Patents by Inventor Tina Bilousova

Tina Bilousova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
    Publication number: 20230113944
    Abstract: Provided herein are compounds of Formula I and their salts, and compositions thereof that are useful for useful for modulating neutral sphingomyelinase 2 (n-SMase2) and/or acetylcholinesterase (AChE) in cells. Also disclosed herein are methods of using the disclosed compounds and compositions for inhibiting the spread of Tau seeds from donor cells to recipient cells. Further disclosed herein are methods of using the disclosed compounds and compositions for treating or preventing a neurodegenerative disorder, such as a tauopathy, Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), Lewy body dementia, frontotemporal dementia, and amyotrophic lateral sclerosis (ALS).
    Type: Application
    Filed: January 8, 2021
    Publication date: April 13, 2023
    Inventors: Varghese John, Tina Bilousova, Bryan Simmons, Neil Garg, Jesus Campagna, Barbara Jagodzinska
  • 3D-exoquant method for the analysis of surface molecules and quantification of tissue-specific exosomes in biological fluids
    Patent number: 11243215
    Abstract: In various embodiments methods are provided for identifying and/or quantifying one or more antigens of interest (biomarkers) on the surface of cell- or tissue-specific exosomes.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: February 8, 2022
    Assignee: The Regents of the University of California
    Inventors: Varghese John, Jesus Campagna, Tina Bilousova, Patricia R. Spilman, Peter James Heinzelman, Asa Hatami, Mohammad Parvez Alam
  • COMPOSITIONS AND METHODS FOR INHIBITING N-SMASE2
    Publication number: 20200270216
    Abstract: Provided herein are compounds of Formula (I) and (II) and their salts, and compositions comprising such compounds that are useful for useful for modulating neutral sphingomyelinase 2 (n-SMase2) in cells. Also disclosed herein are methods of using the disclosed compounds and compositions for inhibiting the spread of Tau seeds from donor cells to recipient cells. Moreover, disclosed herein are methods of using the disclosed compounds and compositions for treating or preventing a neurodegenerative disorder, such as a tauopathy, Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), Lewy body dementia, frontotemporal dementia, and amyotrophic lateral sclerosis (ALS).
    Type: Application
    Filed: September 14, 2018
    Publication date: August 27, 2020
    Inventors: Tina Bilousova, Barbara Jagodzinska, Varghese John
  • 3D-EXOQUANT METHOD FOR THE ANALYSIS OF SURFACE MOLECULES AND QUANTIFICATION OF TISSUE-SPECIFIC EXOSOMES IN BIOLOGICAL FLUIDS
    Publication number: 20190025330
    Abstract: In various embodiments methods are provided for identifying and/or quantifying one or more antigens of interest (biomarkers) on the surface of cell- or tissue-specific exosomes.
    Type: Application
    Filed: January 13, 2017
    Publication date: January 24, 2019
    Inventors: Varghese John, Jesus Campagna, Tina Bilousova, Patricia R. Spilman, Peter James Heinzelman, Asa Hatami, Mohammad Parvez Alam