Abstract: A specimen disrupting apparatus includes: a drive unit that rotates the lower portion of a container having a solution that includes a specimen, a great number of small diameter beads, and a large diameter bead stored therein; and a control unit that controls the drive unit. The control unit controls the drive unit such that the lower portion of the container rotates at two or more different rotational speeds which are changed continuously.

Abstract: A specimen disrupting apparatus includes: a drive unit that rotates the lower portion of a container having a solution that includes a specimen, a great number of small diameter beads, and a large diameter bead stored therein; and a control unit that controls the drive unit. The control unit controls the drive unit such that the lower portion of the container rotates at two or more different rotational speeds which are changed continuously.

Abstract: An object of the present invention is to provide a method for forming a complex between an analyte or an analog thereof, and a substance formable the complex with said analyte or said analog thereof (the complex forming substance), in a short time and in high reaction efficiency, and a method for separating a complex formed, and a complex forming substance not involved in formation of said complex or an analog not involved in formation of said complex rapidly, simply and in high accuracy, along with a method for measuring an analyte in a sample in high sensitivity.

Abstract: To provide an electrode for a dielectrophoretic apparatus in which a background detected by reflecting an excited light on an electrode present under the substance (molecule) is reduced and an S/N ratio is enhanced. Also, there is provided an dielectrophoretic apparatus, in an apparatus in which a liquid containing substances to be separated is present in a non-uniform electric field formed by a dielectrophoretic electrode, and separation is carried out by a dielectrophoretic force exerting on the substances, wherein the collecting ability of substances is enhanced. The present invention is characterized in that a vacant space is provided in an electrode whereby substances subjected to influence by a negative dielectrophoretic force can be concentrated in said vacant space of an electrode, or above or below portion of the space.

Abstract: The present invention relates to a structure (a solution introducing structure) for introducing a plurality of solutions (a sample and/or a reagent solution) in highly accurate volume, in high amount and simply, into a channel, in particular a channel of a micro fluidic device, a micro fluidic device having said structure, a method for introducing a solution using said device, a method for separation of a substance, and a method for separating a complex between an analyte or analogue thereof, and a substance binding to said analyte or analogue thereof (hereinafter may be abbreviated as a complex forming substance or CFS) which is obtained by reacting a plurality of solutions introduced by these, and said CFS or analogue not involved in formation of said complex, rapidly, simply and in high accuracy, along with a method for measuring an analyte or an analogue thereof in a sample in high sensitivity.

Abstract: The present invention relates to a structure (a solution introducing structure) for introducing a plurality of solutions (a sample and/or a reagent solution) in highly accurate volume, in high amount and simply, into a channel, in particular a channel of a micro fluidic device, a micro fluidic device having said structure, a method for introducing a solution using said device, a method for separation of a substance, and a method for separating a complex between an analyte or analogue thereof, and a substance binding to said analyte or analogue thereof (hereinafter may be abbreviated as a complex forming substance or CFS) which is obtained by reacting a plurality of solutions introduced by these, and said CFS or analogue not involved in formation of said complex, rapidly, simply and in high accuracy, along with a method for measuring an analyte or an analogue thereof in a sample in high sensitivity.

Abstract: The invention relates to a method for separating a target for measurement utilizing electrophoresis, particularly capillary electrophoresis efficiently in high sensitivity and in a short period of time. It also relates to a method for measuring said target separated by said method for separation. The invention provides a method for separating a target for measurement and a method for measuring said target separated by said method for separation, characterized by using a substance to which is bound a nucleic acid chain labeled by a marker and which has an affinity for said target for measurement.

Abstract: The present invention relates to a solution introducing structure for introducing a plurality of solutions (a sample and/or a reagent solution) in highly accurate volume, in high amount and simply, into a channel (1) of a micro fluidic device, said channel (1) comprising not less than three side channels (2) for drain and not less than two side channels (3) for introducing a sample or a reagent solution.

Abstract: To provide an electrode for a dielectrophoretic apparatus in which a background detected by reflecting an excited light on an electrode present under the substance (molecule) is reduced and an S/N ratio is enhanced. Also, there is provided an dielectrophoretic apparatus, in an apparatus in which a liquid containing substances to be separated is present in a non-uniform electric field formed by a dielectrophoretic electrode, and separation is carried out by a dielectrophoretic force exerting on the substances, wherein the collecting ability of substances is enhanced. The present invention is characterized in that a vacant space is provided in an electrode whereby substances subjected to influence by a negative dielectrophoretic force can be concentrated in said vacant space of an electrode, or above or below portion of the space.

Abstract: Internal standard concentration is normalized as an independent parameter through measuring a buffer conductance in a system with characterized reagents and in a defined assay device. The conductivity of a fresh internal standard solution is measured whether in isolation or as part of a system that is subject to a uniform variation such as evaporation or condensation. Collected conductance measurements may be used to normalize assay signals that are dependent upon fluidic channel dimensions, such as fluorescence assay signal measurement.

Abstract: To suppress temperature variations of sample fluids within flow channels for electrophoresis, in a method for controlling temperatures within micro flow channels. When controlling the temperatures of sample fluids within micro flow channels of electrophoresis chips, in which flow channels through which electrophoresis occurs by application of electrical potential differences can be switched, temperature variations of the sample fluids within the micro flow channels, caused by differences in heat generated by the sample fluids prior to and following the switching of the flow channels, are predicted. Control properties for temperature control in order to cancel the temperature variations are changed during the switching of the flow channels.

Abstract: [Objective] To control the temperatures of reagents and samples in a clinical analysis apparatus, without causing the apparatus to become large or complex. [Constitution] A clinical analysis apparatus is equipped with a measuring section. The measuring section includes: a dispensing station, at which reagents and samples are dispensed into microchips having micro flow channels formed therein; a detecting station, for detecting measurement target substances included in the samples; and the like. The microchips are continuously rotated relative to the dispensing station, the detecting section, and the like from the upstream side to the downstream side of processes to be administered, to perform measurement repeatedly. A temperature controlling section controls the temperatures of the microchips prior to the microchips being moved to the detecting station, and the measurement target substances included in the samples which are dispensed into the microchips are measured.

Abstract: The present invention relates to a solution introducing structure for introducing a plurality of solutions (a sample and/or a reagent solution) in highly accurate volume, in high amount and simply, into a channel (1) of a micro fluidic device, said channel (1) comprising not less than three side channels (2) for drain and not less than two side channels (3) for introducing a sample or a reagent solution.

Abstract: A liquid suction device used to suction a liquid contained in a well of a microchip which includes the well and a microchannel in fluid communication with the well. The liquid suction device includes: a suction nozzle having a tip opening at a tip thereof and being connected to piping at a rear end thereof, the suction nozzle suctioning the liquid through the tip opening; a pump connected to the piping, the pump supplying a suction pressure to the suction nozzle; and a driving unit for moving the suction nozzle relative to the well. In liquid suction device, the suction nozzle is moved by the driving unit until the tip opening contacts a bottom surface of the well while the suction nozzle applies a suction force produced by the suction pressure, thereby enabling suction of the liquid from the well and/or the microchannel.

Abstract: A dispensing device discharges a liquid into a well of a microchip, which includes the well having an opening at the upper end, and a microchannel in fluid communication with the lower end of the well. The well has a bottom portion formed by an annular step portion projecting inward at the lower end. The dispensing device includes: a nozzle having a tip opening for suctioning and discharging a liquid therethrough; a pump for supplying suction pressure and discharge pressure to the nozzle; moving unit for causing relative movement of the nozzle at least in depth direction of the well; and control unit for causing the moving unit to cause the relative movement of the nozzle until the tip opening reaches the bottom portion, and then causing the liquid to be discharged such that the liquid first contacts a bottom surface and/or an inner circumferential surface of the bottom portion.

Abstract: An object of the present invention is to provide a method for forming a complex between an analyte or an analogue thereof, and a substance formable the complex with said analyte or said analogue thereof (the complex forming substance), in a short time and in high reaction efficiency, and a method for separating a complex formed, and a complex forming substance not involved in formation of said complex or an analogue not involved in formation of said complex rapidly, simply and in high accuracy, along with a method for measuring an analyte in a sample in high sensitivity.

Abstract: The present invention has an object of providing a method by which two kinds or more of molecules can be separated each other by using dielectrophoretic forces. The present invention comprises two methods. The first method is a method comprising forming a complex substance of a “specific molecule” containing in a sample, and a “substance capable of changing dielectrophoretic properties of the specific molecule”, which binds to the “specific molecule” contained therein, and thereby separating the complex substance and the molecules other than the specific molecule in the sample from each other. The second method is a method comprising placing a solution in which two kinds or more of molecules are dissolved under a strong electric field strength, that is, under a nonuniform electric field having an electric field strength of 500 KV/m or higher, by using dielectrophoretic forces.

Abstract: To provide an electrode for a dielectrophoretic apparatus in which a background detected by reflecting an excited light on an electrode present under the substance (molecule) is reduced and an S/N ratio is enhanced. Also, there is provided an dielectrophoretic apparatus, in an apparatus in which a liquid containing substances to be separated is present in a non-uniform electric field formed by a dielectrophoretic electrode, and separation is carried out by a dielectrophoretic force exerting on the substances, wherein the collecting ability of substances is enhanced. The present invention is characterized in that a vacant space is provided in an electrode whereby substances subjected to influence by a negative dielectrophoretic force can be concentrated in said vacant space of an electrode, or above or below portion of the space.

Abstract: This invention provides methods and devices for spatially separating at least first and second components in a sample which in one exemplary embodiment comprises introducing the first and second components into a first microfluidic channel of a microfluidic device in a carrier fluid comprising a spacer electrolyte solution and stacking the first and second components by isotachophoresis between a leading electrolyte solution and a trailing electrolyte solution, wherein the spacer electrolyte solution comprises ions which have an intermediate mobility in an electric field between the mobility of the ions present in the leading and trailing electrolyte solutions and wherein the spacer electrolyte solution comprises at least one of the following spacer ions MOPS, MES, Nonanoic acid, D-Glucuronic acid, Acetylsalicyclic acid, 4-Ethoxybenzoic acid, Glutaric acid, 3-Phenylpropionic acid, Phenoxyacetic acid, Cysteine, hippuric acid, p-hydroxyphenylacetic acid, isopropylmalonic acid, itaconic acid, citraconic acid, 3,

Abstract: To provide An electrode for a dielectrophoretic apparatus in which a background detected by reflecting an excited light on an electrode present under the substance (molecule) is reduced and an S/N ratio is enhanced. Also, there is provided an dielectrophoretic apparatus, in an apparatus in which a liquid containing substances to be separated is present in a non-uniform electric field formed by a dielectrophoretic electrode, and separation is carried out by a dielectrophoretic force exerting on the substances, wherein the collecting ability of substances is enhanced. The present invention is characterized in that a vacant space is provided in an electrode whereby substances subjected to influence by a negative dielectrophoretic force can be concentrated in said vacant space of an electrode, or above or below portion of the space.