Patents by Inventor Toshiaki Banzai

Toshiaki Banzai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8992958
    Abstract: There is provided an ultrasonic cancer treatment enhancer and cell killer that can significantly improve the effect of treating cancer by ultrasonic irradiation while ensuring a high level of safety. The ultrasonic cancer treatment enhancer and cell killer comprise metal semiconductor particles and can be activated upon ultrasonic irradiation to kill or destruct cancer cells.
    Type: Grant
    Filed: October 26, 2006
    Date of Patent: March 31, 2015
    Assignee: Toto Ltd.
    Inventors: Koki Kanehira, Shuji Sonezaki, Yumi Ogami, Toshiaki Banzai
  • Patent number: 8431143
    Abstract: A titanium dioxide composite is provided that can be stably dispersed in an aqueous solvent and easily administered into a living body, such as human, and allows elimination of the drug efficacy of a pharmaceutical compound supported thereon by light irradiation and a dispersion thereof. A composite is used in which a pharmaceutical compound is bound to titanium dioxide having photocatalytic activity through a hydrophilic polymer. The composite is stable in an aqueous solvent and easily administered into a living body, and adverse drug reactions of the pharmaceutical compound can be reduced by administering the composite into the body and irradiating the composite with a light to photoexcite the titanium dioxide to decompose the pharmaceutical compound in a region where the drug efficacy of the pharmaceutical composition is not required.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: April 30, 2013
    Assignee: Toto Ltd.
    Inventors: Shuji Sonezaki, Koki Kanehira, Yumi Ogami, Toshiaki Banzai, Yoshinobu Kubota
  • Patent number: 8071332
    Abstract: The present invention relates to a method of expressing an objective protein at a high level and stably as well as for a long period even in the absence of a selection drug with a recombinant mammal cell. More particularly, the present invention relates to a method of producing an objective protein by providing a recombinant mammal cell having multiple copies of the exogenous objective protein gene expression unit integrated into a hypoxanthine-phosphoribosyl transferase enzyme (hprt) gene locus and culturing said cell.
    Type: Grant
    Filed: August 8, 2008
    Date of Patent: December 6, 2011
    Assignee: Toto Ltd.
    Inventors: Toshiaki Banzai, Yukiko Koyama, Shuji Sonezaki
  • Publication number: 20110137235
    Abstract: Provided is an ultrasonic cancer therapy accelerator comprising titanium oxide-metal complex particles showing a long-lasting antitumor effect imparted thereto while sustaining the dispersibility and catalytic activity thereof which are obtained by dispersing titanium oxide-metal complex particles in an aqueous solvent with the use of a water-soluble polymer and modifying the same with molecules containing a low-valent transition metal via linker molecules having been bound thereto without denaturing the water-soluble polymer. To the titanium oxide surface of titanium oxide-metal complex particles which have been dispersed in an aqueous solvent with the use of a water-soluble polymer, linker molecules are bound via at least one functional group selected from the group consisting of carboxyl, amino, diol, salicylate and phosphate groups followed by the modification with low-valent transition metal-containing molecules via the linker molecules.
    Type: Application
    Filed: August 7, 2009
    Publication date: June 9, 2011
    Applicant: TOTO Ltd.
    Inventors: Koki Kanehira, Shuji Sonezaki, Yumi Ogami, Toshiaki Banzai, Tomomi Nakamura
  • Publication number: 20110060269
    Abstract: Photocatalytic titanium dioxide particles are disclosed having improved dispersibility into an aqueous solvent not only under neutral physiological conditions in vivo but also over a wide pH range, and improved cell affinity and cell uptake property. The photocatalytic titanium dioxide particles comprise particles comprising photocatalytic titanium dioxide and a cationic hydrophilic polymer modifying surfaces of the photocatalytic titanium dioxide particles, wherein the hydrophilic polymer is bonded to the photocatalytic titanium dioxide particles. The particles are very useful for medical applications, such as destruction of cancer cells, e.g., when administered to a mammal the titanium dioxide particles are taken up by cells of the mammal, and if then irradiated with UV light the particles kill the cells via photocatalytic degrading capability.
    Type: Application
    Filed: November 10, 2010
    Publication date: March 10, 2011
    Applicant: TOTO LTD.
    Inventors: Koki KANEHIRA, Shuji SONEZAKI, Yumi OGAMI, Toshiaki BANZAI, Junji KAMESHIMA
  • Publication number: 20110014245
    Abstract: A titanium dioxide composite is provided that can be stably dispersed in an aqueous solvent and easily administered into a living body, such as human, and allows elimination of the drug efficacy of a pharmaceutical compound supported thereon by light irradiation and a dispersion thereof. A composite is used in which a pharmaceutical compound is bound to titanium dioxide having photocatalytic activity through a hydrophilic polymer. The composite is stable in an aqueous solvent and easily administered into a living body, and adverse drug reactions of the pharmaceutical compound can be reduced by administering the composite into the body and irradiating the composite with a light to photoexcite the titanium dioxide to decompose the pharmaceutical compound in a region where the drug efficacy of the pharmaceutical composition is not required.
    Type: Application
    Filed: September 24, 2010
    Publication date: January 20, 2011
    Applicant: TOTO LTD.
    Inventors: Shuji SONEZAKI, Koki KANEHIRA, Yumi OGAMI, Toshiaki BANZAI, Yoshinobu KUBOTA
  • Publication number: 20100136115
    Abstract: Disclosed is a titanium dioxide composite material which can be dispersed in an aqueous solvent stably and can be administered to a living body in a simple manner and in which the pharmacological effect of a therapeutic compound carried on the composite material can be eliminated by irradiation with light. Also disclosed is a dispersion product of the composite material. The composite material comprises titanium dioxide which has a photocatalytic activity and a therapeutic compound attached to the titanium dioxide through a hydrophilic polymer. The composite material is stable in an aqueous solvent and can be administered to a living body in a simple manner.
    Type: Application
    Filed: August 4, 2006
    Publication date: June 3, 2010
    Applicant: Toto Ltd.
    Inventors: Shuji Sonezaki, Koki Kanehira, Yumi Ogami, Toshiaki Banzai, Yoshinobu Kubota
  • Publication number: 20090297620
    Abstract: Titanium oxide-antibody conjugated particles are disclosed, which are provided with selective binding ability without loss of dispersibility and catalytic activity by modifying titanium oxide conjugated particles, dispersed in a water-based solvent by a water-soluble polymer, with an antibody via a linker molecule bound without changing the nature of the water-soluble polymer. The present invention is an antitumor agent, comprising titanium oxide-antibody conjugated particles, wherein a linker molecule is bound to the titanium oxide surface of the titanium oxide conjugated particles, dispersed in a water-based solvent by a water-soluble polymer, via at least one functional group selected from a group consisting of a carboxyl group, an amino group, a diol group, a salicylic acid group, and a phosphoric acid group, and wherein the titanium oxide conjugated particles are further modified with an antibody via the linker molecule.
    Type: Application
    Filed: April 7, 2009
    Publication date: December 3, 2009
    Applicant: Toto Ltd.
    Inventors: Koki Kanehira, Shuji Sonezaki, Yumi Ogami, Tomomi Nakamura, Toshiaki Banzai
  • Publication number: 20090117615
    Abstract: The present invention relates to a method of expressing an objective protein at a high level and stably as well as for a long period even in the absence of a selection drug with a recombinant mammal cell. More particularly, the present invention relates to a method of producing an objective protein by providing a recombinant mammal cell having multiple copies of the exogenous objective protein gene expression unit integrated into a hypoxanthine-phosphoribosyl transferase enzyme (hprt) gene locus and culturing said cell.
    Type: Application
    Filed: August 8, 2008
    Publication date: May 7, 2009
    Inventors: Toshiaki Banzai, Yukiko Koyama, Shuji Sonezaki
  • Publication number: 20080262349
    Abstract: There is provided an ultrasonic cancer treatment enhancer and cell killer that can significantly improve the effect of treating cancer by ultrasonic irradiation while ensuring a high level of safety. The ultrasonic cancer treatment enhancer and cell killer comprise metal semiconductor particles and can be activated upon ultrasonic irradiation to kill or destruct cancer cells.
    Type: Application
    Filed: October 26, 2006
    Publication date: October 23, 2008
    Applicant: TOTO LTD.
    Inventors: Koki Kanehira, Shuji Sonezaki, Yumi Ogami, Toshiaki Banzai
  • Publication number: 20080261805
    Abstract: Photocatalytic titanium dioxide particles are disclosed having improved dispersibility into an aqueous solvent not only under neutral physiological conditions in vivo but also over a wide pH range, and improved cell affinity and cell uptake property. The photocatalytic titanium dioxide particles comprise particles comprising photocatalytic titanium dioxide and a cationic hydrophilic polymer modifying surfaces of the photocatalytic titanium dioxide particles, wherein the hydrophilic polymer is bonded to the photocatalytic titanium dioxide particles. The photocatalytic titanium dioxide particles are very useful for medical applications, such as destruction of cancer cells.
    Type: Application
    Filed: March 27, 2006
    Publication date: October 23, 2008
    Applicant: TOTO LTD.
    Inventors: Koki Kanehira, Shuji Sonezaki, Yumi Ogami, Toshiaki Banzai, Junji Kameshima
  • Publication number: 20060264520
    Abstract: Surface-modified titanium dioxide particles which have a surface chemically modified with a hydrophilic polymer, wherein a carboxyl group of the hydrophilic polymer and titanium dioxide are bound through an ester bonding; and a method for producing the surface-modified titanium dioxide fine particles, which comprises mixing a dispersion comprising titanium dioxide fine particles having a particle size of 2 to 200 nm and a solution of a water-soluble polymer, heating the resultant mixture to a temperature of 80 to 220° C., to thereby bind both the components through an ester bonding, and removing an unbound water-soluble polymer, to purify the resuultant particles. The surface-modified titanium dioxide fine particles exhibit excellent dispersibility and stability in an aqueous solvent over a wide pH region including a neutral range.
    Type: Application
    Filed: March 31, 2004
    Publication date: November 23, 2006
    Inventors: Shuji Sonezaki, Toshiaki Banzai, Koki Kanehira, Shinichi Yagi, Yumi Ogami