Patents by Inventor Tomoko Takeda
Tomoko Takeda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120329846Abstract: Disclosed is an agent for use in the treatment or prevention of inflammatory bowel disease. Also disclosed is an agent for inhibiting the production of TNF-?. A therapeutic or prophylactic agent for inflammatory bowel disease comprising at least one amino acid selected from the group consisting of lysine, histidine, phenylalanine, methionine, tryptophan, glutamine, glycine, cysteine, cystine and threonine, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day; and a TNF-? production inhibitor comprising an amino acid selected from the group consisting of histidine, phenylalanine and tryptophan, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day.Type: ApplicationFiled: March 27, 2012Publication date: December 27, 2012Applicant: Ajinomoto Co., Inc.Inventors: Hideki Matsumoto, Tomohisa Okutsu, Tomoko Takeda, Hideki Suzuki, Tetsuo Yano, Masaki Hashimoto, Miho Ono, Manabu Suzuki
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Patent number: 8278329Abstract: The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc. comprising the compound represented by the following general formula (1) or its analogue to a patient in need of such treatment: wherein, A represents CH?CH, etc., a, b, c and d represents CH etc., R1, R2, R3, R4, R5 and R6 represents H etc., V—W represents C?C, etc., n represents 0 to 3, Y1 represents O etc., B represents —(CH2)vCHR21 wherein v is 0 to 3, R21 represents H, a lower alkyl group or the like, etc., G represents —CO—, a covalent bond, etc., m is 0 to 6, R7 and R8 represents H, a lower alkyl group, —COR18a, —COOR20 wherein R18a and R20 each represents a lower alkyl group or the like, etc.Type: GrantFiled: October 26, 2007Date of Patent: October 2, 2012Assignee: Ajinomoto Co., Inc.Inventors: Takashi Yamamoto, Seiji Niwa, Kayo Otani, Seiji Ohno, Hajime Koganei, Satoshi Iwayama, Akira Takahara, Yukitsugu Ono, Tomoko Takeda, Shinichi Fujita, Keiko Moki
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Patent number: 8168669Abstract: Disclosed is an agent for use in the treatment or prevention of inflammatory bowel disease. Also disclosed is an agent for inhibiting the production of TNF-?. A therapeutic or prophylactic agent for inflammatory bowel disease comprising at least one amino acid selected from the group consisting of lysine, histidine, phenylalanine, methionine, tryptophan, glutamine, glycine, cysteine, cystine and threonine, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day; and a TNF-? production inhibitor comprising an amino acid selected from the group consisting of histidine, phenylalanine and tryptophan, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day.Type: GrantFiled: June 25, 2009Date of Patent: May 1, 2012Assignee: Ajinomoto Co., Inc.Inventors: Hideki Matsumoto, Tomohisa Okutsu, Tomoko Takeda, Hideki Suzuki, Tetsuo Yano, Masaki Hashimoto, Miho Ono, Manabu Suzuki
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Publication number: 20110201110Abstract: The present invention provides a method of producing induced pluripotent stem (iPS) cells, comprising bringing a nuclear reprogramming substance into contact with dental pulp stem cells. By using dental pulp stem cells as a source of somatic cells, the efficiency of establishment of human iPS cells by transfer of 3 or 4 factors can be improved dramatically. Additionally, dental pulp stem cells are easily available because they can be isolated and prepared from extracted wisdom teeth and teeth extracted because of periodontal disease and the like, so that they can be used widely as a source of somatic cells for iPS cell banks.Type: ApplicationFiled: October 2, 2008Publication date: August 18, 2011Applicants: GIFU UNIVERSITY, KYOTO UNIVERSITYInventors: Kenichi Tezuka, Toshiyuki Shibata, Takahiro Kunisada, Naritaka Tamaoki, Tomoko Takeda, Shinya Yamanaka, Kazutoshi Takahashi
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Pharmaceutical composition containing gabapentin or pregabalin and N-type calcium channel antagonist
Patent number: 7713957Abstract: The present invention relates to a pharmaceutical composition useful for preventing/treating pain, which comprises combination of gabapentin or pregabalin, or pharmaceutically acceptable salts thereof and N-type calcium channel antagonists or pharmaceutically acceptable salts thereof such as a compound having the following structure.Type: GrantFiled: August 5, 2004Date of Patent: May 11, 2010Assignee: Ajinomoto Co., Inc.Inventors: Satoshi Iwayama, Hajime Koganei, Shinichi Fujita, Tomoko Takeda, Hiroshi Yamamoto, Seiji Niwa -
Publication number: 20100076044Abstract: Disclosed is an agent for use in the treatment or prevention of inflammatory bowel disease. Also disclosed is an agent for inhibiting the production of TNF-?. A therapeutic or prophylactic agent for inflammatory bowel disease comprising at least one amino acid selected from the group consisting of lysine, histidine, phenylalanine, methionine, tryptophan, glutamine, glycine, cysteine, cystine and threonine, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day; and a TNF-? production inhibitor comprising an amino acid selected from the group consisting of histidine, phenylalanine and tryptophan, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day.Type: ApplicationFiled: June 25, 2009Publication date: March 25, 2010Applicant: Ajinomoto Co., Inc.Inventors: Hideki MATSUMOTO, Tomohisa Okutsu, Tomoko Takeda, Hideki Suzuki, Tetsuo Yano, Masaki Hashimoto, Miho Ono, Manabu Suzuki
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Patent number: 7494989Abstract: Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when they were taken orally. They are useful as therapeutic agents for pains and various diseases associated with the N-type calcium channels.Type: GrantFiled: September 17, 2007Date of Patent: February 24, 2009Assignee: Ajinomoto Co., Inc.Inventors: Seiji Ohno, Kayo Otani, Seiji Niwa, Satoshi Iwayama, Akira Takahara, Hajime Koganei, Yukitsugu Ono, Shinichi Fujita, Tomoko Takeda, Masako Hagihara, Akiko Okajima
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Patent number: 7462630Abstract: The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc. comprising the compound represented by the following general formula (1) or its analogue to a patient in need of such treatment: wherein, A represents CH?CH, etc., a, b, c and d represents CH etc., R1, R2, R3, R4, R5 and R6 represents H etc., V—W represents C?C, etc., n represents 0 to 3, Y1 represents O etc., B represents —(CH2)vCHR21 wherein v is 0 to 3, R21 represents H, a lower alkyl group or the like, etc., G represents —CO—, a covalent bond, etc., m is 0 to 6, R7 and R8 represents H, a lower alkyl group, —COR18a, —COOR20 wherein R18a and R20 each represents a lower alkyl group or the like, etc.Type: GrantFiled: February 27, 2004Date of Patent: December 9, 2008Assignee: Ajinomoto Co., Inc.Inventors: Takashi Yamamoto, Seiji Niwa, Kayo Otani, Seiji Ohno, Hajime Koganei, Satoshi Iwayama, Akira Takahara, Yukitsugu Ono, Tomoko Takeda, Shinichi Fujita, Keiko Moki
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Publication number: 20080108684Abstract: Disclosed is an agent for use in the treatment or prevention of inflammatory bowel disease. Also disclosed is an agent for inhibiting the production of TNF-?. A therapeutic or prophylactic agent for inflammatory bowel disease comprising at least one amino acid selected from the group consisting of lysine, histidine, phenylalanine, methionine, tryptophan, glutamine, glycine, cysteine, cystine and threonine, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day; and a TNF-? production inhibitor comprising an amino acid selected from the group consisting of histidine, phenylalanine and tryptophan, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day.Type: ApplicationFiled: January 2, 2008Publication date: May 8, 2008Applicant: Ajinomoto Co., Inc.Inventors: HIDEKI MATSUMOTO, Tomohisa Okutsu, Tomoko Takeda, Hideki Suzuki, Tetsuo Yano, Masaki Hashimoto, Miho Ono, Manabu Suzuki
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Publication number: 20080070903Abstract: Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when they were taken orally. They are useful as therapeutic agents for pains and various diseases associated with the N-type calcium channels.Type: ApplicationFiled: September 17, 2007Publication date: March 20, 2008Applicant: AJINOMOTO CO., INCInventors: Seiji OHNO, Kayo Otani, Seiji Niwa, Satoshi Iwayama, Akira Takahara, Hajime Koganei, Yukitsugu Ono, Shinichi Fujita, Tomoko Takeda, Masako Hagihara, Akiko Okajima
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Publication number: 20080058311Abstract: The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc. comprising the compound represented by the following general formula (1) or its analogue to a patient in need of such treatment: wherein, A represents CH?CH, etc., a, b, c and d represents CH etc., R1, R2, R3, R4, R5 and R6 represents H etc., V—W represents C?C, etc., n represents 0 to 3, Y1 represents O etc., B represents —(CH2)vCHR21 wherein v is 0 to 3, R21 represents H, a lower alkyl group or the like, etc., G represents —CO—, a covalent bond, etc., m is 0 to 6, R7 and R8 represents H, a lower alkyl group, —COR18a, —COOR20 wherein R18a and R20 each represents a lower alkyl group or the like, etc.Type: ApplicationFiled: October 26, 2007Publication date: March 6, 2008Applicant: AJINOMOTO CO., INC.Inventors: Takashi YAMAMOTO, Seiji Niwa, Kayo Otani, Seiji Ohno, Hajime Koganei, Satoshi Iwayama, Akira Takahara, Yukitsugu Ono, Tomoko Takeda, Shinichi Fujita, Keiko Moki
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Patent number: 7288544Abstract: Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when they were taken orally.Type: GrantFiled: March 14, 2003Date of Patent: October 30, 2007Assignee: Ajinomoto Co., Inc.Inventors: Seiji Ohno, Kayo Otani, Seiji Niwa, Satoshi Iwayama, Akira Takahara, Hajime Koganei, Yukitsugu Ono, Shinichi Fujita, Tomoko Takeda, Masako Hagihara, Akiko Okajima
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Patent number: 7247645Abstract: Compounds having a selective N-type calcium channel antagonistic activity are provided. Dihydropyridine derivatives represented by the following formula: analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel, and they are used as therapeutic agents for various diseases relating to N-type calcium channel.Type: GrantFiled: December 20, 2001Date of Patent: July 24, 2007Assignee: Ajinomoto Co., Inc.Inventors: Chika Nakanishi, Yoko Masuzawa, Masako Hagihara, Takashi Yamamoto, Hiroyuki Matsueda, Seiji Ohno, Seiji Niwa, Morikazu Kito, Akira Takahara, Yukitsugu Ono, Tomoko Takeda, Yuki Kajigaya, Hajime Koganei
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Patent number: 6855716Abstract: Dihydropyrimidine derivatives of the following formula or analogs thereof have selective N-type calcium channel antagonistic activity, and they are used as therapeutic agents for various diseases participating in the N-type calcium channels.Type: GrantFiled: December 26, 2001Date of Patent: February 15, 2005Assignee: Ajinomoto Co., Inc.Inventors: Seiji Ohno, Akiko Okajima, Seiji Niwa, Morikazu Kito, Akira Takahara, Yukitsugu Ono, Yuki Kajigaya, Tomoko Takeda, Hajime Koganei
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Pharmaceutical composition containing gabapentin or pregabalin and N-type calcium channel antagonist
Publication number: 20050009814Abstract: The present invention relates to a pharmaceutical composition useful for preventing/treating pain, which comprises combination of gabapentin or pregabalin, or pharmaceutically acceptable salts thereof and N-type calcium channel antagonists or pharmaceutically acceptable salts thereof such as a compound having the following structure.Type: ApplicationFiled: August 5, 2004Publication date: January 13, 2005Applicant: Ajinomoto Co., Inc.Inventors: Satoshi Iwayama, Hajime Koganei, Shinichi Fujita, Tomoko Takeda, Hiroshi Yamamoto, Seiji Niwa -
Publication number: 20040167118Abstract: The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc.Type: ApplicationFiled: February 27, 2004Publication date: August 26, 2004Applicant: AJINOMOTO CO., INC.Inventors: Takashi Yamamoto, Seiji Niwa, Kayo Otani, Seiji Ohno, Hajime Koganei, Satoshi Iwayama, Akira Takahara, Yukitsugu Ono, Tomoko Takeda, Shinichi Fujita, Keiko Moki
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Publication number: 20040009991Abstract: Achirai pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when they were taken orally. They are useful as therapeutic agents for pains and various diseases associated with the N-type calcium channels.Type: ApplicationFiled: March 14, 2003Publication date: January 15, 2004Applicant: AJINOMOTO CO., INC.Inventors: Seiji Ohno, Kayo Otani, Seiji Niwa, Satoshi Iwayama, Akira Takahara, Hajime Koganei, Yukitsugu Ono, Shinichi Fujita, Tomoko Takeda, Masako Hagihara, Akiko Okajima
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Patent number: 6610717Abstract: Dihydropyridine derivatives represented by the following formula: analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel, and they are used as therapeutic agents for various diseases relating to N-type calcium channel.Type: GrantFiled: December 21, 2001Date of Patent: August 26, 2003Assignee: Ajinomoto Co., Inc.Inventors: Akira Nakajo, Munetaka Tokumasu, Morikazu Kito, Akira Takahara, Yukitsugu Ono, Tomoko Takeda, Yuki Kajigaya, Hajime Koganei
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Publication number: 20020193605Abstract: Dihydropyridine derivatives represented by the following formula: 1Type: ApplicationFiled: December 21, 2001Publication date: December 19, 2002Applicant: AJINOMOTO CO. INCInventors: Akira Nakajo, Munetaka Tokumasu, Morikazu Kito, Akira Takahara, Yukitsugu Ono, Tomoko Takeda, Yuki Kajigaya, Hajime Koganei
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Publication number: 20020147222Abstract: Compounds having a selective N-type calcium channel antagonistic activity are provided.Type: ApplicationFiled: December 20, 2001Publication date: October 10, 2002Applicant: AJINOMOTO CO. INCInventors: Chika Nakanishi, Yoko Masuzawa, Masako Hagihara, Takashi Yamamoto, Hiroyuki Matsueda, Seiji Ohno, Seiji Niwa, Morikazu Kito, Akira Takahara, Yukitsugu Ono, Tomoko Takeda, Yuki Kajigaya, Hajime Koganei