Abstract: The present disclosure provides an allogeneic whole cell cancer vaccine platform that includes compositions and methods for treating and preventing cancer. Provided herein are compositions containing a therapeutically effective amount of cells from one or more cancer cell lines, some or all of which are modified to (i) inhibit or reduce expression of one or more immunosuppressive factors by the cells, and/or (ii) express or increase expression of one or more immunostimulatory factors by the cells, and/or (iii) express or increase expression of one or more tumor-associated antigens (TAAs), including TAAs that have been mutated, and which comprise cancer cell lines that natively express a heterogeneity of tumor associated antigens and/or neoantigens. Also provided herein are methods of making the vaccine compositions, methods of preparing, and methods of use thereof.

Abstract: The present disclosure provides an allogeneic whole cell cancer vaccine platform that includes compositions and methods for treating and preventing cancer. Provided herein are compositions containing a therapeutically effective amount of cells from one or more cancer cell lines, some or all of which are modified to (i) inhibit or reduce expression of one or more immunosuppressive factors by the cells, and/or (ii) express or increase expression of one or more immunostimulatory factors by the cells, and/or (iii) express or increase expression of one or more tumor-associated antigens (TAAs), including TAAs that have been mutated, and which comprise cancer cell lines that natively express a heterogeneity of tumor associated antigens and/or neoantigens. Also provided herein are methods of making the vaccine compositions, methods of preparing, and methods of use thereof.

Abstract: The present disclosure provides an allogeneic whole cell cancer vaccine platform that includes compositions and methods for treating and preventing cancer. Provided herein are compositions containing a therapeutically effective amount of cells from one or more cancer cell lines, some or all of which are modified to (i) inhibit or reduce expression of one or more immunosuppressive factors by the cells, and/or (ii) express or increase expression of one or more immunostimulatory factors by the cells, and/or (iii) express or increase expression of one or more tumor-associated antigens (TAAs), including TAAs that have been mutated, and which comprise cancer cell lines that natively express a heterogeneity of tumor associated antigens and/or neoantigens. Also provided herein are methods of making the vaccine compositions, methods of preparing, and methods of use thereof.

Abstract: The present disclosure provides an allogeneic whole cell cancer vaccine platform that includes compositions and methods for treating and preventing cancer. Provided herein are compositions containing a therapeutically effective amount of cells from one or more cancer cell lines, some or all of which are modified to (i) inhibit or reduce expression of one or more immunosuppressive factors by the cells, and/or (ii) express or increase expression of one or more immunostimulatory factors by the cells, and/or (iii) express or increase expression of one or more tumor-associated antigens (TAAs), including TAAs that have been mutated, and which comprise cancer cell lines that natively express a heterogeneity of tumor associated antigens and/or neoantigens. Also provided herein are methods of making the vaccine compositions, methods of preparing, and methods of use thereof.

Abstract: The present disclosure provides an allogeneic whole cell cancer vaccine platform that includes compositions and methods for treating and preventing colorectal cancer. Provided herein are compositions containing a therapeutically effective amount of cells from one or more cancer cell lines, some or all of which are modified to (i) inhibit or reduce expression of one or more immunosuppressive factors by the cells, and/or (ii) express or increase expression of one or more immunostimulatory factors by the cells, and/or (iii) express or increase expression of one or more tumor-associated antigens (TAAs), including TAAs that have been mutated, and which comprise cancer cell lines that natively express a heterogeneity of tumor associated antigens and/or neoantigens, and/or (iv) express one or more tumor fitness advantage mutations, including but not limited to driver mutations. Also provided herein are methods of making and preparing the colorectal cancer vaccine compositions and methods of use thereof.

Abstract: The present disclosure provides an allogeneic whole cell cancer vaccine platform that includes compositions and methods for treating and preventing cancer.

Abstract: The present disclosure provides an allogeneic whole cell cancer vaccine platform that includes compositions and methods for treating and preventing breast cancer. Provided herein are compositions containing a therapeutically effective amount of cells from one or more cancer cell lines, some or all of which are modified to (i) inhibit or reduce expression of one or more immunosuppressive factors by the cells, and/or (ii) express or increase expression of one or more immunostimulatory factors by the cells, and/or (iii) express or increase expression of one or more tumor-associated antigens (TAAs), including TAAs that have been mutated, and which comprise cancer cell lines that natively express a heterogeneity of tumor associated antigens and/or neoantigens, and/or (iv) express one or more tumor fitness advantage mutations, including but not limited to driver mutations. Also provided herein are methods of making and preparing the breast cancer vaccine compositions and methods of use thereof.

Abstract: The present disclosure provides an allogeneic whole cell cancer vaccine platform that includes compositions and methods for treating and preventing cancer. Provided herein are compositions containing a therapeutically effective amount of cells from one or more cancer cell lines, some or all of which are modified to (i) inhibit or reduce expression of one or more immunosuppressive factors by the cells, and/or (ii) express or increase expression of one or more immunostimulatory factors by the cells, and/or (iii) express or increase expression of one or more tumor-associated antigens (TAAs), including TAAs that have been mutated, and which comprise cancer cell lines that natively express a heterogeneity of tumor associated antigens and/or neoantigens. Also provided herein are methods of making the vaccine compositions, methods of preparing, and methods of use thereof.

Abstract: The present disclosure provides an allogeneic whole cell cancer vaccine platform that includes compositions and methods for treating and preventing cancer. Provided herein are compositions containing a therapeutically effective amount of cells from one or more cancer cell lines, some or all of which are modified to (i) inhibit or reduce expression of one or more immunosuppressive factors by the cells, and/or (ii) express or increase expression of one or more immunostimulatory factors by the cells, and/or (iii) express or increase expression of one or more tumor-associated antigens (TAAs), including TAAs that have been mutated, and which comprise cancer cell lines that natively express a heterogeneity of tumor associated antigens and/or neoantigens. Also provided herein are methods of making the vaccine compositions, methods of preparing, and methods of use thereof.

Abstract: Management of pharmaceutical procurement for a pharmaceutical ordering location. A method includes determining a medication need and a drug product preference for an ordering location. The method includes identifying one or more drug products satisfying the medication need by communicating with one or more pharmaceutical suppliers and selecting at least one of the one or more drug products based on the drug product preference. The method includes generating a recommended order for the ordering location comprising the at least one of the one or more drug products.

Abstract: The Applicants have developed a system and methods for extracting timing and emotional content from recorded audio in order to automate screening decisions for hiring candidates by processing candidate audio responses to predict candidate alignment for given job position. Emotional content is extracted using variable models to optimize detection of specific emotional content of interest. A feedback system is implemented for job supervisors to rate employee performance. Jobs are categorized according to emotional requirements and feedback is used to optimize candidate emotional alignment for a given position.

Abstract: The system and method of the present application utilizes a number of analysis modules to apply analysis techniques to candidate applications. The analysis modules then apply a score for each candidate for each technique with feedback information into an aggregate score. The system and method of the present application controls the collection order of the scores can weight scores by technique, and provide a graphical user interface for ease of evaluation.

Abstract: The Applicant has developed a system and method for extracting a large amount of raw emotional features from candidate audio responses and automatically isolating the relevant features. Relative rankings for each pool of candidates applying for a given position are calculated and candidates are grouped by predictive scores into broad categories.

Abstract: Various systems, methods, and programs embodied in computer-readable mediums are provided for digital authentication using digitally signed images. In one representative embodiment, a method includes extracting a first image portion from an image selected by a first party, where the first image portion including a first encoded part of an second party digital signature, and obtaining a second image portion associated with the first image portion, where the second image portion including a second encoded part of the second party digital signature. The first and second encoded parts of the second party digital signature are decoded and validity of the second party digital signature is confirmed based upon a second party public key.

Abstract: Various systems, methods, and programs embodied in computer-readable mediums are provided for digital authentication using digitally signed images. In one representative embodiment, a method comprising: extracting a first image portion from an image selected by a first party, the first image portion including a first encoded part of an second party digital signature; obtaining a second image portion associated with the first image portion, the second image portion including a second encoded part of the second party digital signature; decoding the first and second encoded parts of the second party digital signature; and confirming validity of the second party digital signature based upon a second party public key.

Abstract: An asymmetrical network is disclosed for coupling customer-premises Internet hosts such as personal computers to the Internet. The head end of a CATV system has a high-bandwidth connection to the Internet. The CATV system supports a plurality of concurrent channels to which an RF modem is capable of tuning. The RE modem is capable of receiving information from the head end that specifies the channel to which the RF modem should tune. Once tuned to the specified channel, the RF modem is capable of utilizing the CATV system for carrying high-speed data traffic. The high-speed data traffic can support Internet access using the Internet Protocol (IP).

Abstract: An asymmetrical network is disclosed for coupling customer-premises Internet hosts such as personal computers to the Internet. The head end of a CATV system has a high-bandwidth connection to the Internet. The down link connecting the personal computers to the Internet is the cables provided by the CATV system; the up link is a telephone connection to the head end. A router is connected to the down link by means of an RF modem, to the up link by means of an analog modem, and to a LAN, which is connected to the PCs. The router routes IP packets for the hosts that are received on the CATV cable to the head end via the LAN; it routes IP packets from the hosts that are destined for the Internet to the head end via the telephone line. The asymmetrical network conserves IP addresses and addresses on the CATV cable by dynamically allocating the IP addresses for an RF modem's hosts and an address on the CATV cable for the RF modem in response to a request made by the RF modem via the telephone line.

Abstract: An asymmetrical network for coupling customer-premises Internet hosts such as personal computers to the Internet. The head end of a CATV system has a high-bandwidth connection to the Internet. The down link connecting the personal computers to the Internet is the cables provided by the CATV system; the up link is a telephone connection to the head end. A router is connected to the down link by means of an RF modem, to the up link by means of an analog modem, and to a LAN which is connected to the Pcs. The router routes IP packets for the hosts that are received on the CATV cable to the hosts via the LAN; it routes IP packets from the hosts that are destined for the Internet to the head end via the telephone line. The asymmetrical network conserves IP addresses and addresses on the CATV cable by dynamically allocating the IP addresses for an RF modem's hosts and an address on the CATV cable for the RF modem in response to a request made by the RF modem via the telephone line.

Abstract: The preferred embodiment of the present invention is a cable modem apparatus for reliably providing a personal computer access to the Internet through a cable television link and a public switched telephone network link. The invention includes: a cable television link failure detector connected to the cable television link; a message generator connected to the cable television link failure detector, where the message generator is configured to generate at least one message responsive to the cable television link failure detector; and a message transmitter connected to the message generator, where the message transmitter is configured to transmit the at least one message through the public switched telephone network link to cause Internet communications to be communicated to the personal computer through the public switch telephone network link.

Abstract: The preferred embodiment of the present invention is a cable modem apparatus for reliably providing a personal computer access to the Internet through a cable television link and a public switched telephone network link. The invention includes: a cable television link failure detector connected to the cable television link; a message generator connected to the cable television link failure detector, where the message generator is configured to generate at least one message responsive to the cable television link failure detector; and a message transmitter connected to the message generator, where the message transmitter is configured to transmit the at least one message through the public switched telephone network link to cause Internet communications to be communicated to the personal computer through the public switch telephone network link.