Abstract: A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, R and OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.

Abstract: Polyethylene glycol for use in fields with application to a living body wherein the sum of the contents of ethylene glycol and diethylene glycol in the polyethylene glycol is less than or equal to that expressed in the following formula [I]: Sum ⁢   ⁢ of ⁢   ⁢ ethylene ⁢   ⁢ glycol ⁢   ⁢ and ⁢   ⁢ diethylene ⁢   ⁢ glycol ⁢   ⁢ contents ⁢  

Abstract: A polyalkylene oxide-modified phospholipid represented by formula (1) defined in the specification, has a monoacyl phospholipid content of not more than 3% by weight and a content of a base having a nitrogen atom of not more than 0.02% by weight.

Abstract: Disclosed is a nitric monoxide metabolite-polyoxyalkylene-hemoglobin complex having a molecular weight of from 100,000 to 2,000,000 daltons, in which a polyoxyalkylene derivative is bound to from 10 to 30% in total of bindable amino groups in hemoglobin and a nitric monoxide metabolite is bound to from 10 to 100% in total of thiol groups of cysteine residues.

Abstract: Polyethylene glycol for use in fields with application to a living body wherein the sum of the contents of ethylene glycol and diethylene glycol in the polyethylene glycol is less than or equal to that expressed in the following formula [I]: 1 Sum ⁢   ⁢ of ⁢   ⁢ ethylene ⁢   ⁢ glycol ⁢   ⁢ and ⁢   ⁢ diethylene ⁢   ⁢ glycol ⁢   ⁢ contents ⁢   ⁢ ( ppm ) = 150 × 2900 × 0.

Abstract: Polyethylene glycol for use in fields with application to a living body wherein the sum of the contents of ethylene glycol and diethylene glycol in the polyethylene glycol is less than or equal to that expressed in the following formula [I]: Sum ⁢   ⁢ of ⁢   ⁢ ethylene ⁢   ⁢ glycol ⁢   ⁢ and ⁢   ⁢ diethylene ⁢   ⁢ glycol ⁢   ⁢ contents ⁢  

Abstract: A cell in which a reaction product of a substance to be modified and an amphipathic compound is non-covalently bound to a cell membrane, wherein said compound has the following features:

Abstract: Polyethylene glycol for use in fields with application to a living body wherein the sum of the contents of ethylene glycol and diethylene glycol in the polyethylene glycol is less than or equal to that expressed in the following formula [I]: 1 Sum ⁢   ⁢ of ⁢   ⁢ ethylene ⁢   ⁢ glycol ⁢   ⁢ and ⁢   ⁢ diethylene ⁢   ⁢ glycol ⁢   ⁢ contents ⁢   ⁢ ( ppm ) = 150 × 2900 × 0.

Abstract: A polyalkylene oxide-modified phospholipid represented by formula (1) defined in the specification, has a monoacyl phospholipid content of not more than 3% by weight and a content of a base having a nitrogen atom of not more than 0.02% by weight.

Abstract: An oxirane derivative and process for preparation of the same, having a high purity characterized in terms of gel permeation chromatography and thin layer chromatography. The oxirane derivative is useful as a starting material for medical purposes, and mainly drug delivery systems.

Abstract: The present invention provides an high purity and high molecular oxirane derivative useful as a starting material for medical purposes, mainly drug delivery system, and a process for the preparation thereof.

Abstract: A composition is provided which comprises catalase modified with a copolymer (A) and a second copolymer, i.e., copolymer (B). The copolymer (A) comprises an alkenyl ether, maleic anhydride, and at least one monomer selected from the group consisting of unsaturated carboxylic acid, vinyl compound and olefin, and copolymer (B) consists of an ethylenically unsaturated monomer and a monomer selected from the group consisting of a monomer having a carboxyl group and a monomer having an acid anhydride group, or a salt of the copolymer (B).

Abstract: A process for producing a polyoxyalkylene derivative substituted with succinimidyl group which comprises reacting a polyoxyalkylene compound having carboxyl group at ends with N-hydroxysuccinimide in an inert solvent in the presence of dicyclohexylcarbodiimide; dissolving an obtained reaction product into chloroform, an amount by weight of chloroform being 0.5 to 10 times as much as an amount by weight of the polyoxyalkylene compound having carboxyl group at ends; and crystallizing the polyoxyalkylene derivative substituted with succinimidyl group by adding an aliphatic hydrocarbon having 5 to 8 carbon atoms to a resultant solution, an amount by weight of the aliphatic hydrocarbon being 2 to 10 times as much as an amount by weight of chloroform. Materials can be handled with safety, and a highly pure polyoxyalkylene derivative substituted with succinimidyl group which does not cause turbidity in an aqueous solution and has an excellent quality as a material for drugs can be produced.

Abstract: A process for producing a polyoxyalkylenecarboxylic acid which comprises: (A) a step of obtaining a salt of a polyoxyalkylenecarboxylic acid by reacting a polyoxyalkylene compound having hydroxyl group at one or both ends of the molecule with a salt of a halogenated acetic acid or a salt of a halogenated propionic acid in an amount of 4 to 50 mol per 1 mol of the polyoxyalkylene compound and an alkali metal hydroxide in an amount of 8 to 70 mol per 1 mol of the polyoxyalkylene compound in the presence of an organic solvent at 80.degree. to 150.degree. C.

Abstract: A process for producing a polyoxyalkylene derivative substituted with succinimidyl group which comprises reacting a polyoxyalkylene compound having carboxyl group at ends with N-hydroxysuccinimide in an inert solvent in the presence of dicyclohexylcarbodiimide; filtering an obtained reaction product; and crystallizing the polyoxyalkylene derivative substituted with succinimidyl group by adding isopropyl alcohol to a filtrate obtained by the filtration, an amount by weight of isopropyl alcohol being 1 to 100 times as much as an amount by weight of the polyoxyalkylene compound having carboxyl group at ends.Materials can be handled with safety in the process of the present invention, and a highly pure polyoxyalkylene derivative substituted with succinimidyl group which does not cause turbidity in an aqueous solution and has an excellent quality as a material for drugs can be produced.

Abstract: A reactive vesicle comprising, as a vesicle-forming component, a reactive phospholipid derivative represented by the following general formula (1) and a functional substance-fixed vesicle prepared by reacting the reactive vesicle with a functional substance: ##STR1## in which R.sup.1 C(.dbd.O) and R.sup.2 C(.dbd.O) each represent an aliphatic acyl group, R.sup.3 denotes hydrogen atom or methyl group, OA represents an oxyalkylene group of 2-4 carbon atoms, n indicates the average number of moles of added oxyalkylene group and is 1-1,000, p is 0 or 1, X represents ##STR2## with q and r each being an integer of 0 to 4 or 1 to 4, respectively, and M denotes hydrogen atom or an alkli metal atom.

Abstract: A novel and useful phospholipid derivative to be used for a reactive vesicle-forming agent, which is represented by the following general formula (1): ##STR1## in which R.sup.1 C(.dbd.O) and R.sup.2 C(.dbd.O) represent each an aliphatic acyl group, R.sup.3 denotes hydrogen atom or methyl group, OA represents an oxyalkylene group of 2-4 carbon atoms, n indicates the average addition mole number of added oxyalkylene group and is 1-1,000, p is 0 or 1, X represents ##STR2## with q and r being each an integer of 0 to 4 or 1 to 4, respectively, and M denotes hydrogen atom or an alkali metal atom.

Abstract: A dispersion stabilizing agent for inorganic powder in an oily material, comprising a copolymer of (i) a polyoxyalkylene derivative represented by the general formula [I] below with (ii) one or more of maleic acid and the derivatives thereof selected from the group of maleic anhydride, maleic acid, maleic acid salts, maleic acid amides, and maleic acid esters, ##STR1## where Z is a residue of a compound having 2-8 hydroxyl groups, AO is an oxyalkylene group having 2-18 carbon atoms, R.sup.1 is an unsaturated hydrocarbon group having 2-5 carbon atoms, R.sup.2 is a hydrocarbon group having 1-40 carbon atoms, a=0 to 1000, b=0 to 1000, c=0 to 1000, l=1 to 8, m=0 to 2, n=0 to 7, (l+m+n)=2 to 8, (al+bm+cn)=1 to 1000, m/(l+n).ltoreq.1/2.

Abstract: A controlled release preparation of an active material comprising a reaction product obtained by reacting (a) a copolymer consisting essentially of maleic anhydride and at least one polyalkylene glycol ether represented by formula (I): ##STR1## wherein B represents a residue of a compound having from 2 to 8 hydroxyl groups; R.sup.1 represents an alkenyl group having from 2 to 5 carbon atoms; AO represents an oxyalkylene group having from 2 to 18 carbon atoms or a combination thereof which may be linked together in blocks or at random; R.sup.2 represents a hydrocarbon group having from 1 to 24 carbon atoms; a represents a positive integer, b and c each represents 0 or a positive integer, and a+b+c=2 to 8; l.gtoreq.0, m.gtoreq.0, n.gtoreq.0, and l+m+n =1 to 1000; and (b) an active material. The preparation is soluble both in water and in an organic solvent and exhibits activity for a prolonged period of time.

Abstract: A lubricating oil comprising a copolymer of monomers comprising as essential ingredients a compound represented by formula (1) and one of maleic anhydride, maleic acid, a salt of maleic acid, and an ester of maleic acid ##STR1## where Z represents a residue of a compound having from 2 to 8 hydroxyl groups; AO represents one or more kinds of oxyalkylene groups each having from 2 to 18 carbon atoms, provided that in the case of two or more kinds of oxyalkylene groups, the oxyalkylene groups are linked to one another in either a block or a random arrangement; R represents an alkenyl group having from 2 to 5 carbon atoms; R.sup.1 represents a hydrocarbon or acyl group having from 1 to 24 carbon atoms; and a.gtoreq.0, b.gtoreq.0, c.gtoreq.0, l is a positive integer, and m and n independently are 0 or a positive integer, provided that l+m+n=2 to 8, n/(l+m).ltoreq.1/2, and al+bm+cn=1 to 1,000.