Patents by Inventor Torsten Hoffmann

Torsten Hoffmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted amino ketone compounds
    Publication number: 20030125304
    Abstract: The present invention relates to compounds of the general formula I
    Type: Application
    Filed: November 4, 2002
    Publication date: July 3, 2003
    Inventors: Hans-Ulrich Demuth, Ulrich Heiser, Torsten Hoffmann, Andre Niestroj
  • Use of dipeptidyl peptidase IV inhibitors
    Publication number: 20030119750
    Abstract: The present invention provides a new use of DP IV-inhibitors. The compounds of the present invention, and their corresponding pharmaceutically acceptable acid addition salt forms, are useful in treating conditions mediated by DP IV or DP IV-like enzymes, such as immune, autoimmune or central nervous system disorder selected from the group consisting of strokes, tumors, ischemia, Parkinson's disease and migraines. In a more preferred embodiment, the compounds of the present invention are useful for the treatment of multiple sclerosis.
    Type: Application
    Filed: April 19, 2002
    Publication date: June 26, 2003
    Inventors: Hans-Ulrich Demuth, Torsten Hoffmann, Konrad Glund, Ulrich Heiser, Stephan von Hoersten
  • Heteroaromatic substituted amides with antagonistic activity to neurokinin 1 receptors
    Patent number: 6576762
    Abstract: The present invention is a heteroaromatic substituted amide showing antagonist activity to neurokinin 1 (NK-1, substance P) receptors.
    Type: Grant
    Filed: July 9, 2001
    Date of Patent: June 10, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Torsten Hoffmann, Patrick Schnider, Heinz Stadler
  • D-proline derivatives
    Publication number: 20030100770
    Abstract: New compounds have the formula: 1
    Type: Application
    Filed: July 1, 2002
    Publication date: May 29, 2003
    Inventors: Cornelia Hertel, Torsten Hoffmann, Roland Jakob-Roetne, Roger D. Norcross
  • NEW EFFECTORS OF DIPEPTIDYL PEPTIDASE IV FOR TOPICAL USE
    Publication number: 20030092630
    Abstract: The invention relates to compounds for topically influencing the activity of dipeptidyl peptidase of the general formula 1 wherein A is an amino acid having at least one functional group in the side chain;B is a chemical compound covalently bound to a functional group of the side chain of A, chosen from the group consisting of (a) oligopeptides having a chain length of up to 20 amino acids, (b) homopolymers of glycine consisting of up to 6 glycine monomers, and (c) polyethylene glycols having molar masses of up to 20 000 g/mol; and C is a group amide-bonded to A chosen from the group consisting of thiazolidine, pyrrolidine, cyanopyrrolidine, hydroxyproline, dehydroproline or piperidine.
    Type: Application
    Filed: February 22, 2002
    Publication date: May 15, 2003
    Applicant: probiodrug AG
    Inventors: Hans-Ulrich Demuth , Torsten Hoffmann , Dagmar Schlenzig , Ulrich Heiser
  • Method of treatment and/or prevention of brain, spinal or nerve injury
    Publication number: 20030083345
    Abstract: The invention relates to a method of treatment and/or prevention of brain, spinal or nerve injury comprising administration to a person in need of such treatment, of a therapeutically effective amount of an NK-1 receptor antagonist compound of the formula 1
    Type: Application
    Filed: July 2, 2002
    Publication date: May 1, 2003
    Inventors: Torsten Hoffmann, Alan Nimmo, Andrew Sleight, Pierre Vankan, Robert Vink
  • Biphenyl derivatives
    Patent number: 6552088
    Abstract: Biphenyl substituted amides with activity as antagonists of the neurokinin 1 (NK-1, substance P) receptor.
    Type: Grant
    Filed: June 21, 2001
    Date of Patent: April 22, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Michael Bös, Guido Galley, Thierry Godel, Torsten Hoffmann, Walter Hunkeler, Patrick Schnider, Heinz Stadler
  • Aromatic and heteroaromatic substituted amides
    Publication number: 20030064983
    Abstract: The invention is the compounds
    Type: Application
    Filed: July 17, 2002
    Publication date: April 3, 2003
    Inventors: Theresa Maria Ballard, Torsten Hoffmann, Sonia Maria Poli, Patrick Schnider, Andrew Sleight
  • D-proline derivatives
    Patent number: 6512001
    Abstract: New compounds have the formula: wherein R, R1, X and Y have the meanings described herein. Methods are set forth for synthesizing these compounds and using these compounds to treat diseases associated with amyloidosis, such as Alzheimer's disease, maturity onset diabetes mellitus, familial amyloid polyneuropathy, scrapie, and Kreuzfeld-Jacob disease.
    Type: Grant
    Filed: August 10, 2000
    Date of Patent: January 28, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Cornelia Hertel, Torsten Hoffmann, Roland Jakob-Roetne, Roger David Norcross
  • Use of NK-1 receptor antagonists against benign prostatic hyperplasia
    Publication number: 20030004157
    Abstract: The invention relates to the use of an NK-1 receptor antagonist for the treatment or prevention of benign prostatic hyperplasia (BPH).
    Type: Application
    Filed: February 8, 2002
    Publication date: January 2, 2003
    Inventors: Susanne Buser, Anthony P.D.W. Ford, Torsten Hoffmann, Barbara Lenz, Andrew John Sleight, Pierre Vankan
  • Substituted heterocyclic siprodecane compound active as an antagonist of neurokinin 1 receptor
    Patent number: 6482829
    Abstract: The invention relates to compounds of the formula as described herein and pharmaceutically acceptable acid addition salts thereof. The described compounds have a good affinity to the NK1 receptor.
    Type: Grant
    Filed: May 21, 2001
    Date of Patent: November 19, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Guido Galley, Thierry Godel, Annick Goergler, Torsten Hoffmann, Sabine Kolczewski, Stephan Roever
  • 4-phenyl-pyridine derivatives
    Patent number: 6479483
    Abstract: Compounds of the present invention are 4-phenyl-pyridine derivatives with activity as NK-1 receptor antagonists.
    Type: Grant
    Filed: July 10, 2001
    Date of Patent: November 12, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Michael Bös, Quirico Branca, Guido Galley, Thierry Godel, Torsten Hoffmann, Walter Hunkeler, Patrick Schnider, Heinz Stadler
  • New effectors of dipeptidyl peptidase IV for topical use
    Publication number: 20020165164
    Abstract: The invention relates to compounds for topically influencing the activity of dipeptidyl peptidase of the general formula 1
    Type: Application
    Filed: February 22, 2002
    Publication date: November 7, 2002
    Inventors: Hans-Ulrich Demuth, Torsten Hoffmann, Dagmar Schlenzig, Ulrich Heiser
  • Phenyl substituted pyridine and benzene derivatives
    Publication number: 20020111367
    Abstract: The present invention is a series of compounds formed from phenyl substituted pyridine or benzene derivatives and their pharmaceutically acceptable salts. These compounds have shown high affinity as antagonists to the NK-1 receptor.
    Type: Application
    Filed: January 17, 2002
    Publication date: August 15, 2002
    Inventors: Michael Bos, Guido Galley, Thierry Godel, Torsten Hoffmann, Walter Hunkeler, Patrick Schnider, Heinz Stadler
  • 4-phenyl-pyridine derivatives
    Publication number: 20020091265
    Abstract: The present invention relates to compounds of the general formula 1
    Type: Application
    Filed: July 10, 2001
    Publication date: July 11, 2002
    Inventors: Michael Bos, Quirico Branca, Guido Galley, Thierry Godel, Torsten Hoffmann, Walter Hunkeler, Patrick Schnider, Heinz Stadler
  • Phenyl substituted pyridine and benzene derivatives
    Patent number: 6407111
    Abstract: The present invention is a series of compounds formed from phenyl substituted pyridine or benzene derivatives and their pharmaceutically acceptable salts. These compounds have shown high affinity as antagonists to the NK-1 receptor.
    Type: Grant
    Filed: February 16, 2000
    Date of Patent: June 18, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Michael Bös, Guido Galley, Thierry Godel, Torsten Hoffmann, Walter Hunkeler, Patrick Schnider, Heinz Stadler
  • Method for raising the blood glucose level in mammals
    Publication number: 20020071838
    Abstract: The invention comprises the use of activity-reducing effectors of dipeptidyl peptidase (DP IV) and DP IV-analogous enzyme activity in the blood of a mammal to raise the blood sugar level in mammalian organisms.
    Type: Application
    Filed: November 2, 2001
    Publication date: June 13, 2002
    Inventors: Hans-Ulrich Demuth, Torsten Hoffmann, Kerstin Kuhn-Wache, Fred Rosche
  • Prodrugs of DP IV-inhibitors
    Publication number: 20020049164
    Abstract: The present invention relates to prodrug compounds of inhibitors of dipeptidyl peptidase IV (DP IV), which prodrug compounds have the general formula A-B-C, wherein
    Type: Application
    Filed: December 22, 2000
    Publication date: April 25, 2002
    Inventors: Hans-Ulrich Demuth, Dagmar Schlenzig, Torsten Hoffmann, Susanne Manhart
  • NK-1 receptor active amine oxide prodrugs
    Publication number: 20020045642
    Abstract: Compounds of the invention are amine oxide prodrugs showing activity on the NK1 receptor.
    Type: Application
    Filed: July 12, 2001
    Publication date: April 18, 2002
    Inventors: Torsten Hoffmann, Sonia M. Poli, Patrick Schnider, Andrew Sleight
  • Substituted 4-phenyl-pyridine compounds with activity as antagonists of neurokinin 1 receptors
    Publication number: 20020040040
    Abstract: Substituted 4-phenyl-pyridine compounds with activity as antagonists of Neurokinin 1 receptors, methods of making these compounds and preparing.
    Type: Application
    Filed: August 3, 2001
    Publication date: April 4, 2002
    Inventors: Thierry Godel, Torsten Hoffmann, Patrick Schnider, Heinz Stadler