Patents by Inventor Timothy W. King

Timothy W. King has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10351568
    Abstract: Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp14 results in increased proteasome efficiency. The present invention therefore provides novel compositions and methods for inhibition of Usp14, enhancement of proteasome activity and treatment of proteinopathies.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: July 16, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: Daniel J. Finley, Randall W. King, Byung-Hoon Lee, Min Jae Lee, Timothy C. Gahman
  • Patent number: 7291348
    Abstract: A cost-effective, scalable technique for producing microspheres loaded with biologically active solid proteins is provided. The microspheres degrade over time and release biologically active VEGF, as demonstrated by the proliferation of HUVECs in vitro compared to negative controls. A defined concentration of microspheres can deliver a quantifiable level of VEGF with known release kinetics. The invention can be used with other growth factors and applied to tissue engineering applications such as the regeneration of peripheral nerve, bone, adipose tissue, and solid organs.
    Type: Grant
    Filed: July 22, 2005
    Date of Patent: November 6, 2007
    Assignee: Board of Regents, The University of Texas System
    Inventors: Timothy W. King, Charles W. Patrick, Jr.
  • Patent number: 6962716
    Abstract: A cost-effective, scalable technique for producing microspheres loaded with biologically active solid proteins is provided. The microspheres degrade over time and release biologically active VEGF, as demonstrated by the proliferation of HUVECs in vitro compared to negative controls. A defined concentration of microspheres can deliver a quantifiable level of VEGF with known release kinetics. The invention can be used with other growth factors and applied to tissue engineering applications such as the regeneration of peripheral nerve, bone, adipose tissue, and solid organs.
    Type: Grant
    Filed: September 27, 2000
    Date of Patent: November 8, 2005
    Assignee: Board of Regents, The University of Texas System
    Inventors: Timothy W. King, Charles W. Patrick, Jr.
  • Patent number: 4695186
    Abstract: Asphalt handling apparatus includes a carriage portion, a hopper portion, a hopper heating portion, an asphalt dispensing portion, a liquid tack material dispensing portion and an equipment lifting portion. The hopper portion includes an elongated trough section with a generally V-shaped cross section. A pair of bi-fold doors selectively cover an open top section. The hopper heating portion includes an enclosed heat transfer medium first chamber disposed immediately below the V-shaped trough section and in direct contact therewith. The first chamber includes sloping wing sections and a deeper central section communicating therewith. A U-shaped burner channel is disposed substantially horizontally within the central section with a gas burner along a first arm and an exhaust stack extends upwardly from a second arm. An elongated electrical heating element is disposed between the arms.
    Type: Grant
    Filed: September 26, 1986
    Date of Patent: September 22, 1987
    Inventor: Timothy W. King
  • Patent number: 4546037
    Abstract: Individual electrical connections between two banks of electrodes can be made by the novel tape, a layer of which contains electrically conductive particles. Each particle has an electrically conductive surface and a ferromagnetic core by which the particles can be magnetically attracted to form nonintersecting stripes, each stripe containing a continuous array of contacting particles and hence being electrically conductive over both its length and thickness.
    Type: Grant
    Filed: September 4, 1984
    Date of Patent: October 8, 1985
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: Timothy W. King
  • Patent number: 4337303
    Abstract: A method of transferring, encapsulating, and fixing dried liquid toner images in electrography is provided. Stable, abrasion-resistant articles exhibiting continuous tone and transmission optical densities within the range of 0 to 4.0 are disclosed.
    Type: Grant
    Filed: August 11, 1980
    Date of Patent: June 29, 1982
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Melville R. V. Sahyun, Tsung-I Chen, Timothy W. King, Valdis Mikelsons, Smarajit Mitra