analgesic compound, methods for administering an opioid agonist compound and an analgesic compound, compositions comprising an opioid agonist compound and an analgesic compound, dosage forms comprising an opioid agonist compound and an analgesic compound, and so on.

Abstract: The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.

Abstract: The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.

Abstract: A multi-lumen sensing system (10) includes medical tubing (20) having a plurality of lumens (22A, 22B) and at least one secondary passageway (24) extending in an axial direction of the medical tubing, wherein the secondary passageway is between the plurality of lumens. The multi-lumen sensing system may include a sensing receptacle (30) defining a channel (32) in which a lengthwise portion of the medical tubing is received. A plurality of ultrasonic transmitting elements (40T, 42T) may be arranged within the secondary passageway of the medical tubing or as part of the sensing receptacle for transmitting respective ultrasonic signals across the lumens to a corresponding plurality of ultrasonic receiving elements (40R, 42R) of the sensing receptacle. Alternatively, the sensing receptacle may include a plurality of ultrasonic transmitting and receiving elements (40, 42, 44) transmitting respective signals across the lumens for return reflection at an interface of the secondary passageway.