Patents by Inventor Tomoji Kawai

Tomoji Kawai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160319342
    Abstract: Devices, systems and methods for sequencing protein samples are provided. In some examples, currents generated when a monomer passes through between electrodes of a nanogap electrode pair are measured for each of several different distances, so that monomers are identified when compared to a reference physical quantity of a known monomer, which may be obtained from a current measured with a similar inter-electrode distance(s) at which each of plural kinds of monomers are identifiable and ordered with predetermined accuracy and based on a detected physical quantity obtained from a tunneling current, which may be further normalized by the use of one or more reference substances.
    Type: Application
    Filed: March 4, 2016
    Publication date: November 3, 2016
    Inventors: Tomoji Kawai, Masateru Taniguchi, Takahito Ohshiro, Mark Oldham, Eric Nordman
  • Patent number: 9429845
    Abstract: A method for performing micro fabrication includes using, as a photomask, a self-organizing material-patterned substrate which is soluble in an organic solvent. A method for emitting light includes emitting the light in a pattern of a nucleic acid which is a self-organizing material immobilized on a self-organizing material-patterned substrate. An immobilization layer containing a binding material capable of binding to a self-organizing material is formed on a substrate. Then this immobilization layer is patterned by transferring a protrusion and recess pattern formed in a mold thereto by the imprint process. The self-organizing material is supplied onto the side having the protrusion and recess pattern of the immobilization layer transferred thereto.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: August 30, 2016
    Assignee: Japan Science and Technology Agency
    Inventors: Toshihito Ohtake, Ken-ichiro Nakamatsu, Shinji Matsui, Hitoshi Tabata, Tomoji Kawai
  • Publication number: 20160245790
    Abstract: The present disclosure provides methods and systems that can reduce the amount of sample necessary to detect or identify, or both detect and identify, a biomolecule, and increase the rate of denaturing of the biomolecule. A device for thermally denaturing a biomolecule may include: a substrate having low thermal conductivity; a heater disposed adjacent to the substrate; a temperature sensor disposed adjacent to the substrate; a semiconductor oxide film disposed adjacent to the substrate, a nanochannel formed in a region of the semiconductor oxide film, and a cover over the nanochannel.
    Type: Application
    Filed: February 19, 2016
    Publication date: August 25, 2016
    Inventors: Tomoji Kawai, Masayuki Furuhashi, Masateru Kawaguchi, Mark Oldham, Eric Nordman
  • Publication number: 20160138101
    Abstract: The present invention provides technology that uses current measurements to identify nucleotides and determine a nucleotide sequence in polynucleotides. The present invention calculates a modal value of a tunnel current that arises when a nucleotide or polynucleotide for analysis passes through between electrodes, and then employs the calculated modal value. The present invention accordingly enables direct rapid implementation to identify nucleotides and to determine a nucleotide sequence in a polynucleotide without marking.
    Type: Application
    Filed: October 14, 2015
    Publication date: May 19, 2016
    Inventors: Masateru Taniguchi, Makusu Tsutsui, Kazumichi Yokota, Tomoji Kawai
  • Patent number: 9194838
    Abstract: The present invention provides technology that uses current measurements to identify nucleotides and determine a nucleotide sequence in polynucleotides. The present invention calculates a modal value of a tunnel current that arises when a nucleotide or polynucleotide for analysis passes through between electrodes, and then employs the calculated modal value. The present invention accordingly enables direct rapid implementation to identify nucleotides and to determine a nucleotide sequence in a polynucleotide without marking.
    Type: Grant
    Filed: March 1, 2011
    Date of Patent: November 24, 2015
    Assignee: OSAKA UNIVERSITY
    Inventors: Masateru Taniguchi, Makusu Tsutsui, Kazumichi Yokota, Tomoji Kawai
  • Publication number: 20150219593
    Abstract: The analysis method allows analysis of samples with high sensitivity, irrespective of interelectrode distance. The method includes: a step of applying a voltage between a first electrode pair such that an electric field is formed in a direction intersecting a migration direction of a sample; a step of placing a solution, including an electrochemically active molecule that produces a redox reaction at the electrode pair, between the first electrode pair; a step of causing the sample to migrate; and a step of measuring an amount of change in current flow between the first electrode pair.
    Type: Application
    Filed: August 2, 2013
    Publication date: August 6, 2015
    Inventors: Tomoji Kawai, Takahito Ohshiro, Masateru Taniguchi
  • Publication number: 20140374255
    Abstract: According to one embodiment, provided is a single particle analyzing device including a measuring vessel, first and second chambers in the vessel defined by an insulating membrane, a pore opening in the membrane to connect the chambers, and first and second electrodes in the chambers. Electric current flows between the electrodes through the pore. Electrical characteristics are measured during migration of the target from the first chamber to the second chamber to measure the size and shape of the target. (a) t<a <d?100a or (b) s<L, s<d?100s, t<L and t<d, wherein a, L and s are the diameter, length and width of the target, d is the diameter of the pore, and t is the thickness of the membrane in the proximity to the pore.
    Type: Application
    Filed: September 12, 2014
    Publication date: December 25, 2014
    Applicants: KABUSHIKI KAISHA TOSHIBA, OSAKA UNIVERSITY
    Inventors: Sadato HONGO, Tomoji KAWAI, Makusu TSUTSUI, Masateru TANIGUCHI, Soh RYUZAKI
  • Publication number: 20140300339
    Abstract: The present invention provides technology that uses current measurements to identify nucleotides and determine a nucleotide sequence in polynucleotides. The present invention calculates a modal value of a tunnel current that arises when a nucleotide or polynucleotide for analysis passes through between electrodes, and then employs the calculated modal value. The present invention accordingly enables direct rapid implementation to identify nucleotides and to determine a nucleotide sequence in a polynucleotide without marking.
    Type: Application
    Filed: March 1, 2011
    Publication date: October 9, 2014
    Applicant: OSAKA UNIVERSITY
    Inventors: Masateru Taniguchi, Makusu Tsutsui, Kazumichi Yokota, Tomoji Kawai
  • Publication number: 20140183040
    Abstract: The present invention provides a method and apparatus for controlling the moving speed of a substance, both of which can adjust the moving speed of a substance to a desired speed. The control method and control apparatus cause a substance to pass through an internal space, in which an electro-osmotic flow is generated, of a surround electrode formed so as to surround part of the moving path of the substance, whereby the control method and control apparatus change the moving speed of the substance.
    Type: Application
    Filed: August 26, 2013
    Publication date: July 3, 2014
    Inventors: Tomoji Kawai, Soh Ryuzaki, Masateru Taniguchi
  • Publication number: 20140055150
    Abstract: A maximum current value and pulse continuation duration are measured for each of plural pulses of tunnel current arising as a polynucleotide passes through between an electrode pair, and the polynucleotide base sequence is determined based on the maximum current value and the pulse continuation duration.
    Type: Application
    Filed: March 29, 2013
    Publication date: February 27, 2014
    Applicant: OSAKA UNIVERSITY
    Inventors: Tomoji Kawai, Takahito Ohshiro, Kazuki Matsubara, Masayuki Furuhashi, Makusu Tsutsui, Masateru Taniguchi
  • Publication number: 20140031995
    Abstract: Provided are: a control method and control device for the movement speed of a substance which are capable of controlling the movement speed of the substance with good precision, and of raising the durability of the device; and a use therefor. An substance with charge is caused to move by a movement path formed by a first electrical field and a second electrical field that are formed in directions that intersect with each other.
    Type: Application
    Filed: January 29, 2013
    Publication date: January 30, 2014
    Applicant: OSAKA UNIVERSITY
    Inventors: Tomoji Kawai, Makusu Tsutsui, Masateru Taniguchi
  • Publication number: 20130330674
    Abstract: A method for performing micro fabrication includes using, as a photomask, a self-organizing material-patterned substrate which is soluble in an organic solvent. A method for emitting light includes emitting the light in a pattern of a nucleic acid which is a self-organizing material immobilized on a self-organizing material-patterned substrate. An immobilization layer containing a binding material capable of binding to a self-organizing material is formed on a substrate. Then this immobilization layer is patterned by transferring a protrusion and recess pattern formed in a mold thereto by the imprint process. The self-organizing material is supplied onto the side having the protrusion and recess pattern of the immobilization layer transferred thereto.
    Type: Application
    Filed: May 20, 2013
    Publication date: December 12, 2013
    Inventors: Toshihito OHTAKE, Ken-ichiro NAKAMATSU, Shinji MATSUI, Hitoshi TABATA, Tomoji KAWAI
  • Patent number: 8372785
    Abstract: A method for immobilizing a self-organizing material or fine particles on a substrate, and a substrate whereupon the self-organizing material or the fine particles are immobilized. More specifically, the method for immobilizing the fine particles including a nucleic acid (for instance, DNA or RNA) or a metal oxide on the substrate, and the substrate whereupon the nucleic acid (for example, DNA or RNA) or the metal oxide is immobilized.
    Type: Grant
    Filed: September 23, 2010
    Date of Patent: February 12, 2013
    Assignee: Japan Science and Technology Agency
    Inventors: Tomoji Kawai, Hitoshi Tabata, Yoichi Otsuka, Fumihiko Yamada, Takuya Matsumoto
  • Patent number: 8304761
    Abstract: In an organic field effect transistor with an electrical conductor-insulator-semiconductor structure, the semiconductor layer is made of an organic compound, and the insulator layer is made of a polymer obtained through polymerization or copolymerization of 2-cyanoethyl acrylate and/or 2-cyanoethyl methacrylate.
    Type: Grant
    Filed: March 25, 2008
    Date of Patent: November 6, 2012
    Assignees: Osaka University, Shin-Etsu Chemical Co., Ltd.
    Inventors: Masateru Taniguchi, Tomoji Kawai, Hideyuki Kawaguchi, Ikuo Fukui
  • Patent number: 8288762
    Abstract: An organic field effect transistor (OFET) having a structure of a conductor layer/an insulator layer/a semiconductor layer is provided. This OFET comprises an insulator layer formed by mixing a polymer compound produced by polymerizing or copolymerizing a monomer represented by the formula (1): CH2?CHCOO—(CH2)2—CN??(1) and/or a monomer represented by the formula (2): CH2?C(CH3)COO—(CH2)2—CN??(2) with a polymerizable and/or crosslinkable organic compound other than the monomer represented by the formula (1) or (2); and a semiconductor layer comprising an organic compound.
    Type: Grant
    Filed: August 31, 2009
    Date of Patent: October 16, 2012
    Assignees: Osaka University, Shin-Etsu Chemical Co., Ltd.
    Inventors: Masateru Taniguchi, Tomoji Kawai, Hideyuki Kawaguchi, Ikuo Fukui
  • Patent number: 8089321
    Abstract: Four stochastic resonators 20-1 to 20-4 outputting a pulse signal in accordance with a stochastic resonance phenomenon are unidirectionally coupled in a ring-like form to constitute a fluctuation oscillator 10. When a signal output from each of the stochastic resonators 20-1 to 20-4 is successively transmitted in the stochastic resonators 20-1 to 20-4 coupled in a ring-like form, the output timings at each stochastic resonator 20 are synchronized with each other due to a cooperation phenomenon between the stochastic resonators 20-1 to 20-4, so that each stochastic resonator 20 is self-excited to oscillate at a constant period of time.
    Type: Grant
    Filed: August 21, 2008
    Date of Patent: January 3, 2012
    Assignee: Osaka University
    Inventors: Yasushi Hotta, Teruo Kanki, Naoki Asakawa, Toshio Kawahara, Tomoji Kawai, Hitoshi Tabata
  • Publication number: 20110068875
    Abstract: Four stochastic resonators 20-1 to 20-4 outputting a pulse signal in accordance with a stochastic resonance phenomenon are unidirectionally coupled in a ring-like form to constitute a fluctuation oscillator 10. When a signal output from each of the stochastic resonators 20-1 to 20-4 is successively transmitted in the stochastic resonators 20-1 to 20-4 coupled in a ring-like form, the output timings at each stochastic resonator 20 are synchronized with each other due to a cooperation phenomenon between the stochastic resonators 20-1 to 20-4, so that each stochastic resonator 20 is self-excited to oscillate at a constant period of time.
    Type: Application
    Filed: August 21, 2008
    Publication date: March 24, 2011
    Applicant: OSAKA UNIVERSITY
    Inventors: Yasushi Hotta, Teruo Kanki, Naoki Asakawa, Toshio Kawahara, Tomoji Kawai, Hitoshi Tabata
  • Publication number: 20110021381
    Abstract: A method for immobilizing a self-organizing material or fine particles on a substrate, and a substrate whereupon the self-organizing material or the fine particles are immobilized. More specifically, the method for immobilizing the fine particles including a nucleic acid (for instance, DNA or RNA) or a metal oxide on the substrate, and the substrate whereupon the nucleic acid (for example, DNA or RNA) or the metal oxide is immobilized.
    Type: Application
    Filed: September 23, 2010
    Publication date: January 27, 2011
    Inventors: Tomoji Kawai, Hitoshi Tabata, Yoichi Otsuka, Fumihiko Yamada, Takuya Matsumoto
  • Patent number: 7874202
    Abstract: In a probe apparatus that intermittently irradiates a sample with excitation light to observe the sample while subjecting a cantilever including a probe arranged to face a surface of the sample to self-excited vibration at a predetermined frequency, the sample is irradiated with the excitation light at a predetermined timing when a distance between the probe and the sample is not greater than a predetermined distance.
    Type: Grant
    Filed: December 30, 2008
    Date of Patent: January 25, 2011
    Assignee: Japan Science and Technology Agency
    Inventors: Takuya Matsumoto, Tomoji Kawai
  • Patent number: 7829546
    Abstract: A method for immobilizing a self-organizing material or fine particles on a substrate, and a substrate whereupon the self-organizing material or the fine particles are immobilized. More specifically, the method for immobilizing the fine particles including a nucleic acid (for instance, DNA or RNA) or a metal oxide on the substrate, and the substrate whereupon the nucleic acid (for example, DNA or RNA) or the metal oxide is immobilized.
    Type: Grant
    Filed: June 26, 2007
    Date of Patent: November 9, 2010
    Assignee: Japan Science and Technology Agency
    Inventors: Tomoji Kawai, Hitoshi Tabata, Yoichi Otsuka, Fumihiko Yamada, Takuya Matsumoto