Patents by Inventor Timothy J. Cunningham

Timothy J. Cunningham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8785401
    Abstract: The present invention relates to methods useful to monitor central and peripheral nervous system neuron/axon destruction resulting from an increase in acute phase inflammatory enzymes. The methods have applicability to monitoring the progress of neurological diseases, including multiple sclerosis and Alzheimer's disease, as well as neuroinflammatory damage that results from sports injuries, vigorous physical activity or any form of physical abuse. The invention further relates to methods of treating multiple sclerosis or other diseases with an inflammatory component related to phospholipase A2.
    Type: Grant
    Filed: July 10, 2006
    Date of Patent: July 22, 2014
    Assignee: Philadelphia Health & Education Corporation
    Inventors: Timothy J. Cunningham, Lihua Yao
  • Patent number: 8716223
    Abstract: A synthetic peptide sequence demonstrating neuroprotective and anti-inflammatory functions is disclosed. Methods of use for the synthetic peptide are also provided.
    Type: Grant
    Filed: May 5, 2009
    Date of Patent: May 6, 2014
    Assignee: Drexel University
    Inventors: Timothy J. Cunningham, Lihua Yao
  • Publication number: 20130143792
    Abstract: The present invention describes compositions and methods for treating and preventing non-degenerative neurological diseases and disorders associated with elevated sPLA2 activity as well as cardiovascular diseases using a CHEC peptide to inhibit sPLA2 activity.
    Type: Application
    Filed: March 28, 2011
    Publication date: June 6, 2013
    Applicant: Philadelphia Health & Education Corporation d/b/a Drexel University College of Medicine
    Inventor: Timothy J. Cunningham
  • Patent number: 8280651
    Abstract: Meter electronics (20) for a flow meter (5) is provided according to an embodiment of the invention. The meter electronics (20) includes an interface (201) for receiving a vibrational response from the flow meter (5) and a processing system (203) in communication with the interface (201). The vibrational response is a response to a vibration of the flow meter (5) at a substantially resonant frequency. The processing system (203) is configured to receive the vibrational response from the interface (201), determine a frequency (?0) of the vibrational response, determine a response voltage (V) and a drive current (I) of the vibrational response, measure a decay characteristic (?) of the flow meter (5), and determine the stiffness parameter (K) from the frequency (?0), the response voltage (V), the drive current (I), and the decay characteristic (?).
    Type: Grant
    Filed: November 17, 2010
    Date of Patent: October 2, 2012
    Assignee: Micro Motion, Inc.
    Inventors: Matthew Joseph Rensing, Andrew Timothy Patten, Timothy J. Cunningham, Mark James Bell
  • Patent number: 8260562
    Abstract: A meter electronics (20) for generating a drive signal for a vibratory flowmeter (5) is provided according to an embodiment of the invention. The meter electronics includes an interface (201) and a processing system (203). The processing system is configured to receive the sensor signal (201) through the interface, phase-shift the sensor signal (210) substantially 90 degrees to create a phase-shifted sensor signal, determine a phase shift value from a frequency response of the vibratory flowmeter, and combine the phase shift value with the sensor signal (201) and the phase-shifted sensor signal in order to generate a drive signal phase (213). The processing system is further configured to determine a sensor signal amplitude (214) from the sensor signal (210) and the phase-shifted sensor signal, and generate a drive signal amplitude (215) based on the sensor signal amplitude (214), wherein the drive signal phase (213) is substantially identical to a sensor signal phase (212).
    Type: Grant
    Filed: March 16, 2011
    Date of Patent: September 4, 2012
    Assignee: Micro Motion, Inc.
    Inventors: Timothy J Cunningham, William M Mansfield, Craig B McAnally
  • Patent number: 8106019
    Abstract: The present invention relates to the discovery of a composition including a seven-amino acid peptide that promotes neuronal survival, inhibits inflammation, and is a potent inhibitor of sPL2A, and uses thereof.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: January 31, 2012
    Assignee: Philadelphia Health & Education Corporation
    Inventors: Timothy J. Cunningham, Lihua Yao, Jeffrey I. Greenstein
  • Publication number: 20110178738
    Abstract: Meter electronics (20) for a flow meter (5) is provided according to an embodiment of the invention. The meter electronics (20) includes an interface (201) for receiving a vibrational response from the flow meter (5) and a processing system (203) in communication with the interface (201). The vibrational response is a response to a vibration of the flow meter (5) at a substantially resonant frequency. The processing system (203) is configured to receive the vibrational response from the interface (201), determine a frequency (?0) of the vibrational response, determine a response voltage (V) and a drive current (I) of the vibrational response, measure a decay characteristic (?) of the flow meter (5), and determine the stiffness parameter (K) from the frequency (?0), the response voltage (V), the drive current (I), and the decay characteristic (?).
    Type: Application
    Filed: November 17, 2010
    Publication date: July 21, 2011
    Applicant: Micro Motion, Inc.
    Inventors: Matthew Joseph RENSING, Andrew Timothy PATTEN, Timothy J. CUNNINGHAM, Mark James BELL
  • Patent number: 7983855
    Abstract: A meter electronics (20) for generating a drive signal for a vibratory flowmeter (5) is provided according to an embodiment of the invention. The meter electronics includes an interface (201) and a processing system (203). The processing system is configured to receive the sensor signal (201) through the interface, phase-shift the sensor signal (210) substantially 90 degrees to create a phase-shifted sensor signal, determine a phase shift value from a frequency response of the vibratory flowmeter, and combine the phase shift value with the sensor signal (201) and the phase-shifted sensor signal in order to generate a drive signal phase (213). The processing system is further configured to determine a sensor signal amplitude (214) from the sensor signal (210) and the phase-shifted sensor signal, and generate a drive signal amplitude (215) based on the sensor signal amplitude (214), wherein the drive signal phase (213) is substantially identical to a sensor signal phase (212).
    Type: Grant
    Filed: September 13, 2006
    Date of Patent: July 19, 2011
    Assignee: Micro Motion, Inc.
    Inventors: Timothy J. Cunningham, William M Mansfield, Craig B McAnally
  • Publication number: 20110166801
    Abstract: A meter electronics (20) for generating a drive signal for a vibratory flowmeter (5) is provided according to an embodiment of the invention. The meter electronics includes an interface (201) and a processing system (203). The processing system is configured to receive the sensor signal (201) through the interface, phase-shift the sensor signal (210) substantially 90 degrees to create a phase-shifted sensor signal, determine a phase shift value from a frequency response of the vibratory flowmeter, and combine the phase shift value with the sensor signal (201) and the phase-shifted sensor signal in order to generate a drive signal phase (213). The processing system is further configured to determine a sensor signal amplitude (214) from the sensor signal (210) and the phase-shifted sensor signal, and generate a drive signal amplitude (215) based on the sensor signal amplitude (214), wherein the drive signal phase (213) is substantially identical to a sensor signal phase (212).
    Type: Application
    Filed: March 16, 2011
    Publication date: July 7, 2011
    Applicant: Micro Motion, Inc.
    Inventors: Timothy J. CUNNINGHAM, William M. Mansfield, Craig B. McAnally
  • Publication number: 20110029259
    Abstract: A method for detecting a deviation in a flow meter parameter of a flow meter that is adapted to measure a fluid flow rate is provided. The method comprises measuring a differential pressure across at least a portion of the flow meter. The method further comprises comparing the measured differential pressure to an expected differential pressure; the expected differential pressure being based on the measured flow rate. The method further comprises detecting a deviation in the flow meter parameter if the difference between the measured differential pressure and the expected differential pressure exceeds a threshold limit.
    Type: Application
    Filed: May 1, 2008
    Publication date: February 3, 2011
    Applicant: MICRO MOTION INC.
    Inventors: Timothy J Cunningham, Andrew Timothy Patten
  • Patent number: 7865318
    Abstract: Meter electronics (20) for a flow meter (5) is provided according to an embodiment of the invention. The meter electronics (20) includes an interface (201) for receiving a vibrational response from the flow meter (5) and a processing system (203) in communication with the interface (201). The vibrational response is a response to a vibration of the flow meter (5) at a substantially resonant frequency. The processing system (203) is configured to receive the vibrational response from the interface (201), determine a frequency (?0) of the vibrational response, determine a response voltage (V) and a drive current (I) of the vibrational response, measure a decay characteristic (?) of the flow meter (5), and determine the stiffness parameter (K) from the frequency (?0), the response voltage (V), the drive current (I), and the decay characteristic (?).
    Type: Grant
    Filed: September 19, 2005
    Date of Patent: January 4, 2011
    Assignee: Micro Motion, Inc.
    Inventors: Matthew Joseph Rensing, Andrew Timothy Patten, Timothy J. Cunningham, Mark James Bell
  • Publication number: 20090286746
    Abstract: A synthetic peptide sequence demonstrating neuroprotective and anti-inflammatory functions is disclosed. Methods of use for the synthetic peptide are also provided.
    Type: Application
    Filed: May 5, 2009
    Publication date: November 19, 2009
    Inventors: Timothy J. Cunningham, Lihua Yao
  • Publication number: 20090181879
    Abstract: The present invention relates to methods useful to monitor central and peripheral nervous system neuron/axon destruction resulting from an increase in acute phase inflammatory enzymes. The methods have applicability to monitoring the progress of neurological diseases, including multiple sclerosis and Alzheimer's disease, as well as neuroinflammatory damage that results from sports injuries, vigorous physical activity or any form of physical abuse. The invention further relates to methods of treating multiple sclerosis or other diseases with an inflammatory component related to phospholipase A2.
    Type: Application
    Filed: July 10, 2006
    Publication date: July 16, 2009
    Applicant: Philadelphia Health & Education Corporation d/b/a Drexel University College of Medicine
    Inventors: Timothy J. Cunningham, Lihua Yao, Jeffrey I. Greenstein
  • Patent number: 7528112
    Abstract: A synthetic peptide sequence demonstrating neuroprotective and anti-inflammatory functions is disclosed. Methods of use for the synthetic peptide are also provided.
    Type: Grant
    Filed: November 17, 2003
    Date of Patent: May 5, 2009
    Assignee: Drexel University
    Inventors: Timothy J. Cunningham, Lihua Yao
  • Publication number: 20080281535
    Abstract: Meter electronics (20) for a flow meter (5) is provided according to an embodiment of the invention. The meter electronics (20) includes an interface (201) for receiving a vibrational response from the flow meter (5) and a processing system (203) in communication with the interface (201). The vibrational response is a response to a vibration of the flow meter (5) at a substantially resonant frequency. The processing system (203) is configured to receive the vibrational response from the interface (201), determine a frequency (?0) of the vibrational response, determine a response voltage (V) and a drive current (I) of the vibrational response, measure a decay characteristic (?) of the flow meter (5), and determine the stiffness parameter (K) from the frequency (?0), the response voltage (V), the drive current (I), and the decay characteristic (?).
    Type: Application
    Filed: September 19, 2005
    Publication date: November 13, 2008
    Inventors: Matthew Joseph Rensing, Andrew Timothy Patten, Timothy J. Cunningham, Mark James Bell
  • Publication number: 20080249027
    Abstract: The present invention relates to the discovery of a composition including a seven-amino acid peptide that promotes neuronal survival, inhibits inflammation, and is a potent inhibitor of sPL2A, and uses thereof.
    Type: Application
    Filed: October 12, 2007
    Publication date: October 9, 2008
    Inventors: Timothy J. Cunningham, Lihua Yao, Jeffrey I. Greenstein
  • Publication number: 20080223148
    Abstract: A meter electronics (20) for generating a drive signal for a vibratory flowmeter (5) is provided according to an embodiment of the invention. The meter electronics includes an interface (201) and a processing system (203). The processing system is configured to receive the sensor signal (201) through the interface, phase-shift the sensor signal (210) substantially 90 degrees to create a phase-shifted sensor signal, determine a phase shift value from a frequency response of the vibratory flowmeter, and combine the phase shift value with the sensor signal (201) and the phase-shifted sensor signal in order to generate a drive signal phase (213). The processing system is further configured to determine a sensor signal amplitude (214) from the sensor signal (210) and the phase-shifted sensor signal, and generate a drive signal amplitude (215) based on the sensor signal amplitude (214), wherein the drive signal phase (213) is substantially identical to a sensor signal phase (212).
    Type: Application
    Filed: September 13, 2006
    Publication date: September 18, 2008
    Inventors: Timothy J Cunningham, William M. Mansfield, Craig B. McAnally
  • Patent number: 7343775
    Abstract: A gas test system (300) is disclosed comprised of a flow loop (302), a blower system (304), a temperature control system (306), a reference meter system (308), and a unit under test (UUT) system (310). The UUT system connects a unit under test (UUT) to the flow loop. The blower system receives the gas under pressure at an inlet (321), and generates a high flow rate of the gas out of an outlet (322) while generating a low pressure rise from the inlet to the outlet. The temperature control system receives the flow of gas from the blower system and controls the temperature of the gas. The reference meter system and the UUT in the UUT system measure a property of the gas circulating through the flow loop. The measurements of the reference meter system can be compared to the measurements of the UUT to calibrate the UUT.
    Type: Grant
    Filed: June 11, 2003
    Date of Patent: March 18, 2008
    Assignee: Micro Motion, Inc.
    Inventors: Timothy J. Cunningham, Andrew Timothy Patten, Charles L. Gray, Dean M. Standiford
  • Publication number: 20040132665
    Abstract: A synthetic peptide sequence demonstrating neuroprotective and anti-inflammatory functions is disclosed. Methods of use for the synthetic peptide are also provided.
    Type: Application
    Filed: November 17, 2003
    Publication date: July 8, 2004
    Inventors: Timothy J. Cunningham, Lihua Yao
  • Patent number: 6694279
    Abstract: Movement of a structure, such a conduit of a Coriolis mass flowmeter, is estimated. A plurality of motion signals representing motion of the structure are mode selective filtered to generate a plurality of mode selective filtered motion signals such that the mode selective filtered motion signals preferentially represent motion associated with a vibrational mode of the structure. A plurality of phase estimates is generated from the plurality of mode selective filtered motion signals. The plurality of phase estimates may be generated using a phase reference derived from a mode selective filtered motion signal of the plurality of mode selective filtered motion signals. According to some embodiments, a frequency of a mode selective filtered motion signal is estimated, and quadrature first and second reference signals are generated based on the estimated frequency. The plurality of phase estimates is generated from the mode selective filtered motion signals and the reference signals.
    Type: Grant
    Filed: February 16, 2001
    Date of Patent: February 17, 2004
    Assignee: Micro Motion, Inc.
    Inventors: Timothy J. Cunningham, David Lee Campbell, Thomas Dean Sharp