Abstract: A hole 30 is formed in the center of the rear end face 20 of a round billet 10. The hole 30 has a predetermined depth from the rear end face 20 and a plurality of grooves 31 are provided in the side surface thereof. Each groove 31 extends in the depth direction of the hole 30. Piercing and rolling of the round billet 10 having the hole 30 is performed using a piercing mill having a plug. During piercing and rolling, the bottom surface of the hole 30 is broken through by the plug and a protrusion which is to be the starting point of burrs is formed, and the protrusion is absorbed by the groove 31 as the plug advances. Consequently, formation of burrs at the rear end of a hollow shell after piercing-rolling thereof can be suppressed.

Abstract: A pusher device 4 includes a cylinder device 30 and a pusher mandrel 34. The cylinder device 30 includes a cylinder shaft 32. The pusher mandrel 34 is attached to the tip end of the cylinder shaft 32. The tip end of the pusher mandrel 34 is abutted against the rear end of a billet 20. The cross sectional area Sp of the pusher mandrel 34 and the cross sectional area Sb of the billet 20 satisfy Expression (1). The length Lp of the pusher mandrel 34 and the cross sectional area Sp of the pusher mandrel 34 satisfy Expression (2). The moving distance Lc of the tip end of the cylinder shaft 32 during piercing and rolling and the outer diameter Dc of the cylinder shaft 32 satisfy Expression (3). Therefore, the pusher device 4 can restrain the wall thickness deviation of the tip end part of a produced hollow shell. 0.3?Sp/Sb??(1) Lp/Sp?1.

Abstract: When a hollow billet is inserted into a container, and hot expanding piercing is downwardly performed by using a plug, hot piercing is performed by using a formed glass complex comprising a ring-shaped formed glass part and a ring-shaped projecting part. The ring-shaped formed glass part assumes a disc shape having a circular opening for allowing a plug to be inserted at the center thereof. The ring-shaped projecting part is attached to the opening of the ring-shaped formed glass part, and assumes a ring shape projecting perpendicularly to the ring-shaped formed glass part. Thereby, the piercing work can be done safely, and defects can be prevented from occurring on the inner surface of the billet.

Abstract: A starting material to be extruded made of a high alloy comprising, in mass %, Cr: 20 to 30% and Ni: more than 22% and 60% or less is heated to a temperature predetermined according to the contents of Mo and W and is subjected to a hot-extrusion process, the heating temperature T (° C.) satisfying a relationship of Formula (1), (2), or (3), which is expressed in terms of the average cross-sectional area A (mm2) of the starting material to be extruded, the extrusion ratio EL (?), and the extrusion speed V (mm/s). As a result, a high-alloy seamless tube can be produced without generating cracking and/or seam flaws. When 0%?Mo+0.5W<4%: T?1343?0.001322×A?1.059×EL?0.129×V??(1) When 4%?Mo+0.5W<7%: T?1316?0.001322×A?1.059×EL?0.129×V??(2) When 7%?Mo+0.5W: T?1289?0.001322×A?1.059×EL?0.

Abstract: Disclosed is a method for producing a seamless pipe by using a piercing mill which pierces and rolls a round billet heated to 1300° C. or lower, wherein the piercing mill is composed of a pair of skew rolls disposed to face each other around a pass line, a pair of guide devices disposed to face each other around the pass line, and a plug disposed along the pass line, between the pair of the skew rolls and also between the pair of the guide devices, wherein the piercing-rolling is performed under the conditions satisfying the following formulas (1) to (3) to prevent wrinkle flaws of the seamless pipe: ?1.0<????(1) ??=?p??r??(2) ?0.37×??+1.47?Rn?0.37×??+2.

Abstract: a billet made of high Cr-high Ni alloy, which contains, by mass percent, 20 to 30% of Cr, 30 to 50% of Ni, and at least one element selected from Mo and W with a value “Mo+0.5W” of 1.5% or more is heated under conditions satisfying the following formula (1), and then the billet is pierced and rolled using an inclined roll type piercing mill with a roll gouge circumferential speed of 2.28 m/sec or higher. This prevents melted rash on the inner surface and lengthens the plug life. T?1575?4.45×Vf?104.7×{?ln(th/ro)}??(1) wherein T indicates a heating temperature (° C.) of the billet, Vf indicates the roll gouge circumferential speed (m/sec), ro indicates a radius (mm) of a billet at an entry-side, and th indicates a radial thickness (mm) of a pipe after piercing.

Abstract: The invention relates to purification of (2S,3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid [hereinafter, referred to as the carboxylic acid] using the salt of the carboxylic acid with an organic amine selected from the group consisting of piperazine, adamantane amines and others. The invention also relates to providing crystalline sodium salt of the carboxylic acid. The sodium salt is usable as a material for preparing medicaments and improved in storage stability, and has the following characteristics: DSC: exothermic peak observed at a temperature in the range of 170 to 175° C. with weight decrease; and characteristic absorption bands of infrared absorption spectrum (KBr tablet): 3255, 2950, 2860, 1670, 1630, 1550, 1460, 1435, 1395, 1365, 1310, 1260, 1110, 890 cm×1.

Abstract: A compound having the following formula (II) or its pharmacologically acceptable salt is used as a P2X4 receptor antagonist: in which R11 represents hydrogen or an alkyl group having 1-8 carbon atoms; R21 represents an alkyl group having 1-8 carbon atoms, an alkoxy group having 1-8 carbon atoms, an alkyl group having 1-8 carbon atoms and having 1-3 halogen substituents, or hydroxyl; and R31 is hydrogen or a halogen atom.

Abstract: An agent comprising, as an active ingredient, a xanthine oxidase inhibitor such as 2-[3-cyano-4-(4-fluorophenoxy)phenyl]-4-hydroxythiazolo[5,4-d]pyrimidine potassium salt, 2-[3-cyano-4-(4-fluorophenoxy)phenyl]thiazolo[5,4-d]pyrimidine, 2-(3-cyano-4-phenoxyphenyl)-4-hydroxythiazolo[5,4-d]pyrimidine, 2-(3-cyano-4-phenoxyphenyl)-4-hydroxythiazolo[5,4-d]pyrimidine potassium salt, 2-(3-cyano-4-phenoxyphenyl)thiazolo[5,4-d]pyrimidine, TMX-67, and FYX-051, which can be used as an agent for overcoming anti-cancer agent resistance.

Abstract: The invention relates to purification of (2S,3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid [hereinafter, referred to as the carboxylic acid] using the salt of the carboxylic acid with an organic amine selected from the group consisting of piperazine, adamantane amines and others. The invention also relates to providing crystalline sodium salt of the carboxylic acid. The sodium salt is usable as a material for preparing medicaments and improved in storage stability, and has the following characteristics: DSC: exothermic peak observed at a temperature in the range of 170 to 175° C. with weight decrease; and characteristic absorption bands of infrared absorption spectrum (KBr tablet) 3255, 2950, 2860, 1670, 1630, 1550, 1460, 1435, 1395, 1365, 1310, 1260, 1110, 890 cm?1.

Abstract: A billet is provided on a pass line between a pusher and a plug, and the billet is advanced and caught between a plurality of inclined rolls. At least between when said caught billet contacts said plug and when the piercing and rolling reaches a steady state, the advancing speed of the billet is not less than the advancing speed of the billet when the piercing and rolling is carried out without pushing the billet forward by the pusher in the steady state. By this manufacturing method, inner surface defects at a tip end of a hollow shell can be restrained.

Abstract: A hole 30 is formed in the center of the rear end face 20 of a round billet 10. The hole 30 has a predetermined depth from the rear end face 20 and a plurality of grooves 31 are provided in the side surface thereof. Each groove 31 extends in the depth direction of the hole 30. Piercing and rolling of the round billet 10 having the hole 30 is performed using a piercing mill having a plug. During piercing and rolling, the bottom surface of the hole 30 is broken through by the plug and a protrusion which is to be the starting point of burrs is formed, and the protrusion is absorbed by the groove 31 as the plug advances. Consequently, formation of burrs at the rear end of a hollow shell after piercing-rolling thereof can be suppressed.

Abstract: Seamless pipes excellent in quality features with high productivity is made by a by carrying out piercing-rolling using a piercer provided with a pair of inclined rolls. The piercing-rolling is carried out under conditions such that the plug tip draft (TDFT) or the root of the product of the plug tip draft (TDFT) are controlled along with the number of billet revolutions (N), namely (TDFT×N)0.5. In addition, positions of the inclined rolls are controlled in connection with the gorge draft (GDFT) indicating the ratio of the roll gap (Rg) which is minimal in the gorge section between the inclined rolls to the billet outside diameter (Bd). The piercing-rolling is carried out using a plug having a particular shape.

Abstract: A pusher device 4 includes a cylinder device 30 and a pusher mandrel 34. The cylinder device 30 includes a cylinder shaft 32. The pusher mandrel 34 is attached to the tip end of the cylinder shaft 32. The tip end of the pusher mandrel 34 is abutted against the rear end of a billet 20. The cross sectional area Sp of the pusher mandrel 34 and the cross sectional area Sb of the billet 20 satisfy Expression (1). The length Lp of the pusher mandrel 34 and the cross sectional area Sp of the pusher mandrel 34 satisfy Expression (2). The moving distance Lc of the tip end of the cylinder shaft 32 during piercing and rolling and the outer diameter Dc of the cylinder shaft 32 satisfy Expression (3). Therefore, the pusher device 4 can restrain the wall thickness deviation of the tip end part of a produced hollow shell. 0.3?Sp/Sb??(1) Lp/Sp?1.

Abstract: A plug 2 used for a piercer according to the invention includes a tip end portion 23, a cylindrical portion 24, a barrel portion 25, a mandrel coupling portion 22, and an injection hole 21. The injection hole 21 penetrates from the surface of the cylindrical portion 24 to the surface of the mandrel coupling portion 22 and an externally supplied lubricant is injected from the hole. A clearance forms between the pierced material and the cylindrical portion 24. The injection hole 21 is formed at the cylindrical portion 24, and therefore the material in the process of piercing does not contact the injection hole 21. Therefore, an inner surface defect attributable to the contact between the material and the injection hole 21 can be prevented from being generated.

Abstract: A compound having the following formula (II) or its salt is used as an activator for PPAR ?: [in which W3 is a nitrogen atom or CH; Z1 is an oxygen atom or a sulfur atom; each of R11 and R12 is a hydrogen atom, a halogen atom, a C1-C8 alkyl group, a C1-C8 alkoxy group, a C1-C8 alkyl group having a halogen substituent, or the like; each of R13 and R14 is a hydrogen atom or a C1-C8 alkyl group; A1 is pyrazole or thiophene which may have a substituent; and m is an integer of 2 to 4].

Abstract: In straightening a tube using a roll straightening machine provided with drum type straightening roll pairs vertically opposingly disposed, at least an outer layer portion of a roll main body is made of elastic material having spring type hardness Hs (JIS K 6301 A type) of 50 to 100 in at least three pairs of straightening rolls on an outlet side of the roll straightening machine, and an offset amount is imparted to a tube engaged in the three pairs, at least, of straightening opposing rolls such that ? defined by an equation (1) ranges from 1.0×10?3 to 1.5×10?3. The offset amount is set at three positions along a tube axis where the upper and lower rolls of each pair horizontally cross. Therefore, an S/N ratio can be enhanced in an eddy current test from inside of the tube to improve inspection efficiency, and excellent quality accuracy can be ensured in a heat transfer tube used in a steam generator and the like.

Abstract: A compound represented by the following general formula (I): (wherein R1 represents phenyl, etc. which can have substituents selected from the group consisting of C1-8 alkyl, C1-8 alkyl having halogen, halogen, hydroxyl, etc.; R2 represents C1-8 alkyl, etc.; A represents oxygen, sulfur, etc.; X represents C1-8 alkylene chain, etc.; Y represents C(?O), CH?CH, etc.; R3, R4, and R5 each represents hydrogen, C1-8 alkyl, etc.; B represents CH or nitrogen; Z represents oxygen or sulfur; R6 and R7 each represents hydrogen, C1-8 alkyl, etc.; and R8 represents hydrogen or C1-8 alkyl; provided that at least one of R3, R4, and R5 is not hydrogen) or a salt of the compound; and a PPAR-? activator which contains the compound or salt as the active ingredient.

Abstract: A piercing mill includes a plurality of inclined rolls, a plug, a pusher, and an undriven guide roll. The pusher pushes a round billet from the rear end at least until the round billet advances for a prescribed distance after contacting the inclined rolls. The guide roll is between the inclined rolls and the pusher and includes a roll shaft and a roll surface, with the roll shaft arranged obliquely with respect to a pass line PL. The sectional shape of the roll surface is a concave arch shape. The round billet is rotated by the guide roll and the friction force generated when the round billet contacts the inclined rolls is reduced. Consequently, the wear of the inclined rolls can be restrained if the round billet is pierced and rolled while it is pushed in between the inclined rolls using the pusher.

Abstract: A compound represented by the following general formula (I): (wherein R1 represents phenyl, etc. which can have substituents selected from the group consisting of C1-8 alkyl, C1-8 alkyl having halogen, halogen, hydroxyl, etc.; R2 represents C1-8 alkyl, etc.; A represents oxygen, sulfur, etc.; X represents C1-8 alkylene chain, etc.; Y represents C(?O), CH?CH, etc.; R3, R4, and R5 each represents hydrogen, C1-8 alkyl, etc.; B represents CH or nitrogen; Z represents oxygen or sulfur; R6 and R7 each represents hydrogen, C1-8 alkyl, etc.; and R8 represents hydrogen or C1-8 alkyl; provided that at least one of R3, R4, and R5 is not hydrogen) or a salt of the compound; and a PPAR-? activator which contains the compound or salt as the active ingredient.