Patents by Inventor Toshihide Takeuchi

Toshihide Takeuchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antisense oligonucleotide controlling expression amount of TDP-43 and use thereof
    Patent number: 11028390
    Abstract: The present invention provides a suppression type antisense oligonucleotide targeting TDP-43 mRNA, containing a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a nucleotide sequence shown in any of SEQ ID NOs: 2-4, and a promotion type antisense oligonucleotide targeting TDP-43 mRNA, containing a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a nucleotide sequence shown in SEQ ID NO: 5.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: June 8, 2021
    Assignees: Osaka University, KNC Laboratories Co., Ltd., Aichi Medical University
    Inventors: Yoshitaka Nagai, Kazuhiro Maeta, Toshihide Takeuchi, Masahiro Neya, Tsuyoshi Fujihara, Seiji Matsuda, Gen Sobue, Shinsuke Ishigaki, Kentaro Sahashi
  • ANTISENSE OLIGONUCLEOTIDE CONTROLLING EXPRESSION AMOUNT OF TDP-43 AND USE THEREOF
    Publication number: 20200165610
    Abstract: The present invention provides a suppression type antisense oligonucleotide targeting TDP-43 mRNA, containing a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a nucleotide sequence shown in any of SEQ ID NOs: 2-4, and a promotion type antisense oligonucleotide targeting TDP-43 mRNA, containing a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a nucleotide sequence shown in SEQ ID NO: 5.
    Type: Application
    Filed: July 6, 2018
    Publication date: May 28, 2020
    Applicants: OSAKA UNIVERSITY, KNC LABORATORIES CO., LTD., NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
    Inventors: Yoshitaka NAGAI, Kazuhiro MAETA, Toshihide TAKEUCHI, Masahiro NEYA, Tsuyoshi FUJIHARA, Seiji MATSUDA, Gen SOBUE, Shinsuke ISHIGAKI, Kentaro SAHASHI
  • Method of manufacturing a corrugated plate by rolling for use as an inner fin of a heat exchanger
    Patent number: 6138354
    Abstract: A metallic corrugated plate applying to a cooling inner fin of a heat exchanger, wherein a bending angle .THETA. of an end bent ridge portion is smaller than bending angle .theta. of the other bent ridge portions. Thus, in case the bending angle .THETA. becomes large by a resilient force after forming the bent ridge portions, preventing a bending rigidity of the end bent ridge portion in the spreading direction from being reduced is possible. Accordingly, preventing the inner fin from being warped from substantially the center ridge of the bent ridge portion is attained.
    Type: Grant
    Filed: June 7, 1999
    Date of Patent: October 31, 2000
    Assignee: DENSO Corporation
    Inventors: Hisashi Kobayashi, Yasuo Abe, Toshihide Takeuchi