Patents by Inventor Tobias Ludwig Ross

Tobias Ludwig Ross has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • F-labelled folates as PET radiotracers
    Patent number: 10961246
    Abstract: The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein fluorine-18 is covalently linked to the glutamate portion of a folate or derivative thereof, a method of their preparation, as well as their use in diagnosis and monitoring of therapy of cancer and inflammatory and autoimmune diseases.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: March 30, 2021
    Assignee: MERCK & CIE
    Inventors: Roger Schibli, Rudolf Moser, Cristina Magdalena Muller, Simon Mensah Ametamey, Tobias Ludwig Ross, Viola Groehn
  • F-labelled folates
    Patent number: 10377756
    Abstract: The present invention is directed towards a new method of synthesis of 18F-folate radiopharmaceuticals, wherein fluorine-18 is attached to a pteroate (or folate) or derivative thereof, through direct radiolabeling with 18[F]fluoride, as well as 18F-folate radiopharmaceuticals obtained by such method of synthesis and their use in diagnosis and monitoring of cancer therapy and therapy of inflammatory and autoimmune diseases.
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: August 13, 2019
    Assignee: MERCK & CIE
    Inventors: Simon Mensah Ametamey, Rudolf Moser, Tobias Ludwig Ross, Phoebe Lam, Viola Groehn
  • 18F-LABELLED FOLATES AS PET RADIOTRACERS
    Publication number: 20180072734
    Abstract: The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein fluorine-18 is covalently linked to the glutamate portion of a folate or derivative thereof, a method of their preparation, as well as their use in diagnosis and monitoring of therapy of cancer and inflammatory and autoimmune diseases.
    Type: Application
    Filed: September 21, 2017
    Publication date: March 15, 2018
    Applicant: MERCK & CIE
    Inventors: Roger SCHIBLI, Rudolf MOSER, Cristina Magdalena MULLER, Simon Mensah AMETAMEY, Tobias Ludwig ROSS, Viola GROEHN
  • F-labelled folates
    Patent number: 9771368
    Abstract: The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein the fluorine-18 is covalently linked to the aminobenzoyl moiety, which connects the condensed pyrimidine heterocycle to the amino acid portion within folate structures, as well as their precursors and their non-radioactive references, a method of their preparation, as well as their use in diagnosis of a cell or population of cells expressing a folate-receptor and monitoring of cancer and inflammatory and autoimmune diseases and therapy thereof.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: September 26, 2017
    Assignee: MERCK & CIE
    Inventors: Simon Mensah Ametamey, Rudolf Moser, Tobias Ludwig Ross, Viola Groehn
  • 18F-labelled folates
    Patent number: 9315506
    Abstract: The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein the fluorine-18 is covalently linked to the aminobenzoyl moiety, which connects the condensed pyrimidine heterocycle to the amino acid portion within folate structures, as well as their precursors and their non-radioactive references, a method of their preparation, as well as their use in diagnosis of a cell or population of cells expressing a folate-receptor and monitoring of cancer and inflammatory and autoimmune diseases and therapy thereof.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: April 19, 2016
    Assignee: MERCK & CIE
    Inventors: Simon Mensah Ametamey, Rudolf Moser, Tobias Ludwig Ross, Viola Groehn
  • 18F-LABELLED FOLATES
    Publication number: 20150315189
    Abstract: The present invention is directed towards a new method of synthesis of 18F-folate radiopharmaceuticals, wherein fluorine-18 is attached to a pteroate (or folate) or derivative thereof, through direct radiolabeling with 18[F]fluoride, as well as 18F-folate radiopharmaceuticals obtained by such method of synthesis and their use in diagnosis and monitoring of cancer therapy and therapy of inflammatory and autoimmune diseases.
    Type: Application
    Filed: July 13, 2015
    Publication date: November 5, 2015
    Applicant: MERCK & CIE
    Inventors: Simon Mensah AMETAMEY, Rudolf MOSER, Tobias Ludwig ROSS, Phoebe LAM, Viola GROEHN
  • F-labelled folates
    Patent number: 8344140
    Abstract: The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein fluorine-18 is covalently linked through a triazole- or tetrazole linker to a folate or derivative thereof, a method of their preparation, as well as their use in diagnosis and monitoring of therapy of cancer and inflammatory and autoimmune diseases.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: January 1, 2013
    Assignee: Merck Eprova AG
    Inventors: Simon Mensah Ametamey, Rudolf Moser, Tobias Ludwig Ross, Thomas Leighton Mindt, Viola Groehn
  • 18F-LABELLED FOLATES AS PET RADIOTRACERS
    Publication number: 20110286921
    Abstract: The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein fluorine-18 is covalently linked to the glutamate portion of a folate or derivative thereof, a method of their preparation, as well as their use in diagnosis and monitoring of therapy of cancer and inflammatory and autoimmune diseases.
    Type: Application
    Filed: October 12, 2009
    Publication date: November 24, 2011
    Applicant: MERCK & CIE
    Inventors: Roger Schibli, Rudolf Moser, Cristina Magdalena Muller, Simon Mensah Ametamey, Tobias Ludwig Ross, Viola Groehn
  • 18F-LABELLED FOLATES
    Publication number: 20100111863
    Abstract: The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein fluorine-18 is covalently linked through a triazole- or tetrazole linker to a folate or derivative thereof, a method of their preparation, as well as their use in diagnosis and monitoring of therapy of cancer and inflammatory and autoimmune diseases.
    Type: Application
    Filed: April 11, 2008
    Publication date: May 6, 2010
    Applicant: Merck Eprova AG
    Inventors: Simon Mensah Ametamey, Rudolf Moser, Tobias Ludwig Ross, Thomas Leighton Mindt, Viola Groehn
  • 18F-LABELLED FOLATES
    Publication number: 20100111864
    Abstract: The present invention is directed towards a new method of synthesis of 18F-folate radiopharmaceuticals, wherein fluorine-18 is attached to a pteroate (or folate) or derivative thereof, through direct radiolabeling with 18[F]fluoride, as well as 18F-folate radiopharmaceuticals obtained by such method of synthesis and their use in diagnosis and monitoring of cancer therapy and therapy of inflammatory and autoimmune diseases.
    Type: Application
    Filed: April 11, 2008
    Publication date: May 6, 2010
    Applicant: MERCK EPROVA AG
    Inventors: Simon Mensah Ametamey, Rudolf Moser, Tobias Ludwig Ross, Phoebe Lam, Viola Groehn
  • 18F-LABELLED FOLATES
    Publication number: 20100056533
    Abstract: The present invention is directed towards new 18F-folate radio-pharmaceuticals, wherein the fluorine-18 is covalently linked to the aminobenzoyl moiety, which connects the condensed pyrimidine heterocycle to the amino acid portion within folate structures, as well as their precursors and their non-radioactive references, a method of their preparation, as well as their use in diagnosis of a cell or population of cells expressing a folate-receptor and monitoring of cancer and inflammatory and autoimmune diseases and therapy thereof.
    Type: Application
    Filed: April 11, 2008
    Publication date: March 4, 2010
    Applicant: Merck Eprova AG
    Inventors: Simon Mensah Ametamey, Rudolf Moser, Tobias Ludwig Ross, Viola Groehn