Abstract: The present invention provides markers that can selectively distinguish pancreatic progenitor cells. The present invention also provides methods for distinguishing pancreatic progenitor cells by using the markers as an indicator, and reagents to be used in the methods. The present inventors successfully identified the surface marker Nephrin-like 3 (Neph3) which is specifically expressed in pancreatic progenitor cells, and isolated pancreatic progenitor cells using the marker as an indicator or such. Viable pancreatic progenitor cells can be selected by using Neph3 as an indicator without using translated products and transcripts of any foreign genes. The marker is useful in preparing and identifying pancreatic progenitor cells which are applied to regenerative medicine or such for treatment of pancreatic diseases.

Abstract: A polymer compound comprising a repeating unit represented by the formula (1): wherein, E1, E2, E3 and E4 represent each independently an aryl group, a mono-valent heterocyclic group or the like, a, b, c, d and e represent each independently 1 or 2, and f represents an integer of 0 to 3, and when f=0, then, 5?a+b+c+e?8 and at least one of b and c is 2, and when there are a plurality of d, these may be the same or different, m, n, o, p, q and l represent each independently an integer of 0 to 4, and when there are a plurality of m, n, o, p and q, these may be the same or different, respectively, j and k represent each independently an integer of 0 to 5.

Abstract: The present invention identified Lmx1a genes, which are expressed in dopaminergic neurons at all differentiation stages, from proliferating dopaminergic neuron progenitor cells before cell cycle exit to cells after cell cycle exit. Lmx1a expression in cells can be used as an indicator when selecting cells suitable for transplantation therapy for neurodegenerative diseases such as Parkinson's disease, and is useful as a marker for screening agents involved in the induction of dopaminergic neuron differentiation.

Abstract: Disclosed is a polymer light-emitting device having a light-emitting layer arranged between an anode and a cathode, and a hole transport layer arranged between the light-emitting layer and the anode. This polymer light-emitting device is characterized in that the hole transport layer is a layer containing a polymer compound which contains a repeating unit represented by the general formula (I) below, a repeating unit represented by the general formula (II) below and a repeating unit represented by the general formula (III) below.

Abstract: The problem to be solved of the present invention is to provide a method for producing a polymer compound having an increased molecular weight through a short-time polymerization process.

Abstract: A composition comprising (1) a first crosslinkable polymer compound having an aromatic conjugated repeating unit and a crosslinkable group and having at least one of a light emitting property and charge transportability, and (2) a second crosslinkable polymer compound having an aromatic conjugated repeating unit and a crosslinkable group at least one of which is different from the aromatic conjugated repeating unit in the first crosslinkable polymer compound and the crosslinkable group in the first crosslinkable polymer compound, and having at least one of a light emitting property and charge transportability, wherein at least one of the first crosslinkable polymer compound and the second crosslinkable polymer compound has a crosslinkable group represented by the following formula (Z-3) or (Z-4): in the formulae, Rc represents a hydrogen atom, or a substituent such as an unsubstituted or substituted alkyl group or the like, the plurality of Rc moieties may be the same or different.

Abstract: Disclosed is a block copolymer characterized by containing a block (A) containing two or more different repeating units respectively composed of a specific divalent heterocyclic group, and a repeating unit composed of an arylene group, and a block (B) containing a repeating unit composed of an arylene group and a repeating unit composed of a divalent aromatic amine residue. Also disclosed are a composition containing a solvent, a light-emitting material other than the block copolymer, a hole-transporting material other than the block copolymer, an electron-transporting material other than the block copolymer or a combination of two or more of them, in addition to the block copolymer; a light-emitting thin film characterized by containing the block copolymer; and a polymer light-emitting device characterized by having an anode, a cathode and an organic layer containing the block copolymer and arranged between the anode and the cathode.

Abstract: A composition comprising (i) a crosslinkable polymer compound having a crosslinkable group and being capable of showing at least one of a light emitting property and charge transportability, and (ii) a crosslinkable low molecular weight compound having a crosslinkable group and being capable of showing at least one of a light emitting property and charge transportability.

Abstract: A luminescent or charge-transporting polymer which has in the backbone optionally substituted fluorenediyl groups as repeating units and further has a functional side chain comprising at least one functional group selected from the group consisting of a hole-injection/transporting group containing one or more heteroatoms other than nitrogen or two or more nitrogen atoms, an electron-injection/transporting group containing one or more heteroatoms other than nitrogen or two or more nitrogen atoms, and a luminescent group comprising a fused aromatic hydrocarbon or heterocycle, characterized in that the functional group is directly bonded to the saturated carbon atom of any of the fluorenediyl groups or is bonded to any of the fluorenediyl groups through —Rk—X— (Rk represents alkylene and X represents a direct bond or connecting group) at the X.

Abstract: A luminescent or charge-transporting polymer which has in the backbone optionally substituted fluorenediyl groups as repeating units and further has a functional side chain comprising at least one functional group selected from the group consisting of a hole-injection/transporting group containing one or more heteroatoms other than nitrogen or two or more nitrogen atoms, an electron-injection/transporting group containing one or more heteroatoms other than nitrogen or two or more nitrogen atoms, and a luminescent group comprising a fused aromatic hydrocarbon or heterocycle, characterized in that the functional group is directly bonded to the saturated carbon atom of any of the fluorenediyl groups or is bonded to any of the fluorenediyl groups through —Rk—X—(Rk represents alkylene and X represents a direct bond or connecting group) at the X.

Abstract: The present invention identified Lmx1a genes, which are expressed in dopaminergic neurons at all differentiation stages, from proliferating dopaminergic neuron progenitor cells before cell cycle exit to cells after cell cycle exit. Lmx1a expression in cells can be used as an indicator when selecting cells suitable for transplantation therapy for neurodegenerative diseases such as Parkinson's disease, and is useful as a marker for screening agents involved in the induction of dopaminergic neuron differentiation.

Abstract: The present invention identified Lmx1a genes, which are expressed in dopaminergic neurons at all differentiation stages, from proliferating dopaminergic neuron progenitor cells before cell cycle exit to cells after cell cycle exit. Lmx1a expression in cells can be used as an indicator when selecting cells suitable for transplantation therapy for neurodegenerative diseases such as Parkinson's disease, and is useful as a marker for screening agents involved in the induction of dopaminergic neuron differentiation.

Abstract: A polymer light emitting material which contains a polymer compound comprising a repeating unit of the following formula (1) or (2) and having a polystyrene-reduced number-average molecular weight of 103 to 108, and which exhibits light emission from the triplet excited state. [wherein Ar1 and Ar2 each independently represent a trivalent aromatic hydrocarbon group or a trivalent heterocyclic group. X1 and X2 each independently represent O, S, C(?O), S(?O), SO2, C(R1)(R2), Si(R3)(R4), N(R5), B(R6), P(R7) or P(?O)(R8). X1 and Ar2 bond to adjacent carbon atoms in the aromatic ring of Ar1; and X2 and Ar1 bond to adjacent carbon atoms in the aromatic ring of Ar2]; [wherein Ar3 and Ar4 each independently represent a trivalent aromatic hydrocarbon group or a trivalent heterocyclic group. X3 and X4 each independently represent N, B, P, C(R9) or Si(R10). X3 and Ar4 bond to adjacent carbon atoms in the aromatic ring of Ar3; and X4 and Ar3 bond to adjacent carbon atoms in the aromatic ring of Ar4].

Abstract: The present invention is a probe, a primer, and an antibody, for detecting a dopaminergic neuron proliferative progenitor cell. According to the present invention, there is provided a polynucleotide probe and a polynucleotide primer for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell, which can hybridize with a polynucleotide consisting of a nucleotide sequence of a Nato3 gene, or a complementary sequence thereto, and an antibody against a Nato3 protein, or a part thereof for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell.

Abstract: A polymer compound comprising a constituent unit represented by the following formula (1a): wherein ring A and ring B represent an aromatic hydrocarbon ring. R1 is a group represented by the following formula (2). R2 represents an aryl group or a monovalent aromatic heterocyclic group. wherein Ar1 represents an arylene group or a divalent group comprising two or more directly bonded arylene groups; Ar4 and Ar5 represent an aryl group or a monovalent aromatic heterocyclic group; Ar2 and Ar3 represent an arylene group or a divalent aromatic heterocyclic group; R6 represents a hydrogen atom, an alkyl group, an aryl group or a monovalent aromatic heterocyclic group.

Abstract: The present invention is a probe, a primer, and an antibody, for detecting a dopaminergic neuron proliferative progenitor cell. According to the present invention, there is provided a polynucleotide probe and a polynucleotide primer for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell, which can hybridize with a polynucleotide consisting of a nucleotide sequence of a Nato3 gene, or a complementary sequence thereto, and an antibody against a Nato3 protein, or a part thereof for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell.

Abstract: The present invention provides markers that can selectively distinguish pancreatic progenitor cells. The present invention also provides methods for distinguishing pancreatic progenitor cells by using the markers as an indicator, and reagents to be used in the methods. The present inventors successfully identified the surface marker Nephrin-like 3 (Neph3) which is specifically expressed in pancreatic progenitor cells, and isolated pancreatic progenitor cells using the marker as an indicator or such. Viable pancreatic progenitor cells can be selected by using Neph3 as an indicator without using translated products and transcripts of any foreign genes. The marker is useful in preparing and identifying pancreatic progenitor cells which are applied to regenerative medicine or such for treatment of pancreatic diseases.

Abstract: A novel gene 65B13 expressed specifically and transiently in dopaminergic neuron precursor cells immediately after cell cycle exit was obtained by the present invention. The cellular expression of 65B13 can be used as an index to select cells that are suitable in terms of their safety, survival rate, and network formation ability, for transplant therapy of neurodegenerative diseases such as Parkinson's disease.

Abstract: The present invention is a probe, a primer, and an antibody, for detecting a dopaminergic neuron proliferative progenitor cell. According to the present invention, there is provided a polynucleotide probe and a polynucleotide primer for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell, which can hybridize with a polynucleotide consisting of a nucleotide sequence of an Msx1 gene or an Msx2 gene, or a complementary sequence thereto, and an antibody against an Msx1 protein or an Msx2 protein, or a part thereof for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell.

Abstract: Disclosed is a compound containing a divalent group represented by formula (I).