Abstract: Molecular determinants of cancer response to immunotherapy are described, as are systems and tools for identifying and/or characterizing cancers likely to respond to immunotherapy. The present invention encompasses the discovery that the likelihood of a favorable response to cancer immunotherapy can be predicted. The present invention further comprises the discovery that cancer cells may harbor somatic mutations that result in neoepitopes that are recognizable by a patient's immune system as non-self. The identification of one or more neoepitopes in a cancer sample is useful for determining which cancer patients are likely to respond favorably to immunotherapy, in particular, treatment with an immune checkpoint modulator.

Abstract: Compounds of formula (I), and pharmaceutically acceptable salts thereof, can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).

Abstract: Compounds of formula (I) wherein: X is —O—, —S(O)r—, —CH2—, or —NR—, wherein r is 0, 1, or 2; X1, X2, and X5 are each independently CR7 or N; one of X3 or X4 is C and is attached by a single bond to -L-, and the other is CR7 or N, provided that no more than three of X1, X2, X3, X or X5 are N; Ring A is monocyclic C5-6scycloalkyl or a 5- to 6-membered monocyclic heterocyclyl comprising from 1 to 5 heteroatoms independently selected from N, S, or O; wherein Ring A is further optionally substituted with from 1 to 3 R4; provided that Ring A is not morpholinyl, thiomorpholinyl or tetrahydro-2H-pyranyl; L is a bond, —O—, —NR—, —S(O)n—, —CH2—, or —C(O)—, wherein n is 0, 1, or 2; 1 2 L1 is an C1-8alkylene, C3-scycloalkylene, —CH2-L2-, or a 3- to 8-membered heterocyclylene comprising 1 to 5; R1 is C6-20alkyl or a monocyclic C3-8cycloalkyl; wherein said C3-8cycloalkyl is substituted with at least one R6 and may be optionally substituted with from 1 to 5 additional R6 substituents, wherein R6 for each occurrence is inde

Abstract: The present invention is directed to a glove system comprising a plurality of closed tip finger sheath with a secondary finger sheath disposed near the finger tips to allow for improved interaction with a portable electronic devices.

Abstract: Methods and kits for assessing risk of metastasis in a cancer patient identified as having breast cancer, colon cancer or glioma use analysis of a classifier for CpG island methylator phenotype.

Abstract: Mechanisms are provided for character-based and image-based media content search and discovery. Character images or entity images are mapped to corresponding media content. Selection of an image or a portion of an image may trigger or search for corresponding media content or begin playback of relevant media content. Character images or entity images need not correspond to a primary program character or object but may correspond to minor characters or tangential entities depicted periodically on particular programs.

Abstract: The present invention relates to modulators of IRAK kinases of formula (I) and provides compositions comprising such modulators, as well as methods therewith for treating IRAK-mediated or IRAK-associated conditions or diseases.

Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for creating a cognitive function index. In one aspect, a method includes receiving first information concerning a person, the first information specifying the person's responses, and lack thereof, for components of a cognitive test administered to the person; generating a cognitive function score for the person by comparing the first information with second information concerning a group of people to whom the cognitive test has been administered; converting the cognitive function score to a value in an index comprising a range of values, wherein a first portion of the range corresponds to a cognitively impaired zone, a second portion of the range corresponds to a cognitively normal zone, and a third portion of the range corresponds to a zone of uncertainty defined by a confidence interval centered on a mid-point of the index; and providing the indexed value for the person.

Abstract: The present invention relates to modulators of IRAK kinases of formula (I) and provides compositions comprising such modulators, as well as methods therewith for treating IRAK-mediated or IRAK-associated conditions or diseases.

Abstract: A method and system for attaching LEDs to circuitry which would protect the LEDs from heat damage and allows for individual LEDs to be removed.

Abstract: A method and apparatus are disclosed for generating a second clock signal, having a second effective clock frequency, from a first clock signal, having a first effective clock frequency. Clock pulses of the first clock signal are counted to generate a count value. When the count value reaches a predetermined blanking value, a blanking signal is generated. The blanking signal blanks at least one clock pulse of the first clock signal. The process is repeated multiple times at a predetermined rate corresponding to the predetermined blanking value to generate the second clock signal.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for creating a cognitive function index. In one aspect, a method includes receiving first information concerning a person, the first information specifying the person's responses, and lack thereof, for components of a cognitive test administered to the person; generating a cognitive function score for the person by comparing the first information with second information concerning a group of people to whom the cognitive test has been administered; converting the cognitive function score to a value in an index comprising a range of values, wherein a first portion of the range corresponds to a cognitively impaired zone, a second portion of the range corresponds to a cognitively normal zone, and a third portion of the range corresponds to a zone of uncertainty defined by a confidence interval centered on a mid-point of the index; and providing the indexed value for the person.

Abstract: A method and apparatus are disclosed for generating a second clock signal, having a second effective clock frequency, from a first clock signal, having a first effective clock frequency. Clock pulses of the first clock signal are counted to generate a count value. When the count value reaches a predetermined blanking value, a blanking signal is generated. The blanking signal blanks at least one clock pulse of the first clock signal. The process is repeated multiple times at a predetermined rate corresponding to the predetermined blanking value to generate the second clock signal.

Abstract: A method and system for attaching LEDs to circuitry which would protect the LEDs from heat damage and allows for individual LEDs to be removed.

Abstract: A method and system for attaching LEDs to circuitry which would protect the LEDs from heat damage and allows for individual LEDs to be replace when a LED fails, without a significant increase in manufacturing cost.

Abstract: A method and apparatus are disclosed for generating a second clock signal, having a second effective clock frequency, from a first clock signal, having a first effective clock frequency. Clock pulses of the first clock signal are counted to generate a count value. When the count value reaches a predetermined blanking value, a blanking signal is generated. The blanking signal blanks at least one clock pulse of the first clock signal. The process is repeated multiple times at a predetermined rate corresponding to the predetermined blanking value to generate the second clock signal.

Abstract: A method and apparatus are disclosed for generating a second clock signal, having a second effective clock frequency, from a first clock signal, having a first effective clock frequency. Clock pulses of the first clock signal are counted to generate a count value. When the count value reaches a predetermined blanking value, a blanking signal is generated. The blanking signal blanks at least one clock pulse of the first clock signal. The process is repeated multiple times at a predetermined rate corresponding to the predetermined blanking value to generate the second clock signal.