Patents by Inventor Toshiaki Sunazuka
Toshiaki Sunazuka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230287009Abstract: Provided is a novel compound that has an excellent ?-lactamase inhibitory effect. More specifically, provided is a compound represented by formula (1a), (1b) or (11) having an excellent ?-lactamase inhibitory effect or a pharmaceutically acceptable salt thereof. By using this compound either in combination with a ?-lactam drug or alone, a useful preventive or therapeutic agent for bacterial infections is provided. Also provided are useful preventive or therapeutic agents for treating various diseases with the combined use of the aforesaid compound and ?-lactam drugs.Type: ApplicationFiled: April 28, 2023Publication date: September 14, 2023Applicants: Sumitomo Pharma Co., Ltd., THE KITASATO INSTITUTEInventors: Toshio KANAI, Sachiko KOIKE, Takayuki FUKAYA, Shunichiro UESUGI, Shingo MIZUSHIMA, Hitoshi SUDA, Yuki MIZUKAMI, Yohei IKUMA, Toshiaki SUNAZUKA, Yoshihiko NOGUCHI
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Patent number: 11702431Abstract: Provided is a novel compound that has an excellent ?-lactamase inhibitory effect. More specifically, provided is a compound represented by formula (1a), (1b) or (11) having an excellent ?-lactamase inhibitory effect or a pharmaceutically acceptable salt thereof. By using this compound either in combination with a ?-lactam drug or alone, a useful preventive or therapeutic agent for bacterial infections is provided. Also provided are useful preventive or therapeutic agents for treating various diseases with the combined use of the aforesaid compound and ?-lactam drugs.Type: GrantFiled: April 26, 2019Date of Patent: July 18, 2023Assignees: Sumitomo Pharma Co., Ltd., THE KITASATO INSTITUTEInventors: Toshio Kanai, Sachiko Koike, Takayuki Fukaya, Shunichiro Uesugi, Shingo Mizushima, Hitoshi Suda, Yuki Mizukami, Yohei Ikuma, Toshiaki Sunazuka, Yoshihiko Noguchi
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Patent number: 11066425Abstract: Provided is a novel compound that has an excellent ?-lactamase inhibitory effect. More specifically, provided is a compound represented by formula (1a), (1b) or (11) having an excellent ?-lactamase inhibitory effect or a pharmaceutically acceptable salt thereof. By using this compound either in combination with a ?-lactam drug or alone, a useful preventive or therapeutic agent for bacterial infections is provided. Also provided are useful preventive or therapeutic agents for treating various diseases with the combined use of the aforesaid compound and ?-lactam drugs.Type: GrantFiled: December 29, 2020Date of Patent: July 20, 2021Assignees: SUMITOMO DAINIPPON PHARMA CO., LTD., THE KITASATO INSTITUTEInventors: Toshio Kanai, Sachiko Koike, Takayuki Fukaya, Shunichiro Uesugi, Shingo Mizushima, Hitoshi Suda, Yuki Mizukami, Yohei Ikuma, Toshiaki Sunazuka, Yoshihiko Noguchi
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Publication number: 20210147448Abstract: Provided is a novel compound that has an excellent ?-lactamase inhibitory effect. More specifically, provided is a compound represented by formula (1a), (1b) or (11) having an excellent ?-lactamase inhibitory effect or a pharmaceutically acceptable salt thereof. By using this compound either in combination with a ?-lactam drug or alone, a useful preventive or therapeutic agent for bacterial infections is provided. Also provided are useful preventive or therapeutic agents for treating various diseases with the combined use of the aforesaid compound and ?-lactam drugs.Type: ApplicationFiled: April 26, 2019Publication date: May 20, 2021Applicants: SUMITOMO DAINIPPON PHARMA CO., LTD., THE KITASATO INSTITUTEInventors: Toshio KANAI, Sachiko KOIKE, Takayuki FUKAYA, Shunichiro UESUGI, Shingo MIZUSHIMA, Hitoshi SUDA, Yuki MIZUKAMI, Yohei IKUMA, Toshiaki SUNAZUKA, Yoshihiko NOGUCHI
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Publication number: 20210130315Abstract: The present invention relates to a method for the synthesis of cyclic depsipeptides, in particular emodepside, from the open form.Type: ApplicationFiled: November 6, 2018Publication date: May 6, 2021Applicants: Bayer Animal Health GmbH, THE KITASATO INSTITUTEInventors: Dirk HEIMBACH, Satoshi OMURA, Toshiaki SUNAZUKA, Tomoyasu HIROSE, Yoshihiko NOGUCHI, Johannes KÖBBERLING, Zhijie WU, Shuibiao FU, Wei WU, Jinfeng QIU, Liu HE, Xudong WEI
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Patent number: 9771389Abstract: The present invention relates to new macrolide derivatives, in particular new tylosin derivatives of the formula (IIa), a pharmaceutical or veterinary composition comprising the derivatives; a method for preparation thereof; a method for treating and/or preventing bacterial infections in an animal, wherein the method comprises administering the derivatives or the composition; and a use of the derivatives for the manufacture of medicaments for treating and/or preventing bacterial infections in an animal.Type: GrantFiled: May 23, 2014Date of Patent: September 26, 2017Assignees: THE KITASAKO INSTITUTE, BAYER ANIMAL HEALTH GMBHInventors: Gerd Kleefeld, Robrecht Froyman, Carolin Ludwig, Satoshi Omura, Toshiaki Sunazuka, Hirose Tomoyasu, Sugawara Akihiro, Shiomi Kazuro
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Publication number: 20170215422Abstract: An objective of the present invention is to provide novel cyclic depsipeptide derivatives and harmful organism control agents including the same as each other. Specifically, the present invention provides compounds represented by formula (1) or stereoisomers thereof, harmful organism control agents containing them, and a process for producing them.Type: ApplicationFiled: April 17, 2017Publication date: August 3, 2017Inventors: Masaaki MITOMI, Masayo SAKAI, Ryo HORIKOSHI, Yasumichi ONOZAKI, Satoshi NAKAMURA, Satoshi OMURA, Toshiaki SUNAZUKA, Tomoyasu HIROSE, Kazuro SHIOMI, Rokuro MASUMA
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Publication number: 20160108077Abstract: The present invention relates to new macrolide derivatives, in particular new tylosin derivatives of the formula (IIa), a pharmaceutical or veterinary composition comprising the derivatives; a method for preparation thereof; a method for treating and/or preventing bacterial infections in an animal, wherein the method comprises administering the derivatives or the composition; and a use of the derivatives for the manufacture of medicaments for treating and/or preventing bacterial infections in an animal.Type: ApplicationFiled: May 23, 2014Publication date: April 21, 2016Applicants: THE KITASAKO INSTITUTE, BAYER ANIMAL HEALTH GMBHInventors: Gerd KLEEFELD, Robrecht FROYMAN, Carolin LUDWIG, Satoshi OMURA, Toshiaki SUNAZUKA, Hirose TOMOYASU, Sugawara AKIHIRO, Shiomi KAZURO
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Publication number: 20150344404Abstract: The present invention to provide a novel pyruvate dehydrogenase kinase inhibitors. A pyruvate dehydrogenase kinase inhibitor comprising a compound represented by the general formula (I) as an active ingredient (wherein, ring A represents a 6-membered aromatic hydrocarbon ring optionally substituted with 2-4 substituents, R1 and R4, which are the same or different, represent a hydrogen atom, a hydroxyl group, an optionally substituted C1-6 alkyl group, R2 and R3, which are the same or different, represent a hydrogen atom, a carboxyl group, an optionally substituted C1-6 alkyl group, an optionally substituted C6-10 aryl group, or a group represented by —C (?R9)—R10), a pharmaceutical composition for treatment or prophylaxis of diseases or disorders that pyruvate dehydrogenase kinase relates to its development or aggravation, and a cosmetic composition, and the like.Type: ApplicationFiled: December 26, 2013Publication date: December 3, 2015Inventors: Satoshi OMURA, Hirofumi NAKANO, Kenzaburo YAMAJI, Tsuyoshi YAMAMOTO, Hiroshi KIDO, Kazuhiko YAMANE, Toshiaki SUNAZUKA, Tomoyasu HIROSE
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Publication number: 20150166608Abstract: An objective of the present invention is to provide novel cyclic depsipeptide derivatives and harmful organism control agents including the same as each other. Specifically, the present invention provides compounds represented by formula (1) or stereoisomers thereof, harmful organism control agents containing them, and a process for producing them.Type: ApplicationFiled: June 13, 2013Publication date: June 18, 2015Inventors: Masaaki Mitomi, Masayo Sakai, Ryo Horikoshi, Yasumichi Onozaki, Satoshi Nakamura, Satoshi Omura, Toshiaki Sunazuka, Tomoyasu Hirose, Kazuro Shiomi, Rokuro Masuma
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Patent number: 8822501Abstract: Disclosed is a composition for use as a pest control agent, comprising a compound represented by formula (I) or an agriculturally and horticulturally acceptable salt thereof as active ingredient and an agriculturally and horticulturally acceptable carrier:Type: GrantFiled: January 3, 2013Date of Patent: September 2, 2014Assignees: Meiji Seika Pharma Co., Ltd., The Kitasato InstituteInventors: Kimihiko Goto, Ryo Horikoshi, Mariko Tsuchida, Kazuhiko Oyama, Satoshi Omura, Hiroshi Tomoda, Toshiaki Sunazuka
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Publication number: 20130131091Abstract: The present invention provides a composition for use as a harmful organism control agent comprising as an active ingredient one or more of compounds represented by formula (I) or salts thereof and an agriculturally or zootechnically acceptable carrier. wherein Het represents pyridyl; X represents an oxygen atom; R1, R2, R3, R7, R10a, R10b, R11, and R12 represent a hydrogen atom; R4, R5, and R6 represent a hydrogen atom, hydroxyl, optionally substituted C1-18 alkylcarbonyloxy, optionally substituted C1-18 alkylsulfonyloxy, optionally substituted arylcarbonyloxy, C1-6 alkyloxy-C1-6 alkyloxy, C1-6 alkyloxy-C1-6 alkyloxy-C1-6 alkyloxy; R8 represents a hydrogen atom; and R13a, R13b, and R13c represent methyl.Type: ApplicationFiled: May 23, 2011Publication date: May 23, 2013Inventors: Kimihiko Goto, Ryo Horikoshi, Kazuhiko Oyama, Yoshimasa Fukuda, Nozomu Nakanishi, Masato Tani, Nobuto Minowa, Masaaki Mitomi, Satoshi Omura, Toshiaki Sunazuka, Hiroshi Tomoda
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Patent number: 8367707Abstract: Disclosed is a composition for use as a pest control agent, comprising a compound represented by formula (I) or an agriculturally and horticulturally acceptable salt thereof as active ingredient and an agriculturally and horticulturally acceptable carrier:Type: GrantFiled: October 13, 2010Date of Patent: February 5, 2013Assignees: Meiji Seika Pharma Co., Ltd., The Kitasato InstituteInventors: Kimihiko Goto, Ryo Horikoshi, Mariko Tsuchida, Kazuhiko Oyama, Satoshi Omura, Hiroshi Tomoda, Toshiaki Sunazuka
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Patent number: 8202890Abstract: Disclosed is a compound usable as a pest control agent and has excellent pest control activity. A compound represented by formula (I) has excellent pest control activity. The compound or an agriculturally or horticulturally acceptable salt thereof is thus useful as a pest control agent.Type: GrantFiled: November 30, 2007Date of Patent: June 19, 2012Assignees: Meiji Seika Pharma Co., Ltd., The Kitasato InstituteInventors: Kimihiko Goto, Ryo Horikoshi, Kazuhiko Oyama, Satoshi Omura, Toshiaki Sunazuka
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Patent number: 8133871Abstract: A compound represented by the formula [I] wherein each symbol is as defined in the specification or a pharmacologically acceptable salt thereof, and a pharmaceutical composition containing the compound as an active ingredient.Type: GrantFiled: October 13, 2006Date of Patent: March 13, 2012Assignees: The Kitasato Institute, Aphoenix, Inc.Inventors: Satoshi Omura, Toshiaki Sunazuka, Kenichiro Nagai, Hideaki Shima, Haruko Yamabe
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Publication number: 20110195998Abstract: Disclosed is a compound usable as a pest control agent and has excellent pest control activity. A compound represented by formula (I) has excellent pest control activity. The compound or an agriculturally or horticulturally acceptable salt thereof is thus useful as a pest control agent.Type: ApplicationFiled: November 30, 2007Publication date: August 11, 2011Inventors: Kimihiko Goto, Ryo Horikoshi, Kazuhiko Oyama, Satoshi Omura, Toshiaki Sunazuka
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Publication number: 20110034404Abstract: Disclosed is a composition for use as a pest control agent, comprising a compound represented by formula (I) or an agriculturally and horticulturally acceptable salt thereof as active ingredient and an agriculturally and horticulturally acceptable carrier:Type: ApplicationFiled: October 13, 2010Publication date: February 10, 2011Inventors: Kimihiko GOTO, Ryo Horikoshi, Mariko Tsuchida, Kazuhiko Oyama, Satoshi Omura, Hiroshi Tomoda, Toshiaki Sunazuka
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Patent number: 7838538Abstract: Disclosed is a composition for use as a pest control agent, comprising a compound represented by formula (I) or an agriculturally and horticulturally acceptable salt thereof as active ingredient and an agriculturally and horticulturally acceptable carrier:Type: GrantFiled: December 23, 2008Date of Patent: November 23, 2010Assignees: Meiji Seika Kaisha, Ltd., The Kitasato InstituteInventors: Kimihiko Goto, Ryo Horikoshi, Mariko Tsuchida, Kazuhiko Oyama, Satoshi Omura, Hiroshi Tomoda, Toshiaki Sunazuka
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Patent number: 7560484Abstract: The present invention provides an adjuvant that is a hydroxy unsaturated fatty acid or a derivative thereof, as well as a vaccine preparation containing the adjuvant as a constituent.Type: GrantFiled: August 28, 2001Date of Patent: July 14, 2009Assignee: The Kitasato InstituteInventors: Haruki Yamada, Hiroaki Kiyohara, Takayuki Nagai, Toshiaki Sunazuka
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Publication number: 20090137634Abstract: Disclosed is a composition for use as a pest control agent, comprising a compound represented by formula (I) or an agriculturally and horticulturally acceptable salt thereof as active ingredient and an agriculturally and horticulturally acceptable carrier:Type: ApplicationFiled: December 23, 2008Publication date: May 28, 2009Inventors: Kimihiko Goto, Ryo Horikoshi, Mariko Tsuchida, Kazuhiko Oyama, Satoshi Omura, Hiroshi Tomoda, Toshiaki Sunazuka