Patents by Inventor Toon Hendrik Evers

Toon Hendrik Evers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200030806
    Abstract: A device is provided comprising a receiving chamber for receiving a patient's sample, a first reagent reservoir and a second reagent reservoir. The receiving chamber may be configured for receiving at least an end portion of a sample collecting element, with the patient's sample being collected by that sample collecting element. The first reagent reservoir may generally be configured to accommodate a liquid reagent which may include a lysing agent, i.e. the liquid may be a kind of a lysis buffer. Likewise, the second reagent reservoir may generally be configured to accommodate a dry reagent which may include magnetic particles. The device may further comprise at least one of the following two actuators, a first actuator for supplying a first reagent from the first reagent reservoir to the sample and a second actuator for supplying a second reagent from the second reagent reservoir to the resulting mixture.
    Type: Application
    Filed: September 29, 2017
    Publication date: January 30, 2020
    Inventors: Matthias IRMSCHER, Toon Hendrik EVERS, Marlieke Joan OVERDIJK, Thomas Johannes VAN GIJSEL, Stefan Johannes Hendrikus TOONEN
  • Publication number: 20200018689
    Abstract: The invention relates to a method and a sensor device (100) for evaluating an assay with a sample. During the assay, optical measurements are made at a sensing surface (112), and at least one “homogeneity-image” of the sensing surface (112) is generated. From this image, an “homogeneity-indicator” is determined for at least one region of interest, and the optical measurements are then evaluated in dependence on said indicator. The homogeneity-indicator may for example be a binary value which indicates if an inhomogeneity was detected or not. If an inhomogeneity was detected, all optical measurements may be rejected, only measurements for the involved region of interest may be rejected, or measurements for a selected sub-area of the involved region of interest (ROI) may be rejected.
    Type: Application
    Filed: September 25, 2019
    Publication date: January 16, 2020
    Inventors: Toon Hendrik EVERS, Derk Jan Wilfred KLUNDER, Jeroen Hans NIEUWENHUIS, Joannes Baptist Adrianus Dionisius VAN ZON
  • Publication number: 20190344263
    Abstract: In order to provide a system allowing an improved and facilitated preparation of a sample for an appropriate analysis, a device for preparing a patient's sample before analysis is provided. The device comprises a housing (10, 30) and an actuator (50). The housing includes a receiving chamber (32). The receiving chamber is configured for receiving a liquid. The actuator is movable relative to the housing. The actuator is configured for extracting a predetermined amount of the liquid received in the receiving chamber and for supplying the extracted liquid to a reagent chamber, so that the reagent is suspended in the liquid. The actuator comprises a metering chamber (52) configured for receiving the predetermined amount of the liquid and for supplying the predetermined amount of the liquid to the reagent chamber.
    Type: Application
    Filed: September 29, 2017
    Publication date: November 14, 2019
    Inventors: Matthias IRMSCHER, Toon Hendrik EVERS, Stefan Johannes Hendrikus TOONEN, Marlieke Joan OVERDIJK, Harma Martine FEITSMA, Thomas Johannes VAN GIJSEL, Wilbert Hendrik BOUWMAN, Eveline Catharina Anna Clasina DEN BIEZEN-TIMMERMANS, Willem-Jan Arend DE WIJS
  • Patent number: 10466163
    Abstract: During an assay, optical measurements are made at a sensing surface (112), and at least one “homogeneity-image” of the sensing surface (112) is generated. From this image, an “homogeneity-indicator” is determined for at least one region of interest, and the optical measurements are then evaluated in dependence on said indicator. The homogeneity-indicator may for example be a binary value which indicates if an inhomogeneity was detected or not. If an inhomogeneity was detected, all optical measurements may be rejected, only measurements for the involved region of interest may be rejected, or measurements for a selected sub-area of the involved region of interest (ROI) may be rejected.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: November 5, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Toon Hendrik Evers, Derk Jan Wilfred Klunder, Jeroen Hans Nieuwenhuis, Joannes Baptist Adrianus Dionisius Van Zon
  • Patent number: 10393735
    Abstract: The invention relates to a method and a processing device for the processing of a fluid containing interfering particles (C). Magnetic particles (MP) are added to the fluid in a processing chamber and distributed, in part, using a magnetic field to provide a blocking zone (BZ) within the processing chamber to impede or prevent such migration of the interfering particles (C) through the processing chamber. The blocking zone (BZ) hence acts as a filter element by which interfering particles (C) can for example be kept away from a detection region at the surface of the processing chamber.
    Type: Grant
    Filed: June 20, 2013
    Date of Patent: August 27, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Toon Hendrik Evers, Ron Martinus Laurentius Van Lieshout, Joannes Baptist Adrianus Dionisius Van Zon
  • Patent number: 10384153
    Abstract: The invention relates to a filter unit (600), a method for manufacturing such a filter unit, and a cartridge (690) comprising such a filter unit. The filter unit (600) is characterized in that it comprises a filter material (601) which is integrated into the aperture of at least one foil (602, 603, 604). In a preferred embodiment, the filter material (601) may be located in the aperture of an intermediate foil (604) which is embedded between a top foil (602) and a bottom foil (603). Such a filter unit (600) can readily be produced in cost-effective processes like roll-to-roll manufacturing technologies.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: August 20, 2019
    Assignee: Minicare B.V.
    Inventors: Jacobus Hermanus Maria Neijzen, Toon Hendrik Evers
  • Patent number: 10258984
    Abstract: The invention relates to a cartridge (10) for processing of a liquid sample, for example for the detection of components in a sample of blood. The cartridge comprises a fluidic system with an intake port (12) leading via an intake capillary channel (13) to a storage chamber (14). Moreover, a feeding capillary channel (15) leads from the storage chamber (14) to a detection chamber (16). The design of the cartridge (10) is such that the intake capillary channel (13) that connects the intake port (12) to the storage chamber (14), has a capillary suction pressure sufficiently high to drive some sample from the intake port to the storage chamber without need of any additional pressure. Furthermore the cartridge a flow control element (18, 20) adapted to be externally controllable such that the sample can be drawn from the storage chamber (14) towards the processing chamber (16) without any active pumping.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: April 16, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Godefridus Johannes Verhoeckx, Toon Hendrik Evers, Marlieke Joan Overdijk, Monica Scholten, Nicole Henrica Maria Smulders, Joost Hubert Maas, Bernardus Jozef Maria Beerling
  • Publication number: 20180315494
    Abstract: Various embodiments described herein relate to a method, computer readable medium, and device including one or more of the following: receiving at least one newly-available patient feature for the patient; adding the newly-available patient feature to an indication of all available patient features previously established for a previous application of one of a collection of trained models to the patient; comparing the indication of all available patient features to metadata describing input features of respective models of the collection of trained models to determine whether the input features are available for applying the respective trained models to the patient; selecting a selected trained model based on determining that the input features for the selected trained model are available for applying the selected trained model to the patient; and invoking the selected trained model.
    Type: Application
    Filed: April 25, 2018
    Publication date: November 1, 2018
    Inventors: Raivo Kolde, Andrew G. Hoss, Toon Hendrik Evers
  • Patent number: 10105478
    Abstract: A cartridge for processing a fluid which features a fluid-treatment element that is permeable to at least a part of the fluid, and a processing chamber that is disposed adjacent to the fluid-treatment element. The treated fluid which passes the fluid-treatment element is processed in the processing chamber.
    Type: Grant
    Filed: January 11, 2013
    Date of Patent: October 23, 2018
    Assignee: Koninklijke Philips N.V.
    Inventors: Jacobus Hermanus Maria Neijzen, Toon Hendrik Evers
  • Patent number: 10079086
    Abstract: The invention relates to an apparatus (100) and a method for the processing of magnetic particles (MP) provided in a processing chamber (114) with a binding region (116) to which said magnetic particles (MP) can (specifically) bind. Removal of unbound magnetic particles (MP) from the binding region (116) is achieved by first separating them from the binding region (116) by gravitational forces and then moving them further away by magnetic forces. Gravitational forces can for example be generated by tilting the binding region with a tilting unit (156). The prior separation by gravitational forces prevents that unbound magnetic particles (MP) are captured in a cluster with bound magnetic particles.
    Type: Grant
    Filed: June 20, 2013
    Date of Patent: September 18, 2018
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Ron Martinus Laurentius Van Lieshout, Joannes Baptist Adrianus Dionisius Van Zon, Toon Hendrik Evers
  • Patent number: 10041939
    Abstract: The present invention relates to a cartridge (1) for the detection of an analyte (2) in a binding assay with magnetic labels (3), the cartridge comprising at least one capture binding agent (4) against a binding site on the analyte and comprising at least two magnetically labelled tracer binding agents (51 and 52) against further different binding sites on the analyte, characterized in that the cartridge comprises at least two regions (61 and 62) wherein a first region (61) comprises the at least one capture binding agent (4) and a first magnetically labelled tracer binding agent (51) and wherein a second region (62) comprises at least one capture binding agent (4) and a second magnetically labelled tracer binding agent (52).
    Type: Grant
    Filed: September 10, 2010
    Date of Patent: August 7, 2018
    Assignee: Minicare B.V.
    Inventors: Jeroen Hans Nieuwennhuis, Toon Hendrik Evers
  • Publication number: 20180141038
    Abstract: The present invention relates to a sensor cartridge (100) comprising: a sample depot (10) which is configured to store a liquid sample; a first cartridge portion (20) comprising a first measurement chamber (22) which is coupled to the sample depot (10) and configured to receive a quantity of the liquid sample from the sample depot (10), wherein the first cartridge portion (20) is configured to measure a first analyte using a first modality on the quantity of the liquid sample and to provide a first analyte test signal; a cartridge portion (30-1) comprising a second measurement chamber (32-1) which is coupled to the first measurement chamber (20), which is configured to receive the quantity of the liquid sample from the first measurement chamber (22), wherein the cartridge portion (30) is configured to measure a second analyte using a second modality on the quantity of the liquid sample and to provide a second analyte test signal.
    Type: Application
    Filed: April 8, 2016
    Publication date: May 24, 2018
    Inventors: PIETER JAN VAN DER ZAAG, JACOBUS HERMANUS MARIA NEIJZEN, MENNO PRINS, JEROEN HANS NIEUWENHUIS, TOON HENDRIK EVERS, ALOYSIUS CORNELIS JOHANNES STROUCKEN
  • Patent number: 9962693
    Abstract: An embodiment of the invention relates to a fluidic system (200) in which a first channel (210) and a second channel (230) are separated by a fluidic stop (220), for example a region with a hydrophobic coating and/or a structure (220) with non-capillary internal dimensions. Moreover, it comprises a flexible element (240) that is deformable to enable a flow of a medium across the fluidic stop.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: May 8, 2018
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Godefridus Johannes Verhoeckx, Nicole Henrica Maria Smulders, Toon Hendrik Evers, Monica Scholten, Menno Willem Jose Prins
  • Patent number: 9841421
    Abstract: The invention relates to a sensor device (100) and a method for the detection of magnetic particles (1) in a sample chamber (2) with a contact surface (11). The sensor device (100) comprises a sensor unit (120, 130) for detecting magnetic particles (1) in a target region (TR) and/or in at least one reference region on the contact surface. Moreover, it comprises a magnetic field generator (140) for generating a magnetic field that shall guide magnetic particles to the contact surface. With the help of these components, an “auxiliary parameter” is determined that is related to the magnetic particles (1) and/or their movement but that is independent of binding processes taking place in the target region between magnetic particles and the contact surface. The auxiliary parameter may for example be related to the degree of mismatch between the positions reached by the magnetic particles (1) under the influence of a magnetic field and the target region (TR).
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: December 12, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Wendy Uyen Dittmer, Mikhail Mikhaylovich Ovsyanko, Toon Hendrik Evers, Jeroen Hans Nieuwenhuis, Joannes Baptist Adrianus Dionisius Van Zon
  • Patent number: 9804089
    Abstract: A sensing device (100) detects a target substance (2) in an investigation region (113). The sensing device (100) includes a sensing surface (112) with an investigation region (113) and a reference region (120). The sensing device (100) further includes a reference element (121) located at the reference region (120). The reference element (121) is adapted to shield the reference region (120) from the target substance (2) such that light reflected at the reference region (120) under total internal reflection conditions remains unaffected by the presence or absence of the target substance (2). This allows measuring a property, typically the intensity, of light reflected at the reference region (120) independent of the presence or absence of the target substance (2). This measured property of the reflected light can be used for performing a correction of light reflected at the investigation region (113).
    Type: Grant
    Filed: February 8, 2010
    Date of Patent: October 31, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Dominique Maria Bruls, Toon Hendrik Evers, Johannes Joseph Hubertina Barbara Schleipen
  • Patent number: 9772272
    Abstract: A substance determining apparatus determines a substance within a fluid where particles, which have attached the substance, are bound to a binding surface. A sensing unit is configured to generate a sensing signal being indicative of at least one of i) a distance between the particles bound on the binding surface and the binding surface, and ii) an in-plane position of the particles bound on the binding surface. A binding discrimination unit is configured to discriminate between different kinds of binding of the particles bound on the binding surface depending on the generated sensing signal. The binding discrimination unit may be a unit for determining the part of the sensing signal being caused by specifically bound particles and for determining the substance based on this determined part of the sensing signal.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: September 26, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Toon Hendrik Evers, Johannes Joseph Hubertina Barbara Schleipen, Joannes Baptist Adrianus Dionisius Van Zon, Derk Jan Wilfred Klunder, Josephus Arnoldus Hendricus Maria Kahlman, Ron Martinus Laurentius Van Lieshout, Mikhail Mikhaylovich Ovsyanko, Kim Van Ommering
  • Patent number: 9720003
    Abstract: The present invention relates to a method for measuring Troponin I in a sample comprising the steps of providing a sample, contacting the sample with a monoclonal anti-Troponin I antibody coupled to a magnetic label, contacting the sample with a polyclonal anti-Troponin I antibody coupled to a sensor surface and detecting the magnetic label on the sensor surface. The invention further relates to a device and a cartridge for measuring Troponin I in a sample.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: August 1, 2017
    Assignee: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Wendy Uyen Dittmer, Toon Hendrik Evers, Peggy De Kievit, Ricky Kamps, Joost Lambert Max Vissers, Michael Franciscus Wilhelmus Cornelis Martens, David Walterus Cornelis Dekkers
  • Publication number: 20170120241
    Abstract: The invention relates to a cartridge (10) for processing of a liquid sample, for example for the detection of components in a sample of blood. The cartridge comprises a fluidic system with an intake port (12) leading via an intake capillary channel (13) to a storage chamber (14). Moreover, a feeding capillary channel (15) leads from the storage chamber (14) to a detection chamber (16). The design of the cartridge (10) is such that the intake capillary channel (13) that connects the intake port (12) to the storage chamber (14), has a capillary suction pressure sufficiently high to drive some sample from the intake port to the storage chamber without need of any additional pressure. Furthermore the cartridge a flow control element (18, 20) adapted to be externally controllable such that the sample can be drawn from the storage chamber (14) towards the processing chamber (16) without any active pumping.
    Type: Application
    Filed: May 28, 2015
    Publication date: May 4, 2017
    Inventors: GODEFRIDUS JOHANNES VERHOECKX, TOON HENDRIK EVERS, MARLIEKE JOAN OVERDIJK, MONICA SCHOLTEN, NICOLE HENRICA MARIA SMULDERS, JOOST HUBERT MAAS, BERNARDUS JOZEF MARIA BEERLING
  • Patent number: 9612239
    Abstract: The invention relates to a substance determining apparatus (19) for determining a substance within a fluid. A location event determination unit (34) determines location events indicating that a particle, which may have attached the substance, is located in a sensing region and a property of the location events from the sensing signal generated by sensing the sensing region. A location events selection unit (70) selects a part of the location events having a property in a predefined property range, and a substance determination unit (40) determines the substance within the fluid (3) based on the selected part of the location events. This allows tuning the determination of the substance within the fluid to a desired property range, which can relate to a desired kind of bound particles, thereby reducing the influence of unwanted effects on the determination of the substance and, thus, improving the determination accuracy.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: April 4, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Joannes Baptist Adrianus Dionisius Van Zon, Toon Hendrik Evers, Ron Martinus Laurentius Van Lieshout, Wilhelmina Maria Hardeman, Derk Jan Wilfred Klunder
  • Patent number: 9612236
    Abstract: The present invention is related to a method for detection of a biological target in an affinity assay, the method comprising the steps of providing a biological sample volume containing the biological target, adding a first capturing moiety to the biological sample volume comprising the biological target, wherein the first capturing moiety is adhered to a particle, concentration of the captured biological target into an elution volume that is smaller than the biological sample volume in step a), cleavage of the first capturing moiety or the biological target from the particle and direct or indirect detection and/or quantification of the biological target in a sandwich or competitive affinity assay format, wherein the biological target is associated with at least one capturing moiety, preferably at least two capturing moieties.
    Type: Grant
    Filed: June 14, 2011
    Date of Patent: April 4, 2017
    Assignee: Koninklijke Philips N.V.
    Inventors: Gwenola Sabatte, Menno Willem Jose Prins, Toon Hendrik Evers, Wilhelmina Maria Hardeman, Joukje Garrelina Orsel