Abstract: Provided herein (among other things) are protease inhibitor compounds having enhanced features, along with methods for administering such compounds. For example, the subject compounds can be administered without concomitant administration of a CYP3A4 inhibitor, have increased therapeutic index and/or increased potency, and are low-resistance inducing in nature.

Abstract: A patient care system is configured for infusing fluid to a patient. The system includes a plurality of fluid infusion pumps, each of which is connected to a respective fluid supply for pumping the contents of a fluid supply to a patient via fluid supply lines. The system includes a pressure sensor downstream of the fluid infusion pumps for determining if a particular fluid is connected to a designated infusion pump.

Abstract: A patient care system is configured for infusing fluid to a patient. The system includes a plurality of fluid infusion pumps, each of which is connected to a respective fluid supply for pumping the contents of a fluid supply to a patient via fluid supply lines. The system includes a pressure sensor downstream of the fluid infusion pumps for determining if a particular fluid is connected to a designated infusion pump.

Abstract: A system and method of managing therapy provided to patients in an institution. The system monitors all aspects of the medication delivery to a patient, as well as other information related to the patient, such as values of vital signs, laboratory results and patient factors such as history, diagnosis, allergies and the like. The system includes one or more databases of information, including institutionally developed rules, guidelines and protocol representing the best medical practices of the institution. The system provides alerts and/or recommendations based on the application of the rules to the information being monitored, and alerts care givers accordingly, providing for dynamic adjustment of the patient's therapy. The system also monitors the status of the alerts, and if no action is taken in a selected period of time, may escalate the priority of the alert and/or halt the delivery of medication to the patient until the alert is resolved.

Abstract: A system and method of managing therapy provided to patients in an institution. The system monitors all aspects of the medication delivery to a patient, as well as other information related to the patient, such as values of vital signs, laboratory results and patient factors such as history, diagnosis, allergies and the like. The system includes one or more databases of information, including institutionally developed rules, guidelines and protocol representing the best medical practices of the institution. The system provides alerts and/or recommendations based on the application of the rules to the information being monitored, and alerts care givers accordingly, providing for dynamic adjustment of the patient's therapy. The system also monitors the status of the alerts, and if no action is taken in a selected period of time, may escalate the priority of the alert and/or halt the delivery of medication to the patient until the alert is resolved.

Abstract: A system and method of managing therapy provided to patients in an institution. The system monitors all aspects of the medication delivery to a patient, as well as other information related to the patient, such as values of vital signs, laboratory results and patient factors such as history, diagnosis, allergies and the like. The system includes one or more databases of information, including institutionally developed rules, guidelines and protocol representing the best medical practices of the institution. The system provides alerts and/or recommendations based on the application of the rules to the information being monitored, and alerts care givers accordingly, providing for dynamic adjustment of the patient's therapy. The system also monitors the status of the alerts, and if no action is taken in a selected period of time, may escalate the priority of the alert and/or halt the delivery of medication to the patient until the alert is resolved.

Abstract: A system and method of managing therapy provided to patients in an institution. The system monitors all aspects of the medication delivery to a patient, as well as other information related to the patient, such as values of vital signs, laboratory results and patient factors such as history, diagnosis, allergies and the like. The system includes one or more databases of information, including institutionally developed rules, guidelines and protocol representing the best medical practices of the institution. The system provides alerts and/or recommendations based on the application of the rules to the information being monitored, and alerts care givers accordingly, providing for dynamic adjustment of the patient's therapy. The system also monitors the status of the alerts, and if no action is taken in a selected period of time, may escalate the priority of the alert and/or halt the delivery of medication to the patient until the alert is resolved.

Abstract: A modular patient care system having a central management unit module and one or more detachable functional units is described. Using unique mechanical and electrical features, the modular patient care system is capable of flexibly, bilaterally, and safely providing electrical power from the central management unit to the attached functional units, with exposed power leads of end units being electrically isolated for safety and security. Functional units are capable of detecting the presence of other functional units more distant from the central management unit for passing power to those units, and for otherwise electrically isolating exposed power leads when no further units are attached.

Abstract: A system and method for determining whether the pressure in a fluid line upstream of an infusion pump is becoming lower as pumping draws fluid from the fluid line and fluid container due to a lack of proper venting. An initial pressure is sensed by an upstream pressure sensor at the start of an infusion. After a period of time, which may be determined either by monitoring infusion time or the number of pump cycles completed, a second pressure is sampled and compared to the initial pressure. Various analytical methods may be applied to the sensed pressures to determine upstream pressures or trends. Where an upstream pressure reading indicates a lack of proper venting, an alert signal is provided. Continuous monitoring may occur in which succeeding samples are compared to preceding samples to determine upstream pressures or trends.

Abstract: A system and method for monitoring changes in the pressure of a fluid line upstream of an infusion pump to determine when a fluid container has emptied, and to provide a signal indicating that the container needs replacement or replenishment. The difference between averaged pressures over separate time periods is monitored to determine when the fluid container is empty. The system and method are applicable to primary and secondary fluid container setups and can detect the point where the secondary has been emptied and the primary flow has resumed.

Abstract: A modular patient care system having a central management unit module and one or more detachable functional units is described. Using unique mechanical and electrical features, the modular patient care system is capable of flexibly, bilaterally, and safely providing electrical power from the central management unit to the attached functional units, with exposed power leads of end units being electrically isolated for safety and security. Functional units are capable of detecting the presence of other functional units more distant from the central management unit for passing power to those units, and for otherwise electrically isolating exposed power leads when no further units are attached.

Abstract: A system and method for verifying that a particular fluid supply is connected to an infusion pump or pump channel. An upstream pressure sensor coupled to a fluid conduit associated with the fluid supply is used to provide pressure signals in response to pressure sensed in the conduit to a processor. In a connection verification mode, the processor is configured to receive the pressure signals and delay the flow control device of the infusion pump from moving fluid through the conduit until the processor detects a pressure change in the conduit indicated by the pressure signals to thereby verify that the particular fluid supply is connected to the infusion pump.

Abstract: A system and method for verifying that a medication delivery device is properly programmed to deliver a medication from a medication source. The system and method insure that the right medication is delivered in the right manner to a patient, and is particularly advantageous where multiple medications are being delivered simultaneously to a patient. The system and method also provides for ensuring that the device is properly programmed each time a medication to be delivered is changed by requiring verification each time an infusion pump is opened. The identification devices contemplated by the system includes barcodes affixed to the delivery device and medication. Other devices besides barcodes, such as RFID devices may also be used.

Abstract: Pending medication orders are presented on the controller of an infusion pump to which a patient has been identified. All pending medication orders are displayed on the screen of the controller and any may be selected by the clinician. Selecting a pending order at the controller that involves an infusion to the patient also results in automatic programming of the infusion pump in accordance with that order. Selection of an oral medication at the controller results, as does selection of any other order, in notification to the healthcare facility server that the order is being administered. Such notification resolves open controlled item transactions as well as provides information that may be relevant to a patient's EMAR. Selection of a pending order may occur manually or automatically through identification of a medication.

Abstract: The present invention is directed to a system and method for providing care to a patient, comprising a patient care device having a number of configuration databases stored in a memory in the device. Each configuration database preferably includes protocols, operating limits, rule sets and/or operating features that collectively define an operating environment, or personality, of the device. Selection of a specific configuration database preferably is based at least in part upon patient-specific information obtained from any location in a distributed hospital network. Examples of such patient-specific information include patient age or size, patient medical characteristics, a location of the patient or a location of the care device. In a preferred embodiment, programming a patient care device to deliver a drug to a patient entails activating a configuration database and scanning a machine-readable drug label identifying a particular protocol stored in the activated database.

Abstract: A modular patient care system having a central management unit module and one or more detachable functional units is described. Using unique mechanical and electrical features, the modular patient care system is capable of flexibly, bilaterally, and safely providing electrical power from the central management unit to the attached functional units, with exposed power leads of end units being electrically isolated for safety and security. Functional units are capable of detecting the presence of other functional units more distant from the central management unit for passing power to those units, and for otherwise electrically isolating exposed power leads when no further units are attached.

Abstract: The present invention is directed to a system and method for providing care to a patient, comprising a patient care device having a number of configuration databases stored in a memory in the device. Each configuration database preferably includes protocols, operating limits, rule sets and/or operating features that collectively define an operating environment, or personality, of the device. Selection of a specific configuration database preferably is based at least in part upon patient-specific information obtained from any location in a distributed hospital network. Examples of such patient-specific information include patient age or size, patient medical characteristics, a location of the patient or a location of the care device. In a preferred embodiment, programming a patient care device to deliver a drug to a patient entails activating a configuration database and scanning a machine-readable drug label identifying a particular protocol stored in the activated database.

Abstract: The present invention is directed to a system and method for providing care to a patient, comprising a patient care device having a number of configuration databases stored in a memory in the device. Each configuration database preferably includes protocols, operating limits, rule sets and/or operating features that collectively define an operating environment, or personality, of the device. Selection of a specific configuration database preferably is based at least in part upon patient-specific information obtained from any location in a distributed hospital network. Examples of such patient-specific information include patient age or size, patient medical characteristics, a location of the patient or a location of the care device. In a preferred embodiment, programming a patient care device to deliver a drug to a patient entails activating a configuration database and scanning a machine-readable drug label identifying a particular protocol stored in the activated database.

Abstract: The present invention is directed to a system and method for providing care to a patient, comprising a patient care device having a number of configuration databases stored in a memory in the device. Each configuration database preferably includes protocols, operating limits, rule sets and/or operating features that collectively define an operating environment, or personality, of the device. Selection of a specific configuration database preferably is based at least in part upon patient-specific information obtained from any location in a distributed hospital network. Examples of such patient-specific information include patient age or size, patient medical characteristics, a location of the patient or a location of the care device. In a preferred embodiment, programming a patient care device to deliver a drug to a patient entails activating a configuration database and scanning a machine-readable drug label identifying a particular protocol stored in the activated database.

Abstract: The present invention is directed to a system and method for providing care to a patient, comprising a patient care device having a number of configuration databases stored in a memory in the device. Each configuration database preferably includes protocols, operating limits, rule sets and/or operating features that collectively define an operating environment, or personality, of the device. Selection of a specific configuration database preferably is based at least in part upon patient-specific information obtained from any location in a distributed hospital network. Examples of such patient-specific information include patient age or size, patient medical characteristics, a location of the patient or a location of the care device. In a preferred embodiment, programming a patient care device to deliver a drug to a patient entails activating a configuration database and scanning a machine-readable drug label identifying a particular protocol stored in the activated database.