Patents by Inventor Timothy Skern

Timothy Skern has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Picornavirus I proteinase and methods of making and using thereof
    Patent number: 6180385
    Abstract: Methods of making and using Picornavirus L proteinase peptides (PLPPs) are provided, including, but not limited to, expression of DNA encoding all or a portion thereof, such as a Picornavirus L proteinase (PLP) and variants thereof, as well as methods for determining active sites and inhibitors of a PLP.
    Type: Grant
    Filed: October 25, 1996
    Date of Patent: January 30, 2001
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Timothy Skern, Regina Kirchweger, Elisabeth Ziegler, Dieter Blaas, Hans-Dieter Liebig, Barry J. Lamphear, Debra Waters, Robert E. Rhoads, Wolfgang Sommergruber, Horst Ahorn
  • Expression of mature proteinase 2A, the partial purification thereof and preparation of substrates having an inhibitory effect
    Patent number: 5559025
    Abstract: The invention relates to the expression of mature HRV proteinase 2A, the partial purification thereof and the preparation of substrates having an inhibitory effect.
    Type: Grant
    Filed: October 11, 1994
    Date of Patent: September 24, 1996
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Horst Ahorn, Ingrid Maurer-Fogy, Wolfgang Sommergruber, Andreas Zophel, Dieter Blaas, Ernst Kuchler, Hans-Dieter Liebig, Timothy Skern
  • Process for the characterization of human rhinoviruses
    Patent number: 5340713
    Abstract: The present invention relates to a method of characterizing viruses and the use thereof for classification. According to the invention, a cDNA copy of a first virus is made and the cDNA is amplified and cleaved using at least one restriction endonuclease. The location of restriction fragments is mapped and compared to that of other viruses. Primers useful for amplifying the cDNA may be derived from sequences found in the 5' non-coding regions of picornavirus including human rhinovirus.
    Type: Grant
    Filed: June 22, 1990
    Date of Patent: August 23, 1994
    Assignee: Boehringer Igelheim International GmbH
    Inventors: Helge Torgersen, Timothy Skern, Dieter Blaas
  • Expression of the virally coded protease P2A of HRV2
    Patent number: 5149783
    Abstract: This invention relates to a DNA molecule or a functional derivative thereof coding for a fusion protein, the fusion protein comprising an enzymatically active component and a non-enzymatically active polypeptide component which may be cleaved therefrom, an expression system which contains the DNA molecule, the use thereof as a test system for inhibitors of viral proteases, and an assay for identifying viral inhibitors.
    Type: Grant
    Filed: December 23, 1988
    Date of Patent: September 22, 1992
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Wolfgang Sommergruber, Friederike Fessl, Ernst Kuechler, Dieter Blaas, Timothy Skern, Manfred Zorn, Markus Duechler, Heinrich Kowalski, Peter Volkmann, Ingrid Maurer-Fogy, Peter Pallai