Abstract: A shopping cart includes a frame having a chassis portion and a handle portion extending upward from the chassis portion, a pair of front casters and a pair of rear casters mounted on the frame, and a basket connected to the frame and supported by the frame, the basket defining a chamber for holding articles, where the frame further includes a support structure connected to the chassis and the basket and supporting a portion of the basket. The shopping cart may include a number of wear resistance features that decrease the wear on the cart and extend the life of the shopping cart.

Abstract: The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: A pet leash attachment comprising a housing attachable to a leash. The housing has a first end, a second end opposing the first end, and at least one side wall extending between the first end and the second end. A first cavity within the housing is configured to store a roll of pet waste bags. An opening extends through the at least one side wall of the housing into the first cavity. A slit extends through the at least one side wall of the housing from the second end. The opening and the slit are radially spaced a distance from one another.

Abstract: A shopping cart basket having a handle region located at the front or the sides of the shopping cart basket is disclosed. The forward handle region may have a plurality of openings along the front, corners, and sides to allow a customer to easily grip the shopping cart basket and guide the shopping cart. The shopping cart basket may be formed from a metallic wire portion and a non-metallic forward handle region, or in some embodiments, the shopping cart basket may be formed from a fully formed from a polymer material. The shopping cart may also include non-metallic corner inserts that form a portion of the side and front walls of the shopping cart as well as a non-metallic bottom insert that forms a portion of the bottom wall of the shopping cart.

Abstract: A rear gate for a shopping cart where a child seat is attached to the rear gate such that the child seat does not move relative to the rear gate. The child seat is fixed to the rear gate, but the rear gate is pivotally attached to the frame of the shopping cart to allow the shopping carts to be nested together.

Abstract: A shopping cart basket having a handle region located at the front or the sides of the shopping cart basket is disclosed. The forward handle region may have a plurality of openings along the front, corners, and sides to allow a customer to easily grip the shopping cart basket and guide the shopping cart. The shopping cart basket may be formed from a metallic wire portion and a non-metallic forward handle region, or in some embodiments, the shopping cart basket may be formed from a fully formed from a polymer material.

Abstract: The present invention relates to compounds of Formula (I) that are useful as inhibitors of the activity of the ubiquitin specific protease USP19. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in therapy.

Abstract: A shopping cart basket having a handle region located at the front or the sides of the shopping cart basket is disclosed. The forward handle region may have a plurality of openings along the front, corners, and sides to allow a customer to easily grip the shopping cart basket and guide the shopping cart. The shopping cart basket may be formed from a metallic wire portion and a non-metallic forward handle region, or in some embodiments, the shopping cart basket may be formed from a fully formed from a polymer material.

Abstract: A retractable tray is configured to be mounted on the wall of the basket of a shopping cart and includes a tray member that is moveable between a retracted position, where the tray member is located adjacent the wall of the basket, and an extended position, where the tray extends horizontally from the wall into the basket to form a shelf for supporting produce or other goods above the bottom of the basket. The retractable tray may be configured and dimensioned so as to not interfere with nesting of the cart in either the extended or retracted position.

Abstract: A retractable tray is configured to be mounted on the wall of the basket of a shopping cart and includes a tray member that is moveable between a retracted position, where the tray member is located adjacent the wall of the basket, and an extended position, where the tray extends horizontally from the wall into the basket to form a shelf for supporting produce or other goods above the bottom of the basket. The retractable tray may be configured and dimensioned so as to not interfere with nesting of the cart in either the extended or retracted position.

Abstract: The present invention relates to compounds that are useful as inhibitors of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in the treatment of cancer and methods of treating cancer.

Abstract: Described herein is a device for the treatment of water and wastewater that provides a biological or chemical reactor a means to enhance performance by initiating a unique flow pattern between the reactive and solids/liquid separation zones. Said device circulates water between the two zones by forcibly directing water that enters the settling zone back toward the reaction zone via an opening in a partition. The fluid motion scours the bottom of the settling chamber to prevent the accumulation of biologically active solids while maximizing the time those solids spend in the reaction zone; thereby increasing the treatment efficiency of the overall process.

Abstract: The present invention relates to compounds that are useful as inhibitors of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in the treatment of cancer and methods of treating cancer.

Abstract: The invention relates to a series of compounds with particular activity as inhibitors of the serine-threonine kinase AKT. Also provided are pharmaceutical compositions comprising same as well as methods for treating cancer.

Abstract: The present invention relates to compounds that are useful as inhibitors of the activity of one or more isoforms of the serine/threonine kinase, AKT. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in the treatment of cancer and methods of treating cancer.

Abstract: The present invention relates to a method for minimizing breakage of wafers during or after a wafer thinning process. A method of forming a rounded edge to the portion of a wafer remaining after surface grinding process is provided. The method comprises providing a semiconductor wafer having an edge and forming a recess in the edge of the wafer using any suitable mechanical or chemical process. The method further comprises forming a substantially continuous curved shape for at least the edge of the wafer located above the recess. Advantageously, the shape of the wafer is formed prior to the backside grind process to prevent problems caused by the otherwise presence of a sharp edge during the backside grind process.